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Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer

  • Authors:
    • Liubiqi Zhao
    • Zongyu Liu
    • Xinyue Deng
    • Jiabin Wang
    • Liankun Sun
    • Limei Fan
    • Yong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China, Department of Pathophysiology, Key Laboratory of Pathophysiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130041, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 513-522
    |
    Published online on: December 2, 2020
       https://doi.org/10.3892/or.2020.7879
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Abstract

Ovarian cancer is a gynecological malignancy with high mortality. Adjuvant therapy such as chemoradiotherapy inevitably leads to side effects and drug resistance. In recent years, traditional Chinese medicine has been widely studied for its safety, effectiveness, and unique pharmacological effects. Polyphyllin VII is an important component of Rhizoma paridis saponins, and has cytotoxic effects on many types of cancer cells. The aim of the present study was to evaluate the anti‑tumor activity of polyphyllin VII in human ovarian cancer cells. Recent studies found that polyphyllin VII induces mitochondrial pathway apoptosis by increasing mitochondrial division, but the specific mechanism was unclear. The results of this study revealed that polyphyllin VII could effectively induce mitochondrial dysfunction, including increased mitochondrial division and reactive oxygen species (ROS) production. Notably, the mitochondrial location of dynamin‑related protein 1 (DRP1) plays an important role in its function. In addition, polyphyllin VII enhanced the mitochondrial localization of DRP1 which is mediated by increased protein phosphatase 2A (PP2A) activity, and decreased AKT activity. A specific PP2A inhibitor, LB100, attenuated mitochondrial division and apoptosis in cells caused by polyphyllin VII, confirming the function of the PP2A/AKT pathway in polyphyllin VII treatment. Additionally, xenotransplantation experiments have also confirmed the anti‑tumor effect of polyphyllin VII in vivo. Therefore, interference of the mitochondrial translocation of DRP1 through PP2A/AKT pathway may be an attractive and effective therapeutic approach by polyphyllin VII in ovarian cancer. This may provide new strategies for polyphyllin VII in the clinical treatment of ovarian cancer.
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View References

1 

Zhang C, Li C, Jia X, Wang K, Tu Y, Wang R, Liu K, Lu T and He C: In vitro and in vivo anti-inflammatory effects of polyphyllin VII through downregulating MAPK and NF-ĸB pathways. Molecules. 24:8752019. View Article : Google Scholar

2 

Liu Z, Li N, Gao W, Man S, Yin S and Liu C: Comparative study on hemostatic, cytotoxic and hemolytic activities of different species of Paris L. J Ethnopharmacol. 142:789–794. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Zhang XF, Cui Y, Huang JJ, Zhang YZ, Nie Z, Wang LF, Yan BZ, Tang YL and Liu Y: Immuno-stimulating properties of diosgenyl saponins isolated from Paris polyphylla. Bioorg Med Chem Lett. 17:2408–2413. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Al Sawah E, Marchion DC, Xiong Y, Ramirez IJ, Abbasi F, Boac BM, Bush SH, Bou Zgheib N, McClung EC, Khulpateea BR, et al: The Chinese herb polyphyllin D sensitizes ovarian cancer cells to cisplatin-induced growth arrest. J Cancer Res Clin Oncol. 141:237–242. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Liu X, Sun Z, Deng J, Liu J, Ma K, Si Y, Zhang T, Feng T, Liu Y and Tan Y: Polyphyllin I inhibits invasion and epithelial-mesenchymal transition via CIP2A/PP2A/ERK signaling in prostate cancer. Int J Oncol. 53:1279–1288. 2018.PubMed/NCBI

6 

He J, Yu S, Guo C, Tan L, Song X, Wang M, Wu J, Long Y, Gong D, Zhang R, et al: Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells. Biomed Pharmacother. 117:1091892019. View Article : Google Scholar : PubMed/NCBI

7 

Hong F, Gu W, Jiang J, Liu X and Jiang H: Anticancer activity of polyphyllin I in nasopharyngeal carcinoma by modulation of lncRNA ROR and P53 signalling. J Drug Target. 27:806–811. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Lin LT, Uen WC, Choong CY, Shi YC, Lee BH and Tai CJ and Tai CJ: Paris polyphylla inhibits colorectal cancer cells via inducing autophagy and enhancing the efficacy of chemotherapeutic drug doxorubicin. Molecules. 24:21022019. View Article : Google Scholar

9 

Yang C, Cai H and Meng X: Polyphyllin D induces apoptosis and differentiation in K562 human leukemia cells. Int Immunopharmacol. 36:17–22. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Liu Y, Dong X, Wang W, You L, Yin X, Yang C, Sai N, Leng X and Ni J: Molecular mechanisms of apoptosis in HepaRG cell line induced by polyphyllin VI via the fas death pathway and mitochondrial-dependent pathway. Toxins (Basel). 10:2012018. View Article : Google Scholar

11 

Zorov DB, Juhaszova M and Sollott SJ: Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev. 94:909–950. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Adam-Vizi V and Chinopoulos C: Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol Sci. 27:639–645. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Choudhury AR and Singh KK: Mitochondrial determinants of cancer health disparities. Semin Cancer Biol. 47:125–146. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Tilokani L, Nagashima S, Paupe V and Prudent J: Mitochondrial dynamics: Overview of molecular mechanisms. Essays Biochem. 62:341–360. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Cannino G, Ciscato F, Masgras I, Sanchez-Martin C and Rasola A: Metabolic plasticity of tumor cell mitochondria. Front Oncol. 8:3332018. View Article : Google Scholar : PubMed/NCBI

16 

Karbowski M, Lee YJ, Gaume B, Jeong SY, Frank S, Nechushtan A, Nechushtan A, Santel A, Fuller M, Smith CL and Youle RJ: Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J Cell Biol. 159:931–938. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Karbowski M, Arnoult D, Chen H, Chan DC, Smith CL and Youle RJ: Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. J Cell Biol. 164:493–499. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Brooks C, Wei Q, Feng L, Dong G, Tao Y, Mei L, Xie ZJ and Dong Z: Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins. Proc Natl Acad Sci USA. 104:11649–11654. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Wasiak S, Zunino R and McBride HM: Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death. J Cell Biol. 177:439–450. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Hasnat M, Yuan Z, Ullah A, Naveed M, Raza F, Baig MMFA, Khan A, Xu D, Su Y, Sun L, et al: Mitochondria-dependent apoptosis in triptolide-induced hepatotoxicity is associated with the Drp1 activation. Toxicol Mech Methods. 30:124–133. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Li G, Zhou J, Budhraja A, Hu X, Chen Y, Cheng Q, Liu L, Zhou T, Li P, Liu E and Gao N: Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis. Oncotarget. 6:1834–1849. 2005. View Article : Google Scholar

22 

O'Connor CW, Perl A, Leonard D, Sangodkar J and Narla G: Therapeutic targeting of PP2A. Int J Biochem Cell Biol. 96:182–193. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Raman D and Pervaiz S: Redox inhibition of protein phosphatase PP2A: Potential implications in oncogenesis and its progression. Redox Biol. 27:1011052019. View Article : Google Scholar : PubMed/NCBI

24 

Rincon R, Cristobal I, Zazo S, Arpi O, Menendez S, Manso R, Lluch A, Eroles P, Rovira A, Albanell J, et al: PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effects. Oncotarget. 6:4299–4314. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Sugiyama M, Imai A, Furui T and Tamaya T: Independent action of serine/threonine protein phosphatase in ovarian cancer plasma membrane and cytosol during gonadotropin-releasing hormone stimulation. Oncol Rep. 10:1885–1889. 2003.PubMed/NCBI

26 

Zheng HY, Shen FJ, Tong YQ and Li Y: PP2A Inhibits cervical cancer cell migration by dephosphorylation of p-JNK, p-p38 and the p-ERK/MAPK signaling pathway. Curr Med Sci. 38:115–123. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Nader CP, Cidem A, Verrills NM and Ammit AJ: Protein phosphatase 2A (PP2A): A key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer. Respir Res. 20:2222019. View Article : Google Scholar : PubMed/NCBI

28 

Perrotti D and Neviani P: Protein phosphatase 2A: A target for anticancer therapy. Lancet Oncol. 14:e229–e238. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Zhang Y, Huang P, Liu X, Xiang Y, Zhang T, Wu Y, Xu J, Sun Z, Zhen W, Zhang L, et al: Polyphyllin I inhibits growth and invasion of cisplatin-resistant gastric cancer cells by partially inhibiting CIP2A/PP2A/Akt signaling axis. J Pharmacol Sci. 137:305–312. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Kim DI, Lee KH, Gabr AA, Choi GE, Kim JS, Ko SH and Han HJ: Aβ-induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis. Biochim Biophys Acta. 1863:2820–2834. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Zhou X, Wang HY, Wu B, Cheng CY, Xiao W, Wang ZZ, Yang YY, Li P and Yang H: Ginkgolide K attenuates neuronal injury after ischemic stroke by inhibiting mitochondrial fission and GSK-3β-dependent increases in mitochondrial membrane permeability. Oncotarget. 8:44682–44693. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Tao A, Xu X, Kvietys P, Kao R, Martin C and Rui T: Experimental diabetes mellitus exacerbates ischemia/reperfusion-induced myocardial injury by promoting mitochondrial fission: Role of down-regulation of myocardial Sirt1 and subsequent Akt/Drp1 interaction. Int J Biochem Cell Biol. 105:94–103. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Samanta K, Douglas S and Parekh AB: Mitochondrial calcium uniporter MCU supports cytoplasmic Ca2+ oscillations, store-operated Ca2+ entry and Ca2+-dependent gene expression in response to receptor stimulation. PLoS One. 9:e1011882014. View Article : Google Scholar : PubMed/NCBI

34 

Simula L, Nazio F and Campello S: The mitochondrial dynamics in cancer and immune-surveillance. Semin Cancer Biol. 47:29–42. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Martinou JC and Youle RJ: Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell. 21:92–101. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Montessuit S, Somasekharan SP, Terrones O, Lucken-Ardjomande S, Herzig S, Schwarzenbacher R, Manstein DJ, Bossy-Wetzel E, Basañez G, Meda P and Martinou JC: Membrane remodeling induced by the dynamin-related protein Drp1 stimulates bax oligomerization. Cell. 142:889–901. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Lee YJ, Jeong SY, Karbowski M, Smith CL and Youle RJ: Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol Biol Cell. 15:5001–5011. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Frank S, Gaume B, Bergmann-Leitner ES, Leitner WW, Robert EG, Catez F, Smith CL and Youle RJ: The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell. 1:515–525. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Alberts AS, Thorburn AM, Shenolikar S, Mumby MC and Feramisco JR: Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases. Proc Natl Acad Sci USA. 90:388–392. 1993. View Article : Google Scholar : PubMed/NCBI

40 

Glenn GM and Eckhart W: Mutation of a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and phosphatidylinositol-3 kinase, activation of c-fos expression, and cellular transformation. J Virol. 67:1945–1952. 1993. View Article : Google Scholar : PubMed/NCBI

41 

Ronne H, Carlberg M, Hu GZ and Nehlin JO: Protein phosphatase 2A in saccharomyces cerevisiae: Effects on cell growth and bud morphogenesis. Mol Cell Biol. 11:4876–4884. 1991. View Article : Google Scholar : PubMed/NCBI

42 

Wlodarchak N and Xing Y: PP2A as a master regulator of the cell cycle. Crit Rev Biochem Mol Biol. 51:162–184. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Tseng LM, Liu CY, Chang KC, Chu PY, Shiau CW and Chen KF: CIP2A is a target of bortezomib in human triple negative breast cancer cells. Breast Cancer Res. 14:R682012. View Article : Google Scholar : PubMed/NCBI

44 

Bockelman C, Lassus H, Hemmes A, Leminen A, Westermarck J, Haglund C, Bützow R and Ristimäki A: Prognostic role of CIP2A expression in serous ovarian cancer. Br J Cancer. 105:989–995. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Shih IeM, Panuganti PK, Kuo KT, Mao TL, Kuhn E, Jones S, Velculescu VE, Kurman RJ and Wang TL: Somatic mutations of PPP2R1A in ovarian and uterine carcinomas. Am J Pathol. 178:1442–1447. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Xu P, Xu XL, Huang Q, Zhang ZH and Zhang YB: CIP2A with survivin protein expressions in human non-small-cell lung cancer correlates with prognosis. Med Oncol. 29:1643–1647. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao L, Liu Z, Deng X, Wang J, Sun L, Fan L and Zhang Y: Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer. Oncol Rep 45: 513-522, 2021.
APA
Zhao, L., Liu, Z., Deng, X., Wang, J., Sun, L., Fan, L., & Zhang, Y. (2021). Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer. Oncology Reports, 45, 513-522. https://doi.org/10.3892/or.2020.7879
MLA
Zhao, L., Liu, Z., Deng, X., Wang, J., Sun, L., Fan, L., Zhang, Y."Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer". Oncology Reports 45.2 (2021): 513-522.
Chicago
Zhao, L., Liu, Z., Deng, X., Wang, J., Sun, L., Fan, L., Zhang, Y."Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer". Oncology Reports 45, no. 2 (2021): 513-522. https://doi.org/10.3892/or.2020.7879
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao L, Liu Z, Deng X, Wang J, Sun L, Fan L and Zhang Y: Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer. Oncol Rep 45: 513-522, 2021.
APA
Zhao, L., Liu, Z., Deng, X., Wang, J., Sun, L., Fan, L., & Zhang, Y. (2021). Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer. Oncology Reports, 45, 513-522. https://doi.org/10.3892/or.2020.7879
MLA
Zhao, L., Liu, Z., Deng, X., Wang, J., Sun, L., Fan, L., Zhang, Y."Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer". Oncology Reports 45.2 (2021): 513-522.
Chicago
Zhao, L., Liu, Z., Deng, X., Wang, J., Sun, L., Fan, L., Zhang, Y."Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer". Oncology Reports 45, no. 2 (2021): 513-522. https://doi.org/10.3892/or.2020.7879
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