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Erb‑B2 Receptor Tyrosine Kinase 2 is negatively regulated by the p53‑responsive microRNA‑3184‑5p in cervical cancer cells

  • Authors:
    • Hongli Liu
    • Yuzhi Li
    • Jing Zhang
    • Nan Wu
    • Fei Liu
    • Lihua Wang
    • Yuan Zhang
    • Jing Liu
    • Xuan Zhang
    • Suyang Guo
    • Hongtao Wang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecological Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233030, P.R. China, Department of Respiration and Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233030, P.R. China, Department of Gynecological Oncology, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China, Department of Immunology and Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 95-106
    |
    Published online on: November 19, 2020
       https://doi.org/10.3892/or.2020.7862
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Abstract

The oncogenic role of Erb‑B2 Receptor Tyrosine Kinase 2 (ERBB2) has been identified in several types of cancer, but less is known on its function and mechanism of action in cervical cancer cells. The present study employed a multipronged approach to investigate the role of ERBB2 in cervical cancer. ERBB2 and microRNA (miR)‑3184‑5p expression was assessed in patient‑derived cervical cancer biopsy tissues, revealing that higher levels of ERBB2 and lower levels of miR‑3184‑5p were associated with clinicopathological indicators of cervical cancer progression. Furthermore, ERBB2 stimulated proliferation, migration and sphere‑formation of cervical cancer cells in vitro. This effect was mediated by enhanced phosphatidylinositol‑4,5‑bisphosphate 3‑kinase catalytic subunit α activity. Additionally, it was revealed that miR‑3184‑5p directly suppressed ERBB2 in cervical cancer cells. The p53 activator Mithramycin A stimulated p53 and miR‑3184‑5p expression, thereby lowering the levels of ERBB2 and attenuating proliferation, migration and sphere‑formation of cervical cancer cells. In conclusion, the findings of the present study suggested ERBB2 as an oncogenic protein that may promote invasiveness in cervical cancer cells. Treatment of cervical cancer cells with the p53 activator Mithramycin A restored the levels of the endogenous ERBB2 inhibitor miR‑3184‑5p and may represent a novel treatment strategy for cervical cancer.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA A Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar

2 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA A Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar

3 

Colombo N, Carinelli S, Colombo A, Marini C, Rollo D and Sessa C; ESMO Guidelines Working Group, : Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 23 (Suppl 7):vii27–vii32. 2012. View Article : Google Scholar

4 

Manzo-Merino J, Contreras-Paredes A, Vázquez-Ulloa E, Rocha-Zavaleta L, Fuentes-Gonzalez AM and Lizano M: The role of signaling pathways in cervical cancer and molecular therapeutic targets. Arch Med Res. 45:525–539. 2014. View Article : Google Scholar

5 

Konno Y, Dong P, Xiong Y, Suzuki F, Lu J, Cai M, Watari H, Mitamura T, Hosaka M, Hanley SJ, et al: MicroRNA-101 targets EZH2, MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells. Oncotarget. 5:6049–6062. 2014. View Article : Google Scholar

6 

Liang X, Liu Y, Zeng L, Yu C, Hu Z, Zhou Q and Yang Z: miR-101 inhibits the G1-to-S phase transition of cervical cancer cells by targeting Fos. Int J Gynecol Cancer. 24:1165–1172. 2014. View Article : Google Scholar

7 

Cheung T, Leung J, Chung TK, Lam S, To K and Wong Y: C-fos overexpression is associated with the pathoneogenesis of invasive cervical cancer. Gynecol Obstet Invest. 43:200–203. 1997. View Article : Google Scholar

8 

Dong P, Ihira K, Hamada J, Watari H, Yamada T, Hosaka M, Hanley SJ, Kudo M and Sakuragi N: Reactivating p53 functions by suppressing its novel inhibitor iASPP: A potential therapeutic opportunity in p53 wild-type tumors. Oncotarget. 6:19968–19975. 2015. View Article : Google Scholar

9 

Dong P, Xiong Y, Watari H, Hanley SJ, Konno Y, Ihira K, Suzuki F, Yamada T, Kudo M, Yue J and Sakuragi N: Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124. Sci Rep. 6:354802016. View Article : Google Scholar

10 

Xiong Y, Sun F, Dong P, Watari H, Yue J, Yu MF, Lan CY, Wang Y and Ma ZB: iASPP induces EMT and cisplatin resistance in human cervical cancer through miR-20a-FBXL5/BTG3 signaling. J Exp Clin Cancer Res. 36:482017. View Article : Google Scholar

11 

Romaine SP, Tomaszewski M, Condorelli G and Samani NJ: MicroRNAs in cardiovascular disease: An introduction for clinicians. Heart. 101:921–928. 2015. View Article : Google Scholar

12 

Sun NX, Ye C, Zhao Q, Zhang Q, Xu C, Wang SB, Jin ZJ, Sun SH, Wang F and Li W: Long noncoding RNA-EBIC promotes tumor cell invasion by binding to EZH2 and repressing E-cadherin in cervical cancer. PLoS One. 9:e1003402014. View Article : Google Scholar

13 

Hu X, Schwarz JK, Lewis JS Jr, Huettner PC, Rader JS, Deasy JO, Grigsby PW and Wang X: A microRNA expression signature for cervical cancer prognosis. Cancer Res. 70:1441–1448. 2010. View Article : Google Scholar

14 

Hattori H, Janky RS, Nietfeld W, Aerts S, Madan Babu M and Venkitaraman AR: p53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response. Cell Cycle. 13:2572–2586. 2014. View Article : Google Scholar

15 

Croessmann S, Formisano L, Kinch LN, Gonzalez-Ericsson PI, Sudhan DR, Nagy RJ, Mathew A, Bernicker EH, Cristofanilli M, He J, et al: Combined blockade of activating ERBB2 mutations and ER results in synthetic lethality of ER+/HER2 mutant breast cancer. Clin Cancer Res. 25:277–289. 2019. View Article : Google Scholar

16 

Sanchez-Vega F, Hechtman JF, Castel P, Castel P, Ku GY, Tuvy Y, Won H, Fong CJ, Bouvier N, Nanjangud GJ, et al: EGFR and MET amplifications determine response to HER2 inhibition in ERBB2-amplified esophagogastric cancer. Cancer Discov. 9:199–209. 2019. View Article : Google Scholar

17 

Ross JS, Fakih M, Ali SM, Elvin JA, Schrock AB, Suh J, Vergilio JA, Ramkissoon S, Severson E, Daniel S, et al: Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3. Cancer. 124:1358–1373. 2018. View Article : Google Scholar

18 

Xiang L, Jiang W, Ye S, He T, Pei X, Li J, Chan DW, Ngan HYS, Li F, Tao P, et al: ERBB2 mutation: A promising target in non-squamous cervical cancer. Gynecol Oncol. 148:311–316. 2018. View Article : Google Scholar

19 

Barceló F, Ortiz-Lombardia M, Martorell M, Oliver M, Méndez C, Salas JA and Portugal J: DNA binding characteristics of mithramycin and chromomycin analogues obtained by combinatorial biosynthesis. Biochemistry. 49:10543–10552. 2010. View Article : Google Scholar

20 

Kennedy B and Torkelson JL: Long-term follow-up of stage III testicular carcinoma treated with mithramycin (Plicamycin). Med Pediatr Oncol. 24:327–328. 1995. View Article : Google Scholar

21 

Dutcher JP, Coletti D, Paietta E and Wiernik PH: A pilot study of alpha-interferon and plicamycin for accelerated phase of chronic myeloid leukemia. Leuk Res. 21:375–380. 1997. View Article : Google Scholar

22 

Fernández-Guizán A, Mansilla S, Barceló F, Barceló F, Vizcaíno C, Núñez LE, Morís F, González S and Portugal J: The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription. Chem Biol Interact. 219:123–132. 2014. View Article : Google Scholar

23 

Choi ES, Nam JS, Jung JY, Cho NP and Cho SD: Modulation of specificity protein 1 by mithramycin A as a novel therapeutic strategy for cervical cancer. Sci Rep. 4:71622014. View Article : Google Scholar

24 

Rao M, Atay SM, Shukla V, Hong Y, Upham T, Ripley RT, Hong JA, Zhang M, Reardon E, Fetsch P, et al: Mithramycin depletes specificity protein 1 and activates p53 to mediate senescence and apoptosis of malignant pleural mesothelioma cells. Clin Cancer Res. 22:1197–1210. 2016. View Article : Google Scholar

25 

Thorpe LM, Yuzugullu H and Zhao JJ: PI3K in cancer: Divergent roles of isoforms, modes of activation and therapeutic targeting. Nat Rev Cancer. 15:72015. View Article : Google Scholar

26 

Wright AA, Howitt BE, Myers AP, Dahlberg SE, Palescandolo E, Van Hummelen P, MacConaill LE, Shoni M, Wagle N, Jones RT, et al: Oncogenic mutations in cervical cancer: Genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix. Cancer. 119:3776–3783. 2013. View Article : Google Scholar

27 

Benedet J, Pecorelli S, Ngan H and Hacker NF: Staging classifications and clinical practice guidelines for gynaecological cancers. Int J Gynecol Obstetr. 70:207–312. 2000. View Article : Google Scholar

28 

Gioia G, Werner B, Nydam D and Moroni P: Validation of a mycoplasma molecular diagnostic test and distribution of mycoplasma species in bovine milk among New York State dairy farms. J Dairy Sci. 99:4668–4677. 2016. View Article : Google Scholar

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

30 

Dong P, Xiong Y, Watari H, Hanley SJ, Konno Y, Ihira K, Yamada T, Kudo M, Yue J and Sakuragi N: MiR-137 and miR-34a directly target Snail and inhibit EMT, invasion and sphere-forming ability of ovarian cancer cells. J Exp Clin Cancer Res. 35:1322016. View Article : Google Scholar

31 

Ihira K, Dong P, Xiong Y, Watari H, Konno Y, Hanley SJ, Noguchi M, Hirata N, Suizu F, Yamada T, et al: EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis. Oncotarget. 8:13509–13520. 2017. View Article : Google Scholar

32 

Hsiao YH, Hsieh MJ, Yang SF, Chen SP, Tsai WC and Chen PN: Phloretin suppresses metastasis by targeting protease and inhibits cancer stemness and angiogenesis in human cervical cancer cells. Phytomedicine. 62:1529642019. View Article : Google Scholar

33 

Hu Y, Ma Y, Liu J, Cai Y, Zhang M and Fang X: LINC01128 expedites cervical cancer progression by regulating miR-383-5p/SFN axis. BMC Cancer. 19:1–11. 2019. View Article : Google Scholar

34 

Lv Y, Cang W, Li Q, Liao X, Zhan M, Deng H, Li S, Jin W, Pang Z, Qiu X, et al: Erlotinib overcomes paclitaxel-resistant cancer stem cells by blocking the EGFR-CREB/GRβ-IL-6 axis in MUC1-positive cervical cancer. Oncogenesis. 8:702019. View Article : Google Scholar

35 

Han SA, Jang JH, Won KY, Lim SJ and Song JY: Prognostic value of putative cancer stem cell markers (CD24, CD44, CD133, and ALDH1) in human papillary thyroid carcinoma. Pathol Res Pract. 213:956–963. 2017. View Article : Google Scholar

36 

Mizukami T, Kamachi H, Mitsuhashi T, Tsuruga Y, Hatanaka Y, Kamiyama T, Matsuno Y and Taketomi A: Immunohistochemical analysis of cancer stem cell markers in pancreatic adenocarcinoma patients after neoadjuvant chemoradiotherapy. BMC Cancer. 14:6872014. View Article : Google Scholar

37 

Engelman JA: Targeting PI3K signalling in cancer: Opportunities, challenges and limitations. Nat Rev Cancer. 9:550–562. 2009. View Article : Google Scholar

38 

Siegel PM, Ryan ED, Cardiff RD and Muller WJ: Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: Implications for human breast cancer. EMBO J. 18:2149–2164. 1999. View Article : Google Scholar

39 

Zhou BP, Hu MC, Miller SA, Yu Z, Xia W, Lin SY and Hung MC: HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway. J Biol Chem. 275:8027–8031. 2000. View Article : Google Scholar

40 

Prigent SA and Gullick WJ: Identification of c-erbB-3 binding sites for phosphatidylinositol 3′-kinase and SHC using an EGF receptor/c-erbB-3 chimera. EMBO J. 13:2831–2841. 1994. View Article : Google Scholar

41 

Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, et al: AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell. 16:21–32. 2009. View Article : Google Scholar

42 

Bonazzoli E, Cocco E, Lopez S, Bellone S, Zammataro L, Bianchi A, Manzano A, Yadav G, Manara P, Perrone E, et al: PI3K oncogenic mutations mediate resistance to afatinib in HER2/neu overexpressing gynecological cancers. Gynecol Oncol. 153:158–164. 2019. View Article : Google Scholar

43 

Suzuki HI, Yamagata K, Sugimoto K, Iwamoto T, Kato S and Miyazono K: Modulation of microRNA processing by p53. Nature. 460:529–533. 2009. View Article : Google Scholar

44 

Dong P, Xiong Y, Hanley SJ, Yue J and Watari H: Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation. J Exp Clin Cancer Res. 36:1502017. View Article : Google Scholar

45 

Cousin S, Khalifa E, Crombe A, Laizet Y, Lucchesi C, Toulmonde M, Le Moulec S, Auzanneau C, Soubeyran I and Italiano A: Targeting ERBB2 mutations in solid tumors: Biological and clinical implications. J Hematol Oncol. 11:862018. View Article : Google Scholar

46 

Breyer J, Wirtz RM, Laible M, Schlombs K, Erben P, Kriegmair MC, Stoehr R, Eidt S, Denzinger S, Burger M, et al: ESR1, ERBB2, and Ki67 mRNA expression predicts stage and grade of non-muscle-invasive bladder carcinoma (NMIBC). Virchows Arch. 469:547–552. 2016. View Article : Google Scholar

47 

Ursini-Siegel J, Schade B, Cardiff RD and Muller WJ: Insights from transgenic mouse models of ERBB2-induced breast cancer. Nat Rev Cancer. 7:389–397. 2007. View Article : Google Scholar

48 

Di Cosimo S and Baselga J: Targeted therapies in breast cancer: Where are we now? Eur J Cancer. 44:2781–2790. 2008. View Article : Google Scholar

49 

Hynes NE and Lane HA: ERBB receptors and cancer: The complexity of targeted inhibitors. Nat Rev Cancer. 5:341–354. 2005. View Article : Google Scholar

50 

Olayioye MA, Neve RM, Lane HA and Hynes NE: The ErbB signaling network: Receptor heterodimerization in development and cancer. EMBO J. 19:3159–3167. 2000. View Article : Google Scholar

51 

Knuefermann C, Lu Y, Liu B, Jin W, Liang K, Wu L, Schmidt M, Mills GB, Mendelsohn J and Fan Z: HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells. Oncogene. 22:3205–3212. 2003. View Article : Google Scholar

52 

Hurtado A, Holmes KA, Geistlinger TR, Hutcheson IR, Nicholson RI, Brown M, Jiang J, Howat WJ, Ali S and Carroll JS: Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen. Nature. 456:663–666. 2008. View Article : Google Scholar

53 

Demidov ON, Kek C, Shreeram S, Timofeev O, Fornace AJ, Appella E and Bulavin DV: The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis. Oncogene. 26:2502–2506. 2007. View Article : Google Scholar

54 

Daly JM, Jannot CB, Beerli RR, Graus-Porta D, Maurer FG and Hynes NE: Neu differentiation factor induces ErbB2 down-regulation and apoptosis of ErbB2-overexpressing breast tumor cells. Cancer Res. 57:3804–3811. 1997.

55 

Wang Y, Zhang X, Chao Z, Kung HF, Lin MC, Dress A, Wardle F, Jiang BH and Lai L: MiR-34a modulates ErbB2 in breast cancer. Cell Biol Int. 41:93–101. 2017. View Article : Google Scholar

56 

He XH, Zhu W, Yuan P, Jiang S, Li D, Zhang HW and Liu MF: miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells. Oncogene. 35:6015–6025. 2016. View Article : Google Scholar

57 

Malek A, Núñez LE, Magistri M, Brambilla L, Jovic S, Carbone GM, Morís F and Catapano CV: Modulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer. PLoS One. 7:e351302012. View Article : Google Scholar

58 

Wang L, Guan X, Zhang J, Jia Z, Wei D, Li Q, Yao J and Xie K: Targeted inhibition of Sp1-mediated transcription for antiangiogenic therapy of metastatic human gastric cancer in orthotopic nude mouse models. Int J Oncol. 33:161–167. 2008.

59 

Haupt S, Raghu D and Haupt Y: Mutant p53 drives cancer by subverting multiple tumor suppression pathways. Front Oncol. 6:122016. View Article : Google Scholar

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Spandidos Publications style
Liu H, Li Y, Zhang J, Wu N, Liu F, Wang L, Zhang Y, Liu J, Zhang X, Guo S, Guo S, et al: Erb‑B2 Receptor Tyrosine Kinase 2 is negatively regulated by the p53‑responsive microRNA‑3184‑5p in cervical cancer cells. Oncol Rep 45: 95-106, 2021.
APA
Liu, H., Li, Y., Zhang, J., Wu, N., Liu, F., Wang, L. ... Wang, H. (2021). Erb‑B2 Receptor Tyrosine Kinase 2 is negatively regulated by the p53‑responsive microRNA‑3184‑5p in cervical cancer cells. Oncology Reports, 45, 95-106. https://doi.org/10.3892/or.2020.7862
MLA
Liu, H., Li, Y., Zhang, J., Wu, N., Liu, F., Wang, L., Zhang, Y., Liu, J., Zhang, X., Guo, S., Wang, H."Erb‑B2 Receptor Tyrosine Kinase 2 is negatively regulated by the p53‑responsive microRNA‑3184‑5p in cervical cancer cells". Oncology Reports 45.1 (2021): 95-106.
Chicago
Liu, H., Li, Y., Zhang, J., Wu, N., Liu, F., Wang, L., Zhang, Y., Liu, J., Zhang, X., Guo, S., Wang, H."Erb‑B2 Receptor Tyrosine Kinase 2 is negatively regulated by the p53‑responsive microRNA‑3184‑5p in cervical cancer cells". Oncology Reports 45, no. 1 (2021): 95-106. https://doi.org/10.3892/or.2020.7862
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Spandidos Publications style
Liu H, Li Y, Zhang J, Wu N, Liu F, Wang L, Zhang Y, Liu J, Zhang X, Guo S, Guo S, et al: Erb‑B2 Receptor Tyrosine Kinase 2 is negatively regulated by the p53‑responsive microRNA‑3184‑5p in cervical cancer cells. Oncol Rep 45: 95-106, 2021.
APA
Liu, H., Li, Y., Zhang, J., Wu, N., Liu, F., Wang, L. ... Wang, H. (2021). Erb‑B2 Receptor Tyrosine Kinase 2 is negatively regulated by the p53‑responsive microRNA‑3184‑5p in cervical cancer cells. Oncology Reports, 45, 95-106. https://doi.org/10.3892/or.2020.7862
MLA
Liu, H., Li, Y., Zhang, J., Wu, N., Liu, F., Wang, L., Zhang, Y., Liu, J., Zhang, X., Guo, S., Wang, H."Erb‑B2 Receptor Tyrosine Kinase 2 is negatively regulated by the p53‑responsive microRNA‑3184‑5p in cervical cancer cells". Oncology Reports 45.1 (2021): 95-106.
Chicago
Liu, H., Li, Y., Zhang, J., Wu, N., Liu, F., Wang, L., Zhang, Y., Liu, J., Zhang, X., Guo, S., Wang, H."Erb‑B2 Receptor Tyrosine Kinase 2 is negatively regulated by the p53‑responsive microRNA‑3184‑5p in cervical cancer cells". Oncology Reports 45, no. 1 (2021): 95-106. https://doi.org/10.3892/or.2020.7862
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