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Dehydrocrenatidine extracted from Picrasma quassioides induces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways

  • Authors:
    • Ming-Chang Hsieh
    • Yu-Sheng Lo
    • Yi-Ching Chuang
    • Chia-Chieh Lin
    • Hsin-Yu Ho
    • Ming-Ju Hsieh
    • Jen-Tsun Lin
  • View Affiliations / Copyright

    Affiliations: School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan, R.O.C., Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan, R.O.C., Post Baccalaureate Medicine, National Chung Hsing University, Taichung 402, Taiwan, R.O.C.
    Copyright: © Hsieh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 166
    |
    Published online on: June 18, 2021
       https://doi.org/10.3892/or.2021.8117
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Abstract

Nasopharyngeal carcinoma (NPC) is an indicator disease in Asia due to its unique geographical and ethnic distribution. Dehydrocrenatidine (DC) is a β‑carboline alkaloid abundantly present in Picrasma quassioides (D. Don) Benn, a deciduous shrub or small tree native to temperate regions of southern Asia, and β‑carboline alkaloids play anti‑inflammatory and antiproliferative roles in various cancers. However, the mechanism and function of DC in human NPC cells remain only partially explored. The present study aimed to examine the cytotoxicity and biochemical role of DC in human NPC cells. The MTT method, cell cycle analysis, DAPI determination, Annexin V/PI double staining, and mitochondrial membrane potential examination were performed to evaluate the effects of DC treatment on human NPC cell lines. In addition, western blotting analysis was used to explore the effect of DC on apoptosis and signaling pathways in related proteins. The analysis results confirmed that DC significantly reduced the viability of NPC cell lines in a dose‑ and time‑dependent manner and induced apoptosis through internal and external apoptotic pathways (including cell cycle arrest, altered mitochondrial membrane potential, and activated death receptors). Western blot analysis illustrated that DC's effect on related proteins in the mitogen‑activated protein kinase pathway can induce apoptosis by enhancing ERK phosphorylation and inhibiting Janus kinase (JNK) phosphorylation. Notably, DC induced apoptosis by affecting the phosphorylation of JNK and ERK, and DC and inhibitors (SP600125 and U0126) in combination restored the overexpression of p‑JNK and p‑ERK. To date, this is the first study to confirm the apoptosis pathway induced by DC phosphorylation of p‑JNK and p‑REK in human NPC. On the basis of evidence obtained from this study, DC targeting the inhibition of NPC cell lines may be a promising future strategy for NPC treatment.
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View References

1 

Du T, Xiao J, Qiu Z and Wu K: The effectiveness of intensity-modulated radiation therapy versus 2D-RT for the treatment of nasopharyngeal carcinoma: A systematic review and meta-analysis. PLoS One. 14:e02196112019. View Article : Google Scholar : PubMed/NCBI

2 

Chen YP, Chan AT, Le QT, Blanchard P, Sun Y and Ma J: Nasopharyngeal carcinoma. Lancet. 394:64–80. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Chan KC, Woo JK, King A, Zee BC, Lam WK, Chan SL, Chu SW, Mak C, Tse IO, Leung SY, et al: Analysis of plasma Epstein-Barr virus DNA to screen for nasopharyngeal cancer. N Engl J Med. 377:513–522. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Tsang RK: Nasopharyngeal carcinoma-improving cure with technology and clinical trials. World J Otorhinolaryngol Head Neck Surg. 6:1–3. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Sun XS, Li XY, Chen QY, Tang LQ and Mai HQ: Future of radiotherapy in nasopharyngeal carcinoma. Br J Radiol. 92:201902092019. View Article : Google Scholar : PubMed/NCBI

6 

Guo SS, Hu W, Chen QY, Li JM, Zhu SH, He Y, Li JW, Xia L, Ji L, Lin CY, et al: Pretreatment quality of life as a predictor of survival for patients with nasopharyngeal carcinoma treated with IMRT. BMC Cancer. 18:1142018. View Article : Google Scholar : PubMed/NCBI

7 

Liu LT, Liang YJ, Guo SS, Mo HY, Guo L, Wen YF, Xie HJ, Tang QN, Sun XS, Liu SL, et al: Induction chemotherapy followed by radiotherapy versus concurrent chemoradiotherapy in the treatment of different risk locoregionally advanced nasopharyngeal carcinoma. Ther Adv Med Oncol. 12:17588359209282142020. View Article : Google Scholar : PubMed/NCBI

8 

Zhao WY, Shang XY, Zhao L, Yao GD, Sun Z, Huang XX and Song SJ: Bioactivity-guided isolation of β-carboline alkaloids with potential anti-hepatoma effect from Picrasma quassioides (D. Don) Benn. Fitoterapia. 130:66–72. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Lee HE, Choi ES, Shin JA, Kim LH, Cho NP and Cho SD: Apoptotic effect of methanol extract of Picrasma quassioides by regulating specificity protein 1 in human cervical cancer cells. Cell Biochem Funct. 32:229–235. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Xie DP, Gong YX, Jin YH, Ren CX, Liu Y, Han YH, Jin MH, Zhu D, Pan QZ, Yu LY, et al: Anti-tumor properties of Picrasma quassioides extracts in H-RasG12V liver cancer are mediated through ROS-dependent mitochondrial dysfunction. nticancer Res. 40:3819–3830. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Shin NR, Shin IS, Jeon CM, Hong JM, Oh SR, Hahn KW and Ahn KS: Inhibitory effects of Picrasma quassioides (D.Don) Benn. On airway inflammation in a murine model of allergic asthma. Mol Med Rep. 10:1495–1500. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Ma Y and Wink M: The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells. Phytother Res. 24:146–149. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Zhao F, Tang Q, Xu J, Wang S, Li S, Zou X and Cao Z: Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain. Toxins (Basel). 11:2292019. View Article : Google Scholar : PubMed/NCBI

14 

Zhao WY, Chen JJ, Zou CX, Zhou WY, Yao GD, Wang XB, Lin B, Huang XX and Song SJ: Effects of enantiomerically Pure β-carboline alkaloids from Picrasma quassioides on human hepatoma cells. Planta Med. 85:648–656. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Zhao F, Gao Z, Jiao W, Chen L, Chen L and Yao X: In vitro anti-inflammatory effects of beta-carboline alkaloids, isolated from Picrasma quassioides, through inhibition of the iNOS pathway. Planta Med. 78:1906–1911. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Jiao WH, Chen GD, Gao H, Li J, Gu BB, Xu TT, Yu HB, Shi GH, Yang F, Yao XS and Lin HW: (±)-Quassidines I and J, two pairs of cytotoxic bis-β-carboline alkaloid enantiomers from Picrasma quassioides. J Nat Prod. 78:125–130. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Gong YX, Liu Y, Jin YH, Jin MH, Han YH, Li J, Shen GN, Xie DP, Ren CX, Yu LY, et al: Picrasma quassioides extract elevates the cervical cancer cell apoptosis through ROS-mitochondrial axis activated p38 MAPK signaling pathway. In Vivo. 34:1823–1833. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Zhang J, Zhu N, Du Y, Bai Q, Chen X, Nan J, Qin X, Zhang X, Hou J, Wang Q and Yang J: Dehydrocrenatidine is a novel janus kinase inhibitor. Mol Pharmacol. 87:572–581. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Liao SK, Perng YP, Shen YC, Chung PJ, Chang YS and Wang CH: Chromosomal abnormalities of a new nasopharyngeal carcinoma cell line (NPC-BM1) derived from a bone marrow metastatic lesion. Cancer Genet Cytogenet. 103:52–58. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Liu YT, Chuang YC, Lo YS, Lin CC, His YT, Hsieh MJ and Chen MK: Asiatic acid, extracted from centella asiatica and induces apoptosis pathway through the phosphorylation p38 mitogen-activated protein kinase in cisplatin-resistant nasopharyngeal carcinoma cells. Biomolecules. 10:1842020. View Article : Google Scholar : PubMed/NCBI

21 

Jana A, Das A, Krett NL, Guzman G, Thomas A, Mancinelli G, Bauer J, Ushio-Fukai M, Fukai T and Jung B: Nuclear translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer. PLoS One. 15:e02279162020. View Article : Google Scholar : PubMed/NCBI

22 

Chen YT, Hsieh MJ, Chen PN, Weng CJ, Yang SF and Lin CW: Erianin induces apoptosis and autophagy in oral squamous cell carcinoma cells. Am J Chin Med. 48:183–200. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Hsieh MY, Hsieh MJ, Lo YS, Lin CC, Chuang YC, Chen MK and Chou MC: Modulating effect of coronarin D in 5-fluorouracil resistance human oral cancer cell lines induced apoptosis and cell cycle arrest through JNK1/2 signaling pathway. Biomed Pharmacother. 128:1103182020. View Article : Google Scholar : PubMed/NCBI

24 

Tunc D, Dere E, Karakas D, Cevatemre B, Yilmaz VT and Ulukaya E: Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines. Bioorg Med Chem. 25:1717–1723. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Zhao L, Fong AH, Liu N and Cho WC: Molecular subtyping of nasopharyngeal carcinoma (NPC) and a microRNA-based prognostic model for distant metastasis. J Biomed Sci. 25:162018. View Article : Google Scholar : PubMed/NCBI

26 

Sun PY, Chen YH, Feng XB, Yang CX, Wu F and Wang RS: High-dose static and dynamic intensity-modulated radiotherapy combined with chemotherapy for patients with locally advanced nasopharyngeal carcinoma improves survival and reduces brainstem toxicity. Med Sci Monit. 24:8849–8859. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Wang F, Jiang C, Wang L, Yan F, Sun Q, Ye Z, Liu T, Fu Z and Jiang Y: Influence of concurrent chemotherapy on locoregionally advanced nasopharyngeal carcinoma treated with neoadjuvant chemotherapy plus intensity-modulated radiotherapy: A retrospective matched analysis. Sci Rep. 10:24892020. View Article : Google Scholar : PubMed/NCBI

28 

Zheng ZQ, Li ZX, Zhou GQ, Lin L, Zhang LL, Lv JW, Huang XD, Liu RQ, Chen F, He XJ, et al: Long noncoding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and upregulate ITGB3. Cancer Res. 79:4612–4626. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Jain CK, Majumder HK and Roychoudhury S: Natural compounds as anticancer agents targeting DNA topoisomerases. Curr Genomics. 18:75–92. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Cao R, Peng W, Wang Z and Xu A: beta-Carboline alkaloids: Biochemical and pharmacological functions. Curr Med Chem. 14:479–500. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Mansoor TA, Ramalho RM, Mulhovo S, Rodrigues CM and Ferreira MJ: Induction of apoptosis in HuH-7 cancer cells by monoterpene and beta-carboline indole alkaloids isolated from the leaves of tabernaemontana elegans. Bioorg Med Chem Lett. 19:4255–4258. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Bemis DL, Capodice JL, Gorroochurn P, Katz AE and Buttyan R: Anti-prostate cancer activity of a beta-carboline alkaloid enriched extract from rauwolfia vomitoria. Int J Oncol. 29:1065–1073. 2006.PubMed/NCBI

33 

Bai J, Li Y and Zhang G: Cell cycle regulation and anticancer drug discovery. Cancer Biol Med. 14:348–362. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Yam CH, Fung TK and Poon RY: Cyclin A in cell cycle control and cancer. Cell Mol Life Sci. 59:1317–1326. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Vigneron S, Sundermann L, Labbé JC, Pintard L, Radulescu O, Castro A and Lorca T: Cyclin A-cdk1-dependent phosphorylation of bora is the triggering factor promoting mitotic entry. Dev Cell. 45:637–650.e7. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Sun X, Zhangyuan G, Shi L, Wang Y, Sun B and Ding Q: Prognostic and clinicopathological significance of cyclin B expression in patients with breast cancer: A meta-analysis. Medicine (Baltimore). 96:e68602017. View Article : Google Scholar : PubMed/NCBI

37 

Ujiki MB, Ding XZ, Salabat MR, Bentrem DJ, Golkar L, Milam B, Talamonti MS, Bell RH Jr, Iwamura T and Adrian TE: Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest. Mol Cancer. 5:762006. View Article : Google Scholar : PubMed/NCBI

38 

Pomerening JR, Kim SY and Ferrell JE Jr: Systems-level dissection of the cell-cycle oscillator: Bypassing positive feedback produces damped oscillations. Cell. 122:565–578. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Sha W, Moore J, Chen K, Lassaletta AD, Yi CS, Tyson JJ and Sible JC: Hysteresis drives cell-cycle transitions in xenopus laevis egg extracts. Proc Natl Acad Sci USA. 100:975–980. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Mota NSRS, Kviecinski MR, Felipe KB, Grinevicius VMAS, Siminski T, Almeida GM, Zeferino RC, Pich CT, Filho DW and Pedrosa RC: β-carboline alkaloid harmine induces DNA damage and triggers apoptosis by a mitochondrial pathway: Study in silico, in vitro and in vivo. Int J Funct Nutr. 1:12020.

41 

Johnson J, Thijssen B, McDermott U, Garnett M, Wessels LF and Bernards R: Targeting the RB-E2F pathway in breast cancer. Oncogene. 35:4829–4835. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Ahmad I, Fakhri S, Khan H, Jeandet P, Aschner M and Yu ZL: Targeting cell cycle by β-carboline alkaloids in vitro: Novel therapeutic prospects for the treatment of cancer. Chem Biol Interact. 330:1092292020. View Article : Google Scholar : PubMed/NCBI

43 

Cao MR, Li Q, Liu ZL, Liu HH, Wang W, Liao XL, Pan YL and Jiang JW: Harmine induces apoptosis in HepG2 cells via mitochondrial signaling pathway. Hepatobiliary Pancreat Dis Int. 10:599–604. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Abdelsalam MA, AboulWafa OM, Badawey EA, El-Shoukrofy MS, El-Miligy MM and Gouda N: Design and synthesis of some β-carboline derivatives as multi-target anticancer agents. Future Med Chem. 10:2791–2814. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Portt L, Norman G, Clapp C, Greenwood M and Greenwood MT: Anti-apoptosis and cell survival: A review. Biochim Biophys Acta. 1813:238–259. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B and Bao JK: Programmed cell death pathways in cancer: A review of apoptosis, autophagy and programmed necrosis. Cell Prolif. 45:487–498. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Wang S and El-Deiry WS: TRAIL and apoptosis induction by TNF-family death receptors. Oncogene. 22:8628–8633. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Elrod HA and Sun SY: Modulation of death receptors by cancer therapeutic agents. Cancer Biol Ther. 7:163–173. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Kischkel FC, Lawrence DA, Chuntharapai A, Schow P, Kim KJ and Ashkenazi A: Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity. 12:611–620. 2000. View Article : Google Scholar : PubMed/NCBI

50 

Lin Y, Devin A, Rodriguez Y and Liu ZG: Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev. 13:2514–2526. 1999. View Article : Google Scholar : PubMed/NCBI

51 

Deng Z, Gao P, Yu L, Ma B, You Y, Chan L, Mei C and Chen T: Ruthenium complexes with phenylterpyridine derivatives target cell membrane and trigger death receptors-mediated apoptosis in cancer cells. Biomaterials. 129:111–126. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Derakhshan A, Chen Z and Van Waes C: Therapeutic small molecules target inhibitor of apoptosis proteins in cancers with deregulation of extrinsic and intrinsic cell death pathways. Clin Cancer Res. 23:1379–1387. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Han NN, Zhou Q, Huang Q and Liu KJ: Carnosic acid cooperates with tamoxifen to induce apoptosis associated with caspase-3 activation in breast cancer cells in vitro and in vivo. Biomed Pharmacother. 89:827–837. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Debatin KM: Apoptosis pathways in cancer and cancer therapy. Cancer Immunol Immunother. 53:153–159. 2004. View Article : Google Scholar : PubMed/NCBI

55 

Li-Weber M: Targeting apoptosis pathways in cancer by Chinese medicine. Cancer Lett. 332:304–312. 2013. View Article : Google Scholar : PubMed/NCBI

56 

Li C, Wang Y, Wang C, Yi X, Li M and He X: Anticancer activities of harmine by inducing a pro-death autophagy and apoptosis in human gastric cancer cells. Phytomedicine. 28:10–18. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Hamsa TP and Kuttan G: Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma. Chin Med. 6:112011. View Article : Google Scholar : PubMed/NCBI

58 

Zaid H, Silbermann M, Amash A, Gincel D, Abdel-Sattar E and Sarikahya NB: Medicinal plants and natural active compounds for cancer chemoprevention/chemotherapy. Evid Based Complement Alternat Med. 2017:79524172017. View Article : Google Scholar : PubMed/NCBI

59 

Zhang P, Huang CR, Wang W, Zhang XK, Chen JJ, Wang JJ, Lin C and Jiang JW: Harmine hydrochloride triggers G2 phase arrest and apoptosis in MGC-803 cells and SMMC-7721 cells by upregulating p21, activating caspase-8/Bid, and downregulating ERK/bad pathway. Phytother Res. 30:31–40. 2016. View Article : Google Scholar : PubMed/NCBI

60 

Yue J and López JM: Understanding MAPK signaling pathways in apoptosis. Int J Mol Sci. 21:23462020. View Article : Google Scholar : PubMed/NCBI

61 

Junttila MR, Li SP and Westermarck J: Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22:954–965. 2008. View Article : Google Scholar : PubMed/NCBI

62 

Fan Y, Patima A, Chen Y, Zeng F, He W, Luo L, Jie Y, Zhu Y, Zhang L, Lei J, et al: Cytotoxic effects of β-carboline alkaloids on human gastric cancer SGC-7901 cells. Int J Clin Exp Med. 8:12977–12982. 2015.PubMed/NCBI

63 

Chien CC, Wu MS, Shen SC, Ko CH, Chen CH, Yang LL and Chen YC: Activation of JNK contributes to evodiamine-induced apoptosis and G2/M arrest in human colorectal carcinoma cells: A structure-activity study of evodiamine. PLoS One. 9:e997292014. View Article : Google Scholar : PubMed/NCBI

64 

Lee YJ, Choi SY and Yang JH: NMDA receptor-mediated ERK 1/2 pathway is involved in PFHxS-induced apoptosis of PC12 cells. Sci Total Environ. 491-492:227–234. 2014. View Article : Google Scholar : PubMed/NCBI

65 

Al-Ejeh F, Kumar R, Wiegmans A, Lakhani SR, Brown MP and Khanna KK: Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes. Oncogene. 29:6085–6098. 2010. View Article : Google Scholar : PubMed/NCBI

66 

Boutros R, Lobjois V and Ducommun B: CDC25 phosphatases in cancer cells: Key players? Good targets? Nat Rev Cancer. 7:495–507. 2007. View Article : Google Scholar : PubMed/NCBI

67 

Freed-Pastor WA, Mizuno H, Zhao X, Langerød A, Moon SH, Rodriguez-Barrueco R, Barsotti A, Chicas A, Li W, Polotskaia A, et al: Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell. 148:244–258. 2012. View Article : Google Scholar : PubMed/NCBI

68 

Freed-Pastor WA and Prives C: Mutant p53: One name, many proteins. Genes Dev. 26:1268–1286. 2012. View Article : Google Scholar : PubMed/NCBI

69 

Fang EF, Zhang CZ, Ng TB, Wong JH, Pan WL, Ye XJ, Chan YS and Fong WP: Momordica Charantia lectin, a type II ribosome inactivating protein, exhibits antitumor activity toward human nasopharyngeal carcinoma cells in vitro and in vivo. Cancer Prev Res (Phila). 5:109–121. 2012. View Article : Google Scholar : PubMed/NCBI

70 

Song Y, Yang J, Bai WL and Ji WY: Antitumor and immunoregulatory effects of astragalus on nasopharyngeal carcinoma in vivo and in vitro. Phytother Res. 25:909–915. 2011. View Article : Google Scholar : PubMed/NCBI

71 

Zeng M, Wu X, Li F, She W, Zhou L, Pi B, Xu Z and Huang X: Laminaria japonica polysaccharides effectively inhibited the growth of nasopharyngeal carcinoma cells in vivo and in vitro study. Exp Toxicol Pathol. 69:527–532. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hsieh M, Lo Y, Chuang Y, Lin C, Ho H, Hsieh M and Lin J: Dehydrocrenatidine extracted from <em>Picrasma quassioides</em> induces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways. Oncol Rep 46: 166, 2021.
APA
Hsieh, M., Lo, Y., Chuang, Y., Lin, C., Ho, H., Hsieh, M., & Lin, J. (2021). Dehydrocrenatidine extracted from <em>Picrasma quassioides</em> induces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways. Oncology Reports, 46, 166. https://doi.org/10.3892/or.2021.8117
MLA
Hsieh, M., Lo, Y., Chuang, Y., Lin, C., Ho, H., Hsieh, M., Lin, J."Dehydrocrenatidine extracted from <em>Picrasma quassioides</em> induces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways". Oncology Reports 46.2 (2021): 166.
Chicago
Hsieh, M., Lo, Y., Chuang, Y., Lin, C., Ho, H., Hsieh, M., Lin, J."Dehydrocrenatidine extracted from <em>Picrasma quassioides</em> induces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways". Oncology Reports 46, no. 2 (2021): 166. https://doi.org/10.3892/or.2021.8117
Copy and paste a formatted citation
x
Spandidos Publications style
Hsieh M, Lo Y, Chuang Y, Lin C, Ho H, Hsieh M and Lin J: Dehydrocrenatidine extracted from <em>Picrasma quassioides</em> induces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways. Oncol Rep 46: 166, 2021.
APA
Hsieh, M., Lo, Y., Chuang, Y., Lin, C., Ho, H., Hsieh, M., & Lin, J. (2021). Dehydrocrenatidine extracted from <em>Picrasma quassioides</em> induces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways. Oncology Reports, 46, 166. https://doi.org/10.3892/or.2021.8117
MLA
Hsieh, M., Lo, Y., Chuang, Y., Lin, C., Ho, H., Hsieh, M., Lin, J."Dehydrocrenatidine extracted from <em>Picrasma quassioides</em> induces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways". Oncology Reports 46.2 (2021): 166.
Chicago
Hsieh, M., Lo, Y., Chuang, Y., Lin, C., Ho, H., Hsieh, M., Lin, J."Dehydrocrenatidine extracted from <em>Picrasma quassioides</em> induces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways". Oncology Reports 46, no. 2 (2021): 166. https://doi.org/10.3892/or.2021.8117
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