Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
July-2020 Volume 44 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2020 Volume 44 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

1‑Palmitoyl‑2‑linoleoyl‑3‑acetyl‑rac‑glycerol ameliorates EGF‑induced MMP‑9 expression by promoting receptor desensitization in MDA‑MB‑231 cells

  • Authors:
    • Kwang Hoon Yang
    • Guen Tae Kim
    • Solji Choi
    • Sun Young Yoon
    • Jae Wha Kim
  • View Affiliations / Copyright

    Affiliations: Cell Factory Research Center, Division of Systems Biology and Bioengineering, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea, Division of Global New Drug Development, ENZYCHEM Lifesciences, Jecheon, Chungcheongbukdo 27159, Republic of Korea
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 241-251
    |
    Published online on: April 28, 2020
       https://doi.org/10.3892/or.2020.7599
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Activated epidermal growth factor receptors (EGFRs) are crucial for inducing metastasis in cancer cells by promoting matrix metalloproteinase (MMP) expression. The present study was designed to investigate the effects of 1‑palmitoyl‑2‑linoleoyl‑3‑acetyl‑rac‑glycerol (PLAG) on MMP expression in epidermal growth factor (EGF)‑stimulated breast cancer cells in vitro. EGF stimulation induced internalization of its cognate receptor, EGFR, for stimulus‑desensitization. These internalized receptors, complexed with the ubiquitin ligase c‑Cbl and EGFR pathway substrate 15 (EPS15) (for degradation), were evaluated by confocal microscopy at 5‑90 min time intervals. During intracellular trafficking of EGFRs, EGF‑induced signaling cascades were analyzed by examining EGFR and SHC phosphorylation. Modulation of MMP expression was assessed by evaluating the activity of transcription factor AP‑1 using a luciferase assay. PLAG accelerated the assembly of EGFRs with c‑Cbl and EPS15 and promoted receptor degradation. This faster intracellular EGFR degradation reduced AP‑1‑mediated MMP expression. PLAG stimulation upregulated thioredoxin‑interacting protein (TXNIP) expression, and this mediated the accelerated receptor internalization. This PLAG‑induced increase in EGFR trafficking was blocked in TXNIP‑silenced cells. By downregulating MMP expression, PLAG effectively attenuated EGF‑induced mobility and invasiveness in these cancer cells. These data suggest that PLAG may be a potential therapeutic agent for blocking metastasis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Seyfried TN and Huysentruyt LC: On the origin of cancer metastasis. Crit Rev Oncog. 18:43–73. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Mehner C, Hockla A, Miller E, Ran S, Radisky DC and Radisky ES: Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer. Oncotarget. 5:2736–2749. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Shay G, Lynch CC and Fingleton B: Moving targets: Emerging roles for MMPs in cancer progression and metastasis. Matrix Biol 44–46. 200–206. 2015. View Article : Google Scholar

4 

Radisky ES, Raeeszadeh-Sarmazdeh M and Radisky DC: Therapeutic potential of matrix metalloproteinase inhibition in breast cancer. J Cell Biochem. 118:3531–3548. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Bauvois B: New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: Outside-in signaling and relationship to tumor progression. Biochim Biophys Acta. 1825:29–36. 2012.PubMed/NCBI

6 

Zhang M, Teng XD, Guo XX, Li ZG, Han JG and Yao L: Expression of tissue levels of matrix metalloproteinases and their inhibitors in breast cancer. Breast. 22:330–334. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Wee P and Wang Z: Epidermal growth factor receptor cell proliferation signaling pathways. Cancers. 9:522017. View Article : Google Scholar

8 

Sigismund S, Avanzato D and Lanzetti L: Emerging functions of the EGFR in cancer. Mol Oncol. 12:3–20. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Wang Q, Chen X and Wang Z: Dimerization drives EGFR endocytosis through two sets of compatible endocytic codes. J Cell Sci. 128:935–950. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Kyriakopoulou K, Kefali E, Piperigkou Z, Bassiony H and Karamanos NK: Advances in targeting epidermal growth factor receptor signaling pathway in mammary cancer. Cell Signal. 51:99–109. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Yamamoto H, Higa-Nakamine S, Noguchi N, Maeda N, Kondo Y, Toku S, Kukita I and Sugahara K: Desensitization by different strategies of epidermal growth factor receptor and ErbB4. J Pharmacol Sci. 124:287–293. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Conte A and Sigismund S: Chapter six-the ubiquitin network in the control of EGFR endocytosis and signaling. Prog Mol Biol Transl Sci. 141:225–276. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Salova AV, Belyaeva TN, Leontieva EA and Kornilova ES: EGF receptor lysosomal degradation is delayed in the cells stimulated with EGF-Quantum dot bioconjugate but earlier key events of endocytic degradative pathway are similar to that of native EGF. Oncotarget. 8:44335–44350. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Tan X, Lambert PF, Rapraeger AC and Anderson RA: Stress-induced EGFR trafficking: Mechanisms, functions, and therapeutic implications. Trends Cell Biol. 26:352–366. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Tomas A, Futter CE and Eden ER: EGF receptor trafficking: Consequences for signaling and cancer. Trends Cell Biol. 24:26–34. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Arakaki AKS, Pan WA, Lin H and Trejo J: The α-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein-coupled receptor lysosomal sorting and signaling. J Biol Chem. 293:3350–3362. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Liu S, Wu X, Zong M, Tempel W, Loppnau P and Liu Y: Structural basis for a novel interaction between TXNIP and Vav2. FEBS Lett. 590:857–865. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Spindel ON, Yan C and Berk BC: Thioredoxin-interacting protein mediates nuclear-to-plasma membrane communication: Role in vascular endothelial growth factor 2 signaling. Arterioscler Thromb Vasc Biol. 32:1264–1270. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Park SY, Shi X, Pang J, Yan C and Berk BC: Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis. Arterioscler Thromb Vasc Biol. 33:737–743. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Shin IS, Ahn KS, Shin NR, Lee HJ, Ryu HW, Kim JW, Sohn KY, Kim HJ, Han YH and Oh SR: Protective effect of EC-18, a synthetic monoacetyldiglyceride on lung inflammation in a murine model induced by cigarette smoke and lipopolysaccharide. Int Immunopharmacol. 30:62–68. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Yoo N, Lee HR, Shin SH, Sohn KY, Kim HJ, Han YH, Chong S, Kim MH, Yoon SY and Kim JW: PLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol) augments the therapeutic effect of pegfilgrastim on gemcitabine-induced neutropenia. Cancer Lett. 377:25–31. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Lee HR, Yoo N, Kim JH, Sohn KY, Kim HJ, Kim MH, Han MY, Yoon SY and Kim JW: The therapeutic effect of PLAG against oral mucositis in hamster and mouse model. Front Oncol. 6:2092016. View Article : Google Scholar : PubMed/NCBI

23 

Jeong J, Kim YJ, Lee DY, Moon BG, Sohn KY, Yoon SY and Kim JW: 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) attenuates gemcitabine-induced neutrophil extravasation. Cell Biosci. 9:42019. View Article : Google Scholar : PubMed/NCBI

24 

Karagiannis GS, Condeelis JS and Oktay MH: Chemotherapy- induced metastasis: Mechanisms and translational opportunities. Clin Exp Metastasis. 35:269–284. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Zheng H, Yang Y, Hong YG, Wang MC, Yuan SX, Wang ZG, Bi FR, Hao LQ, Yan HL and Zhou WP: Tropomodulin 3 modulates EGFR-PI3K-AKT signaling to drive hepatocellular carcinoma metastasis. Mol Carcinog. 58:1897–1907. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Zhou X, Xie S, Wu S, Qi Y, Wang Z, Zhang H, Lu D, Wang X, Dong Y, Liu G, et al: Golgi phosphoprotein 3 promotes glioma progression via inhibiting Rab5-mediated endocytosis and degradation of epidermal growth factor receptor. Neuro-oncol. 19:1628–1639. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Ng EL, Gan BQ, Ng F and Tang BL: Rab GTPases regulating receptor trafficking at the late endosome-lysosome membranes. Cell Biochem Funct. 30:515–523. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Li L, Fan P, Chou H, Li J, Wang K and Li H: Herbacetin suppressed MMP9 mediated angiogenesis of malignant melanoma through blocking EGFR-ERK/AKT signaling pathway. Biochimie. 162:198–207. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Begley MJ, Yun CH, Gewinner CA, Asara JM, Johnson JL, Coyle AJ, Eck MJ, Apostolou I and Cantley LC: EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src. Nat Struct Mol Biol. 22:983–990. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Goh LK and Sorkin A: Endocytosis of receptor tyrosine kinases. Cold Spring Harb Perspect Biol. 5:a0174592013. View Article : Google Scholar : PubMed/NCBI

31 

Merrifield CJ and Kaksonen M: Endocytic accessory factors and regulation of clathrin-mediated endocytosis. Cold Spring Harb Perspect Biol. 6:a0167332014. View Article : Google Scholar : PubMed/NCBI

32 

Lyle CL, Belghasem M and Chitalia VC: c-Cbl: An important regulator and a target in angiogenesis and tumorigenesis. Cells. 8:4982019. View Article : Google Scholar

33 

Gucwa AL and Brown DA: UIM domain-dependent recruitment of the endocytic adaptor protein Eps15 to ubiquitin-enriched endosomes. BMC Cell Biol. 15:342014. View Article : Google Scholar : PubMed/NCBI

34 

Garvalov BK, Foss F, Henze AT, Bethani I, Gräf-Höchst S, Singh D, Filatova A, Dopeso H, Seidel S, Damm M, et al: PHD3 regulates EGFR internalization and signalling in tumours. Nat Commun. 5:55772014. View Article : Google Scholar : PubMed/NCBI

35 

Tong D, Liang YN, Stepanova AA, Liu Y, Li X, Wang L, Zhang F and Vasilyeva NV: Increased Eps15 homology domain 1 and RAB11FIP3 expression regulate breast cancer progression via promoting epithelial growth factor receptor recycling. Tumour Biol. 39:10104283176910102017. View Article : Google Scholar : PubMed/NCBI

36 

Yuan W, Liu B, Wang X, Li T, Xue H, Mo X, Yang S, Ding S and Han W: CMTM3 decreases EGFR expression and EGF-mediated tumorigenicity by promoting Rab5 activity in gastric cancer. Cancer Lett. 386:77–86. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Guerra F and Bucci C: Multiple roles of the small GTPase Rab7. Cells. 5:342016. View Article : Google Scholar

38 

Mukherjee R, Das A, Chakrabarti S and Chakrabarti O: Calcium dependent regulation of protein ubiquitination-Interplay between E3 ligases and calcium binding proteins. Biochim Biophys Acta Mol Cell Res. 1864:1227–1235. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Sasaki T, Hiroki K and Yamashita Y: The role of epidermal growth factor receptor in cancer metastasis and microenvironment. BioMed Res Int. 2013:5463182013. View Article : Google Scholar : PubMed/NCBI

40 

Suen KM, Lin CC, Seiler C, George R, Poncet-Montange G, Biter AB, Ahmed Z, Arold ST and Ladbury JE: Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells. Int J Biochem Cell Biol. 94:89–97. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Majumder A, Ray S and Banerji A: Epidermal growth factor receptor-mediated regulation of matrix metalloproteinase-2 and matrix metalloproteinase-9 in MCF-7 breast cancer cells. Mol Cell Biochem. 452:111–121. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Saby C, Collin G, Sinane M, Buache E, Van Gulick L, Saltel F, Maquoi E and Morjani H: DDR1 and MT1-MMP expression levels are determinant for triggering BIK-mediated apoptosis by 3D type I collagen matrix in invasive basal-like breast carcinoma cells. Front Pharmacol. 10:4622019. View Article : Google Scholar : PubMed/NCBI

43 

Cepeda MA, Evered CL, Pelling JJH and Damjanovski S: Inhibition of MT1-MMP proteolytic function and ERK1/2 signalling influences cell migration and invasion through changes in MMP-2 and MMP-9 levels. J Cell Commun Signal. 11:167–179. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Masutani H, Yoshihara E, Masaki S, Chen Z and Yodoi J: Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus. J Clin Biochem Nutr. 50:23–34. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Lee HR, Shin SH, Kim JH, Sohn KY, Yoon SY and Kim JW: 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) rapidly resolves LPS-induced acute lung injury through the effective control of neutrophil recruitment. Front Immunol. 10:21772019. View Article : Google Scholar : PubMed/NCBI

46 

Kim GT, Hahn KW, Sohn KY, Yoon SY and Kim JW: PLAG enhances macrophage mobility for efferocytosis of apoptotic neutrophils via membrane redistribution of P2Y2. FEBS J. 286:5016–5029. 2019. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang KH, Kim GT, Choi S, Yoon SY and Kim JW: 1‑Palmitoyl‑2‑linoleoyl‑3‑acetyl‑rac‑glycerol ameliorates EGF‑induced MMP‑9 expression by promoting receptor desensitization in MDA‑MB‑231 cells. Oncol Rep 44: 241-251, 2020.
APA
Yang, K.H., Kim, G.T., Choi, S., Yoon, S.Y., & Kim, J.W. (2020). 1‑Palmitoyl‑2‑linoleoyl‑3‑acetyl‑rac‑glycerol ameliorates EGF‑induced MMP‑9 expression by promoting receptor desensitization in MDA‑MB‑231 cells. Oncology Reports, 44, 241-251. https://doi.org/10.3892/or.2020.7599
MLA
Yang, K. H., Kim, G. T., Choi, S., Yoon, S. Y., Kim, J. W."1‑Palmitoyl‑2‑linoleoyl‑3‑acetyl‑rac‑glycerol ameliorates EGF‑induced MMP‑9 expression by promoting receptor desensitization in MDA‑MB‑231 cells". Oncology Reports 44.1 (2020): 241-251.
Chicago
Yang, K. H., Kim, G. T., Choi, S., Yoon, S. Y., Kim, J. W."1‑Palmitoyl‑2‑linoleoyl‑3‑acetyl‑rac‑glycerol ameliorates EGF‑induced MMP‑9 expression by promoting receptor desensitization in MDA‑MB‑231 cells". Oncology Reports 44, no. 1 (2020): 241-251. https://doi.org/10.3892/or.2020.7599
Copy and paste a formatted citation
x
Spandidos Publications style
Yang KH, Kim GT, Choi S, Yoon SY and Kim JW: 1‑Palmitoyl‑2‑linoleoyl‑3‑acetyl‑rac‑glycerol ameliorates EGF‑induced MMP‑9 expression by promoting receptor desensitization in MDA‑MB‑231 cells. Oncol Rep 44: 241-251, 2020.
APA
Yang, K.H., Kim, G.T., Choi, S., Yoon, S.Y., & Kim, J.W. (2020). 1‑Palmitoyl‑2‑linoleoyl‑3‑acetyl‑rac‑glycerol ameliorates EGF‑induced MMP‑9 expression by promoting receptor desensitization in MDA‑MB‑231 cells. Oncology Reports, 44, 241-251. https://doi.org/10.3892/or.2020.7599
MLA
Yang, K. H., Kim, G. T., Choi, S., Yoon, S. Y., Kim, J. W."1‑Palmitoyl‑2‑linoleoyl‑3‑acetyl‑rac‑glycerol ameliorates EGF‑induced MMP‑9 expression by promoting receptor desensitization in MDA‑MB‑231 cells". Oncology Reports 44.1 (2020): 241-251.
Chicago
Yang, K. H., Kim, G. T., Choi, S., Yoon, S. Y., Kim, J. W."1‑Palmitoyl‑2‑linoleoyl‑3‑acetyl‑rac‑glycerol ameliorates EGF‑induced MMP‑9 expression by promoting receptor desensitization in MDA‑MB‑231 cells". Oncology Reports 44, no. 1 (2020): 241-251. https://doi.org/10.3892/or.2020.7599
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team