DJ‑1 is a new prognostic marker and predicts chemotherapy efficacy in colorectal cancer

Wang,Weimin; Wang,Haibo; Xiang,Liangliang; Ni,Tengyang; Jin,Feng; Deng,Jianliang; Zhang,Yunlei; Shintaro,Ishikawa; Zhou,Yan; Liu,Yanqing

doi:10.3892/or.2020.7593

DJ‑1 is a new prognostic marker and predicts chemotherapy efficacy in colorectal cancer

Authors:
- Weimin Wang
- Haibo Wang
- Liangliang Xiang
- Tengyang Ni
- Feng Jin
- Jianliang Deng
- Yunlei Zhang
- Ishikawa Shintaro
- Yan Zhou
- Yanqing Liu
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Affiliations: Department of Oncology, Yixing Hospital Affiliated to the Medical College of Yangzhou University, Yangzhou University, Yixing, Jiangsu 214200, P.R. China, Institute of Combination of Chinese Traditional and Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China, Department of Physiology, School of Medicine, Showa University, Shinagawa‑ku, Tokyo 142‑8555, Japan
Published online on: April 23, 2020 https://doi.org/10.3892/or.2020.7593
Pages: 77-90
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Protein/nucleic acid deglycase DJ‑1 (DJ‑1) is a 20‑kDa conserved protein, which belongs to the DJ‑1/ThiJ/Pfp Ⅰ protein superfamily. Immunohistochemistry was performed to investigate the expression of DJ‑1 in a colorectal cancer (CRC) tissue microarray containing tumor and corresponding adjacent normal tissues. In the present study, DJ‑1 expression was significantly upregulated in CRC cells and tissues, compared with that in normal colon cells and adjacent normal tissues, respectively. In addition, patients with high DJ‑1 expression levels had a worse overall survival (OS) compared with patients with low expression levels. Multivariate Cox regression analysis revealed that high DJ‑1 expression levels was an independent prognostic factor for patients with CRC. Moreover, DJ‑1 was able to regulate the PI3K/Akt/p27/cyclin E and PI3K/Akt/mTOR signaling pathways to promote CRC cell growth and metastasis in vitro and in vivo. In addition, DJ‑1 regulated the NF‑κB/Snail signaling pathway to induce CRC cell epithelial‑mesenchymal transition to promote migration and invasion. Notably, patients receiving LFP treatment (oxaliplatin, 5‑FU and tetrahydrofolate) had an increased OS compared with patients who underwent only surgery and low DJ‑1 expression levels. The findings from the present study suggest that DJ‑1 may serve as a promising prognostic marker and predicts chemotherapy efficacy in patients with CRC.

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