Intrahepatic metastases may be specific to hepatocellular carcinoma due to the coagulation and fibrinolytic systems (Review)

  • Authors:
    • Xuemei Li
    • Baohong Gu
    • Bofang Wang
    • Zedong Feng
    • Yanling Ma
    • Haiyuan Li
    • Alexandra Lucas
    • Hao Chen
  • View Affiliations

  • Published online on: October 9, 2020     https://doi.org/10.3892/or.2020.7800
  • Pages: 2345-2352
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Abstract

Hepatocellular carcinoma (HCC) is different from other solid tumors because it is commonly associated with the occurrence of intrahepatic metastasis. Additionally, the liver, unlike other organs, is the main site of coagulation and fibrinolytic factor production. Therefore, it was speculated that coagulation and fibrinolytic factors could be associated with intrahepatic metastasis of HCC. Do the coagulation and fibrinolytic systems protect HCC cells against anoikis during infiltration and metastasis? Conversely, do the coagulation and fibrinolytic systems lead to immune escape of HCC cells by affecting the immune microenvironment of patients? The current review aimed to present a number of novel hypotheses for the treatment of HCC by exploring the mechanisms of coagulation and fibrinolytic factors in the regulation of cancer growth.
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December-2020
Volume 44 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Li X, Gu B, Wang B, Feng Z, Ma Y, Li H, Lucas A and Chen H: Intrahepatic metastases may be specific to hepatocellular carcinoma due to the coagulation and fibrinolytic systems (Review). Oncol Rep 44: 2345-2352, 2020
APA
Li, X., Gu, B., Wang, B., Feng, Z., Ma, Y., Li, H. ... Chen, H. (2020). Intrahepatic metastases may be specific to hepatocellular carcinoma due to the coagulation and fibrinolytic systems (Review). Oncology Reports, 44, 2345-2352. https://doi.org/10.3892/or.2020.7800
MLA
Li, X., Gu, B., Wang, B., Feng, Z., Ma, Y., Li, H., Lucas, A., Chen, H."Intrahepatic metastases may be specific to hepatocellular carcinoma due to the coagulation and fibrinolytic systems (Review)". Oncology Reports 44.6 (2020): 2345-2352.
Chicago
Li, X., Gu, B., Wang, B., Feng, Z., Ma, Y., Li, H., Lucas, A., Chen, H."Intrahepatic metastases may be specific to hepatocellular carcinoma due to the coagulation and fibrinolytic systems (Review)". Oncology Reports 44, no. 6 (2020): 2345-2352. https://doi.org/10.3892/or.2020.7800