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Long non‑coding RNA CCAT1 enhances human non‑small cell lung cancer growth through downregulation of microRNA‑218

  • Authors:
    • Lijiang Zhao
    • Limin Wang
    • Yongfeng Wang
    • Ping Ma
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Linyi Central Hospital, Linyi, Shandong 276400, P.R. China, Department of Respiratory Medicine, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei 063000, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1045-1052
    |
    Published online on: February 12, 2020
       https://doi.org/10.3892/or.2020.7500
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Abstract

Long non‑coding RNAs (lncRNAs) have critical functions in non‑small cell lung cancer (NSCLC) growth. In the present study, we showed that lncRNA‑CCAT1 was upregulated in NSCLC tissues. High expression of lncRNA‑CCAT1 was related to tumor growth and reduced survival rate. We used short hairpin RNAs (shRNAs) to inhibit the expression of lncRNA‑CCAT1 in NSCLC cells. In vitro and in vivo results demonstrated that lncRNA‑CCAT1 knockdown suppressed tumor proliferation and induced apoptosis. Furthermore, microRNA‑218 (miR‑218) was confirmed as an effective target of lncRNA‑CCAT1 in NSCLC. B lymphoma Mo‑MLV insertion region 1 homolog (BMI‑1), which served as a downstream target of miR‑218, was also inhibited by lncRNA‑CCAT1 knockdown. In conclusion, the present study indicated that upregulation of lncRNA‑CCAT1 in NSCLC is associated with tumor malignant potential. lncRNA‑CCAT1 enhances tumor growth in NSCLC by directly inhibiting miR‑218 and indirectly increasing BMI‑1 expression.
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1 

Yu Y, Guan H, Xing LG and Xiang YB: Role of gross tumor volume in the prognosis of non-small cell lung cancer treated with 3D conformal radiotherapy: a meta-analysis. Clin Ther. 37:2256–2266. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Daga A, Ansari A, Patel S, Mirza S, Rawal R and Umrania V: Current drugs and drug targets in non-small cell lung cancer: limitations and opportunities. Asian Pac J Cancer Prev. 16:4147–4156. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Schmitt AM and Chang HY: Long non-coding RNAs in cancer pathways. Cancer Cell. 29:452–463. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Tang Y, He R, An J, Deng P, Huang L and Yang W: lncRNA XIST interacts with miR-140 to modulate lung cancer growth by targeting iASPP. Oncol Rep. 38:941–948. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Chen W, Zhu H, Yin L, Wang T, Wu J, Xu J, Tao H, Liu J and He X: lncRNA-PVT1 facilitates invasion through upregulation of MMP9 in nonsmall cell lung cancer cell. DNA Cell Biol. 36:787–793. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Castellano JJ, Navarro A, Viñolas N, Marrades RM, Moises J, Cordeiro A, Saco A, Muñoz C, Fuster D, Molins L, et al: LincRNA-p21 impacts prognosis in resected non-small cell lung cancer patients through angiogenesis regulation. J Thorac Oncol. 11:2173–2182. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Guo X and Hua Y: CCAT1: an oncogenic long non-coding RNA in human cancers. J Cancer Res Clin Oncol. 143:555–562. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Zhao J and Cheng L: Long non-coding RNA CCAT1/miR-148a axis promotes osteosarcoma proliferation and migration through regulating PIK3IP1. Acta Biochim Biophys Sin. 49:503–512. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Chen S, Ma P, Li B, Zhu D, Chen X, Xiang Y, Wang T, Ren X, Liu C and Jin X: LncRNA CCAT1 inhibits cell apoptosis of renal cell carcinoma through up-regulation of Livin protein. Mol Cell Biochem. May 3–2017.(Epub ahead of print). doi: 10.1007/s11010-017-3043-8. View Article : Google Scholar

10 

Arunkumar G, Murugan AK, Prasanna Srinivasa Rao H, Subbiah S, Rajaraman R and Munirajan AK: Long non-coding RNA CCAT1 is overexpressed in oral squamous cell carcinomas and predicts poor prognosis. Biomed Rep. 6:455–462. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Li C, Miao R, Liu S, Wan Y, Zhang S, Deng Y, Bi J, Qu K, Zhang J and Liu C: Down-regulation of miR-146b-5p by long non-coding RNA MALAT1 in hepatocellular carcinoma promotes cancer growth and metastasis. Oncotarget. 8:28683–28695. 2017.PubMed/NCBI

13 

Sanchez-Palencia A, Gomez-Morales M, Gomez-Capilla JA, Pedraza V, Boyero L, Rosell R and Fárez-Vidal ME: Gene expression profiling reveals novel biomarkers in nonsmall cell lung cancer. Int J Cancer. 129:355–364. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Feng J, Sun Y, Zhang EB, Lu XY, Jin SD and Guo RH: A novel long non-coding RNA IRAIN regulates cell proliferation in non small cell lung cancer. Int J Clin Exp Pathol. 8:12268–12275. 2015.PubMed/NCBI

15 

Cheng N, Li X, Zhao C, Ren S, Chen X, Cai W, Zhao M, Zhang Y, Li J, Wang Q, et al: Microarray expression profile of long non-coding RNAs in EGFR-TKIs resistance of human non-small cell lung cancer. Oncol Rep. 33:833–839. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Lu KH, Li W, Liu XH, Sun M, Zhang ML, Wu WQ, Xie WP and Hou YY: Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression. BMC Cancer. 13:4612013. View Article : Google Scholar : PubMed/NCBI

17 

Su L, Han D, Wu J and Huo X: Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163. Tumour Biol. 37:3925–3931. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Nie FQ, Sun M, Yang JS, Xie M, Xu TP, Xia R, Liu YW, Liu XH, Zhang EB, Lu KH, et al: Long non-coding RNA ANRIL promotes non-small cell lung cancer cell proliferation and inhibits apoptosis by silencing KLF2 and P21 expression. Mol Cancer Ther. 14:268–277. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Zhang XF, Liu T, Li Y and Li S: Overexpression of long non-coding RNA CCAT1 is a novel biomarker of poor prognosis in patients with breast cancer. Int J Clin Exp Pathol. 8:9440–9445. 2015.PubMed/NCBI

20 

Yang F, Xue X, Bi J, Zheng L, Zhi K, Gu Y and Fang G: Long non-coding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma. J Cancer Res Clin Oncol. 139:437–445. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Liu SP, Yang JX, Cao DY and Shen K: Identification of differentially expressed long non-coding RNAs in human ovarian cancer cells with different metastatic potentials. Cancer Biol Med. 10:138–141. 2013.PubMed/NCBI

22 

Bischof O and Martínez-Zamudio RI: MicroRNAs and lncRNAs in senescence: A re-view. IUBMB Life. 67:255–267. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Deng L, Yang SB, Xu FF and Zhang JH: Long non-coding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge. J Exp Clin Cancer Res. 34:182015. View Article : Google Scholar : PubMed/NCBI

24 

Wang ZH, Guo XQ, Zhang QS, Zhang JL, Duan YL, Li GF and Zheng DL: Long non-coding RNA CCAT1 promotes glioma cell proliferation via inhibiting microRNA-410. Biochem Biophys Res Commun. 480:715–720. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Wang Q, Zhang W and Hao S: LncRNA CCAT1 modulates the sensitivity of paclitaxel in nasopharynx cancers cells via miR-181a/CPEB2 axis. Cell Cycle. 16:795–801. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Tu K, Li C, Zheng X, Yang W, Yao Y and Liu Q: Prognostic significance of miR-218 in human hepatocellular carcinoma and its role in cell growth. Oncol Rep. 32:1571–1577. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Cao L, Bombard J, Cintron K, Sheedy J, Weetall ML and Davis TW: BMI1 as a novel target for drug discovery in cancer. J Cell Biochem. 112:2729–2741. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Xiong D, Ye Y, Fu Y, Wang J, Kuang B, Wang H, Wang X, Zu L, Xiao G, Hao M, et al: Bmi-1 expression modulates non-small cell lung cancer progression. Cancer Biol Ther. 16:756–763. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Zhang X, Tian T, Sun W, Liu C and Fang X: Bmi-1 overexpression as an efficient prognostic marker in patients with nonsmall cell lung cancer. Medicine. 96:e73462017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao L, Wang L, Wang Y and Ma P: Long non‑coding RNA CCAT1 enhances human non‑small cell lung cancer growth through downregulation of microRNA‑218. Oncol Rep 43: 1045-1052, 2020.
APA
Zhao, L., Wang, L., Wang, Y., & Ma, P. (2020). Long non‑coding RNA CCAT1 enhances human non‑small cell lung cancer growth through downregulation of microRNA‑218. Oncology Reports, 43, 1045-1052. https://doi.org/10.3892/or.2020.7500
MLA
Zhao, L., Wang, L., Wang, Y., Ma, P."Long non‑coding RNA CCAT1 enhances human non‑small cell lung cancer growth through downregulation of microRNA‑218". Oncology Reports 43.4 (2020): 1045-1052.
Chicago
Zhao, L., Wang, L., Wang, Y., Ma, P."Long non‑coding RNA CCAT1 enhances human non‑small cell lung cancer growth through downregulation of microRNA‑218". Oncology Reports 43, no. 4 (2020): 1045-1052. https://doi.org/10.3892/or.2020.7500
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao L, Wang L, Wang Y and Ma P: Long non‑coding RNA CCAT1 enhances human non‑small cell lung cancer growth through downregulation of microRNA‑218. Oncol Rep 43: 1045-1052, 2020.
APA
Zhao, L., Wang, L., Wang, Y., & Ma, P. (2020). Long non‑coding RNA CCAT1 enhances human non‑small cell lung cancer growth through downregulation of microRNA‑218. Oncology Reports, 43, 1045-1052. https://doi.org/10.3892/or.2020.7500
MLA
Zhao, L., Wang, L., Wang, Y., Ma, P."Long non‑coding RNA CCAT1 enhances human non‑small cell lung cancer growth through downregulation of microRNA‑218". Oncology Reports 43.4 (2020): 1045-1052.
Chicago
Zhao, L., Wang, L., Wang, Y., Ma, P."Long non‑coding RNA CCAT1 enhances human non‑small cell lung cancer growth through downregulation of microRNA‑218". Oncology Reports 43, no. 4 (2020): 1045-1052. https://doi.org/10.3892/or.2020.7500
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