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Article

Role of glucose metabolism in the differential antileukemic effect of melatonin on wild‑type and FLT3‑ITD mutant cells

  • Authors:
    • Noelia Puente‑Moncada
    • Maria Turos‑Cabal
    • Ana M. Sánchez‑Sánchez
    • Isaac Antolín
    • Federico Herrera
    • Jezabel Rodriguez‑Blanco
    • Cristina Duarte‑Olivenza
    • Carmen Rodriguez
    • Vanesa Martín
  • View Affiliations / Copyright

    Affiliations: Departamento de Morfología y Biología Celular, Facultad de Medicina, University of Oviedo, 33006 Oviedo, Spain, Facultade de Ciencias, Biosystems and Integrative Sciences Institute, Universidade de Lisboa, 1749‑016 Lisbon, Portugal, Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
  • Pages: 293-302
    |
    Published online on: April 15, 2020
       https://doi.org/10.3892/or.2020.7584
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Abstract

The FMS‑like tyrosine kinase 3 internal tandem duplication (FLT3‑ITD) mutation represents the most frequent genetic alteration in acute myeloid leukemia (AML) and is associated with poor prognosis. The mutation promotes cancer cell survival and proliferation, and shifts their glucose metabolism towards aerobic glycolysis, a frequent alteration in cancer. In the present study, the impact of melatonin on the viability of AML cell lines with (MV‑4‑11 and MOLM‑13) or without the FLT3‑ITD mutation (OCI‑AML3 and U‑937) was evaluated. Melatonin induces cell death in AML cells carrying the FLT3‑ITD mutation, but only inhibits the proliferation of AML cells without this mutation. Consistently, melatonin decreases tumor growth and increases animal survival in a xenograft model of FLT3‑ITD AML. Toxicity is related to a decrease in glucose uptake, lactate dehydrogenase activity, lactate production and hypoxia‑inducible factor‑1α activation. Melatonin also regulates the expression of glucose metabolism‑related genes, impairing the balance between anaplerosis and cataplerosis, through the upregulation of the expression of phosphoenolpyruvate carboxykinase 2 (PCK2). Collectively, the present findings highlight the regulation of glucose metabolism, currently considered a possible therapeutic target in cancer, as a key event in melatonin‑induced cytotoxicity, suggesting its potential as a therapeutic tool for the treatment of patients with AML, particularly those carrying the FLT3‑ITD mutation that results in low basal expression levels of PCK2.
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View References

1 

Döhner H, Weisdorf DJ and Bloomfield CD: Acute myeloid leukemia. N Engl J Med. 373:1136–1152. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Patel JP, Gönen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J, Van Vlierberghe P, Dolgalev I, Thomas S, Aminova O, et al: Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med. 366:1079–1089. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Leung AY, Man CH and Kwong YL: FLT3 inhibition: A moving and evolving target in acute myeloid leukaemia. Leukemia. 27:260–268. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Huang A, Ju HQ, Liu K, Zhan G, Liu D, Wen S, Garcia-Manero G, Huang P and Hu Y: Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation. Cancer Lett. 377:149–157. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Ju HQ, Zhan G, Huang A, Sun Y, Wen S, Yang J, Lu WH, Xu RH, Li J, Li Y, et al: ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition. Leukemia. 31:2143–2150. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Chen WL, Wang JH, Zhao AH, Xu X, Wang YH, Chen TL, Li JM, Mi JQ, Zhu YM, Liu YF, et al: A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value. Blood. 124:1645–1654. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Favero G, Moretti E, Bonomini F, Reiter RJ, Rodella LF and Rezzani R: Promising. Antineoplastic Actions of Melatonin. Front Pharmacol. 9:10862018. View Article : Google Scholar : PubMed/NCBI

8 

Rodriguez C, Martín V, Herrera F, García-Santos G, Rodriguez-Blanco J, Casado-Zapico S, Sánchez-Sánchez AM, Suárez S, Puente-Moncada N, Anítua MJ and Antolín I: Mechanisms involved in the pro-apoptotic effect of melatonin in cancer cells. Int J Mol Sci. 14:6597–6613. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Chuffa LG, Lupi Júnior LA, Seiva FR, Martinez M, Domeniconi RF, Pinheiro PF, Dos Santos LD and Martinez FE: Quantitative proteomic profiling reveals that diverse metabolic pathways are influenced by melatonin in an in vivo model of ovarian carcinoma. J Proteome Res. 15:3872–3882. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Mao L, Dauchy RT, Blask DE, Dauchy EM, Slakey LM, Brimer S, Yuan L, Xiang S, Hauch A, Smith K, et al: Melatonin suppression of aerobic glycolysis (Warburg effect), survival signalling and metastasis in human leiomyosarcoma. J Pineal Res. 60:167–177. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Sanchez-Sanchez AM, Antolin I, Puente-Moncada N, Suarez S, Gomez-Lobo M, Rodriguez C and Martin V: Melatonin cytotoxicity is associated to Warburg effect inhibition in Ewing sarcoma cells. PLoS One. 10:e01354202015. View Article : Google Scholar : PubMed/NCBI

12 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Warburg O, Wind F and Negelein E: The metabolism of tumors in the body. J Gen Physiol. 8:519–530. 1927. View Article : Google Scholar : PubMed/NCBI

14 

Gunawardane RN, Nepomuceno RR, Rooks AM, Hunt JP, Ricono JM, Belli B and Armstrong RC: Transient exposure to quizartinib mediates sustained inhibition of FLT3 signaling while specifically inducing apoptosis in FLT3-activated leukemia cells. Mol Cancer Ther. 12:438–447. 2013. View Article : Google Scholar : PubMed/NCBI

15 

León J, Casado J, Jiménez Ruiz SM, Zurita MS, González-Puga C, Rejón JD, Gila A, Muñoz de Rueda P, Pavón EJ, Reiter RJ, et al: Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NF-κβ. J Pineal Res. 56:415–426. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Martin V, Herrra F, Carrera-Gonzalez P, García-Santos G, Antolín I, Rodriguez-Blanco J and Rodriguez C: Intracellular signaling pathways involved in the cell growth inhibition of glioma cells by melatonin. Cancer Res. 66:1081–1088. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Puente-Moncada N, Costales P, Antolín I, Núñez LE, Oro P, Hermosilla MA, Pérez-Escuredo J, Ríos-Lombardía N, Sanchez-Sanchez AM, Luño E, et al: Inhibition of FLT3 and PIM kinases by EC-70124 exerts potent activity in preclinical models of acute myeloid leukemia. Mol Cancer Ther. 17:614–624. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Stubbs M and Griffiths JR: The altered metabolism of tumors: HIF-1 and its role in the Warburg effect. Adv Enzyme Regul. 50:44–55. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Majmundar AJ, Wong WJ and Simon MC: Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell. 40:294–309. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Marini C, Ravera S, Buschiazzo A, Bianchi G, Orengo AM, Bruno S, Bottoni G, Emionite L, Pastorino F, Monteverde E, et al: Discovery of a novel glucose metabolism in cancer: The role of endoplasmic reticulum beyond glycolysis and pentose phosphate shunt. Sci Rep. 6:250922016. View Article : Google Scholar : PubMed/NCBI

21 

Rogoff D, Black K, McMillan DR and White PC: Contribution of hexose-6-phosphate dehydrogenase to NADPH content and redox environment in the endoplasmic reticulum. Redox Rep. 15:64–70. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Sánchez-Sánchez AM, Martín V, García-Santos G, Rodríguez-Blanco J, Casado-Zapico S, Suarez-Garnacho S, Antolín I and Rodriguez C: Intracellular redox state as determinant for melatonin antiproliferative vs. cytotoxic effects in cancer cells. Free Radic Res. 45:1333–1341. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Ambrus A: An updated view on the molecular pathomechanisms of human dihydrolipoamide dehydrogenase deficiency in light of novel crystallographic evidence. Neurochem Res. 44:2307–2313. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Owen OE, Kalhan SC and Hanson RW: The key role of anaplerosis and cataplerosis for citric acid cycle function. J Biol Chem. 277:30409–30412. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Montal ED, Dewi R, Bhalla K, Ou L, Hwang BJ, Ropell AE, Gordon C, Liu WJ, DeBerardinis RJ, Sudderth J, et al: PEPCK coordinates the regulation of central carbon metabolism to promote cancer cell growth. Mol Cell. 60:571–583. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Grasmann G, Smolle E, Olschewski H and Leithner K: Gluconeogenesis in cancer cells-repurposing of a starvation-induced metabolic pathway? Biochim Biophys Acta Rev Cancer. 1872:24–36. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Liu MX, Jin L, Sun SJ, Liu P, Feng X, Cheng ZL, Liu WR, Guan KL, Shi YH, Yuan HX and Xiong Y: Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. Oncogene. 37:1637–1653. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Ma R, Zhang W, Tang K, Zhang H, Zhang Y, Li D, Li Y, Xu P, Luo S, Cai W, et al: Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma. Nat Commun. 4:25082013. View Article : Google Scholar : PubMed/NCBI

29 

Park EJ, Woo SM, Min KJ and Kwon TK: Transcriptional and post-translational regulation of Bim controls apoptosis in melatonin-treated human renal cancer Caki cells. J Pineal Res. 56:97–106. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Wang TH, Wu CH, Yeh CT, Su SC, Hsia SM, Liang KH, Chen CC, Hsueh C and Chen CY: Melatonin suppresses hepatocellular carcinoma progression via lncRNA-CPS1-IT-mediated HIF-1α inactivation. Oncotarget. 8:82280–82293. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Cardaci S, Desideri E and Ciriolo MR: Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug. J Bioenerg Biomembr. 44:17–29. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Zhao Y, Butler EB and Tan M: Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis. 4:e5322013. View Article : Google Scholar : PubMed/NCBI

33 

Akers LJ, Fang W, Levy AG, Franklin AR, Huang P and Zweidler-McKay PA: Targeting glycolysis in leukemia: A novel inhibitor 3-BrOP in combination with rapamycin. Leuk Res. 35:814–820. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Hevia D, Gonzalez-Menendez P, Fernandez-Fernandez M, Cueto S, Rodriguez-Gonzalez P, Garcia-Alonso JI, Mayo JC and Sainz RM: Melatonin decreases glucose metabolism in prostate cancer cells: A 13C stable isotope-resolved metabolomic study. Int J Mol Sci. 18:E16202017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Puente‑Moncada N, Turos‑Cabal M, Sánchez‑Sánchez AM, Antolín I, Herrera F, Rodriguez‑Blanco J, Duarte‑Olivenza C, Rodriguez C and Martín V: Role of glucose metabolism in the differential antileukemic effect of melatonin on wild‑type and FLT3‑ITD mutant cells. Oncol Rep 44: 293-302, 2020.
APA
Puente‑Moncada, N., Turos‑Cabal, M., Sánchez‑Sánchez, A.M., Antolín, I., Herrera, F., Rodriguez‑Blanco, J. ... Martín, V. (2020). Role of glucose metabolism in the differential antileukemic effect of melatonin on wild‑type and FLT3‑ITD mutant cells. Oncology Reports, 44, 293-302. https://doi.org/10.3892/or.2020.7584
MLA
Puente‑Moncada, N., Turos‑Cabal, M., Sánchez‑Sánchez, A. M., Antolín, I., Herrera, F., Rodriguez‑Blanco, J., Duarte‑Olivenza, C., Rodriguez, C., Martín, V."Role of glucose metabolism in the differential antileukemic effect of melatonin on wild‑type and FLT3‑ITD mutant cells". Oncology Reports 44.1 (2020): 293-302.
Chicago
Puente‑Moncada, N., Turos‑Cabal, M., Sánchez‑Sánchez, A. M., Antolín, I., Herrera, F., Rodriguez‑Blanco, J., Duarte‑Olivenza, C., Rodriguez, C., Martín, V."Role of glucose metabolism in the differential antileukemic effect of melatonin on wild‑type and FLT3‑ITD mutant cells". Oncology Reports 44, no. 1 (2020): 293-302. https://doi.org/10.3892/or.2020.7584
Copy and paste a formatted citation
x
Spandidos Publications style
Puente‑Moncada N, Turos‑Cabal M, Sánchez‑Sánchez AM, Antolín I, Herrera F, Rodriguez‑Blanco J, Duarte‑Olivenza C, Rodriguez C and Martín V: Role of glucose metabolism in the differential antileukemic effect of melatonin on wild‑type and FLT3‑ITD mutant cells. Oncol Rep 44: 293-302, 2020.
APA
Puente‑Moncada, N., Turos‑Cabal, M., Sánchez‑Sánchez, A.M., Antolín, I., Herrera, F., Rodriguez‑Blanco, J. ... Martín, V. (2020). Role of glucose metabolism in the differential antileukemic effect of melatonin on wild‑type and FLT3‑ITD mutant cells. Oncology Reports, 44, 293-302. https://doi.org/10.3892/or.2020.7584
MLA
Puente‑Moncada, N., Turos‑Cabal, M., Sánchez‑Sánchez, A. M., Antolín, I., Herrera, F., Rodriguez‑Blanco, J., Duarte‑Olivenza, C., Rodriguez, C., Martín, V."Role of glucose metabolism in the differential antileukemic effect of melatonin on wild‑type and FLT3‑ITD mutant cells". Oncology Reports 44.1 (2020): 293-302.
Chicago
Puente‑Moncada, N., Turos‑Cabal, M., Sánchez‑Sánchez, A. M., Antolín, I., Herrera, F., Rodriguez‑Blanco, J., Duarte‑Olivenza, C., Rodriguez, C., Martín, V."Role of glucose metabolism in the differential antileukemic effect of melatonin on wild‑type and FLT3‑ITD mutant cells". Oncology Reports 44, no. 1 (2020): 293-302. https://doi.org/10.3892/or.2020.7584
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