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Review

Roles of kinesin superfamily proteins in colorectal cancer carcinogenesis (Review)

  • Authors:
    • Da Huo
    • Hua Yang
    • Jian-Dong Huang
    • Jian-Ping Cai
    • Ju Cui
  • View Affiliations / Copyright

    Affiliations: The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing 100730, P.R. China, Department of General Surgery, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing 100730, P.R. China, School of Biomedical Sciences and Shenzhen Institute of Research and Innovation, University of Hong Kong, Hong Kong, SAR, P.R. China
  • Article Number: 121
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    Published online on: May 5, 2021
       https://doi.org/10.3892/or.2021.8072
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Abstract

Colorectal cancer (CRC), a commonly occurring carcinoma, now ranks the second in terms of cancer‑associated deaths around the world. Among the numerous factors that contribute to CRC tumor progression, a class of motor proteins known as the kinesins has been found to play a vital role. Kinesins are responsible for the intracellular trafficking of functional proteins, organelles and biomacromolecules along microtubules. Dysregulation of kinesins has been revealed to influence the cell cycle to cause abnormal cell growth and affect cell adhesion to promote epithelial‑mesenchymal transition in breast, bladder, ovarian and prostate cancer. Studies on the function of kinesins in CRC have also been performed, although, to the best of our knowledge, little is known about the underlying mechanisms of kinesins in CRC progression. The present review outlines the roles played by different kinesins in CRC carcinogenesis, mainly discussing the most studied subfamilies (kinesin 3‑6, 8, 10, 11 and 13), This review aims to illustrate the functions of kinesins in CRC cell growth, cancer metastasis and chemoresistance to provide insights regarding kinesins as potential targets for determining CRC prognosis and selecting therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Huo D, Yang H, Huang J, Cai J and Cui J: Roles of kinesin superfamily proteins in colorectal cancer carcinogenesis (Review). Oncol Rep 46: 121, 2021.
APA
Huo, D., Yang, H., Huang, J., Cai, J., & Cui, J. (2021). Roles of kinesin superfamily proteins in colorectal cancer carcinogenesis (Review). Oncology Reports, 46, 121. https://doi.org/10.3892/or.2021.8072
MLA
Huo, D., Yang, H., Huang, J., Cai, J., Cui, J."Roles of kinesin superfamily proteins in colorectal cancer carcinogenesis (Review)". Oncology Reports 46.1 (2021): 121.
Chicago
Huo, D., Yang, H., Huang, J., Cai, J., Cui, J."Roles of kinesin superfamily proteins in colorectal cancer carcinogenesis (Review)". Oncology Reports 46, no. 1 (2021): 121. https://doi.org/10.3892/or.2021.8072
Copy and paste a formatted citation
x
Spandidos Publications style
Huo D, Yang H, Huang J, Cai J and Cui J: Roles of kinesin superfamily proteins in colorectal cancer carcinogenesis (Review). Oncol Rep 46: 121, 2021.
APA
Huo, D., Yang, H., Huang, J., Cai, J., & Cui, J. (2021). Roles of kinesin superfamily proteins in colorectal cancer carcinogenesis (Review). Oncology Reports, 46, 121. https://doi.org/10.3892/or.2021.8072
MLA
Huo, D., Yang, H., Huang, J., Cai, J., Cui, J."Roles of kinesin superfamily proteins in colorectal cancer carcinogenesis (Review)". Oncology Reports 46.1 (2021): 121.
Chicago
Huo, D., Yang, H., Huang, J., Cai, J., Cui, J."Roles of kinesin superfamily proteins in colorectal cancer carcinogenesis (Review)". Oncology Reports 46, no. 1 (2021): 121. https://doi.org/10.3892/or.2021.8072
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