Effects of m6A modifications on signaling pathways in human cancer (Review)

Liu,Fangyuan; Su,Xiulan

doi:10.3892/or.2021.7987

Effects of m6A modifications on signaling pathways in human cancer (Review)

Authors:
- Fangyuan Liu
- Xiulan Su
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Affiliations: Clinical Medical Research Center, The Affiliated Hospital, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China
Published online on: February 19, 2021 https://doi.org/10.3892/or.2021.7987
Article Number: 36

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Abstract

N6‑methyladenosine (m6A) is one of the most prevalent post‑transcriptional RNA modifications. The enzymes involved in the regulation of m6A include methyltransferase (writers), demethylase (erasers) and m6A recognition proteins (readers). Accumulating studies have demonstrated that m6A modifications have a distinct effect on various biological processes, including tumorigenesis, cell differentiation, embryonic development and neurogenic diseases, while our knowledge of the specific mechanism underlying m6A methylation in various cancer types is still limited. Various signaling pathways have an effect on tumorigenesis, invasion and apoptosis of malignant tumors. The present review summarizes the recent progress in research regarding the role of m6A in human cancer and discusses the influence of m6A on classic signaling pathways in malignant tumors.

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