Molecular alterations and clinical relevance in cervical carcinoma and precursors (Review)
- Authors:
- Jiayi Sheng
- Yi Xiang
- Li Shang
- Qiongqiong He
-
Affiliations: School of Basic Medical Science, Central South University, Changsha, Hunan 410013, P.R. China, Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China - Published online on: October 12, 2020 https://doi.org/10.3892/or.2020.7804
- Pages: 2397-2405
This article is mentioned in:
Abstract
|
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Schiffman M, Wentzensen N, Wacholder S, Kinney W, Gage JC and Castle PE: Human papillomavirus testing in the prevention of cervical cancer. J Natl Cancer Inst. 103:368–383. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
zur Hausen H: Papillomaviruses and cancer: From basic studies to clinical application. Nat Rev Cancer. 2:342–350. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Lu Z and Chen J: Introduction of WHO classification of tumours of female reproductive organs, fourth edition. Zhonghua Bing Li Xue Za Zhi. 43:649–650. 2014.(In Chinese). PubMed/NCBI | |
|
Dalla Palma P, Giorgi Rossi P, Collina G, Buccoliero AM, Ghiringhello B, Gilioli E, Onnis GL, Aldovini D, Galanti G, Casadei G, et al: The reproducibility of CIN diagnoses among different pathologists: Data from histology reviews from a multicenter randomized study. Am J Clin Pathol. 132:125–132. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang SK, Kang LN, Chang IJ, Zhao FH, Hu SY, Chen W, Shi JF, Zhang X, Pan QJ, Li SM and Qiao YL: The natural history of cervical cancer in Chinese women: Results from an 11-year follow-up study in China using a multistate model. Cancer Epidemiol Biomarkers Prev. 23:1298–1305. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Tainio K, Athanasiou A, Tikkinen KAO, Aaltonen R, Cardenas J, Hernandes, Glazer-Livson S, Jakobsson M, Joronen K, Kiviharju M, et al: Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: Systematic review and meta-analysis. BMJ. 360:k4992018. View Article : Google Scholar : PubMed/NCBI | |
|
Policht FA, Song M, Sitailo S, O'Hare A, Ashfaq R, Muller CY, Morrison LE, King W and Sokolova IA: Analysis of genetic copy number changes in cervical disease progression. BMC Cancer. 10:4322010. View Article : Google Scholar : PubMed/NCBI | |
|
Rodolakis A, Biliatis I, Symiakaki H, Kershnar E, Kilpatrick MW, Haidopoulos D, Thomakos N and Antsaklis A: Role of chromosome 3q26 gain in predicting progression of cervical dysplasia. Int J Gynecol Cancer. 22:742–747. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Koeneman MM, Ovestad IT, Janssen EAM, Ummelen M, Kruitwagen RFPM, Hopman AH and Kruse AJ: Gain of chromosomal region 3q26 as a prognostic biomarker for high-grade cervical intraepithelial neoplasia: Literature overview and pilot study. Pathol Oncol Res. 25:549–557. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Kudela E, Visnovsky J, Balharek T, Farkasova A, Zubor P, Plank L and Danko J: Different amplification patterns of 3q26 and 5p15 regions in cervical intraepithelial neoplasia and cervical cancer. Ann Diagn Pathol. 35:16–20. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Cezar-Dos-Santos F, Ferreira RS, Okuyama NCM, Trugilo KP, Sena MM, Pereira ER, Pereira APL, Watanabe MAE and de Oliveira KB: FOXP3 immunoregulatory gene variants are independent predictors of human papillomavirus infection and cervical cancer precursor lesions. J Cancer Res Clin Oncol. 145:2013–2025. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Isakova J, Vinnikov D, Bukuev N, Talaibekova E and Aldasheva N: TP53 Codon 72 polymorphism and human papilloma virus-associated cervical cancer in Kyrgyz women. Asian Pac J Cancer Prev. 20:1057–1062. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Chen B, Jiao Y, Yaolong F, Li T, Liu Y, Wang M, Xiuli G and Feng X: The POLR2E rs3787016 polymorphism is strongly associated with the risk of female breast and cervical cancer. Pathol Res Pract. 215:1061–1065. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Sui S, Chen H, Han L, Wang L, Niyazi M and Zhu K: Correlation of APOBEC3G polymorphism with human papillomavirus (HPV) persistent infection and progression of cervical lesions. Med Sci Monit. 25:6990–6997. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L, Zhao W, Hong J, Niu F, Li J, Zhang S and Jin T: Association between IL1B gene and cervical cancer susceptibility in Chinese Uygur population: A case-control study. Mol Genet Genomic Med. 7:e7792019. View Article : Google Scholar : PubMed/NCBI | |
|
Yang S, Zhao J and Li L: NAD(P)H: Quinone oxidoreductase 1 gene rs1800566 polymorphism increases the risk of cervical cancer in a Chinese Han sample: A STROBE-complaint case-control study. Medicine (Baltimore). 99:e199412020. View Article : Google Scholar : PubMed/NCBI | |
|
Hu S, Pu D, Xia X, Guo B and Zhang C: CTLA-4 rs5742909 polymorphism and cervical cancer risk: A meta-analysis. Medicine (Baltimore). 99:e194332020. View Article : Google Scholar : PubMed/NCBI | |
|
Ye F, Wang H, Liu J, Cheng Q, Chen X and Chen H: Genetic variants of the dUTPase-encoding gene DUT increase HR-HPV infection rate and cervical squamous cell carcinoma risk. Sci Rep. 9:5132019. View Article : Google Scholar : PubMed/NCBI | |
|
Sakane J, Taniyama K, Miyamoto K, Saito A, Kuraoka K, Nishimura T, Sentani K, Oue N and Yasui W: Aberrant DNA methylation of DLX4 and SIM1 is a predictive marker for disease progression of uterine cervical low-grade squamous intraepithelial lesion. Diagn Cytopathol. 43:462–470. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Luan T, Hua Q, Liu X, Xu P, Gu Y, Qian H, Yan L, Xu X, Geng R, Zeng X and Li P: PAX1 methylation as a potential biomarker to predict the progression of cervical intraepithelial neoplasia: A Meta-analysis of related studies. Int J Gynecol Cancer. 27:1480–1488. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang J, Yao T, Lin Z and Gao Y: Aberrant Methylation of MEG3 functions as a potential plasma-based biomarker for cervical cancer. Sci Rep. 7:62712017. View Article : Google Scholar : PubMed/NCBI | |
|
Rogeri CD, Silveira HCS, Causin RL, Villa LL, Stein MD, de Carvalho AC, Arantes LM, Scapulatempo-Neto C, Possati-Resende JC, Antoniazzi M, et al: Methylation of the hsa-miR-124, SOX1, TERT, and LMX1A genes as biomarkers for precursor lesions in cervical cancer. Gynecol Oncol. 150:545–551. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Verlaat W, Snijders PJ, Novianti PW, Wilting SM, De Strooper LM, Trooskens G, Vandersmissen J, Van Criekinge W, Wisman GB, Meijer CJ, et al: Genome-wide DNA methylation profiling reveals methylation markers associated with 3q gain for detection of cervical precancer and cancer. Clin Cancer Res. 23:3813–3822. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
De Strooper LM, Berkhof J, Steenbergen RD, Lissenberg-Witte BI, Snijders PJ, Meijer CJ and Heideman DA: Cervical cancer risk in HPV-positive women after a negative FAM19A4/mir124-2 methylation test: A post hoc analysis in the POBASCAM trial with 14 year follow-up. Int J Cancer. 143:1541–1548. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Beyer S, Zhu J, Mayr D, Kuhn C, Schulze S, Hofmann S, Dannecker C, Jeschke U and Kost BP: Histone H3 Acetyl K9 and Histone H3 Tri Methyl K4 as prognostic markers for patients with cervical cancer. Int J Mol Sci. 18:4772017. View Article : Google Scholar | |
|
Zhang L, Tian S, Pei M, Zhao M, Wang L, Jiang Y, Yang T, Zhao J, Song L and Yang X: Crosstalk between histone modification and DNA methylation orchestrates the epigenetic regulation of the costimulatory factors, Tim3 and galectin9, in cervical cancer. Oncol Rep. 42:2655–2669. 2019.PubMed/NCBI | |
|
Shi Y, Ma HL, Zhuang YW, Wang XX, Jiang Y and Xu HE: C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels. Acta Pharmacol Sin. 40:1457–1465. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Egger G, Liang G, Aparicio A and Jones PA: Epigenetics in human disease and prospects for epigenetic therapy. Nature. 429:457–463. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Zeng K, Zheng W, Mo X, Liu F, Li M, Liu Z, Zhang W and Hu X: Dysregulated microRNAs involved in the progression of cervical neoplasm. Arch Gynecol Obstet. 292:905–913. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu Y, Han Y, Tian T, Su P, Jin G, Chen J and Cao Y: MiR-21-5p, miR-34a, and human telomerase RNA component as surrogate markers for cervical cancer progression. Pathol Res Pract. 214:374–379. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Sommerova L, Anton M, Bouchalova P, Jasickova H, Rak V, Jandakova E, Selingerova I, Bartosik M, Vojtesek B and Hrstka R: The role of miR-409-3p in regulation of HPV16/18-E6 mRNA in human cervical high-grade squamous intraepithelial lesions. Antiviral Res. 163:185–192. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Jin Y, Zhou X, Yao X, Zhang Z, Cui M and Lin Y: MicroRNA-612 inhibits cervical cancer progression by targeting NOB1. J Cell Mol Med. 24:3149–3156. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao XQ, Tang H, Yang J, Gu XY, Wang SM and Ding Y: MicroRNA-15a-5p down-regulation inhibits cervical cancer by targeting TP53INP1 in vitro. Eur Rev Med Pharmacol Sci. 23:8219–8229. 2019.PubMed/NCBI | |
|
Sun Y, Cheng Y, Zhang Y and Han K: MicroRNA-889-3p targets FGFR2 to inhibit cervical cancer cell viability and invasion. Exp Ther Med. 18:1440–1448. 2019.PubMed/NCBI | |
|
Yu Y, Zhao JD and Yang H: MiR-299-3p inhibits proliferation and invasion of cervical cancer cell via targeting TCF4. Eur Rev Med Pharmacol Sci. 23:5621–5627. 2019.PubMed/NCBI | |
|
Ma J, Zhang F and Sun P: miR-140-3p impedes the proliferation of human cervical cancer cells by targeting RRM2 to induce cell-cycle arrest and early apoptosis. Bioorg Med Chem. 28:1152832020. View Article : Google Scholar : PubMed/NCBI | |
|
Kapora E, Feng S, Liu W, Sakhautdinova I, Gao B and Tan W: MicroRNA-505-5p functions as a tumor suppressor by targeting cyclin-dependent kinase 5 in cervical cancer. Biosci Rep. 39:BSR201912212019. View Article : Google Scholar : PubMed/NCBI | |
|
Meng F, Ou J, Liu J, Li X, Meng Y, Yan L, Deng P and Sun B: MicroRNA-877 is downregulated in cervical cancer and directly targets MACC1 to inhibit cell proliferation and invasion. Exp Ther Med. 18:3650–3658. 2019.PubMed/NCBI | |
|
Hu QL, Xu ZP, Lan YF and Li B: miR-636 represses cell survival by targeting CDK6/Bcl-2 in cervical cancer. Kaohsiung J Med Sci. 36:328–335. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Wu J, Zhao Y, Li F and Qiao B: MiR-144-3p: A novel tumor suppressor targeting MAPK6 in cervical cancer. J Physiol Biochem. 75:143–152. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Ji X, Guo H, Yin S and Du H: miR-139-5p functions as a tumor suppressor in cervical cancer by targeting TCF4 and inhibiting Wnt/β-catenin signaling. Onco Targets Ther. 12:7739–7748. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Xu J, Wang H, Wang H, Chen Q, Zhang L, Song C, Zhou Q and Hong Y: The inhibition of miR-126 in cell migration and invasion of cervical cancer through regulating ZEB1. Hereditas. 156:112019. View Article : Google Scholar : PubMed/NCBI | |
|
Yuan M, Zhao S, Chen R, Wang G, Bie Y, Wu Q and Cheng J: MicroRNA-138 inhibits tumor growth and enhances chemosensitivity in human cervical cancer by targeting H2AX. Exp Ther Med. 19:630–638. 2020.PubMed/NCBI | |
|
Li H, Wang J, Xu F, Wang L, Sun G, Wang J and Yang Y: By downregulating PBX3, miR-526b suppresses the epithelial-mesenchymal transition process in cervical cancer cells. Future Oncol. 15:1577–1591. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Wang S, Gao B, Yang H, Liu X, Wu X and Wang W: MicroRNA-432 is downregulated in cervical cancer and directly targets FN1 to inhibit cell proliferation and invasion. Oncol Lett. 18:1475–1482. 2019.PubMed/NCBI | |
|
Liu X, Gan L and Zhang J: miR-543 inhibites cervical cancer growth and metastasis by targeting TRPM7. Chem Biol Interact. 302:83–92. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Fu Y, Meng Y, Gu X, Tian S, Hou X and Ji M: miR-503 expression is downregulated in cervical cancer and suppresses tumor growth by targeting AKT2. J Cell Biochem. Jan 29–2019.(Epub ahead of print). doi: 10.1002/jcb.28099. View Article : Google Scholar | |
|
Li J, Chu ZP, Han H, Zhang Y, Tian F, Zhang JQ and Huang XH: Suppression of miR-93-5p inhibits high-risk HPV-positive cervical cancer progression via targeting of BTG3. Hum Cell. 32:160–171. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu J and Han S: miR-150-5p promotes the proliferation and epithelial-mesenchymal transition of cervical carcinoma cells via targeting SRCIN1. Pathol Res Pract. 215:738–747. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Luo Q, Wang H and Li J: Serum miR-3142 could be used as a potential biomarker to screen cervical cancer patients from healthy controls. Clin Lab. 65:2019. View Article : Google Scholar | |
|
Zheng M, Hou L, Ma Y, Zhou L, Wang F, Cheng B, Wang W, Lu B, Liu P, Lu W and Lu Y: Exosomal let-7d-3p and miR-30d-5p as diagnostic biomarkers for non-invasive screening of cervical cancer and its precursors. Mol Cancer. 18:762019. View Article : Google Scholar : PubMed/NCBI | |
|
Hayes J, Peruzzi PP and Lawler S: MicroRNAs in cancer: Biomarkers, functions and therapy. Trends Mol Med. 20:460–469. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Miyamoto S, Hasegawa J, Morioka M, Hirota Y, Kushima M and Sekizawa A: The association between p16 and Ki-67 immunohistostaining and the progression of cervical intraepithelial neoplasia grade 2. Int J Gynaecol Obstet. 134:45–48. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Miralpeix E, Genoves J, Maria Sole-Sedeno J, Mancebo G, Lloveras B, Bellosillo B, Alameda F and Carreras R: Usefulness of p16(INK4a) staining for managing histological high-grade squamous intraepithelial cervical lesions. Mod Pathol. 30:304–310. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Sagasta A, Castillo P, Saco A, Torne A, Esteve R, Marimon L, Ordi J and Del Pino M: p16 staining has limited value in predicting the outcome of histological low-grade squamous intraepithelial lesions of the cervix. Mod Pathol. 29:51–59. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Rodriguez-Trujillo A, Marti C, Angeles MA, Sierra A, Esteve R, Saco A, Barnadas E, Marimon L, Nicolas I, Torne A, et al: Value of HPV 16/18 genotyping and p16/Ki-67 dual staining to predict progression to HSIL/CIN2+ in negative cytologies from a colposcopy referral population. Am J Clin Pathol. 150:432–440. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Negri G, Bellisano G, Zannoni GF, Rivasi F, Kasal A, Vittadello F, Antoniazzi S, Faa G, Ambu R and Egarter-Vigl E: p16 ink4a and HPV L1 immunohistochemistry is helpful for estimating the behavior of low-grade dysplastic lesions of the cervix uteri. Am J Surg Pathol. 32:1715–1720. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Hoshikawa S, Sano T, Yoshida T, Ito H, Oyama T and Fukuda T: Immunohistological analysis of HPV L1 capsid protein and p16 protein in low-grade dysplastic lesions of the uterine cervix. Pathol Res Pract. 206:816–820. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Jia WL, Ding L, Ren ZY, Wu TT, Zhao WM, Fan SL and Wang JT: Effects of both folic acid, p16 protein expression and their interaction on progression of cervical cancerization. Zhonghua Liu Xing Bing Xue Za Zhi. 37:1647–1652. 2016.(In Chinese). PubMed/NCBI | |
|
Paquette C, Mills AM and Stoler MH: Predictive value of cytokeratin 7 immunohistochemistry in cervical low-grade squamous intraepithelial lesion as a marker for risk of progression to a high-grade lesion. Am J Surg Pathol. 40:236–243. 2016.PubMed/NCBI | |
|
Mills AM, Paquette C, Terzic T, Castle PE and Stoler MH: CK7 immunohistochemistry as a predictor of CIN1 progression: A retrospective study of patients from the quadrivalent HPV vaccine trials. Am J Surg Pathol. 41:143–152. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Cao L, Sun PL, Yao M, Chen S and Gao H: Clinical significance of CK7, HPV-L1, and koilocytosis for patients with cervical low-grade squamous intraepithelial lesions: A retrospective analysis. Hum Pathol. 65:194–200. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wu Y, Gu TT and Zheng PS: CIP2A cooperates with H-Ras to promote epithelial-mesenchymal transition in cervical-cancer progression. Cancer Lett. 356:646–655. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Cavatorta AL, Di Gregorio A, Bugnon Valdano M, Marziali F, Cabral M, Bottai H, Cittadini J, Nocito AL and Gardiol D: DLG1 polarity protein expression associates with the disease progress of low-grade cervical intraepithelial lesions. Exp Mol Pathol. 102:65–69. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang HR, Lai SY, Huang LJ, Zhang ZF, Liu J, Zheng SR, Ding K, Bai X and Zhou JY: Myosin 1b promotes cell proliferation, migration, and invasion in cervical cancer. Gynecol Oncol. 149:188–197. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Jin Y, Kim SC and Kim HJ, Ju W, Kim YH and Kim HJ: Use of protein-based biomarkers of exfoliated cervical cells for primary screening of cervical cancer. Arch Pharm Res. 41:438–449. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Wu Q, Li N, Che S, Jin T, Nan Y, Lin Z and Chen L: Upregulation of Tiam1 contributes to cervical cancer disease progression and indicates poor survival outcome. Hum Pathol. 75:179–188. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Mizushima T, Asai-Sato M, Akimoto K, Nagashima Y, Taguri M, Sasaki K, Nakaya MA, Asano R, Tokinaga A, Kiyono T, et al: Aberrant expression of the cell polarity regulator aPKCλ/ι is associated with disease progression in cervical intraepithelial neoplasia (CIN): A possible marker for predicting CIN prognosis. Int J Gynecol Pathol. 35:106–117. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Hester A, Ritzer M, Kuhn C, Schmoeckel E, Mayr D, Kolben T, Dannecker C, Mahner S, Jeschke U and Kolben TM: The role of EP3-receptor expression in cervical dysplasia. J Cancer Res Clin Oncol. 145:313–319. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Sawada M, Oishi T, Komatsu H, Sato S, Chikumi J, Nonaka M, Kudoh A, Osaku D and Harada T: Serum vascular endothelial growth factor A and vascular endothelial growth factor receptor 2 as prognostic biomarkers for uterine cervical cancer. Int J Clin Oncol. 24:1612–1619. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Maestri CA, Nisihara R, Mendes HW, Jensenius J, Thiel S, Messias-Reason I and de Carvalho NS: MASP-1 and MASP-2 serum levels are associated with worse prognostic in cervical cancer progression. Front Immunol. 9:27422018. View Article : Google Scholar : PubMed/NCBI | |
|
Pascoal-Xavier MA, Figueiredo AC, Gomes LI, Peruhype-Magalhaes V, Calzavara-Silva CE, Costa MA, Reis IA, Bonjardim CA, Kroon EG, Oliveira JG and Ferreira PC: RAP1 GTPase overexpression is associated with cervical intraepithelial neoplasia. PLoS One. 10:e01235312015. View Article : Google Scholar : PubMed/NCBI | |
|
Fukazawa EM, Baiocchi G, Soares FA, Kumagai LY, Faloppa CC, Badiglian-Filho L, Coelho FR, Goncalves WJ, Costa RL and Goes JC: Cox-2, EGFR, and ERBB-2 expression in cervical intraepithelial neoplasia and cervical cancer using an automated imaging system. Int J Gynecol Pathol. 33:225–234. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Meng GZ, Zi Y, Li HQ, Huang M and Gao T: Nucleolin expression is correlated with carcinogenesis and progression of cervical squamous cell carcinoma. Nan Fang Yi Ke Da Xue Xue Bao. 35:1511–1514. 2015.(In Chinese). PubMed/NCBI | |
|
Li N, Wang Y, Che S, Yang Y, Piao J, Liu S and Lin Z: HBXIP over expression as an independent biomarker for cervical cancer. Exp Mol Pathol. 102:133–137. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Fan SL, Ding L, Ren ZY, Chen X, Sun XS, Li CC, Liu CL, Jia WL, Li QL and Wang JT: Effect of extracellular signal-regulated kinas 1/2 expression and HPV16 infection and their interaction in progression of cervical cancerization. Zhonghua Liu Xing Bing Xue Za Zhi. 38:96–101. 2017.(In Chinese). PubMed/NCBI | |
|
Iizuka T, Wakae K, Nakamura M, Kitamura K, Ono M, Fujiwara H and Muramatsu M: APOBEC3G is increasingly expressed on the human uterine cervical intraepithelial neoplasia along with disease progression. Am J Reprod Immunol. 78:2017. View Article : Google Scholar : PubMed/NCBI | |
|
Ding L, Feng MJ, Liu CL, Wang L, Song ZC, Yang Q, Li XX, Song L, Gao W and Wang JT: Effect of hnRNP K and its interaction with HPV16 on cervical intraepithelial neoplasia. Zhonghua Liu Xing Bing Xue Za Zhi. 39:1630–1635. 2018.(In Chinese). PubMed/NCBI | |
|
Ahn SY, Li C, Zhang X and Hyun YM: Mitofusin-2 expression is implicated in cervical cancer pathogenesis. Anticancer Res. 38:3419–3426. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Y, Wang H, Lin W and Shuai P: ADAR1 overexpression is associated with cervical cancer progression and angiogenesis. Diagn Pathol. 12:122017. View Article : Google Scholar : PubMed/NCBI | |
|
Xing Y, Wang C and Wu J: Expression of geminin, p16, and Ki67 in cervical intraepithelial neoplasm and normal tissues. Medicine (Baltimore). 96:e73022017. View Article : Google Scholar : PubMed/NCBI | |
|
Velez-Perez A, Wang XI, Li M and Zhang S: SIRT1 overexpression in cervical squamous intraepithelial lesions and invasive squamous cell carcinoma. Hum Pathol. 59:102–107. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Zhang J, Qian W, Dong Y, Yang Y, Liu Z, Feng Y, Ma D, Zhang Z and Wu S: Gankyrin is frequently overexpressed in cervical high grade disease and is associated with cervical carcinogenesis and metastasis. PLoS One. 9:e950432014. View Article : Google Scholar : PubMed/NCBI |
