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Article

miR‑375/Yes‑associated protein axis regulates IL‑6 and TGF‑β expression, which is involved in the cisplatin‑induced resistance of liver cancer cells

  • Authors:
    • Kanru Yu
    • Hao Li
    • Zhongyi Jiang
    • Han-Jen Hsu
    • Hsing-Chun Hsu
    • Yumei Zhang
    • Kunwei Wang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China, Department of Urology, Shanghai ZhongShan Hospital, Fudan University School of Medicine, Shanghai 200123, P.R. China, Department of Surgery, Shanghai Ruibo Clinic, Shanghai 200023, P.R. China, Department of VIP Clinical, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200123, P.R. China, Department of Endocrinology, Shanghai Tianyou Hospital, School of Medicine, Tongji University, Shanghai 200331, P.R. China
  • Article Number: 162
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    Published online on: June 14, 2021
       https://doi.org/10.3892/or.2021.8112
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Abstract

Chemotherapy resistance is one of the major challenges in the treatment of liver cancer (LC). The present study aimed to investigate the potential roles of Yes‑associated protein (YAP), the core component of the Hippo signaling pathway, in chemoresistance of LC. YAP expression and its function in chemoresistance of LC cells were investigated. It was revealed that the expression levels and nuclear localization of YAP were increased in cisplatin (CDDP)‑resistant LC (LC/CDDP) cells. The targeted inhibition of YAP using small interfering RNA or an inhibitor restored the CDDP sensitivity of LC cells. YAP overexpression was discovered to be essential for the increase of IL‑6 and TGF‑β expression levels in LC/CDDP cells. Furthermore, it was identified that increased mRNA stability was the primary reason for the upregulation of YAP expression in LC/CDDP cells, which was due to the downregulation of microRNA (miR)‑375 expression in LC/CDDP cells. In conclusion, the findings of the present study suggested that the miR‑375/YAP axis may regulate the expression levels of IL‑6 and TGF‑β, which may subsequently be involved in the CDDP resistance of LC cells. The current results indicated that the targeted inhibition of this axis and signaling pathway may be helpful in overcoming CDDP resistance.
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Copy and paste a formatted citation
Spandidos Publications style
Yu K, Li H, Jiang Z, Hsu H, Hsu H, Zhang Y and Wang K: miR‑375/Yes‑associated protein axis regulates IL‑6 and TGF‑β expression, which is involved in the cisplatin‑induced resistance of liver cancer cells. Oncol Rep 46: 162, 2021.
APA
Yu, K., Li, H., Jiang, Z., Hsu, H., Hsu, H., Zhang, Y., & Wang, K. (2021). miR‑375/Yes‑associated protein axis regulates IL‑6 and TGF‑β expression, which is involved in the cisplatin‑induced resistance of liver cancer cells. Oncology Reports, 46, 162. https://doi.org/10.3892/or.2021.8112
MLA
Yu, K., Li, H., Jiang, Z., Hsu, H., Hsu, H., Zhang, Y., Wang, K."miR‑375/Yes‑associated protein axis regulates IL‑6 and TGF‑β expression, which is involved in the cisplatin‑induced resistance of liver cancer cells". Oncology Reports 46.2 (2021): 162.
Chicago
Yu, K., Li, H., Jiang, Z., Hsu, H., Hsu, H., Zhang, Y., Wang, K."miR‑375/Yes‑associated protein axis regulates IL‑6 and TGF‑β expression, which is involved in the cisplatin‑induced resistance of liver cancer cells". Oncology Reports 46, no. 2 (2021): 162. https://doi.org/10.3892/or.2021.8112
Copy and paste a formatted citation
x
Spandidos Publications style
Yu K, Li H, Jiang Z, Hsu H, Hsu H, Zhang Y and Wang K: miR‑375/Yes‑associated protein axis regulates IL‑6 and TGF‑β expression, which is involved in the cisplatin‑induced resistance of liver cancer cells. Oncol Rep 46: 162, 2021.
APA
Yu, K., Li, H., Jiang, Z., Hsu, H., Hsu, H., Zhang, Y., & Wang, K. (2021). miR‑375/Yes‑associated protein axis regulates IL‑6 and TGF‑β expression, which is involved in the cisplatin‑induced resistance of liver cancer cells. Oncology Reports, 46, 162. https://doi.org/10.3892/or.2021.8112
MLA
Yu, K., Li, H., Jiang, Z., Hsu, H., Hsu, H., Zhang, Y., Wang, K."miR‑375/Yes‑associated protein axis regulates IL‑6 and TGF‑β expression, which is involved in the cisplatin‑induced resistance of liver cancer cells". Oncology Reports 46.2 (2021): 162.
Chicago
Yu, K., Li, H., Jiang, Z., Hsu, H., Hsu, H., Zhang, Y., Wang, K."miR‑375/Yes‑associated protein axis regulates IL‑6 and TGF‑β expression, which is involved in the cisplatin‑induced resistance of liver cancer cells". Oncology Reports 46, no. 2 (2021): 162. https://doi.org/10.3892/or.2021.8112
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