Hsa_circ_0008537 facilitates liver carcinogenesis by upregulating MCL1 and Snail1 expression via miR‑153‑3p

Yang,Ge; Li,Xianyong; Liu,Jingbo; Huang,Shengjie; Weng,Yaguang; Zhu,Jing; Lin,Daiqiong; Jiang,Ou

doi:10.3892/or.2021.7941

Hsa_circ_0008537 facilitates liver carcinogenesis by upregulating MCL1 and Snail1 expression via miR‑153‑3p

Authors:
- Ge Yang
- Xianyong Li
- Jingbo Liu
- Shengjie Huang
- Yaguang Weng
- Jing Zhu
- Daiqiong Lin
- Ou Jiang
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Affiliations: Department of Clinical Laboratory, Affiliated Neijiang Second People's Hospital of Southwest Medical University, Neijiang, Sichuan 641000, P.R. China
Published online on: January 19, 2021 https://doi.org/10.3892/or.2021.7941
Pages: 1072-1082
Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The biological functions of circular RNAs in liver tumorigenesis have been well demonstrated by a number of studies. Nevertheless, to the best of our knowledge, the role and mechanism of action of hsa_circ_0008537 (circ_0008537) in liver cancer pathogenesis remain undetermined. In the present study, circ_0008537 expression was associated with the GLI3 gene and was markedly increased in liver cancer tissue specimens and cells. High expression levels of circ_0008537 exhibited a poor prognosis. In addition, circ_0008537 overexpression resulted in an increased proliferation, migration and invasion of liver cancer cells, whereas circ_0008537 knockdown exhibited opposite effects. circ_0008537 acted as a sponge of microRNA‑153‑3p (miR‑153‑3p), and a negative correlation was observed between circ_0008537 and miR‑153‑3p expression in liver cancer. Transfection with miR‑153‑3p further abolished the effects of circ_0008537 on the malignant behavior of liver cancer cells. Furthermore, circ_0008537 indirectly affected the expression levels of pro‑survival protein myeloid cell leukemia 1 (MCL1) and snail family zinc finger 1 (Snail1) via miR‑153‑3p in liver cancer cells. In conclusion, the data indicated that circ_0008537 facilitated liver carcinogenesis by indirectly regulating miR‑153‑3p and leading to the release of MCL1 and Snail1.

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