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IGF‑IR promotes clonal cell proliferation in myelodysplastic syndromes via inhibition of the MAPK pathway

  • Authors:
    • Qi He
    • Qingqing Zheng
    • Feng Xu
    • Wenhui Shi
    • Juan Guo
    • Zheng Zhang
    • Sida Zhao
    • Xiao Li
    • Chunkang Chang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1094-1104
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    Published online on: June 19, 2020
       https://doi.org/10.3892/or.2020.7652
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Abstract

Type 1 insulin‑like growth factor receptor (IGF‑IR) signaling is considered to serve a key role in the development of cancer. However, the effects of IGF‑IR on the malignant characteristics of myelodysplastic syndrome (MDS) clonal cells remains to be determined. In the present study it was demonstrated that knockdown of IGF‑IR reduced the proliferation and increased the apoptosis of MDS/leukemia cells. Integrated analysis of gene expression profiles using bioinformatics identified the MAPK signaling pathway as a critical downstream factor of IGF‑IR, and this was confirmed in vitro using western blotting which revealed that IGF‑IR knockdown significantly increased the expression of activated MAPK. Furthermore, IGF‑IR signaling was inhibited to investigate the potential of IGF‑IR as a therapeutic target of MDS. The results revealed that the IGF‑IR inhibitor picropodophyllin (PPP) inhibited cell proliferation, promoted cell apoptosis and arrested the cell cycle at the G2/M phase in MDS/leukemia cells. Similar to the effects of IGF‑IR knockdown, PPP treatment also increased MAPK signaling in vitro. In conclusion, IGF‑IR may serve as a potential therapeutic target of MDS.
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1 

Tiu R, Gondek L, O'Keefe C and Maciejewski JP: Clonality of the stem cell compartment during evolution of myelodysplastic syndromes and other bone marrow failure syndromes. Leukemia. 21:1648–1657. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP and Ebert BL: Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. Blood. 126:9–16. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Qi H, Qingxia Z, Xiao L, Lingyun W, Feng X, Zheng Z and Chunkang C: Recurrent abnormal clones in myelodysplastic syndrome marrow originate from cells at a pluripotent stem level and maintain their early differentiation potency. Cancer Invest. 33:369–377. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Smith MA, Choudhary GS, Pellagatti A, Choi K, Bolanos LC, Bhagat TD, Gordon-Mitchell S, Von Ahrens D, Pradhan K, Steeples V, et al: U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies. Nat Cell Biol. 21:640–650. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Kennedy AL and Shimamura A: Genetic predisposition to MDS: Clinical features and clonal evolution. Blood. 133:1071–1085. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Nolte F and Hofmann WK: Molecular mechanisms involved in the progression of myelodysplastic syndrome. Future Oncol. 6:445–455. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Issa JP: Epigenetic changes in the myelodysplastic syndrome. Hematol Oncol Clin North Am. 24:317–330. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Zhang Z, Zhao L, Wei X, Guo Q, Zhu X, Wei R, Yin X, Zhang Y, Wang B and Li X: Integrated bioinformatic analysis of microarray data reveals shared gene signature between MDS and AML. Oncol Lett. 16:5147–5159. 2018.PubMed/NCBI

9 

Gao J, Chang YS, Jallal B and Viner J: Targeting the insulin-like growth factor axis for the development of novel therapeutics in oncology. Cancer Res. 72:3–12. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Guerreiro AS, Boller D, Doepfner KT and Arcaro A: IGF-IR: Potential role in antitumor agents. Drug News Perspect. 19:261–272. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Strömberg T, Ekman S, Girnita L, Dimberg LY, Larsson O, Axelson M, Lennartsson J, Hellman U, Carlson K, Osterborg A, et al: IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells. Blood. 107:669–678. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Tazzari PL, Tabellini G, Bortul R, Papa V, Evangelisti C, Grafone T, Martinelli G, McCubrey JA and Martelli AM: The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion. Leukemia. 21:886–896. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Shi P, Chandra J, Sun X, Gergely M, Cortes JE, Garcia-Manero G, Arlinghaus RB, Lai R and Amin HM: Inhibition of IGF-IR tyrosine kinase induces apoptosis and cell cycle arrest in imatinib-resistant chronic myeloid leukaemia cells. J Cell Mol Med. 14:1777–1792. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Whelan JT, Ludwig DL and Bertrand FE: HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia. Leukemia. 22:1161–1169. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Schillaci R, Galeano A, Becu-Villalobos D, Spinelli O, Sapia S and Bezares RF: Autocrine/paracrine involvement of insulin-like growth factor-I and its receptor in chronic lymphocytic leukaemia. Br J Haematol. 130:58–66. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Malaguarnera R and Belfiore A: The emerging role of insulin and insulin-like growth factor signaling in cancer stem cells. Front Endocrinol (Lausanne). 5:102014. View Article : Google Scholar : PubMed/NCBI

17 

Muraguchi T, Nanba D, Nishimura EK and Tashiro T: IGF-1R deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance. J Dermatol Sci. 94:298–305. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Teng CF, Jeng LB and Shyu WC: Role of insulin-like growth factor 1 receptor signaling in stem cell stemness and therapeutic efficacy. Cell Transplant. 27:1313–1319. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Qi H, Xiao L, Lingyun W, Ying T, Yi-Zhi L, Shao-Xu Y and Quan P: Expression of type 1 insulin-like growth factor receptor in marrow nucleated cells in malignant hematological disorders: Correlation with apoptosis. Ann Hematol. 85:95–101. 2006. View Article : Google Scholar : PubMed/NCBI

20 

He Q, Li X, Zhang Z, Zhang Q, Xu F, Yang L, Tao Y and Liu Y: Overexpression of IGF-IR in malignant clonal cells in bone marrow of myelodysplastic syndromes. Cancer Invest. 28:983–988. 2010. View Article : Google Scholar : PubMed/NCBI

21 

He Q, Chang CK, Xu F, Zhang QX, Shi WH and Li X: Purification of bone marrow clonal cells from patients with myelodysplastic syndrome via IGF-IR. PLoS One. 10:e01403722015. View Article : Google Scholar : PubMed/NCBI

22 

Valent P, Horny HP, Bennett JM, Fonatsch C, Germing U, Greenberg P, Haferlach T, Haase D, Kolb HJ, Krieger O, et al: Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conference. Leuk Res. 31:727–736. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Vardiman JW, Harris NL and Brunning RD: The world health organization (WHO) classification of the myeloid neoplasms. Blood. 100:2292–2302. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Delacrétaz F, Schmidt PM, Piguet D, Bachmann F and Costa J: Histopathology of myelodysplastic syndromes. The FAB classification (proposals) applied to bone marrow biopsy. Am J Clin Pathol. 87:180–186. 1987. View Article : Google Scholar : PubMed/NCBI

25 

Greenberg P, Cox C, LeBeau MM, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, et al: International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood. 89:2079–2088. 1997. View Article : Google Scholar : PubMed/NCBI

26 

Shaffer LG and Tommerup N: ISCN: An international system for human cytogenetics nomenclature. S Karger; Basel 2005: 2005

27 

Nakagawa T, Matozaki S, Murayama T, Nishimura R, Tsutsumi M, Kawaguchi R, Yokoyama Y, Hikiji K, Isobe T and Chihara K: Establishment of a leukaemic cell line from a patient with acquisition of chromosomal abnormalities during disease progression in myelodysplastic syndrome. Br J Haematol. 85:469–476. 1993. View Article : Google Scholar : PubMed/NCBI

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Hosono N: Genetic abnormalities and pathophysiology of MDS. Int J Clin Oncol. 24:885–892. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Xu F, Wu LY, Chang CK, He Q, Zhang Z, Liu L, Shi WH, Guo J, Zhu Y, Zhao YS, et al: Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes. Nat Commun. 6:88062015. View Article : Google Scholar : PubMed/NCBI

31 

Gonçalves AC, Alves R, Baldeiras I, Cortesão E, Carda JP, Branco CC, Oliveiros B, Loureiro L, Pereira A, Nascimento Costa JM, et al: Genetic variants involved in oxidative stress, base excision repair, DNA methylation, and folate metabolism pathways influence myeloid neoplasias susceptibility and prognosis. Mol Carcinog. 56:130–148. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Yuen JS and Macaulay VM: Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer. Expert Opin Ther Targets. 12:589–603. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Narla G, Sangodkar J and Ryder CB: The impact of phosphatases on proliferative and survival signaling in cancer. Cell Mol Life Sci. 75:2695–2718. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Xu Y, Li N, Xiang R and Sun P: Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence. Trends Biochem Sci. 39:268–276. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Li Q, Chen M, Liu H, Yang L, Yang T and He G: The dual role of ERK signaling in the apoptosis of neurons. Front Biosci (Landmark Ed). 19:1411–1417. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Paul M, Manikanta K, Hemshekhar M, Sundaram MS, Naveen S, Ramesh TN, Kemparaju K and Girish KS: Bisdemethoxycurcumin promotes apoptosis in human platelets via activation of ERK signaling pathway. Toxicol In Vitro. 63:1047432019. View Article : Google Scholar : PubMed/NCBI

37 

Zhang DX, Ma DY, Yao ZQ, Fu CY, Shi YX, Wang QL and Tang QQ: ERK1/2/p53 and NF-κB dependent-PUMA activation involves in doxorubicin-induced cardiomyocyte apoptosis. Eur Rev Med Pharmacol Sci. 20:2435–2442. 2016.PubMed/NCBI

38 

Navas TA, Mohindru M, Estes M, Ma JY, Sokol L, Pahanish P, Parmar S, Haghnazari E, Zhou L, Collins R, et al: Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors. Blood. 108:4170–4177. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Bhagat TD, Zhou L, Sokol L, Kessel R, Caceres G, Gundabolu K, Tamari R, Gordon S, Mantzaris I, Jodlowski T, et al: miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling. Blood. 121:2875–2881. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Follo MY, Mongiorgi S, Bosi C, Cappellini A, Finelli C, Chiarini F, Papa V, Libra M, Martinelli G, Cocco L and Martelli AM: The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation. Cancer Res. 67:4287–4294. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Boehrer S, Adès L, Braun T, Galluzzi L, Grosjean J, Fabre C, Le Roux G, Gardin C, Martin A, de Botton S, et al: Erlotinib exhibits antineoplastic off-target effects in AML and MDS: A preclinical study. Blood. 111:2170–2180. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Ekman S, Frödin JE, Harmenberg J, Bergman A, Hedlund A, Dahg P, Alvfors C, Ståhl B, Bergström S and Bergqvist M: Clinical phase I study with an insulin-like growth factor-1 receptor inhibitor: Experiences in patients with squamous non-small cell lung carcinoma. Acta Oncol. 50:441–447. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Wu X, Sooman L, Wickström M, Fryknäs M, Dyrager C, Lennartsson J and Gullbo J: Alternative cytotoxic effects of the postulated IGF-IR inhibitor picropodophyllin in vitro. Mol Cancer Ther. 12:1526–1536. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Rodrigues Alves APN, Fernandes JC, Fenerich BA, Coelho-Silva JL, Scheucher PS, Simões BP, Rego EM, Ridley AJ, Machado-Neto JA and Traina F: IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells. Cancer Lett. 456:59–68. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
He Q, Zheng Q, Xu F, Shi W, Guo J, Zhang Z, Zhao S, Li X and Chang C: IGF‑IR promotes clonal cell proliferation in myelodysplastic syndromes via inhibition of the MAPK pathway. Oncol Rep 44: 1094-1104, 2020.
APA
He, Q., Zheng, Q., Xu, F., Shi, W., Guo, J., Zhang, Z. ... Chang, C. (2020). IGF‑IR promotes clonal cell proliferation in myelodysplastic syndromes via inhibition of the MAPK pathway. Oncology Reports, 44, 1094-1104. https://doi.org/10.3892/or.2020.7652
MLA
He, Q., Zheng, Q., Xu, F., Shi, W., Guo, J., Zhang, Z., Zhao, S., Li, X., Chang, C."IGF‑IR promotes clonal cell proliferation in myelodysplastic syndromes via inhibition of the MAPK pathway". Oncology Reports 44.3 (2020): 1094-1104.
Chicago
He, Q., Zheng, Q., Xu, F., Shi, W., Guo, J., Zhang, Z., Zhao, S., Li, X., Chang, C."IGF‑IR promotes clonal cell proliferation in myelodysplastic syndromes via inhibition of the MAPK pathway". Oncology Reports 44, no. 3 (2020): 1094-1104. https://doi.org/10.3892/or.2020.7652
Copy and paste a formatted citation
x
Spandidos Publications style
He Q, Zheng Q, Xu F, Shi W, Guo J, Zhang Z, Zhao S, Li X and Chang C: IGF‑IR promotes clonal cell proliferation in myelodysplastic syndromes via inhibition of the MAPK pathway. Oncol Rep 44: 1094-1104, 2020.
APA
He, Q., Zheng, Q., Xu, F., Shi, W., Guo, J., Zhang, Z. ... Chang, C. (2020). IGF‑IR promotes clonal cell proliferation in myelodysplastic syndromes via inhibition of the MAPK pathway. Oncology Reports, 44, 1094-1104. https://doi.org/10.3892/or.2020.7652
MLA
He, Q., Zheng, Q., Xu, F., Shi, W., Guo, J., Zhang, Z., Zhao, S., Li, X., Chang, C."IGF‑IR promotes clonal cell proliferation in myelodysplastic syndromes via inhibition of the MAPK pathway". Oncology Reports 44.3 (2020): 1094-1104.
Chicago
He, Q., Zheng, Q., Xu, F., Shi, W., Guo, J., Zhang, Z., Zhao, S., Li, X., Chang, C."IGF‑IR promotes clonal cell proliferation in myelodysplastic syndromes via inhibition of the MAPK pathway". Oncology Reports 44, no. 3 (2020): 1094-1104. https://doi.org/10.3892/or.2020.7652
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