Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
July-2020 Volume 44 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2020 Volume 44 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer

  • Authors:
    • Ryotaro Ohkuma
    • Erica Yada
    • Shumpei Ishikawa
    • Daisuke Komura
    • Yutaro Kubota
    • Kazuyuki Hamada
    • Atsushi Horiike
    • Tomoyuki Ishiguro
    • Yuya Hirasawa
    • Hirotsugu Ariizumi
    • Midori Shida
    • Makoto Watanabe
    • Rie Onoue
    • Kiyohiro Ando
    • Junji Tsurutani
    • Kiyoshi Yoshimura
    • Tetsuro Sasada
    • Takeshi Aoki
    • Masahiko Murakami
    • Tomoko Norose
    • Nobuyuki Ohike
    • Masafumi Takimoto
    • Shinichi Kobayashi
    • Takuya Tsunoda
    • Satoshi Wada
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Tokyo 157‑8577, Japan, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa 241‑8515, Japan, Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113‑0033, Japan, Department of Medicine, Division of Medical Oncology, School of Medicine, Showa University, Tokyo 142‑8555, Japan, Department of Surgery, Division of General and Gastroenterological Surgery, Showa University, Tokyo 142‑8555, Japan, Department of Pathology and Laboratory Medicine, School of Medicine, Showa University, Tokyo 142‑8555, Japan, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Tokyo 157‑8577, Japan
    Copyright: © Ohkuma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 252-262
    |
    Published online on: May 11, 2020
       https://doi.org/10.3892/or.2020.7610
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Pancreatic cancer has extremely poor prognosis, warranting the discovery of novel therapeutic and prognostic markers. The expression of polymeric immunoglobulin receptor (pIgR), a key component of the mucosal immune system, is increased in several cancers. However, its clinical relevance in pancreatic cancer remains unclear. In the present study, the prognostic value of pIgR in pancreatic cancer patients after surgical resection was assessed and it was determined that the expression of pIgR was correlated with poor prognosis. Ten pancreatic cancer patient‑derived xenograft (PDX) lines were established, followed by next‑generation sequencing of tumor tissues from these lines after standard chemotherapy. Immunohistochemical analysis of chemoresistance‑related molecules using 77 pancreatic cancer tissues was also performed. The expression of pIgR mRNA in the PDX group treated with anticancer drugs was higher than in the untreated group. High pIgR expression in tissue specimens from 77 pancreatic cancer patients was significantly associated with poor prognosis and was revealed to be an independent prognostic factor, predicting poor outcomes. High pIgR mRNA and protein levels were independent prognostic factors, indicating that pIgR could be a novel predictor for poor prognosis of pancreatic cancer patients.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Hidalgo M, Cascinu S, Kleeff J, Labianca R, Löhr JM, Neoptolemos J, Real FX, Van Laethem JL and Heinemann V: Addressing the challenges of pancreatic cancer: Future directions for improving outcomes. Pancreatology. 15:8–18. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Lefebvre AC, Maurel J, Boutreux S, Bouvier V, Reimund JM, Launoy G and Arsene D: Pancreatic cancer: Incidence, treatment and survival trends-1175 cases in Calvados (France) from 1978 to 2002. Gastroenterol Clin Biol. 33:1045–1051. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Kocher HM and Alrawashdeh W: Pancreatic cancer. BMJ Clin Evid. 2010(pii): 04092010.PubMed/NCBI

4 

Siegel RL, Miller KD and Jemal A: Cancer statistics in USA, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Li HB, Zhou J and Zhao FQ: A prognostic nomogram for disease-specific survival in patients with pancreatic ductal adenocarcinoma of the head of the pancreas following pancreaticoduodenectomy. Med Sci Monit. 24:6313–6321. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM and Matrisian LM: Projecting cancer incidence and deaths to 2030: The unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 74:2913–2921. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Kamisawa T, Wood LD, Itoi T and Takaori K: Pancreatic cancer. Lancet. 388:73–85. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, Seay T, Tjulandin SA, Ma WW, Saleh MN, et al: Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 369:1691–1703. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Goldstein D, El-Maraghi RH, Hammel P, Heinemann V, Kunzmann V, Sastre J, Scheithauer W, Siena S, Tabernero J, Teixeira L, et al: Nab-Paclitaxel plus gemcitabine for metastatic pancreatic cancer: Long-term survival from a phase III trial. J Natl Cancer Inst. 107:1–10. 2015. View Article : Google Scholar

10 

Conroy T, Desseigne F, Ychou M, Bouché O, Guimbaud R, Bécouarn Y, Adenis A, Raoul JL, Gourgou-Bourgade S, de la Fouchardière C, et al: FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 364:1817–1825. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Cecconi D, Palmieri M and Donadelli M: Proteomics in pancreatic cancer research. Proteomics. 11:816–828. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Mostov KE, Kraehenbuhl JP and Blobel G: Receptor-mediated transcellular transport of immunoglobulin: Synthesis of secretory component as multiple and larger transmembrane forms. Proc Natl Acad Sci USA. 77:7257–7261. 1980. View Article : Google Scholar : PubMed/NCBI

13 

Rojas R and Apodaca G: Immunoglobulin transport across polarized epithelial cells. Nat Rev Mol Cell Biol. 3:944–955. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Kaetzel CS: The polymeric immunoglobulin receptor: Bridging innate and adaptive immune responses at mucosal surfaces. Immunol Rev. 206:83–99. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Phalipon A and Corthésy B: Novel functions of the polymeric Ig receptor: Well beyond transport of immunoglobulins. Trends Immunol. 24:55–58. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Denning GM: IL-4 and IFN-gamma synergistically increase total polymeric IgA receptor levels in human intestinal epithelial cells. Role of protein tyrosine kinases. J Immunol. 156:4807–4814. 1996.PubMed/NCBI

17 

Kvale D, Løvhaug D, Sollid LM and Brandtzaeg P: Tumor necrosis factor-alpha up-regulates expression of secretory component, the epithelial receptor for polymeric Ig. J Immunol. 140:3086–3089. 1988.PubMed/NCBI

18 

Poger ME, Hirsch BR and Lamm ME: Synthesis of secretory component by colonic neoplasms. Am J Pathol. 82:327–338. 1976.PubMed/NCBI

19 

Harris JP, Caleb MH and South MA: Secretory component in human mammary carcinoma. Cancer Res. 35:1861–1864. 1975.PubMed/NCBI

20 

Harris JP and South MA: Secretory component: A glandular epithelial cell marker. Am J Pathol. 105:47–53. 1981.PubMed/NCBI

21 

DeSouza LV, Krakovska O, Darfler MM, Krizman DB, Romaschin AD, Colgan TJ and Siu KW: mTRAQ-based quantification of potential endometrial carcinoma biomarkers from archived formalin-fixed paraffin-embedded tissues. Proteomics. 10:3108–3116. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Rossel M, Billerey C, Bittard H, Ksiazek P, Alber D, Revillard JP and Vuitton DA: Alterations in polymeric immunoglobulin receptor expression and secretory component levels in bladder carcinoma. Urol Res. 19:361–366. 1991. View Article : Google Scholar : PubMed/NCBI

23 

Rossel M, Seilles E, Voigt JJ, Vuitton D, Legait N and Revillard JP: Polymeric Ig receptor expression in hepatocellular carcinoma. Eur J Cancer. 28:1120–1124. 1992. View Article : Google Scholar

24 

Ai J, Tang Q, Wu Y, Xu Y, Feng T, Zhou R, Chen Y, Gao X, Zhu Q, Yue X, et al: The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma. J Natl Cancer Inst. 103:1696–1712. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Berntsson J, Lundgren S, Nodin B, Uhlén M, Gaber A and Jirström K: Expression and prognostic significance of the polymeric immunoglobulin receptor in epithelial ovarian cancer. J Ovarian Res. 7:262014. View Article : Google Scholar : PubMed/NCBI

26 

Fristedt R, Gaber A, Hedner C, Nodin B, Uhlén M, Eberhard J and Jirström K: Expression and prognostic significance of the polymeric immunoglobulin receptor in esophageal and gastric adenocarcinoma. J Transl Med. 12:832014. View Article : Google Scholar : PubMed/NCBI

27 

Xiao T, Ying W, Li L, Hu Z, Ma Y, Jiao L, Ma J, Cai Y, Lin D, Guo S, et al: An approach to studying lung cancer-related proteins in human blood. Mol Cell Proteomics. 4:1480–1486. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Rossel M, Brambilla E, Billaud M, Vuitton DA, Blanc-Jouvan F, Biichle S and Revillard JP: Nonspecific increased serum levels of secretory component in lung tumors: Relationship to the gene expression of the transmembrane receptor form. Am J Respir Cell Mol Biol. 9:341–346. 1993. View Article : Google Scholar : PubMed/NCBI

29 

Makawita S, Smith C, Batruch I, Zheng Y, Rückert F, Grützmann R, Pilarsky C, Gallinger S and Diamandis EP: Integrated proteomic profiling of cell line conditioned media and pancreatic juice for the identification of pancreatic cancer biomarkers. Mol Cell Proteomics. 10:M111.008599. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Kvale D, Norstein J, Meling GI, Børmer OP, Brandtzaeg P, Langmark F and Rognum TO: Circulating secretory component in relation to early diagnosis and treatment of liver metastasis from colorectal carcinomas. J Clin Pathol. 45:568–571. 1992. View Article : Google Scholar : PubMed/NCBI

31 

Morton CL and Houghton PJ: Establishment of human tumor xenografts in immunodeficient mice. Nat Protoc. 2:247–250. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Chijiwa T, Kawai K, Noguchi A, Sato H, Hayashi A, Cho H, Shiozawa M, Kishida T, Morinaga S, Yokose T, et al: Establishment of patient-derived cancer xenografts in immunodeficient NOG mice. Int J Oncol. 47:61–70. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Langmead B, Trapnell C, Pop M and Salzberg SL: Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 10:R252009. View Article : Google Scholar : PubMed/NCBI

34 

Komura D, Isagawa T, Kishi K, Suzuki R, Sato R, Tanaka M, Katoh H, Yamamoto S, Tatsuno K, Fukayama M, et al: CASTIN: A system for comprehensive analysis of cancer-stromal interactome. BMC Genomics. 17:8992016. View Article : Google Scholar : PubMed/NCBI

35 

Pontén F, Jirström K and Uhlen M: The human protein atlas-A tool for pathology. J Pathol. 216:387–393. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Iida Y, Tanaka H, Sano H, Suzuki Y, Shimizu H and Urano T: Ectopic expression of PCSK9 by smooth muscle cells contributes to aortic dissection. Ann Vasc Surg. 48:195–203. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Zijlstra M, Bernards N, de Hingh IH, van de Wouw AJ, Goey SH, Jacobs EM, Lemmens VE and Creemers GJ: Does long-term survival exist in pancreatic adenocarcinoma? Acta Oncol. 55:259–264. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Ying H, Dey P, Yao W, Kimmelman AC, Draetta GF, Maitra A and DePinho RA: Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev. 30:355–385. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Jin K, Li G, Cui B, Zhang J, Lan H, Han N, Xie B, Cao F, He K, Wang H, et al: Assessment of a novel VEGF targeted agent using patient-derived tumor tissue xenograft models of colon carcinoma with lymphatic and hepatic metastases. PLoS One. 6:e283842011. View Article : Google Scholar : PubMed/NCBI

40 

Yada E, Wada S, Yoshida S and Sasada T: Use of patient-derived xenograft mouse models in cancer research and treatment. Futur Sci OA. 4:FSO2712018. View Article : Google Scholar

41 

Hidalgo M, Amant F, Biankin AV, Budinská E, Byrne AT, Caldas C, Clarke RB, de Jong S, Jonkers J, Mælandsmo GM, et al: Patient-derived xenograft models: An emerging platform for translational cancer research. Cancer Discov. 4:998–1013. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Cho SY, Kang W, Han JY, Min S, Kang J, Lee A, Kwon JY, Lee C and Park H: An integrative approach to precision cancer medicine using patient-derived xenografts. Mol Cells. 39:77–86. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Fujii E, Suzuki M, Matsubara K, Watanabe M, Chen YJ, Adachi K, Ohnishi Y, Tanigawa M, Tsuchiya M and Tamaoki N: Establishment and characterization of in vivo human tumor models in the NOD/SCID/γcnull mouse. Pathol Int. 58:559–567. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Erickson RA, Sayage-Rabie L and Beissner RS: Factors predicting the number of EUS-guided fineneedle passes for diagnosis of pancreatic malignancies. Gastrointest Endosc. 51:184–190. 2000. View Article : Google Scholar : PubMed/NCBI

45 

LeBlanc JK, Ciaccia D, Al-Assi MT, McGrath K, Imperiale T, Tao LC, Vallery S, DeWitt J, Sherman S and Collins E: Optimal number of EUS-guided fineneedle passes needed to obtain acorrect diagnosis. Gastrointest Endosc. 59:475–481. 2004. View Article : Google Scholar : PubMed/NCBI

46 

Ohkuma R, Yada E, Ishikawa S, Komura D, Ishizaki H, Tamada K, Kubota Y, Hamada K, Ishida H, Hirasawa Y, et al: High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer. PLoS One. 15:e02267072020. View Article : Google Scholar : PubMed/NCBI

47 

De Sousa Abreu R, Penalva LO, Marcotte EM and Vogel C: Global signatures of protein and mRNA expression levels. Mol Biosyst. 5:1512–1526. 2009.PubMed/NCBI

48 

Schwanhüusser B, Busse D, Li N, Dittmar G, Schuchhardt J, Wolf J, Chen W and Selbach M: Global quantification of mammalian gene expression control. Nature. 473:337–342. 2011. View Article : Google Scholar : PubMed/NCBI

49 

Wu L, Candille SI, Choi Y, Xie D, Jiang L, Li-Pook-Than J, Tang H and Snyder M: Variation and genetic control of protein abundance in humans. Nature. 499:79–82. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Zhang B, Wang J, Wang X, Zhu J, Liu Q, Shi Z, Chambers MC, Zimmerman LJ, Shaddox KF, Kim S, et al: Proteogenomic characterization of human colon and rectal cancer. Nature. 513:382–387. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Arumugam P, Bhattacharya S, Chin-Aleong J, Capaso M and Kocher HM: Expression of polymeric immunoglobulin receptor and stromal activity in pancreatic ductal adenocarcinoma. Pancreatology. 17:295–302. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Fristedt R, Elebro J, Gaber A, Jonsson L, Heby M, Yudina Y, Nodin B, Uhlén M, Eberhard J and Jirström K: Reduced expression of the polymeric immunoglobulin receptor in pancreatic and periampullary adenocarcinoma signifies tumour progression and poor prognosis. PLoS One. 9:e1127282014. View Article : Google Scholar : PubMed/NCBI

53 

Liu F, Ye P, Bi T, Teng L, Xiang C, Wang H, Li Y, Jin K and Mou X: COLORECTAL polymeric immunoglobulin receptor expression is correlated with hepatic metastasis and poor prognosis in colon carcinoma patients with hepatic metastasis. Hepatogastroenterology. 61:652–659. 2014.PubMed/NCBI

54 

Wang X, Du J, Gu P, Jin R and Lin X: Polymeric immunoglobulin receptor expression is correlated with poor prognosis in patients with osteosarcoma. Mol Med Rep. 9:2105–2110. 2014. View Article : Google Scholar : PubMed/NCBI

55 

Niu H, Wang K and Wang Y: Polymeric immunoglobulin receptor expression is predictive of poor prognosis in glioma patients. Int J Clin Exp Med. 7:21852014.PubMed/NCBI

56 

Aguilar-Mahecha A, Hassan S, Ferrario C and Basik M: Microarrays as validation strategies in clinical samples: Tissue and protein microarrays. OMICS. 10:311–326. 2006. View Article : Google Scholar : PubMed/NCBI

57 

Simon R and Sauter G: Tissue microarrays for miniaturized high-throughput molecular profiling of tumors. Exp Hematol. 30:1365–1372. 2002. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ohkuma R, Yada E, Ishikawa S, Komura D, Kubota Y, Hamada K, Horiike A, Ishiguro T, Hirasawa Y, Ariizumi H, Ariizumi H, et al: High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer. Oncol Rep 44: 252-262, 2020.
APA
Ohkuma, R., Yada, E., Ishikawa, S., Komura, D., Kubota, Y., Hamada, K. ... Wada, S. (2020). High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer. Oncology Reports, 44, 252-262. https://doi.org/10.3892/or.2020.7610
MLA
Ohkuma, R., Yada, E., Ishikawa, S., Komura, D., Kubota, Y., Hamada, K., Horiike, A., Ishiguro, T., Hirasawa, Y., Ariizumi, H., Shida, M., Watanabe, M., Onoue, R., Ando, K., Tsurutani, J., Yoshimura, K., Sasada, T., Aoki, T., Murakami, M., Norose, T., Ohike, N., Takimoto, M., Kobayashi, S., Tsunoda, T., Wada, S."High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer". Oncology Reports 44.1 (2020): 252-262.
Chicago
Ohkuma, R., Yada, E., Ishikawa, S., Komura, D., Kubota, Y., Hamada, K., Horiike, A., Ishiguro, T., Hirasawa, Y., Ariizumi, H., Shida, M., Watanabe, M., Onoue, R., Ando, K., Tsurutani, J., Yoshimura, K., Sasada, T., Aoki, T., Murakami, M., Norose, T., Ohike, N., Takimoto, M., Kobayashi, S., Tsunoda, T., Wada, S."High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer". Oncology Reports 44, no. 1 (2020): 252-262. https://doi.org/10.3892/or.2020.7610
Copy and paste a formatted citation
x
Spandidos Publications style
Ohkuma R, Yada E, Ishikawa S, Komura D, Kubota Y, Hamada K, Horiike A, Ishiguro T, Hirasawa Y, Ariizumi H, Ariizumi H, et al: High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer. Oncol Rep 44: 252-262, 2020.
APA
Ohkuma, R., Yada, E., Ishikawa, S., Komura, D., Kubota, Y., Hamada, K. ... Wada, S. (2020). High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer. Oncology Reports, 44, 252-262. https://doi.org/10.3892/or.2020.7610
MLA
Ohkuma, R., Yada, E., Ishikawa, S., Komura, D., Kubota, Y., Hamada, K., Horiike, A., Ishiguro, T., Hirasawa, Y., Ariizumi, H., Shida, M., Watanabe, M., Onoue, R., Ando, K., Tsurutani, J., Yoshimura, K., Sasada, T., Aoki, T., Murakami, M., Norose, T., Ohike, N., Takimoto, M., Kobayashi, S., Tsunoda, T., Wada, S."High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer". Oncology Reports 44.1 (2020): 252-262.
Chicago
Ohkuma, R., Yada, E., Ishikawa, S., Komura, D., Kubota, Y., Hamada, K., Horiike, A., Ishiguro, T., Hirasawa, Y., Ariizumi, H., Shida, M., Watanabe, M., Onoue, R., Ando, K., Tsurutani, J., Yoshimura, K., Sasada, T., Aoki, T., Murakami, M., Norose, T., Ohike, N., Takimoto, M., Kobayashi, S., Tsunoda, T., Wada, S."High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer". Oncology Reports 44, no. 1 (2020): 252-262. https://doi.org/10.3892/or.2020.7610
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team