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Association of tricellulin expression with poor colorectal cancer prognosis and metastasis

  • Authors:
    • Jin‑Xiu Zhang
    • Meng‑Bin Qin
    • Zhe Ye
    • Peng Peng
    • Si‑Man Li
    • Qian Song
    • Lan Lin
    • Shi‑Quan Liu
    • Li‑Hua Xie
    • Ye Zhu
    • Jie‑An Huang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530007, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2174-2184
    |
    Published online on: September 17, 2020
       https://doi.org/10.3892/or.2020.7773
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Abstract

Tricellulin is a tight‑junction transmembrane protein that regulates cell‑cell interactions. Altered tricellulin expression could promote tumor cell invasions and metastasis in human cancers. The present study assessed tricellulin expression in colorectal cancer tissues for any association with clinicopathological features of colorectal cancer patients and then investigated the underlying molecular events using quantitative proteomic analysis and in vitro experiments. Tissue samples from 98 colorectal cancer patients and 15 volunteers were collected for immunohistochemistry. Colorectal cell lines were used to overexpress or knockdown tricellulin expression in various assays. The data revealed that upregulated tricellulin expression was associated with lymph node and distant metastases and poor prognosis, while tricellulin overexpression promoted colorectal cancer cell migration and invasion in vitro. In contrast, tricellulin knockdown had positive effects on the tumor cells. Furthermore, TMT‑LC‑MS/MS and bioinformatics analyses revealed that tricellulin was involved in EMT and reduction of apoptosis through the NF‑κB signaling pathway. These findings highlight for the first time the significance of tricellulin in colorectal cancer development and progression. Further study may validate tricellulin as a novel biomarker and target for colorectal cancer.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Dekker E, Tanis PJ, Vleugels JL, Kasi PM and Wallace MB: Colorectal cancer. Lancet. 394:1467–1480. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Fujita T: Colorectal cancer. Lancet. 376:331–332. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Stein A, Atanackovic D and Bokemeyer C: Current standards and new trends in the primary treatment of colorectal cancer. Eur J Cancer. 47 (Suppl 3):S312–S314. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Fakih MG: Metastatic colorectal cancer: Current state and future directions. J Clin Oncol. 33:1809–1824. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Boland PM and Ma WW: Immunotherapy for colorectal cancer. Cancers (Basel). 9:502017. View Article : Google Scholar

7 

Syn NL, Teng MWL, Mok TSK and Soo RA: De-novo and acquired resistance to immune checkpoint targeting. Lancet Oncol. 18:e731–e741. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Brenner H and Chen C: The colorectal cancer epidemic: Challenges and opportunities for primary, secondary and tertiary prevention. Br J Cancer. 119:785–792. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Wang W, Kandimalla R, Huang H, Zhu L, Li Y, Gao F, Goel A and Wang X: Molecular subtyping of colorectal cancer: Recent progress, new challenges and emerging opportunities. Semin Cancer Biol. 55:37–52. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Zacharakis M, Xynos ID, Lazaris A, Smaro T, Kosmas C, Dokou A, Felekouras E, Antoniou E, Polyzos A, Sarantonis J, et al: Predictors of survival in stage IV metastatic colorectal cancer. Anticancer Res. 30:653–660. 2010.PubMed/NCBI

11 

Garcia MA, Nelson WJ and Chavez N: Cell-cell junctions organize structural and signaling networks. Cold Spring Harb Perspect Biol. 10:a0291812018. View Article : Google Scholar : PubMed/NCBI

12 

Anderson JM and Van Itallie CM: Physiology and function of the tight junction. Cold Spring Harb Perspect Biol. 1:a0025842009. View Article : Google Scholar : PubMed/NCBI

13 

Martin TA: The role of tight junctions in cancer metastasis. Semin Cell Dev Biol. 36:224–231. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Schuetz A, Radusheva V, Krug SM and Heinemann U: Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization. Ann NY Acad Sci. 1405:147–159. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Oda Y, Otani T, Ikenouchi J and Furuse M: Tricellulin regulates junctional tension of epithelial cells at tricellular contacts through Cdc42. J Cell Sci. 127:4201–4212. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Morampudi V, Graef FA, Stahl M, Dalwadi U, Conlin VS, Huang T, Vallance BA, Yu HB and Jacobson K: Tricellular tight junction protein tricellulin is targeted by the enteropathogenic escherichia coli effector EspG1, leading to epithelial barrier disruption. Infect Immun. 85:e00700–16. 2016.PubMed/NCBI

17 

Takasawa A, Murata M, Takasawa K, Ono Y, Osanai M, Tanaka S, Nojima M, Kono T, Hirata K, Kojima T and Sawada N: Nuclear localization of tricellulin promotes the oncogenic property of pancreatic cancer. Sci Rep. 6:335822016. View Article : Google Scholar : PubMed/NCBI

18 

Benson AB III, Venook AP, Cederquist L, Chan E, Chen YJ, Cooper HS, Deming D, Engstrom PF, Enzinger PC, Fichera A, et al: Colon cancer, version 1.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 15:370–398. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Yang F, Xu J, Li H, Tan M, Xiong X and Sun Y: FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation. Nat Commun. 10:13822019. View Article : Google Scholar : PubMed/NCBI

20 

Sadeghi MR, Jeddi F, Soozangar N, Somi MH, Shirmohamadi M, Khaze V and Samadi N: Nrf2/P-glycoprotein axis is associated with clinicopathological characteristics in colorectal cancer. Biomed Pharmacother. 104:458–464. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Hwang JY, Park JH, Kim MJ, Kim WJ, Ha KT, Choi BT, Lee SY and Shin HK: Isolinderalactone regulates the BCL-2/caspase-3/PARP pathway and suppresses tumor growth in a human glioblastoma multiforme xenograft mouse model. Cancer Lett. 443:25–33. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Qin M, Zhang J, Xu C, Peng P, Tan L, Liu S and Huang J: Knockdown of NIK and IKKβ-binding protein (NIBP) reduces colorectal cancer metastasis through down-regulation of the canonical NF-κΒ signaling pathway and suppression of MAPK signaling mediated through ERK and JNK. PLoS One. 12:e01705952017. View Article : Google Scholar : PubMed/NCBI

24 

Ting L, Rad R, Gygi SP and Haas W: MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics. Nat Methods. 8:937–940. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Tolonen AC and Haas W: Quantitative proteomics using reductive dimethylation for stable isotope labeling. J Vis Exp. 514162014.

26 

Wang K, Shan Z, Duan L, Gong T, Liu F, Zhang Y, Wang Z, Shen J and Lei L: iTRAQ-based quantitative proteomic analysis of Yamanaka factors reprogrammed breast cancer cells. Oncotarget. 8:34330–34339. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Kanehisa M, Sato Y, Kawashima M, Furumichi M and Tanabe M: KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 44:D457–D462. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43:D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Zhao GX, Xu YY, Weng SQ, Zhang S, Chen Y, Shen XZ, Dong L and Chen S: CAPS1 promotes colorectal cancer metastasis via Snail mediated epithelial mesenchymal transformation. Oncogene. 38:4574–4589. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Xu CY, Qin MB, Tan L, Liu SQ and Huang JA: NIBP impacts on the expression of E-cadherin, CD44 and vimentin in colon cancer via the NF-κB pathway. Mol Med Rep. 13:5379–5385. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Zeisel MB, Dhawan P and Baumert TF: Tight junction proteins in gastrointestinal and liver disease. Gut. 68:547–561. 2019. View Article : Google Scholar : PubMed/NCBI

33 

France MM and Turner JR: The mucosal barrier at a glance. J Cell Sci. 130:307–314. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Pastushenko I and Blanpain C: EMT transition states during tumor progression and metastasis. Trends Cell Biol. 29:212–226. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Gonzalez DM and Medici D: Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal. 7:re82014. View Article : Google Scholar : PubMed/NCBI

36 

Xu CY, Liu SQ, Qin MB, Zhuge CF, Qin L, Qin N, Lai MY and Huang JA: SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells. Int J Mol Med. 39:1277–1284. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Ikenouchi J, Furuse M, Furuse K, Sasaki H and Tsukita S and Tsukita S: Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J Cell Biol. 171:939–945. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Shimada H, Satohisa S, Kohno T, Takahashi S, Hatakeyama T, Konno T, Tsujiwaki M, Saito T and Kojima T: The roles of tricellular tight junction protein lipolysis-stimulated lipoprotein receptor in malignancy of human endometrial cancer cells. Oncotarget. 7:27735–27752. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Schlachter K, Gyugos M, Halasz J, Lendvai G, Baghy K, Garami M, Gyöngyösi B, Schaff Z and Kiss A: High tricellulin expression is associated with better survival in human hepatoblastoma. Histopathology. 65:631–641. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Masuda R, Semba S, Mizuuchi E, Yanagihara K and Yokozaki H: Negative regulation of the tight junction protein tricellulin by snail-induced epithelial-mesenchymal transition in gastric carcinoma cells. Pathobiology. 77:106–113. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Somorácz A, Korompay A, Törzsök P, Patonai A, Erdélyi-Belle B, Lotz G, Schaff Z and Kiss A: Tricellulin expression and its prognostic significance in primary liver carcinomas. Pathol Oncol Res. 20:755–764. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Naugler WE and Karin M: NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev. 18:19–26. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Gilmore TD: Introduction to NF-kappaB: Players, pathways, perspectives. Oncogene. 25:6680–6684. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Escarcega RO, Fuentes-Alexandro S, Garcia-Carrasco M, Gatica A and Zamora A: The transcription factor nuclear factor-kappa B and cancer. Clin Oncol (R Coll Radiol). 19:154–161. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Kojima T, Fuchimoto J, Yamaguchi H, Ito T, Takasawa A, Ninomiya T, Kikuchi S, Ogasawara N, Ohkuni T, Masaki T, et al: c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells. J Cell Physiol. 225:720–733. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Xia Y, Shen S and Verma IM: NF-κB, an active player in human cancers. Cancer Immunol Res. 2:823–830. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang JX, Qin MB, Ye Z, Peng P, Li SM, Song Q, Lin L, Liu SQ, Xie LH, Zhu Y, Zhu Y, et al: Association of tricellulin expression with poor colorectal cancer prognosis and metastasis. Oncol Rep 44: 2174-2184, 2020.
APA
Zhang, J., Qin, M., Ye, Z., Peng, P., Li, S., Song, Q. ... Huang, J. (2020). Association of tricellulin expression with poor colorectal cancer prognosis and metastasis. Oncology Reports, 44, 2174-2184. https://doi.org/10.3892/or.2020.7773
MLA
Zhang, J., Qin, M., Ye, Z., Peng, P., Li, S., Song, Q., Lin, L., Liu, S., Xie, L., Zhu, Y., Huang, J."Association of tricellulin expression with poor colorectal cancer prognosis and metastasis". Oncology Reports 44.5 (2020): 2174-2184.
Chicago
Zhang, J., Qin, M., Ye, Z., Peng, P., Li, S., Song, Q., Lin, L., Liu, S., Xie, L., Zhu, Y., Huang, J."Association of tricellulin expression with poor colorectal cancer prognosis and metastasis". Oncology Reports 44, no. 5 (2020): 2174-2184. https://doi.org/10.3892/or.2020.7773
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang JX, Qin MB, Ye Z, Peng P, Li SM, Song Q, Lin L, Liu SQ, Xie LH, Zhu Y, Zhu Y, et al: Association of tricellulin expression with poor colorectal cancer prognosis and metastasis. Oncol Rep 44: 2174-2184, 2020.
APA
Zhang, J., Qin, M., Ye, Z., Peng, P., Li, S., Song, Q. ... Huang, J. (2020). Association of tricellulin expression with poor colorectal cancer prognosis and metastasis. Oncology Reports, 44, 2174-2184. https://doi.org/10.3892/or.2020.7773
MLA
Zhang, J., Qin, M., Ye, Z., Peng, P., Li, S., Song, Q., Lin, L., Liu, S., Xie, L., Zhu, Y., Huang, J."Association of tricellulin expression with poor colorectal cancer prognosis and metastasis". Oncology Reports 44.5 (2020): 2174-2184.
Chicago
Zhang, J., Qin, M., Ye, Z., Peng, P., Li, S., Song, Q., Lin, L., Liu, S., Xie, L., Zhu, Y., Huang, J."Association of tricellulin expression with poor colorectal cancer prognosis and metastasis". Oncology Reports 44, no. 5 (2020): 2174-2184. https://doi.org/10.3892/or.2020.7773
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