Open Access

Glycogen synthase kinase 3β in tumorigenesis and oncotherapy (Review)

  • Authors:
    • Rui He
    • Suya Du
    • Tiantian Lei
    • Xiaofang Xie
    • Yi Wang
  • View Affiliations

  • Published online on: October 20, 2020     https://doi.org/10.3892/or.2020.7817
  • Pages: 2373-2385
  • Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glycogen synthase kinase 3β (GSK 3β), a multifunctional serine and threonine kinase, plays a critical role in a variety of cellular activities, including signaling transduction, protein and glycogen metabolism, cell proliferation, cell differentiation, and apoptosis. Therefore, aberrant regulation of GSK 3β results in a broad range of human diseases, such as tumors, diabetes, inflammation and neurodegenerative diseases. Accumulating evidence has suggested that GSK 3β is correlated with tumorigenesis and progression. However, GSK 3β is controversial due to its bifacial roles of tumor suppression and activation. In addition, overexpression of GSK 3β is involved in tumor growth, whereas it contributes to the cell sensitivity to chemotherapy. However, the underlying regulatory mechanisms of GSK 3β in tumorigenesis remain obscure and require further in‑depth investigation. In this review, we comprehensively summarize the roles of GSK 3β in tumorigenesis and oncotherapy, and focus on its potentials as an available target in oncotherapy.
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December-2020
Volume 44 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
He R, Du S, Lei T, Xie X and Wang Y: Glycogen synthase kinase 3β in tumorigenesis and oncotherapy (Review). Oncol Rep 44: 2373-2385, 2020
APA
He, R., Du, S., Lei, T., Xie, X., & Wang, Y. (2020). Glycogen synthase kinase 3β in tumorigenesis and oncotherapy (Review). Oncology Reports, 44, 2373-2385. https://doi.org/10.3892/or.2020.7817
MLA
He, R., Du, S., Lei, T., Xie, X., Wang, Y."Glycogen synthase kinase 3β in tumorigenesis and oncotherapy (Review)". Oncology Reports 44.6 (2020): 2373-2385.
Chicago
He, R., Du, S., Lei, T., Xie, X., Wang, Y."Glycogen synthase kinase 3β in tumorigenesis and oncotherapy (Review)". Oncology Reports 44, no. 6 (2020): 2373-2385. https://doi.org/10.3892/or.2020.7817