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Article Open Access

miR‑146b‑5p inhibits tumorigenesis and metastasis of gallbladder cancer by targeting Toll‑like receptor 4 via the nuclear factor‑κB pathway

Corrigendum in: /10.3892/or.2024.8699
  • Authors:
    • Bin Ouyang
    • Ningfeng Pan
    • Haifeng Zhang
    • Chuanming Xing
    • Wu Ji
  • View Affiliations / Copyright

    Affiliations: Research Institute of General Surgery, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, Jiangsu 210002, P.R. China, Department of Neurology, Nanjing Central Hospital, Nanjing, Jiangsu 210018, P.R. China, Department of General Surgery, Nanjing Central Hospital, Nanjing, Jiangsu 210018, P.R. China
    Copyright: © Ouyang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 15
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    Published online on: February 3, 2021
       https://doi.org/10.3892/or.2021.7966
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Abstract

Gallbladder cancer (GBC) is a carcinoma of the biliary tract, which is common in developing countries and is associated with a high fatality rate. The aim of the present study was to investigate the mechanisms underlying the occurrence and development of GBC. A decrease in the expression of miR‑146b‑5p and an increase in the expression of its target gene Toll‑like receptor 4 (TLR4) were first observed in GBC tissues. Further study demonstrated that an increase in TLR4 expression caused by a decrease in miR‑146b‑5p expression led to activation of nuclear factor (NF)‑κB signaling. GBC cells were cultured in vitro, and it was observed that overexpression of miR‑146b‑5p effectively inhibited their viability, proliferation, migration and invasion, and increased their apoptosis. Using a BALB/c nude mouse xenograft model, it was demonstrated that overexpression of miR‑146b‑5p was sufficient to reduce tumor volume and alleviate pathological characteristics. Overall, the results of the present study indicated that the decrease in the expression of miR‑146b‑5p increased TLR4 expression and indirectly activated the NF‑κB signaling pathway, thereby regulating the development of GBC.
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Copy and paste a formatted citation
Spandidos Publications style
Ouyang B, Pan N, Zhang H, Xing C and Ji W: miR‑146b‑5p inhibits tumorigenesis and metastasis of gallbladder cancer by targeting Toll‑like receptor 4 via the nuclear factor‑κB pathway Corrigendum in /10.3892/or.2024.8699. Oncol Rep 45: 15, 2021.
APA
Ouyang, B., Pan, N., Zhang, H., Xing, C., & Ji, W. (2021). miR‑146b‑5p inhibits tumorigenesis and metastasis of gallbladder cancer by targeting Toll‑like receptor 4 via the nuclear factor‑κB pathway Corrigendum in /10.3892/or.2024.8699. Oncology Reports, 45, 15. https://doi.org/10.3892/or.2021.7966
MLA
Ouyang, B., Pan, N., Zhang, H., Xing, C., Ji, W."miR‑146b‑5p inhibits tumorigenesis and metastasis of gallbladder cancer by targeting Toll‑like receptor 4 via the nuclear factor‑κB pathway Corrigendum in /10.3892/or.2024.8699". Oncology Reports 45.4 (2021): 15.
Chicago
Ouyang, B., Pan, N., Zhang, H., Xing, C., Ji, W."miR‑146b‑5p inhibits tumorigenesis and metastasis of gallbladder cancer by targeting Toll‑like receptor 4 via the nuclear factor‑κB pathway Corrigendum in /10.3892/or.2024.8699". Oncology Reports 45, no. 4 (2021): 15. https://doi.org/10.3892/or.2021.7966
Copy and paste a formatted citation
x
Spandidos Publications style
Ouyang B, Pan N, Zhang H, Xing C and Ji W: miR‑146b‑5p inhibits tumorigenesis and metastasis of gallbladder cancer by targeting Toll‑like receptor 4 via the nuclear factor‑κB pathway Corrigendum in /10.3892/or.2024.8699. Oncol Rep 45: 15, 2021.
APA
Ouyang, B., Pan, N., Zhang, H., Xing, C., & Ji, W. (2021). miR‑146b‑5p inhibits tumorigenesis and metastasis of gallbladder cancer by targeting Toll‑like receptor 4 via the nuclear factor‑κB pathway Corrigendum in /10.3892/or.2024.8699. Oncology Reports, 45, 15. https://doi.org/10.3892/or.2021.7966
MLA
Ouyang, B., Pan, N., Zhang, H., Xing, C., Ji, W."miR‑146b‑5p inhibits tumorigenesis and metastasis of gallbladder cancer by targeting Toll‑like receptor 4 via the nuclear factor‑κB pathway Corrigendum in /10.3892/or.2024.8699". Oncology Reports 45.4 (2021): 15.
Chicago
Ouyang, B., Pan, N., Zhang, H., Xing, C., Ji, W."miR‑146b‑5p inhibits tumorigenesis and metastasis of gallbladder cancer by targeting Toll‑like receptor 4 via the nuclear factor‑κB pathway Corrigendum in /10.3892/or.2024.8699". Oncology Reports 45, no. 4 (2021): 15. https://doi.org/10.3892/or.2021.7966
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