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Article Open Access

Next‑generation sequencing analysis reveals that MTH‑3, a novel curcuminoid derivative, suppresses the invasion of MDA‑MB‑231 triple‑negative breast adenocarcinoma cells

Corrigendum in: /10.3892/or.2024.8750
  • Authors:
    • Yu-Jen Chiu
    • Fuu-Jen Tsai
    • Da-Tian Bau
    • Ling-Chu Chang
    • Min-Tsang Hsieh
    • Chi-Cheng Lu
    • Sheng-Chu Kuo
    • Jai-Sing Yang
  • View Affiliations / Copyright

    Affiliations: Division of Plastic and Reconstructive Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11217, Taiwan, R.O.C., Human Genetic Center, China Medical University, Taichung 40402, Taiwan, R.O.C., Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan, R.O.C., Chinese Medicinal Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan, R.O.C., Department of Sport Performance, National Taiwan University of Sport, Taichung 40402, Taiwan, R.O.C.
    Copyright: © Chiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 133
    |
    Published online on: May 19, 2021
       https://doi.org/10.3892/or.2021.8084
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Abstract

Triple‑negative breast cancer (TNBC) behaves aggressively in the invasive and metastatic states. Our research group recently developed a novel curcumin derivative, (1E,3Z,6E)-3-hydroxy-5-oxohepta-1,3,6-triene-1,7-diyl)bis(2‑methoxy-4,1‑phenylene)bis(3-hydroxy2-hydroxymethyl)-2‑methyl propanoate (MTH‑3), and previous studies showed that MTH‑3 inhibits TNBC proliferation and induces apoptosis in vitro and in vivo with a superior bioavailability and absorption than curcumin. In the present study, the effects of MTH‑3 on TNBC cell invasion were examined using various assays and gelatin zymography, and western blot analysis. Treatment with MTH‑3 inhibited MDA‑MB‑231 cell invasion and migration, as shown by Transwell assay, 3D spheroid invasion assay, and wound healing assay. The results of the gelatin zymography experiments revealed that MTH‑3 decreased matrix metalloproteinase‑9 activity. The potential signaling pathways were revealed by next‑generation sequencing analysis, antibody microarray analysis and western blot analysis. In conclusion, the results of the present study show that, MTH‑3 inhibited tumor cell invasion through the MAPK/ERK/AKT signaling pathway and cell cycle regulatory cascade, providing significant information about the potential molecular mechanisms of the effects of MTH‑3 on TNBC.
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1 

McGuire A, Brown JA, Malone C, McLaughlin R and Kerin MJ: Effects of age on the detection and management of breast cancer. Cancers (Basel). 7:908–929. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Feng Y, Spezia M, Huang S, Yuan C, Zeng Z, Zhang L, Ji X, Liu W, Huang B, Luo W, et al: Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes Dis. 5:77–106. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Key TJ, Bradbury KE, Perez-Cornago A, Sinha R, Tsilidis KK and Tsugane S: Diet, nutrition, and cancer risk: What do we know and what is the way forward? BMJ. 368:m5112020. View Article : Google Scholar : PubMed/NCBI

4 

Wang X, Zhang H and Chen X: Drug resistance and combating drug resistance in cancer. Cancer Drug Resist. 2:141–160. 2019.

5 

Chen T, Xiong H, Yang JF, Zhu XL, Qu RY and Yang GF: Diaryl ether: A privileged scaffold for drug and agrochemical discovery. J Agric Food Chem. 68:9839–9877. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Newman DJ and Cragg GM: Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod. 75:311–335. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Niwa T, Yokoyama Si, Mochizuki M and Osawa T: Curcumin metabolism by human intestinal bacteria in vitro. J Func Foods. 61:1034632019. View Article : Google Scholar

8 

Yang H, Du Z, Wang W, Song M, Sanidad K, Sukamtoh E, Zheng J, Tian L, Xiao H, Liu Z and Zhang G: Structure-activity relationship of curcumin: Role of the methoxy group in anti-inflammatory and anticolitis effects of curcumin. J Agric Food Chem. 65:4509–4515. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Jing S, Zou H, Wu Z, Ren L, Zhang T, Zhang J and Wei Z: Cucurbitacins: Bioactivities and synergistic effect with small-molecule drugs. J Func Foods. 72:1040422020. View Article : Google Scholar

10 

Mathew D and Hsu WL: Antiviral potential of curcumin. J func foods. 40:692–699. 2018. View Article : Google Scholar

11 

Zaheri Z, Fahremand F, Rezvani ME, Karimollah A and Moradi A: Curcumin exerts beneficial role on insulin resistance through modulation of SOCS3 and Rac-1 pathways in type 2 diabetic rats. J Func Foods. 60:1034302019. View Article : Google Scholar

12 

Tomeh MA, Hadianamrei R and Zhao X: A review of curcumin and its derivatives as anticancer agents. Int J Mol Sci. 20:10332019. View Article : Google Scholar : PubMed/NCBI

13 

Bondì ML, Emma MR, Botto C, Augello G, Azzolina A, Di Gaudio F, Craparo EF, Cavallaro G, Bachvarov D and Cervello M: Biocompatible lipid nanoparticles as carriers to improve curcumin efficacy in ovarian cancer treatment. J Agric Food Chem. 65:1342–1352. 2017. View Article : Google Scholar

14 

DiMarco-Crook C, Rakariyatham K, Li Z, Du Z, Zheng J, Wu X and Xiao H: Synergistic anticancer effects of curcumin and 3′,4′-didemethylnobiletin in combination on colon cancer cells. J Food Sci. 85:1292–1301. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Shehzad A, Wahid F and Lee YS: Curcumin in cancer chemoprevention: Molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm (Weinheim). 343:489–499. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Shanmugam MK, Rane G, Kanchi MM, Arfuso F, Chinnathambi A, Zayed ME, Alharbi SA, Tan BK, Kumar AP and Sethi G: The multifaceted role of curcumin in cancer prevention and treatment. Molecules. 20:2728–2769. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Yang KY, Lin LC, Tseng TY, Wang SC and Tsai TH: Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 853:183–189. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Marczylo TH, Verschoyle RD, Cooke DN, Morazzoni P, Steward WP and Gescher AJ: Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother Pharmacol. 60:171–177. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Ma Y, Chen S, Liao W, Zhang L, Liu J and Gao Y: Formation, physicochemical stability, and redispersibility of curcumin-loaded rhamnolipid nanoparticles using the pH-Driven method. J Agric Food Chem. 68:7103–7111. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Cuomo F, Perugini L, Marconi E, Messia MC and Lopez F: Enhanced curcumin bioavailability through nonionic surfactant/caseinate mixed nanoemulsions. J Food Sci. 84:2584–2591. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Hsieh MT, Chang LC, Hung HY, Lin HY, Shih MH, Tsai CH, Kuo SC and Lee KH: New bis (hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo. Eur J Med Chem. 131:141–151. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Chang LC, Hsieh MT, Yang JS, Lu CC, Tsai FJ, Tsao JW, Chiu YJ, Kuo SC and Lee KH: Effect of bis (hydroxymethyl) alkanoate curcuminoid derivative MTH-3 on cell cycle arrest, apoptotic and autophagic pathway in triple-negative breast adenocarcinoma MDA-MB-231 cells: An in vitro study. Int J Oncol. 52:67–76. 2018.PubMed/NCBI

23 

Wu KM, Hsu YM, Ying MC, Tsai FJ, Tsai CH, Chung JG, Yang JS, Tang CH, Cheng LY, Su PH, et al: High-density lipoprotein ameliorates palmitic acid-induced lipotoxicity and oxidative dysfunction in H9c2 cardiomyoblast cells via ROS suppression. Nutr Metab (Lond). 16:362019. View Article : Google Scholar : PubMed/NCBI

24 

Lin KH, Li CY, Hsu YM, Tsai CH, Tsai FJ, Tang CH, Yang JS, Wang ZH and Yin MC: Oridonin, A natural diterpenoid, protected NGF-differentiated PC12 cells against MPP+-and kainic acid-induced injury. Food Chem Toxicol. 133:1107652019. View Article : Google Scholar : PubMed/NCBI

25 

Ha HA, Chiang JH, Tsai FJ, Bau DT, Juan YN, Lo YH, Hour MJ and Yang JS: Novel quinazolinone MJ-33 induces AKT/mTOR-mediated autophagy-associated apoptosis in 5FU-resistant colorectal cancer cells. Oncol Rep. 45:680–692. 2021. View Article : Google Scholar : PubMed/NCBI

26 

Chiu YJ, Hour MJ, Jin YA, Lu CC, Tsai FJ, Chen TL, Ma H, Juan YN and Yang JS: Disruption of IGF-1R signaling by a novel quinazoline derivative, HMJ-30, inhibits invasiveness and reverses epithelial-mesenchymal transition in osteosarcoma U-2 OS cells. Int J Oncol. 52:1465–1478. 2018.PubMed/NCBI

27 

Liu SC, Tsai CH, Wu TY, Tsai CH, Tsai FJ, Chung JG, Huang CY, Yang JS, Hsu YM, Yin MC, et al: Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: Implications for the treatment of osteoarthritis. Food Agric Immunol. 30:620–632. 2019. View Article : Google Scholar

28 

Vinci M, Box C and Eccles SA: Three-dimensional (3D) tumor spheroid invasion assay. J Vis Exp. e526862015.PubMed/NCBI

29 

Howes AL, Richardson RD, Finlay D and Vuori K: 3-Dimensional culture systems for anti-cancer compound profiling and high-throughput screening reveal increases in EGFR inhibitor-mediated cytotoxicity compared to monolayer culture systems. PLoS One. 9:e1082832014. View Article : Google Scholar : PubMed/NCBI

30 

Stacchiotti S, Pantaleo MA, Negri T, Astolfi A, Tazzari M, Dagrada GP, Urbini M, Indio V, Maestro R, Gronchi A, et al: Efficacy and biological activity of imatinib in metastatic dermatofibrosarcoma protuberans (DFSP). Clin Cancer Res. 22:837–846. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Kim D, Langmead B and Salzberg SL: HISAT: A fast spliced aligner with low memory requirements. Nat Methods. 12:357–360. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Kanehisa M: Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28:1947–1951. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Cheadle C, Vawter MP, Freed WJ and Becker KG: Analysis of microarray data using Z score transformation. J Mol Diagn. 5:73–81. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Chiu YJ, Yang JS, Hsu HS, Tsai CH and Ma H: Adipose-derived stem cell conditioned medium attenuates cisplatin-triggered apoptosis in tongue squamous cell carcinoma. Oncol Rep. 39:651–658. 2018.PubMed/NCBI

35 

Plaimas K, Mallm JP, Oswald M, Svara F, Sourjik V, Eils R and König R: Machine learning based analyses on metabolic networks supports high-throughput knockout screens. BMC Syst Biol. 2:672008. View Article : Google Scholar : PubMed/NCBI

36 

Zhang Z, Rui W, Wang ZC, Liu DX and Du L: Anti-proliferation and anti-metastasis effect of barbaloin in non-small cell lung cancer via inactivating p38MAPK/Cdc25B/Hsp27 pathway. Oncol Rep. 38:1172–1180. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Mirzaei H, Shakeri A, Rashidi B, Jalili A, Banikazemi Z and Sahebkar A: Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies. Biomed Pharmacother. 85:102–112. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Hoehle SI, Pfeiffer E, Sólyom AM and Metzler M: Metabolism of curcuminoids in tissue slices and subcellular fractions from rat liver. J Agric Food Chem. 54:756–764. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Vareed SK, Kakarala M, Ruffin MT, Crowell JA, Normolle DP, Djuric Z and Brenner DE: Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. Cancer Epidemiol Biomarkers Prev. 17:1411–1417. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Lu CC, Chen HP, Chiang JH, Jin YA, Kuo SC, Wu TS, Hour MJ, Yang JS and Chiu YJ: Quinazoline analog HMJ-30 inhibits angiogenesis: Involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling. Oncol Rep. 32:597–606. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Shimokawa Ki K, Katayama M, Matsuda Y, Takahashi H, Hara I, Sato H and Kaneko S: Matrix metalloproteinase (MMP)-2 and MMP-9 activities in human seminal plasma. Mol Hum Reprod. 8:32–36. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Nishio K, Motozawa K, Omagari D, Gojoubori T, Ikeda T, Asano M and Gionhaku N: Comparison of MMP2 and MMP9 expression levels between primary and metastatic regions of oral squamous cell carcinoma. J Oral Sci. 58:59–65. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Fan L, Zhang Y, Zhou Q, Liu Y, Gong B, Lü J, Zhu H, Zhu G, Xu Y and Huang G: Casticin inhibits breast cancer cell migration and invasion by down-regulation of PI3K/Akt signaling pathway. Biosci Rep. 38:BSR201807382018. View Article : Google Scholar : PubMed/NCBI

44 

Palange AL, Di Mascolo D, Singh J, De Franceschi MS, Carallo C, Gnasso A and Decuzzi P: Modulating the vascular behavior of metastatic breast cancer cells by curcumin treatment. Front Oncol. 2:1612012. View Article : Google Scholar : PubMed/NCBI

45 

Coker-Gurkan A, Celik M, Ugur M, Arisan ED, Obakan-Yerlikaya P, Durdu ZB and Palavan-Unsal N: Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cells. Amino Acids. 50:1045–1069. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Gallardo M and Calaf GM: Curcumin inhibits invasive capabilities through epithelial mesenchymal transition in breast cancer cell lines. Int J Oncol. 49:1019–1027. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Hu C, Li M, Guo T, Wang S, Huang W, Yang K, Liao Z, Wang J, Zhang F and Wang H: Anti-metastasis activity of curcumin against breast cancer via the inhibition of stem cell-like properties and EMT. Phytomedicine. 58:1527402019. View Article : Google Scholar : PubMed/NCBI

48 

Guan F, Ding Y, Zhang Y, Zhou Y, Li M and Wang C: Curcumin suppresses proliferation and migration of MDA-MB-231 breast cancer cells through autophagy-dependent Akt degradation. PLoS One. 11:e01465532016. View Article : Google Scholar : PubMed/NCBI

49 

Turro E, Astle WJ, Megy K, Gräf S, Greene D, Shamardina O, Allen HL, Sanchis-Juan A, Frontini M, Thys C, et al: Whole-genome sequencing of patients with rare diseases in a national health system. Nature. 583:96–102. 2020. View Article : Google Scholar : PubMed/NCBI

50 

Collado-Torres L, Nellore A, Kammers K, Ellis SE, Taub MA, Hansen KD, Jaffe AE, Langmead B and Leek JT: Reproducible RNA-seq analysis using recount2. Nat Biotechnol. 35:319–321. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Vamathevan J, Clark D, Czodrowski P, Dunham I, Ferran E, Lee G, Li B, Madabhushi A, Shah P, Spitzer M and Zhao S: Applications of machine learning in drug discovery and development. Nat Rev Drug Discov. 18:463–477. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Zhou W, Yui MA, Williams BA, Yun J, Wold BJ, Cai L and Rothenberg EV: Single-cell analysis reveals regulatory gene expression dynamics leading to lineage commitment in early T cell development. Cell Syst. 9:321–337. e9. 2019. View Article : Google Scholar : PubMed/NCBI

53 

Byrne A, Cole C, Volden R and Vollmers C: Realizing the potential of full-length transcriptome sequencing. Philos Trans R Soc Lond B Biol Sci. 374:201900972019. View Article : Google Scholar : PubMed/NCBI

54 

Zhang Y, Moerkens M, Ramaiahgari S, de Bont H, Price L, Meerman J and van de Water B: Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes. Breast Cancer Res. 13:R522011. View Article : Google Scholar : PubMed/NCBI

55 

Lin CC, Chen KB, Tsai CH, Tsai FJ, Huang CY, Tang CH, Yang JS, Hsu YM, Peng SF and Chung JG: Casticin inhibits human prostate cancer DU 145 cell migration and invasion via Ras/Akt/NF-κB signaling pathways. J Food Biochem. 43:e129022019. View Article : Google Scholar : PubMed/NCBI

56 

Chen WC, Lai YA, Lin YC, Ma JW, Huang LF, Yang NS, Ho CT, Kuo SC and Way TD: Curcumin suppresses doxorubicin-induced epithelial-mesenchymal transition via the inhibition of TGF-β and PI3K/AKT signaling pathways in triple-negative breast cancer cells. J Agric Food Chem. 61:11817–11824. 2013. View Article : Google Scholar : PubMed/NCBI

57 

Berrak Ö, Akkoç Y, Arısan ED, Çoker-Gürkan A, Obakan-Yerlikaya P and Palavan-Ünsal N: The inhibition of PI3K and NFκB promoted curcumin-induced cell cycle arrest at G2/M via altering polyamine metabolism in Bcl-2 overexpressing MCF-7 breast cancer cells. Biomed Pharmacother. 77:150–160. 2016. View Article : Google Scholar : PubMed/NCBI

58 

Fusté NP, Fernández-Hernández R, Cemeli T, Mirantes C, Pedraza N, Rafel M, Torres-Rosell J, Colomina N, Ferrezuelo F, Dolcet X and Garí E: Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin. Nat Commun. 7:115812016. View Article : Google Scholar

59 

Maldonado MDM and Dharmawardhane S: Targeting rac and Cdc42 GTPases in cancer. Cancer Res. 78:3101–3111. 2018. View Article : Google Scholar : PubMed/NCBI

60 

Stengel K and Zheng Y: Cdc42 in oncogenic transformation, invasion, and tumorigenesis. Cell Signal. 23:1415–1423. 2011. View Article : Google Scholar : PubMed/NCBI

61 

Huang TY, Peng SF, Huang YP, Tsai CH, Tsai FJ, Huang CY, Tang CH, Yang JS, Hsu YM, Yin MC, et al: Combinational treatment of all-trans retinoic acid (ATRA) and bisdemethoxycurcumin (BDMC)-induced apoptosis in liver cancer Hep3B cells. J Food Biochem. 44:e131222020. View Article : Google Scholar : PubMed/NCBI

62 

Body S, Esteve-Arenys A, Miloudi H, Recasens-Zorzo C, Tchakarska G, Moros A, Bustany S, Vidal-Crespo A, Rodriguez V, Lavigne R, et al: Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells. Sci Rep. 7:139462017. View Article : Google Scholar : PubMed/NCBI

63 

Chen K, Jiao X, Ashton A, Di Rocco A, Pestell TG, Sun Y, Zhao J, Casimiro MC, Li Z, Lisanti MP, et al: The membrane-associated form of cyclin D1 enhances cellular invasion. Oncogenesis. 9:832020. View Article : Google Scholar : PubMed/NCBI

64 

Du DS, Yang XZ, Wang Q, Dai WJ, Kuai WX, Liu YL, Chu D and Tang XJ: Effects of CDC42 on the proliferation and invasion of gastric cancer cells. Mol Med Rep. 13:550–554. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chiu Y, Tsai F, Bau D, Chang L, Hsieh M, Lu C, Kuo S and Yang J: Next‑generation sequencing analysis reveals that MTH‑3, a novel curcuminoid derivative, suppresses the invasion of MDA‑MB‑231 triple‑negative breast adenocarcinoma cells Corrigendum in /10.3892/or.2024.8750. Oncol Rep 46: 133, 2021.
APA
Chiu, Y., Tsai, F., Bau, D., Chang, L., Hsieh, M., Lu, C. ... Yang, J. (2021). Next‑generation sequencing analysis reveals that MTH‑3, a novel curcuminoid derivative, suppresses the invasion of MDA‑MB‑231 triple‑negative breast adenocarcinoma cells Corrigendum in /10.3892/or.2024.8750. Oncology Reports, 46, 133. https://doi.org/10.3892/or.2021.8084
MLA
Chiu, Y., Tsai, F., Bau, D., Chang, L., Hsieh, M., Lu, C., Kuo, S., Yang, J."Next‑generation sequencing analysis reveals that MTH‑3, a novel curcuminoid derivative, suppresses the invasion of MDA‑MB‑231 triple‑negative breast adenocarcinoma cells Corrigendum in /10.3892/or.2024.8750". Oncology Reports 46.1 (2021): 133.
Chicago
Chiu, Y., Tsai, F., Bau, D., Chang, L., Hsieh, M., Lu, C., Kuo, S., Yang, J."Next‑generation sequencing analysis reveals that MTH‑3, a novel curcuminoid derivative, suppresses the invasion of MDA‑MB‑231 triple‑negative breast adenocarcinoma cells Corrigendum in /10.3892/or.2024.8750". Oncology Reports 46, no. 1 (2021): 133. https://doi.org/10.3892/or.2021.8084
Copy and paste a formatted citation
x
Spandidos Publications style
Chiu Y, Tsai F, Bau D, Chang L, Hsieh M, Lu C, Kuo S and Yang J: Next‑generation sequencing analysis reveals that MTH‑3, a novel curcuminoid derivative, suppresses the invasion of MDA‑MB‑231 triple‑negative breast adenocarcinoma cells Corrigendum in /10.3892/or.2024.8750. Oncol Rep 46: 133, 2021.
APA
Chiu, Y., Tsai, F., Bau, D., Chang, L., Hsieh, M., Lu, C. ... Yang, J. (2021). Next‑generation sequencing analysis reveals that MTH‑3, a novel curcuminoid derivative, suppresses the invasion of MDA‑MB‑231 triple‑negative breast adenocarcinoma cells Corrigendum in /10.3892/or.2024.8750. Oncology Reports, 46, 133. https://doi.org/10.3892/or.2021.8084
MLA
Chiu, Y., Tsai, F., Bau, D., Chang, L., Hsieh, M., Lu, C., Kuo, S., Yang, J."Next‑generation sequencing analysis reveals that MTH‑3, a novel curcuminoid derivative, suppresses the invasion of MDA‑MB‑231 triple‑negative breast adenocarcinoma cells Corrigendum in /10.3892/or.2024.8750". Oncology Reports 46.1 (2021): 133.
Chicago
Chiu, Y., Tsai, F., Bau, D., Chang, L., Hsieh, M., Lu, C., Kuo, S., Yang, J."Next‑generation sequencing analysis reveals that MTH‑3, a novel curcuminoid derivative, suppresses the invasion of MDA‑MB‑231 triple‑negative breast adenocarcinoma cells Corrigendum in /10.3892/or.2024.8750". Oncology Reports 46, no. 1 (2021): 133. https://doi.org/10.3892/or.2021.8084
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