Roles of kinesin superfamily proteins in colorectal cancer carcinogenesis (Review)
- Authors:
- Da Huo
- Hua Yang
- Jian-Dong Huang
- Jian-Ping Cai
- Ju Cui
-
Affiliations: The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing 100730, P.R. China, Department of General Surgery, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing 100730, P.R. China, School of Biomedical Sciences and Shenzhen Institute of Research and Innovation, University of Hong Kong, Hong Kong, SAR, P.R. China - Published online on: May 5, 2021 https://doi.org/10.3892/or.2021.8072
- Article Number: 121
This article is mentioned in:
Abstract
 |
 |
 |
 |
 |
|
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. Feb 4–2021.(Epub ahead of print). doi: 10.3322/caac.21660. View Article : Google Scholar : PubMed/NCBI | |
|
Dekker E, Tanis PJ, Vleugels JLA, Kasi PM and Wallace MB: Colorectal cancer. Lancet. 394:1467–1480. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Vale RD and Milligan RA: The way things move: Looking under the hood of molecular motor proteins. Science. 288:88–95. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M and Hirokawa N: Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell. 95:829–837. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Goldstein LS: Kinesin molecular motors: Transport pathways, receptors, and human disease. Proc Natl Acad Sci USA. 98:6999–7003. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Morel M, Héraud C, Nicaise C, Suain V and Brion JP: Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer's disease: Implications for axoplasmic transport. Acta neuropathol. 123:71–84. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Fan X, Wang X, Zhu H, Wang W, Zhang S and Wang Z: KIF2A overexpression and its association with clinicopathologic characteristics and unfavorable prognosis in colorectal cancer. Tumour Biol. 36:8895–8902. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Matsumoto Y, Saito M, Saito K, Kanke Y, Watanabe Y, Onozawa H, Hayase S, Sakamoto W, Ishigame T, Momma T, et al: Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis. Oncol Lett. 15:2188–2194. 2018.PubMed/NCBI | |
|
Hou PF, Jiang T, Chen F, Shi PC, Li HQ, Bai J and Song J: KIF4A facilitates cell proliferation via induction of p21-mediated cell cycle progression and promotes metastasis in colorectal cancer. Cell Death Dis. 9:4772018. View Article : Google Scholar : PubMed/NCBI | |
|
Nagahara M, Nishida N, Iwatsuki M, Ishimaru S, Mimori K, Tanaka F, Nakagawa T, Sato T, Sugihara K, Hoon DS and Mori M: Kinesin 18A expression: Clinical relevance to colorectal cancer progression. Int J Cancer. 129:2543–2552. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Ishikawa K, Kamohara Y, Tanaka F, Haraguchi N, Mimori K, Inoue H and Mori M: Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer. Br J Cancer. 98:1824–1829. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Lin WF, Lin XL, Fu SW, Yang L, Tang CT, Gao YJ, Chen HY and Ge ZZ: Pseudopod-associated protein KIF20B promotes Gli1-induced epithelial-mesenchymal transition modulated by pseudopodial actin dynamic in human colorectal cancer. Mol Carcinog. 57:911–925. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Wang J, Cui F, Wang X, Xue Y, Chen J, Yu Y, Lu H, Zhang M, Tang H and Peng Z: Elevated kinesin family member 26B is a prognostic biomarker and a potential therapeutic target for colorectal cancer. J Exp Clin Cancer Res. 34:132015. View Article : Google Scholar : PubMed/NCBI | |
|
Li B, Zhu FC, Yu SX, Liu SJ and Li BY: Suppression of KIF22 inhibits cell proliferation and xenograft tumor growth in colon cancer. Cancer Biother Radiopharm. 35:50–57. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Xiong M, Zhuang K, Luo Y, Lai Q, Luo X, Fang Y, Zhang Y, Li A and Liu S: KIF20A promotes cellular malignant behavior and enhances resistance to chemotherapy in colorectal cancer through regulation of the JAK/STAT3 signaling pathway. Aging (Albany NY). 11:11905–11921. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Imai T, Oue N, Sentani K, Sakamoto N, Uraoka N, Egi H, Hinoi T, Ohdan H, Yoshida K and Yasui W: KIF11 is required for spheroid formation by oesophageal and colorectal cancer cells. Anticancer Res. 37:47–55. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wang ZZ, Yang J, Jiang BH, Di JB, Gao P, Peng L and Su XQ: KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer. Int J Oncol. 53:1939–1952. 2018.PubMed/NCBI | |
|
Ritter A, Sanhaji M, Friemel A, Roth S, Rolle U, Louwen F and Yuan J: Functional analysis of phosphorylation of the mitotic centromere-associated kinesin by Aurora B kinase in human tumor cells. Cell cycle. 14:3755–3767. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, et al: A standardized kinesin nomenclature. J Cell Biol. 167:19–22. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Hirokawa N, Noda Y, Tanaka Y and Niwa S: Kinesin superfamily motor proteins and intracellular transport. Nat Rev Mol Cell Biol. 10:682–696. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Woehlke G and Schliwa M: Walking on two heads: The many talents of kinesin. Nat Rev Mol Cell Biol. 1:50–58. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Sack S, Kull FJ and Mandelkow E: Motor proteins of the kinesin family. Structures, variations, and nucleotide binding sites. Eur J Biochem. 262:1–11. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Hua W, Chung J and Gelles J: Distinguishing inchworm and hand-over-hand processive kinesin movement by neck rotation measurements. Science. 295:844–848. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Vale RD: The molecular motor toolbox for intracellular transport. Cell. 112:467–480. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Ruane PT, Gumy LF, Bola B, Anderson B, Wozniak MJ, Hoogenraad CC and Allan VJ: Tumour suppressor adenomatous polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2. Sci Rep. 6:274562016. View Article : Google Scholar : PubMed/NCBI | |
|
Lin R, Duan Z, Sun H, Fung ML, Chen H, Wang J, Lau CF, Yang D, Liu Y, Ni Y, et al: Kinesin-1 regulates extrasynaptic targeting of NMDARs and neuronal vulnerability toward excitotoxicity. iScience. 13:82–97. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Hirokawa N, Niwa S and Tanaka Y: Molecular motors in neurons: Transport mechanisms and roles in brain function, development, and disease. Neuron. 68:610–638. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Cui J, Wang Z, Cheng Q, Lin R, Zhang XM, Leung PS, Copeland NG, Jenkins NA, Yao KM and Huang JD: Targeted inactivation of kinesin-1 in pancreatic β-cells in vivo leads to insulin secretory deficiency. Diabetes. 60:320–330. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Cui J, Pang J, Lin YJ, Gong H, Wang ZH, Li YX, Li J, Wang Z, Jiang P, Dai DP, et al: Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity. FASEB J. 31:2533–2547. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Tanaka Y, Kanai Y, Okada Y, Nonaka S, Takeda S, Harada A and Hirokawa N: Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria. Cell. 93:1147–1158. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Tigchelaar W, de Jong AM, Bloks VW, van Gilst WH, de Boer RA and Silljé HH: Hypertrophy induced KIF5B controls mitochondrial localization and function in neonatal rat cardiomyocytes. J Mol Cell Cardiol. 97:70–81. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, Fan JB, Abraham RT and Jiang W: Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell. 16:3187–3199. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Lukong KE and Richard S: Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration. Cell Signal. 20:432–442. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Corson TW, Zhu CQ, Lau SK, Shepherd FA, Tsao MS and Gallie BL: KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer. Clin Cancer Res. 13:3229–3234. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Miki H, Okada Y and Hirokawa N: Analysis of the kinesin superfamily: Insights into structure and function. Trends Cell Biol. 15:467–476. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Siddiqui N and Straube A: Intracellular cargo transport by Kinesin-3 motors. Biochemistry (Mosc). 82:803–815. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Corson TW, Huang A, Tsao MS and Gallie BL: KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers. Oncogene. 24:4741–4753. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Mazumdar M, Sundareshan S and Misteli T: Human chromokinesin KIF4A functions in chromosome condensation and segregation. J Cell Biol. 166:613–620. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Karimian A, Ahmadi Y and Yousefi B: Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage. DNA Repair (Amst). 42:63–71. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Waitzman JS and Rice SE: Mechanism and regulation of kinesin-5, an essential motor for the mitotic spindle. Biol Cell. 106:1–12. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang M, Zhuang H, Xia R, Gan L, Wu Y, Ma J, Sun Y and Zhuang Z: KIF11 is required for proliferation and self-renewal of docetaxel resistant triple negative breast cancer cells. Oncotarget. 8:92106–92118. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Takaishi S, Okumura T and Wang TC: Gastric cancer stem cells. J Clin Oncol. 26:2876–2882. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Imai T, Oue N, Nishioka M, Mukai S, Oshima T, Sakamoto N, Sentani K, Matsusaki K, Yoshida K and Yasui W: Overexpression of KIF11 in gastric cancer with intestinal mucin phenotype. Pathobiology. 84:16–24. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Cesario JM, Jang JK, Redding B, Shah N, Rahman T and McKim KS: Kinesin 6 family member Subito participates in mitotic spindle assembly and interacts with mitotic regulators. J Cell Sci. 119:4770–4780. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Imai K, Hirata S, Irie A, Senju S, Ikuta Y, Yokomine K, Harao M, Inoue M, Tomita Y, Tsunoda T, et al: Identification of HLA-A2-restricted CTL epitopes of a novel tumour-associated antigen, KIF20A, overexpressed in pancreatic cancer. Br J Cancer. 104:300–307. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang C, Wang Y, Feng Y, Zhang Y, Ji B, Wang S and Sun Y, Zhu C, Zhang D and Sun Y: Gli1 promotes colorectal cancer metastasis in a Foxm1-dependent manner by activating EMT and PI3K-AKT signaling. Oncotarget. 7:86134–86147. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Pinder C, Matsuo Y, Maurer SP and Toda T: Kinesin-8 and Dis1/TOG collaborate to limit spindle elongation from prophase to anaphase A for proper chromosome segregation in fission yeast. J Cell Sci. 132:jcs2323062019. View Article : Google Scholar : PubMed/NCBI | |
|
Edzuka T and Goshima G: Drosophila kinesin-8 stabilizes the kinetochore-microtubule interaction. J Cell Biol. 218:474–488. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Gardner MK, Odde DJ and Bloom K: Kinesin-8 molecular motors: Putting the brakes on chromosome oscillations. Trends Cell Biol. 18:307–310. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Mayr MI, Hümmer S, Bormann J, Grüner T, Adio S, Woehlke G and Mayer TU: The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression. Curr Biol. 17:488–498. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu H, Xu W, Zhang H, Liu J, Xu H, Lu S, Dang S, Kuang Y, Jin X and Wang Z: Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation. Biochem Biophys Res Commun. 438:97–102. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Levesque AA and Compton DA: The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles. J Cell Biol. 154:1135–1146. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Tahara K, Takagi M, Ohsugi M, Sone T, Nishiumi F, Maeshima K, Horiuchi Y, Tokai-Nishizumi N, Imamoto F, Yamamoto T, et al: Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid. J Cell Biol. 180:493–506. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, Yonemura S, Tsukita S, Inoue J and Yamamota T: Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle. EMBO J. 15:457–467. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Yu Y, Wang XY, Sun L, Wang YL, Wan YF, Li XQ and Feng YM: Inhibition of KIF22 suppresses cancer cell proliferation by delaying mitotic exit through upregulating CDC25C expression. Carcinogenesis. 35:1416–1425. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou R, Niwa S, Homma N, Takei Y and Hirokawa N: KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development. Cell. 139:802–813. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Orellana C, Roselló M, Monfort S, Oltra S, Quiroga R, Ferrer I and Martínez F: Corpus callosum abnormalities and the controversy about the candidate genes located in 1q44. Cytogenet Genome Res. 127:5–8. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Miyamoto T, Hosoba K, Ochiai H, Royba E, Izumi H, Sakuma T, Yamamoto T, Dynlacht BD and Matsuura S: The Microtubule-Depolymerizing activity of a mitotic kinesin protein KIF2A drives primary cilia disassembly coupled with cell proliferation. Cell Rep. 10:664–673. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Vasudevan KK, Jiang YY, Lechtreck KF, Kushida Y, Alford LM, Sale WS, Hennessey T and Gaertig J: Kinesin-13 regulates the quantity and quality of tubulin inside cilia. Mol Biol Cell. 26:478–494. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wordeman L and Mitchison TJ: Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis. J Cell Biol. 128:95–104. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Helenius J, Brouhard G, Kalaidzidis Y, Diez S and Howard J: The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends. Nature. 441:115–119. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Kumar A, Rajendran V, Sethumadhavan R and Purohit R: Evidence of colorectal cancer-associated mutation in MCAK: A computational report. Cell Biochem Biophys. 67:837–851. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Aoki S, Ohta K, Yamazaki T, Sugawara F and Sakaguchi K: Mammalian mitotic centromere-associated kinesin (MCAK): A new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents. FEBS J. 272:2132–2140. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Scanlan MJ, Welt S, Gordon CM, Chen YT, Gure AO, Stockert E, Jungbluth AA, Ritter G, Jäger D, Jäger E, et al: Cancer-related serological recognition of human colon cancer: Identification of potential diagnostic and immunotherapeutic targets. Cancer Res. 62:4041–4047. 2002.PubMed/NCBI | |
|
Gnjatic S, Cao Y, Reichelt U, Yekebas EF, Nölker C, Marx AH, Erbersdobler A, Nishikawa H, Hildebrandt Y, Bartels K, et al: NY-CO-58/KIF2C is overexpressed in a variety of solid tumors and induces frequent T cell responses in patients with colorectal cancer. Int J Cancer. 127:381–393. 2010.PubMed/NCBI | |
|
Osaki M, Oshimura M and Ito H: PI3K-Akt pathway: Its functions and alterations in human cancer. Apoptosis. 9:667–676. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Carpenter RL and Lo HW: STAT3 target genes relevant to human cancers. Cancers (Basel). 6:897–925. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Kramer HB, Lai CF, Patel H, Periyasamy M, Lin ML, Feller SM, Fuller-Pace FV, Meek DW, Ali S and Buluwela L: LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner. Nucleic Acids Res. 44:582–594. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Lim S and Kaldis P: Cdks, cyclins and CKIs: Roles beyond cell cycle regulation. Development. 140:3079–3093. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Braun A, Dang K, Buslig F, Baird MA, Davidson MW, Waterman CM and Myers KA: Rac1 and Aurora A regulate MCAK to polarize microtubule growth in migrating endothelial cells. J Cell Biol. 206:97–112. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Shimo A, Tanikawa C, Nishidate T, Lin ML, Matsuda K, Park JH, Ueki T, Ohta T, Hirata K, Fukuda M, et al: Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis. Cancer Sci. 99:62–70. 2008.PubMed/NCBI | |
|
Yamada Y, Takahari D, Matsumoto H, Baba H, Nakamura M, Yoshida K, Yoshida M, Iwamoto S, Shimada K, Komatsu Y, et al: Leucovorin, fluorouracil, and oxaliplatin plus bevacizumab versus S-1 and oxaliplatin plus bevacizumab in patients with metastatic colorectal cancer (SOFT): An open-label, non-inferiority, randomised phase 3 trial. Lancet Oncol. 14:1278–1286. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Douillard JY, Siena S, Cassidy J, Tabernero J, Burkes R, Barugel M, Humblet Y, Bodoky G, Cunningham D, Jassem J, et al: Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study. J Clin Oncol. 28:4697–4705. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Lucanus AJ and Yip GW: Kinesin superfamily: Roles in breast cancer, patient prognosis and therapeutics. Oncogene. 37:833–838. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Rath O and Kozielski F: Kinesins and cancer. Nat Rev Cancer. 12:527–539. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang W, Zhai L, Lu W, Boohaker RJ, Padmalayam I and Li Y: Discovery of novel allosteric Eg5 Inhibitors through structure-based virtual screening. Chem Biol Drug Des. 88:178–187. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Nakai R, Iida S, Takahashi T, Tsujita T, Okamoto S, Takada C, Akasaka K, Ichikawa S, Ishida H, Kusaka H, et al: K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. Cancer Res. 69:3901–3909. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Zong H, Carnes SK, Moe C, Walczak CE and Ems-McClung SC: The far C-terminus of MCAK regulates its conformation and spindle pole focusing. Mol Biol Cell. 27:1451–1464. 2016. View Article : Google Scholar : PubMed/NCBI |
