Anticancer effects and potential mechanisms of ginsenoside Rh2 in various cancer types (Review)

  • Authors:
    • Haibo Zhang
    • Song Park
    • Hai Huang
    • Eungyung Kim
    • Junkoo Yi
    • Seong-Kyoon Choi
    • Zaeyoung Ryoo
    • Myoungok Kim
  • View Affiliations

  • Published online on: February 19, 2021     https://doi.org/10.3892/or.2021.7984
  • Article Number: 33
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Abstract

Ginsenoside Rh2 (G‑Rh2) is a natural bioactive product derived from Panax ginseng Meyer (P. ginseng). G‑Rh2 exhibits anticancer activity in various human cancer cell lines both in vitro and in vivo by modulating several signaling pathways, such as those of PDZ‑binding kinase/T‑LAK cell‑originated protein kinase, phosphatidylinositol 3‑kinase, protein kinase B, mammalian target of rapamycin, epidermal growth factor receptor, p53, and reactive oxygen species. Moreover, G‑Rh2 could effectively reverse drug resistance and enhance therapeutic effects in cancer therapy. This review summarizes the chemical properties, in vitro and in vivo anticancer activity, and underlying molecular mechanisms of G‑Rh2 to facilitate cancer chemoprevention studies.
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April-2021
Volume 45 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang H, Park S, Huang H, Kim E, Yi J, Choi S, Ryoo Z and Kim M: Anticancer effects and potential mechanisms of ginsenoside Rh2 in various cancer types (Review). Oncol Rep 45: 33, 2021
APA
Zhang, H., Park, S., Huang, H., Kim, E., Yi, J., Choi, S. ... Kim, M. (2021). Anticancer effects and potential mechanisms of ginsenoside Rh2 in various cancer types (Review). Oncology Reports, 45, 33. https://doi.org/10.3892/or.2021.7984
MLA
Zhang, H., Park, S., Huang, H., Kim, E., Yi, J., Choi, S., Ryoo, Z., Kim, M."Anticancer effects and potential mechanisms of ginsenoside Rh2 in various cancer types (Review)". Oncology Reports 45.4 (2021): 33.
Chicago
Zhang, H., Park, S., Huang, H., Kim, E., Yi, J., Choi, S., Ryoo, Z., Kim, M."Anticancer effects and potential mechanisms of ginsenoside Rh2 in various cancer types (Review)". Oncology Reports 45, no. 4 (2021): 33. https://doi.org/10.3892/or.2021.7984