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Article Open Access

Hsa_circ_0008537 facilitates liver carcinogenesis by upregulating MCL1 and Snail1 expression via miR‑153‑3p

  • Authors:
    • Ge Yang
    • Xianyong Li
    • Jingbo Liu
    • Shengjie Huang
    • Yaguang Weng
    • Jing Zhu
    • Daiqiong Lin
    • Ou Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Affiliated Neijiang Second People's Hospital of Southwest Medical University, Neijiang, Sichuan 641000, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1072-1082
    |
    Published online on: January 19, 2021
       https://doi.org/10.3892/or.2021.7941
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Abstract

The biological functions of circular RNAs in liver tumorigenesis have been well demonstrated by a number of studies. Nevertheless, to the best of our knowledge, the role and mechanism of action of hsa_circ_0008537 (circ_0008537) in liver cancer pathogenesis remain undetermined. In the present study, circ_0008537 expression was associated with the GLI3 gene and was markedly increased in liver cancer tissue specimens and cells. High expression levels of circ_0008537 exhibited a poor prognosis. In addition, circ_0008537 overexpression resulted in an increased proliferation, migration and invasion of liver cancer cells, whereas circ_0008537 knockdown exhibited opposite effects. circ_0008537 acted as a sponge of microRNA‑153‑3p (miR‑153‑3p), and a negative correlation was observed between circ_0008537 and miR‑153‑3p expression in liver cancer. Transfection with miR‑153‑3p further abolished the effects of circ_0008537 on the malignant behavior of liver cancer cells. Furthermore, circ_0008537 indirectly affected the expression levels of pro‑survival protein myeloid cell leukemia 1 (MCL1) and snail family zinc finger 1 (Snail1) via miR‑153‑3p in liver cancer cells. In conclusion, the data indicated that circ_0008537 facilitated liver carcinogenesis by indirectly regulating miR‑153‑3p and leading to the release of MCL1 and Snail1.
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Copy and paste a formatted citation
Spandidos Publications style
Yang G, Li X, Liu J, Huang S, Weng Y, Zhu J, Lin D and Jiang O: Hsa_circ_0008537 facilitates liver carcinogenesis by upregulating MCL1 and Snail1 expression via miR‑153‑3p. Oncol Rep 45: 1072-1082, 2021.
APA
Yang, G., Li, X., Liu, J., Huang, S., Weng, Y., Zhu, J. ... Jiang, O. (2021). Hsa_circ_0008537 facilitates liver carcinogenesis by upregulating MCL1 and Snail1 expression via miR‑153‑3p. Oncology Reports, 45, 1072-1082. https://doi.org/10.3892/or.2021.7941
MLA
Yang, G., Li, X., Liu, J., Huang, S., Weng, Y., Zhu, J., Lin, D., Jiang, O."Hsa_circ_0008537 facilitates liver carcinogenesis by upregulating MCL1 and Snail1 expression via miR‑153‑3p". Oncology Reports 45.3 (2021): 1072-1082.
Chicago
Yang, G., Li, X., Liu, J., Huang, S., Weng, Y., Zhu, J., Lin, D., Jiang, O."Hsa_circ_0008537 facilitates liver carcinogenesis by upregulating MCL1 and Snail1 expression via miR‑153‑3p". Oncology Reports 45, no. 3 (2021): 1072-1082. https://doi.org/10.3892/or.2021.7941
Copy and paste a formatted citation
x
Spandidos Publications style
Yang G, Li X, Liu J, Huang S, Weng Y, Zhu J, Lin D and Jiang O: Hsa_circ_0008537 facilitates liver carcinogenesis by upregulating MCL1 and Snail1 expression via miR‑153‑3p. Oncol Rep 45: 1072-1082, 2021.
APA
Yang, G., Li, X., Liu, J., Huang, S., Weng, Y., Zhu, J. ... Jiang, O. (2021). Hsa_circ_0008537 facilitates liver carcinogenesis by upregulating MCL1 and Snail1 expression via miR‑153‑3p. Oncology Reports, 45, 1072-1082. https://doi.org/10.3892/or.2021.7941
MLA
Yang, G., Li, X., Liu, J., Huang, S., Weng, Y., Zhu, J., Lin, D., Jiang, O."Hsa_circ_0008537 facilitates liver carcinogenesis by upregulating MCL1 and Snail1 expression via miR‑153‑3p". Oncology Reports 45.3 (2021): 1072-1082.
Chicago
Yang, G., Li, X., Liu, J., Huang, S., Weng, Y., Zhu, J., Lin, D., Jiang, O."Hsa_circ_0008537 facilitates liver carcinogenesis by upregulating MCL1 and Snail1 expression via miR‑153‑3p". Oncology Reports 45, no. 3 (2021): 1072-1082. https://doi.org/10.3892/or.2021.7941
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