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Article

MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3

  • Authors:
    • Ming Cheng
    • Ping‑Guo Duan
    • Zhi‑Zeng Gao
    • Min Dai
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
  • Pages: 2691-2700
    |
    Published online on: October 19, 2020
       https://doi.org/10.3892/or.2020.7814
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Abstract

Metastasis and chemoresistance indicate poor prognosis in patients with osteosarcoma (OS). In the present study, the expression level of microRNA(miR)‑487b‑3p in OS specimens and cell lines was found to be decreased, and the expression level of miR‑487b‑3p was associated with overall survival in patients with OS. The inhibition of miR‑487b‑3p stimulated OS cell migration and contributed to the development of chemoresistance. In contrast, the overexpression of miR‑487b‑3p significantly inhibited OS cell migration and enhanced the sensitivity of OS cells to doxorubicin treatment. In addition, the results from the present study revealed that the suppression of miR‑487b‑3p stimulates OS stemness, while the overexpression of miR‑487b‑3p suppresses OS stemness. Notably, in vivo experiments also revealed that the overexpression of miR‑487b‑3p inhibited cancer stem cell (CSC)‑induced tumor formation, and the combination treatment of miR‑487b‑3p and doxorubicin significantly inhibited CSC‑induced tumor growth. Furthermore, miR‑487b‑3p exerts its anticancer role by targeting aldehyde dehydrogenase 1 family member A3 in OS. Taken together, the results from the present study suggests that miR‑487b‑3p is a tumor suppressor and that the overexpression of miR‑487b‑3p is a novel strategy to inhibit tumor metastasis and chemoresistance in OS.
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Copy and paste a formatted citation
Spandidos Publications style
Cheng M, Duan PG, Gao ZZ and Dai M: MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3. Oncol Rep 44: 2691-2700, 2020.
APA
Cheng, M., Duan, P., Gao, Z., & Dai, M. (2020). MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3. Oncology Reports, 44, 2691-2700. https://doi.org/10.3892/or.2020.7814
MLA
Cheng, M., Duan, P., Gao, Z., Dai, M."MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3". Oncology Reports 44.6 (2020): 2691-2700.
Chicago
Cheng, M., Duan, P., Gao, Z., Dai, M."MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3". Oncology Reports 44, no. 6 (2020): 2691-2700. https://doi.org/10.3892/or.2020.7814
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng M, Duan PG, Gao ZZ and Dai M: MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3. Oncol Rep 44: 2691-2700, 2020.
APA
Cheng, M., Duan, P., Gao, Z., & Dai, M. (2020). MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3. Oncology Reports, 44, 2691-2700. https://doi.org/10.3892/or.2020.7814
MLA
Cheng, M., Duan, P., Gao, Z., Dai, M."MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3". Oncology Reports 44.6 (2020): 2691-2700.
Chicago
Cheng, M., Duan, P., Gao, Z., Dai, M."MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3". Oncology Reports 44, no. 6 (2020): 2691-2700. https://doi.org/10.3892/or.2020.7814
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