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Hypochlorous acid selectively promotes toxicity and the expression of danger signals in human abdominal cancer cells

  • Authors:
    • Eric Freund
    • Lea Miebach
    • Matthias B. Stope
    • Sander Bekeschus
  • View Affiliations / Copyright

    Affiliations: Centre for Innovation Competence (ZIK) Plasmatis, Leibniz Institute for Plasma Science and Technology (INP Greifswald), D‑17489 Greifswald, Germany, Department of Gynecology and Gynecological Oncology, Bonn University Medical Center, D‑53217 Bonn, Germany
    Copyright: © Freund et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 71
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    Published online on: March 22, 2021
       https://doi.org/10.3892/or.2021.8022
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Abstract

Tumors of the abdominal cavity, such as colorectal, pancreatic and ovarian cancer, frequently metastasize into the peritoneum. Large numbers of metastatic nodules hinder curative surgical resection, necessitating lavage with hyperthermic intraperitoneal chemotherapy (HIPEC). However, HIPEC not only causes severe side effects but also has limited therapeutic efficacy in various instances. At the same time, the age of immunotherapies such as biological agents, checkpoint‑ inhibitors or immune‑cell therapies, increasingly emphasizes the critical role of anticancer immunity in targeting malignancies. The present study investigated the ability of three types of long‑lived reactive species (oxidants) to inactivate cancer cells and potentially complement current HIPEC regimens, as well as to increase tumor cell expression of danger signals that stimulate innate immunity. The human abdominal cancer cell lines HT‑29, Panc‑01 and SK‑OV‑3 were exposed to different concentrations of hydrogen peroxide (H2O2), hypochlorous acid (HOCl) and peroxynitrite (ONOO‑). Metabolic activity was measured, as well as determination of cell death and danger signal expression levels via flow cytometry and detection of intracellular oxidation via high‑content microscopy. Oxidation of tumor decreased intracellular levels of the antioxidant glutathione and induced oxidation in mitochondria, accompanied by a decrease in metabolic activity and an increase in regulated cell death. At similar concentrations, HOCl showed the most potent effects. Non‑malignant HaCaT keratinocytes were less affected, suggesting the approach to be selective to some extent. Pro‑immunogenic danger molecules were investigated by assessing the expression levels of calreticulin (CRT), and heat‑shock protein (HSP)70 and HSP90. CRT expression was greatest following HOCl and ONOO‑ treatment, whereas HOCl and H2O2 resulted in the greatest increase in HSP70 and HSP90 expression levels. These results suggested that HOCl may be a promising agent to complement current HIPEC regimens targeting peritoneal carcinomatosis.
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1 

Dakwar GR, Shariati M, Willaert W, Ceelen W, De Smedt SC and Remaut K: Nanomedicine-based intraperitoneal therapy for the treatment of peritoneal carcinomatosis-mission possible? Adv Drug Deliv Rev. 108:13–24. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Piso P and Arnold D: Multimodal treatment approaches for peritoneal carcinosis in colorectal cancer. Dtsch Arztebl Int. 108:802–808. 2011.PubMed/NCBI

3 

Oettle H, Neuhaus P, Hochhaus A, Hartmann JT, Gellert K, Ridwelski K, Niedergethmann M, Zülke C, Fahlke J, Arning MB, et al: Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: The CONKO-001 randomized trial. JAMA. 310:1473–1481. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Esposito I, Kleeff J, Bergmann F, Reiser C, Herpel E, Friess H, Schirmacher P and Büchler MW: Most pancreatic cancer resections are R1 resections. Ann Surg Oncol. 15:1651–1660. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Shida D, Tsukamoto S, Ochiai H and Kanemitsu Y: Long-term outcomes after R0 resection of synchronous peritoneal metastasis from colorectal cancer without cytoreductive surgery or hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 25:173–178. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Tentes AA, Pallas N, Karamveri C, Kyziridis D and Hristakis C: Cytoreduction and HIPEC for peritoneal carcinomatosis of pancreatic cancer. J BUON. 23:482–487. 2018.PubMed/NCBI

7 

Jayson GC, Kohn EC, Kitchener HC and Ledermann JA: Ovarian cancer. Lancet. 384:1376–1388. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Pelz JO, Chua TC, Esquivel J, Stojadinovic A, Doerfer J, Morris DL, Maeder U, Germer CT and Kerscher AG: Evaluation of best supportive care and systemic chemotherapy as treatment stratified according to the retrospective peritoneal surface disease severity score (PSDSS) for peritoneal carcinomatosis of colorectal origin. BMC Cancer. 10:6892010. View Article : Google Scholar : PubMed/NCBI

9 

Goéré D, Souadka A, Faron M, Cloutier AS, Viana B, Honoré C, Dumont F and Elias D: Extent of colorectal peritoneal carcinomatosis: Attempt to define a threshold above which HIPEC does not offer survival benefit: A comparative study. Ann Surg Oncol. 22:2958–2964. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Solass W, Kerb R, Mürdter T, Giger-Pabst U, Strumberg D, Tempfer C, Zieren J, Schwab M and Reymond MA: Intraperitoneal chemotherapy of peritoneal carcinomatosis using pressurized aerosol as an alternative to liquid solution: First evidence for efficacy. Ann Surg Oncol. 21:553–559. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Pinto A and Pocard M: Photodynamic therapy and photothermal therapy for the treatment of peritoneal metastasis: A systematic review. Pleura Peritoneum. 3:201801242018. View Article : Google Scholar : PubMed/NCBI

12 

Farooqi AA, Li KT, Fayyaz S, Chang YT, Ismail M, Liaw CC, Yuan SS, Tang JY and Chang HW: Anticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress. Tumour Biol. 36:5743–5752. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Galadari S, Rahman A, Pallichankandy S and Thayyullathil F: Reactive oxygen species and cancer paradox: To promote or to suppress? Free Radic Biol Med. 104:144–164. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Glasauer A and Chandel NS: Targeting antioxidants for cancer therapy. Biochem Pharmacol. 92:90–101. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Gorrini C, Harris IS and Mak TW: Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 12:931–947. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Brigger I, Dubernet C and Couvreur P: Nanoparticles in cancer therapy and diagnosis. Adv Drug Del Rev. 64:24–36. 2012. View Article : Google Scholar

17 

Manshian BB, Poelmans J, Saini S, Pokhrel S, Grez JJ, Himmelreich U, Mädler L and Soenen SJ: Nanoparticle-induced inflammation can increase tumor malignancy. Acta Biomater. 68:99–112. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Manke A, Wang L and Rojanasakul Y: Mechanisms of nanoparticle-induced oxidative stress and toxicity. Biomed Res Int. 2013:9429162013. View Article : Google Scholar : PubMed/NCBI

19 

Hou JT, Wang B, Zhang Y, Cui B, Cao X, Zhang M, Ye Y and Wang S: Observation of peroxynitrite overproduction in cells during 5-fluorouracil treatment via a ratiometric fluorescent probe. Chem Commun (Camb). 56:2759–2762. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Kepp O, Menger L, Vacchelli E, Locher C, Adjemian S, Yamazaki T, Martins I, Sukkurwala AQ, Michaud M, Senovilla L, et al: Crosstalk between ER stress and immunogenic cell death. Cytokine Growth Factor Rev. 24:311–318. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick SO, Hahn SM, Hamblin MR, Juzeniene A, Kessel D, et al: Photodynamic therapy of cancer: An update. CA Cancer J Clin. 61:250–281. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Garg AD and Agostinis P: ER stress, autophagy and immunogenic cell death in photodynamic therapy-induced anti-cancer immune responses. Photochem Photobiol Sci. 13:474–487. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Bekeschus S, Schmidt A, Niessner F, Gerling T, Weltmann KD and Wende K: Basic research in plasma medicine-a throughput approach from liquids to cells. J Vis Exp. 563312017.

24 

Jablonowski H, Santos Sousa J, Weltmann KD, Wende K and Reuter S: Quantification of the ozone and singlet delta oxygen produced in gas and liquid phases by a non-thermal atmospheric plasma with relevance for medical treatment. Sci Rep. 8:121952018. View Article : Google Scholar : PubMed/NCBI

25 

Bekeschus S, Wende K, Hefny MM, Rödder K, Jablonowski H, Schmidt A, Woedtke TV, Weltmann KD and Benedikt J: Oxygen atoms are critical in rendering THP-1 leukaemia cells susceptible to cold physical plasma-induced apoptosis. Sci Rep. 7:27912017. View Article : Google Scholar : PubMed/NCBI

26 

Bekeschus S, Clemen R, Nießner F, Sagwal SK, Freund E and Schmidt A: Medical gas plasma jet technology targets murine melanoma in an immunogenic fashion. Adv Sci (Weinh). 7:19034382020. View Article : Google Scholar : PubMed/NCBI

27 

Lin A, Gorbanev Y, De Backer J, Van Loenhout J, Van Boxem W, Lemière F, Cos P, Dewilde S, Smits E and Bogaerts A: Non-thermal plasma as a unique delivery system of short-lived reactive oxygen and nitrogen species for immunogenic cell death in melanoma cells. Adv Sci (Weinh). 6:18020622019. View Article : Google Scholar : PubMed/NCBI

28 

Bekeschus S, Clemena R and Metelmann HR: Potentiating anti-tumor immunity with physical plasma. Clin Plas Med. 12:17–22. 2018. View Article : Google Scholar

29 

Garg AD, Nowis D, Golab J, Vandenabeele P, Krysko DV and Agostinis P: Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation. Biochim Biophys Acta. 1805:53–71. 2010.PubMed/NCBI

30 

Khalili M, Daniels L, Lin A, Krebs FC, Snook AE, Bekeschus S, Bowne WB and Miller V: Non-thermal plasma-induced immunogenic cell death in cancer: A topical review. J Phys D Appl Phys. 52:4230012019. View Article : Google Scholar : PubMed/NCBI

31 

Galluzzi L, Buqué A, Kepp O, Zitvogel L and Kroemer G: Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol. 17:97–111. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Ledford H, Else H and Warren M: Cancer immunologists scoop medicine nobel prize. Nature. 562:20–21. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Leebmann H and Piso P: PIPAC and HIPEC-competing or supplementary therapeutic procedures for peritoneal metastases. Chirurg. 89:693–698. 2018.(In German). View Article : Google Scholar : PubMed/NCBI

34 

Obeid M, Tesniere A, Ghiringhelli F, Fimia GM, Apetoh L, Perfettini JL, Castedo M, Mignot G, Panaretakis T, Casares N, et al: Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med. 13:54–61. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Freund E and Bekeschus S: Gas plasma-oxidized liquids for cancer treatment: Pre-clinical relevance, immuno-oncology, and clinical obstacles. IEEE Trans Radiat Plasma Med Sci. 1. 2020. View Article : Google Scholar

36 

Kholmukhamedov A, Schwartz JM and Lemasters JJ: Isolated mitochondria infusion mitigates ischemia-reperfusion injury of the liver in rats: Mitotracker probes and mitochondrial membrane potential. Shock. 39:5432013. View Article : Google Scholar : PubMed/NCBI

37 

Freund E, Liedtke KR, van der Linde J, Metelmann HR, Heidecke CD, Partecke LI and Bekeschus S: Physical plasma-treated saline promotes an immunogenic phenotype in CT26 colon cancer cells in vitro and in vivo. Sci Rep. 9:6342019. View Article : Google Scholar : PubMed/NCBI

38 

Yamao T, Yamashita YI, Yamamura K, Nakao Y, Tsukamoto M, Nakagawa S, Okabe H, Hayashi H, Imai K and Baba H: Cellular senescence, represented by expression of caveolin-1, in cancer-associated fibroblasts promotes tumor invasion in pancreatic cancer. Ann Surg Oncol. 26:1552–1559. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Waris G and Ahsan H: Reactive oxygen species: Role in the development of cancer and various chronic conditions. J Carcinog. 5:142006. View Article : Google Scholar : PubMed/NCBI

40 

Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M and Telser J: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 39:44–84. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Zhang J, Wang X, Vikash V, Ye Q, Wu D, Liu Y and Dong W: ROS and ROS-mediated cellular signaling. Oxid Med Cell Longev. 2016:43509652016. View Article : Google Scholar : PubMed/NCBI

42 

Yu FX and Guan KL: The hippo pathway: Regulators and regulations. Genes Dev. 27:355–371. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Freund E, Liedtke KR, Miebach L, Wende K, Heidecke A, Kaushik NK, Choi EH, Partecke LI and Bekeschus S: Identification of two kinase inhibitors with synergistic toxicity with low-dose hydrogen peroxide in colorectal cancer cells in vitro. Cancers (Basel). 12:1222020. View Article : Google Scholar

44 

Bagheri M, Nair RR, Singh KK and Saini DK: ATM- ROS-iNOS axis regulates nitric oxide mediated cellular senescence. Biochim Biophys Acta Mol Cell Res. 1864:177–190. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton JP, Athineos D, Kang TW, Lasitschka F, Andrulis M, et al: A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol. 15:978–990. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Weyemi U, Redon CE, Parekh PR, Dupuy C and Bonner WM: NADPH oxidases NOXs and DUOXs as putative targets for cancer therapy. Anticancer Agents Med Chem. 13:502–514. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Bauer G: Central signaling elements of intercellular reactive oxygen/nitrogen species-dependent induction of apoptosis in malignant cells. Anticancer Res. 37:499–513. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Navarro-Yepes J, Burns M, Anandhan A, Khalimonchuk O, del Razo LM, Quintanilla-Vega B, Pappa A, Panayiotidis MI and Franco R: Oxidative stress, redox signaling, and autophagy: Cell death versus survival. Antioxid Redox Signal. 21:66–85. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Speckmann B, Steinbrenner H, Grune T and Klotz LO: Peroxynitrite: From interception to signaling. Arch Biochem Biophys. 595:153–160. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Perkins A, Tudorica DA, Amieva MR, Remington SJ and Guillemin K: Helicobacter pylori senses bleach (HOCl) as a chemoattractant using a cytosolic chemoreceptor. PLoS Biol. 17:e30003952019. View Article : Google Scholar : PubMed/NCBI

51 

Vandenberk L, Belmans J, Van Woensel M, Riva M and Van Gool SW: Exploiting the immunogenic potential of cancer cells for improved dendritic cell vaccines. Front Immunol. 6:6632016. View Article : Google Scholar : PubMed/NCBI

52 

Bansal A and Simon MC: Glutathione metabolism in cancer progression and treatment resistance. J Cell Biol. 217:2291–2298. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Acharya A, Das I, Chandhok D and Saha T: Redox regulation in cancer: A double-edged sword with therapeutic potential. Oxid Med Cell Longev. 3:23–34. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Balazy M, Kaminski PM, Mao K, Tan J and Wolin MS: S-nitroglutathione, a product of the reaction between peroxynitrite and glutathione that generates nitric oxide. J Biol Chem. 273:32009–32015. 1998. View Article : Google Scholar : PubMed/NCBI

55 

Padmaja S, Squadrito GL and Pryor WA: Inactivation of glutathione peroxidase by peroxynitrite. Arch Biochem Biophys. 349:1–6. 1998. View Article : Google Scholar : PubMed/NCBI

56 

Tesniere A, Apetoh L, Ghiringhelli F, Joza N, Panaretakis T, Kepp O, Schlemmer F, Zitvogel L and Kroemer G: Immunogenic cancer cell death: A key-lock paradigm. Curr Opinc Immunol. 20:504–511. 2008. View Article : Google Scholar

57 

Fucikova J, Kasikova L, Truxova I, Laco J, Skapa P, Ryska A and Spisek R: Relevance of the chaperone-like protein calreticulin for the biological behavior and clinical outcome of cancer. Immunol Lett. 193:25–34. 2018. View Article : Google Scholar : PubMed/NCBI

58 

Adkins I, Sadilkova L, Hradilova N, Tomala J, Kovar M and Spisek R: Severe, but not mild heat-shock treatment induces immunogenic cell death in cancer cells. Oncoimmunology. 6:e13114332017. View Article : Google Scholar : PubMed/NCBI

59 

Panaretakis T, Kepp O, Brockmeier U, Tesniere A, Bjorklund AC, Chapman DC, Durchschlag M, Joza N, Pierron G, van Endert P, et al: Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J. 28:578–590. 2009. View Article : Google Scholar : PubMed/NCBI

60 

Gordon S: The role of the macrophage in immune regulation. Res Immunol. 149:685–688. 1998. View Article : Google Scholar : PubMed/NCBI

61 

Liedtke KR, Freund E, Hackbartha C, Heideckea CD, Parteckea LI and Bekeschus S: A myeloid and lymphoid infiltrate in murine pancreatic tumors exposed to plasma-treated medium. Clin Plas Med. 11:10–17. 2018. View Article : Google Scholar

62 

Freund E, Moritz J, Stope M, Seebauer C, Schmidt A and Bekeschus S: Plasma-derived reactive species shape a differentiation profile in human monocytes. Appl Sci. 9:25302019. View Article : Google Scholar

63 

Panzarini E, Inguscio V and Dini L: Immunogenic cell death: Can it be exploited in photodynamic therapy for cancer? Biomed Res Int. 2013:4821602013. View Article : Google Scholar : PubMed/NCBI

64 

Garg AD, Krysko DV, Vandenabeele P and Agostinis P: Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin. Cancer Immunol Immunother. 61:215–221. 2012. View Article : Google Scholar : PubMed/NCBI

65 

Tcyganov E and Gabrilovich DI: Peroxynitrite affects MHC I peptide repertoire presented on tumor cells and impedes the efficacy of antitumor cytotoxic T-lymphocytes. J Immunol. 202 (Suppl 1):S137.12. 2019.

66 

Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, Leitch AM, Johnson TM, DeBerardinis RJ and Morrison SJ: Oxidative stress inhibits distant metastasis by human melanoma cells. Nature. 527:186–191. 2015. View Article : Google Scholar : PubMed/NCBI

67 

Palmer LJ, Cooper PR, Ling MR, Wright HJ, Huissoon A and Chapple IL: Hypochlorous acid regulates neutrophil extracellular trap release in humans. Clin Exp Immunol. 167:261–268. 2012. View Article : Google Scholar : PubMed/NCBI

68 

Prokopowicz ZM, Arce F, Biedroń R, Chiang CL, Ciszek M, Katz DR, Nowakowska M, Zapotoczny S, Marcinkiewicz J and Chain BM: Hypochlorous acid: A natural adjuvant that facilitates antigen processing, cross-priming, and the induction of adaptive immunity. J Immunol. 184:824–835. 2010. View Article : Google Scholar : PubMed/NCBI

69 

Zhou R, Huang WJ, Ma C, Zhou Y, Yao YQ, Wang YX, Gou LT, Yi C and Yang JL: HOCl oxidation-modified CT26 cell vaccine inhibits colon tumor growth in a mouse model. Asian Pac J Cancer Prev. 13:4037–4043. 2012. View Article : Google Scholar : PubMed/NCBI

70 

Chiang CL, Kandalaft LE, Tanyi J, Hagemann AR, Motz GT, Svoronos N, Montone K, Mantia-Smaldone GM, Smith L, Nisenbaum HL, et al: A dendritic cell vaccine pulsed with autologous hypochlorous acid-oxidized ovarian cancer lysate primes effective broad antitumor immunity: From bench to bedside. Clin Cancer Res. 19:4801–4815. 2013. View Article : Google Scholar : PubMed/NCBI

71 

Tanyi JL, Bobisse S, Ophir E, Tuyaerts S, Roberti A, Genolet R, Baumgartner P, Stevenson BJ, Iseli C, Dangaj D, et al: Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer. Sci Transl Med. 10:eaao59312018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Freund E, Miebach L, Stope MB and Bekeschus S: Hypochlorous acid selectively promotes toxicity and the expression of danger signals in human abdominal cancer cells. Oncol Rep 45: 71, 2021.
APA
Freund, E., Miebach, L., Stope, M.B., & Bekeschus, S. (2021). Hypochlorous acid selectively promotes toxicity and the expression of danger signals in human abdominal cancer cells. Oncology Reports, 45, 71. https://doi.org/10.3892/or.2021.8022
MLA
Freund, E., Miebach, L., Stope, M. B., Bekeschus, S."Hypochlorous acid selectively promotes toxicity and the expression of danger signals in human abdominal cancer cells". Oncology Reports 45.5 (2021): 71.
Chicago
Freund, E., Miebach, L., Stope, M. B., Bekeschus, S."Hypochlorous acid selectively promotes toxicity and the expression of danger signals in human abdominal cancer cells". Oncology Reports 45, no. 5 (2021): 71. https://doi.org/10.3892/or.2021.8022
Copy and paste a formatted citation
x
Spandidos Publications style
Freund E, Miebach L, Stope MB and Bekeschus S: Hypochlorous acid selectively promotes toxicity and the expression of danger signals in human abdominal cancer cells. Oncol Rep 45: 71, 2021.
APA
Freund, E., Miebach, L., Stope, M.B., & Bekeschus, S. (2021). Hypochlorous acid selectively promotes toxicity and the expression of danger signals in human abdominal cancer cells. Oncology Reports, 45, 71. https://doi.org/10.3892/or.2021.8022
MLA
Freund, E., Miebach, L., Stope, M. B., Bekeschus, S."Hypochlorous acid selectively promotes toxicity and the expression of danger signals in human abdominal cancer cells". Oncology Reports 45.5 (2021): 71.
Chicago
Freund, E., Miebach, L., Stope, M. B., Bekeschus, S."Hypochlorous acid selectively promotes toxicity and the expression of danger signals in human abdominal cancer cells". Oncology Reports 45, no. 5 (2021): 71. https://doi.org/10.3892/or.2021.8022
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