Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
August-2021 Volume 46 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2021 Volume 46 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Nuclear IGF1R interacts with NuMA and regulates 53BP1‑dependent DNA double‑strand break repair in colorectal cancer

  • Authors:
    • Chen Yang
    • Yifan Zhang
    • Nelly Segar
    • Changhao Huang
    • Pengwei Zeng
    • Xiangzhou Tan
    • Linfeng Mao
    • Zhikang Chen
    • Felix Haglund
    • Olle Larsson
    • Zihua Chen
    • Yingbo Lin
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410000, P.R. China, Department of Clinical Pathology and Cytology, Karolinska University Hospital Solna, 171 64 Solna, Stockholm, Sweden, Department of Oncology and Pathology, Karolinska Institute, 171 77 Stockholm, Sweden
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 168
    |
    Published online on: June 22, 2021
       https://doi.org/10.3892/or.2021.8119
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Nuclear insulin‑like growth factor 1 receptor (nIGF1R) has been associated with poor overall survival and chemotherapy resistance in various types of cancer; however, the underlying mechanism remains unclear. In the present study, immunoprecipitation‑coupled mass spectrometry was performed in an IGF1R‑overexpressing SW480‑OE colorectal cancer cell line to identify the nIGF1R interactome. Network analysis revealed 197 proteins of interest which were involved in several biological pathways, including RNA processing, DNA double‑strand break (DSB) repair and SUMOylation pathways. Nuclear mitotic apparatus protein (NuMA) was identified as one of nIGF1R's colocalizing partners. Proximity ligation assay (PLA) revealed different levels of p53‑binding protein 1 (53BP1)‑NuMA colocalization between IGF1R‑positive (R+) and IGF1R‑negative (R‑) mouse embryonic fibroblasts following exposure to ionizing radiation (IR). 53BP1 was retained by NuMA in the R‑ cells during IR‑induced DNA damage. By contrast, the level of NuMA‑53BP1 was markedly lower in R+ cells compared with R‑ cells. The present data suggested a regulatory role of nIGF1R in 53BP1‑dependent DSB repair through its interaction with NuMA. Bright‑field PLA analysis on a paraffin‑embedded tissue microarray from patients with colorectal cancer revealed a significant association between increased nuclear colocalizing signals of NuMA‑53BP1 and a shorter overall survival. These results indicate that nIGF1R plays a role in facilitating 53BP1‑dependent DDR by regulating the NuMA‑53BP1 interaction, which in turn might affect the clinical outcome of patients with colorectal cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Dekker E, Tanis PJ, Vleugels JLA, Kasi PM and Wallace MB: Colorectal cancer. Lancet. 394:1467–1480. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Mahar AL, Compton C, Halabi S, Hess KR, Weiser MR and Groome PA: Personalizing prognosis in colorectal cancer: A systematic review of the quality and nature of clinical prognostic tools for survival outcomes. J Surg Oncol. 116:969–982. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Fakih MG: Metastatic colorectal cancer: Current state and future directions. J Clin Oncol. 33:1809–1824. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Martini G, Troiani T, Cardone C, Vitiello P, Sforza V, Ciardiello D, Napolitano S, Della Corte CM, Morgillo F, Raucci A, et al: Present and future of metastatic colorectal cancer treatment: A review of new candidate targets. World J Gastroenterol. 23:4675–4688. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Dyer AH, Vahdatpour C, Sanfeliu A and Tropea D: The role of insulin-like growth factor 1 (IGF-1) in brain development, maturation and neuroplasticity. Neuroscience. 325:89–99. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Lin Y, Liu H, Waraky A, Haglund F, Agarwal P, Jernberg-Wiklund H, Warsito D and Larsson O: SUMO-modified insulin-like growth factor 1 receptor (IGF-1R) increases cell cycle progression and cell proliferation. J Cell Physiol. 232:2722–2730. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Heidegger I, Kern J, Ofer P, Klocker H and Massoner P: Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth, cell migration and angiogenesis. Oncotarget. 5:2723–2735. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Riedemann J and Macaulay VM: IGF1R signalling and its inhibition. Endocr Relat Cancer. 13 (Suppl 1):S33–S43. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Rodrigues Alves APN, Fernandes JC, Fenerich BA, Coelho-Silva JL, Scheucher PS, Simões BP, Rego EM, Ridley AJ, Machado-Neto JA and Traina F: IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells. Cancer Lett. 456:59–68. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Zorea J, Prasad M, Cohen L, Li N, Schefzik R, Ghosh S, Rotblat B, Brors B and Elkabets M: IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer. Cell Death Dis. 9:9442018. View Article : Google Scholar : PubMed/NCBI

11 

Warsito D, Lin Y, Gnirck AC, Sehat B and Larsson O: Nuclearly translocated insulin-like growth factor 1 receptor phosphorylates histone H3 at tyrosine 41 and induces SNAI2 expression via Brg1 chromatin remodeling protein. Oncotarget. 7:42288–42302. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Packham S, Warsito D, Lin Y, Sadi S, Karlsson R, Sehat B and Larsson O: Nuclear translocation of IGF-1R via p150(Glued) and an importin-β/RanBP2-dependent pathway in cancer cells. Oncogene. 34:2227–2238. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Warsito D, Sjostrom S, Andersson S, Larsson O and Sehat B: Nuclear IGF1R is a transcriptional co-activator of LEF1/TCF. EMBO Rep. 13:244–250. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Sehat B, Tofigh A, Lin Y, Trocmé E, Liljedahl U, Lagergren J and Larsson O: SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor. Sci Signal. 3:ra102010. View Article : Google Scholar : PubMed/NCBI

15 

Aleksic T, Verrill C, Bryant RJ, Han C, Worrall AR, Brureau L, Larré S, Higgins GS, Fazal F, Sabbagh A, et al: IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer. Br J Cancer. 117:1600–1606. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Wang Y, Yuan JL, Zhang YT, Ma JJ, Xu P, Shi CH, Zhang W, Li YM, Fu Q, Zhu GF, et al: Inhibition of both EGFR and IGF1R sensitized prostate cancer cells to radiation by synergistic suppression of DNA homologous recombination repair. PLoS One. 8:e687842013. View Article : Google Scholar : PubMed/NCBI

17 

Guerard M, Robin T, Perron P, Hatat AS, David-Boudet L, Vanwonterghem L, Busser B, Coll JL, Lantuejoul S, Eymin B, et al: Nuclear translocation of IGF1R by intracellular amphiregulin contributes to the resistance of lung tumour cells to EGFR-TKI. Cancer Lett. 420:146–155. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Her J and Bunting SF: How cells ensure correct repair of DNA double-strand breaks. J Biol Chem. 293:10502–10511. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Wright WD, Shah SS and Heyer WD: Homologous recombination and the repair of DNA double-strand breaks. J Biol Chem. 293:10524–10535. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Chang HHY, Pannunzio NR, Adachi N and Lieber MR: Non-homologous DNA end joining and alternative pathways to double-strand break repair. Nat Rev Mol Cell Biol. 18:495–506. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Escribano-Diaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tkáč J, Cook MA, Rosebrock AP, Munro M, Canny MD, et al: A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol Cell. 49:872–883. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Chapman JR, Barral P, Vannier JB, Borel V, Steger M, Tomas-Loba A, Sartori AA, Adams IR, Batista FD and Boulton SJ: RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol Cell. 49:858–871. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Salvador Moreno N, Liu J, Haas KM, Parker LL, Chakraborty C, Kron SJ, Hodges K, Miller LD, Langefeld C, Robinson PJ, et al: The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair. Nucleic Acids Res. 47:2703–2715. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Chitnis MM, Lodhia KA, Aleksic T, Gao S, Protheroe AS and Macaulay VM: IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination. Oncogene. 33:5262–5273. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Waraky A, Lin Y, Warsito D, Haglund F, Aleem E and Larsson O: Nuclear insulin-like growth factor 1 receptor phosphorylates proliferating cell nuclear antigen and rescues stalled replication forks after DNA damage. J Biol Chem. 292:18227–18239. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Doncheva NT, Morris JH, Gorodkin J and Jensen LJ: Cytoscape StringApp: Network analysis and visualization of proteomics data. J Proteome Res. 18:623–632. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Bindea G, Mlecnik B, Hackl H, Charoentong P, Tosolini M, Kirilovsky A, Fridman WH, Pagès F, Trajanoski Z and Galon J: ClueGO: A Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics. 25:1091–1093. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Huang C, Yuan W, Lai C, Zhong S, Yang C, Wang R, Mao L and Chen Z and Chen Z: EphA2-to-YAP pathway drives gastric cancer growth and therapy resistance. Int J Cancer. 146:1937–1949. 2020. View Article : Google Scholar : PubMed/NCBI

29 

ten Have S, Boulon S, Ahmad Y and Lamond AI: Mass spectrometry-based immuno-precipitation proteomics-the user's guide. Proteomics. 11:1153–1159. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Kakarougkas A and Jeggo PA: DNA DSB repair pathway choice: An orchestrated handover mechanism. Br J Radiol. 87:201306852014. View Article : Google Scholar : PubMed/NCBI

31 

Xu Y and Her C: Inhibition of topoisomerase (DNA) I (TOP1): DNA damage repair and anticancer therapy. Biomolecules. 5:1652–1670. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Rocha JC, Busatto FF, Guecheva TN and Saffi J: Role of nucleotide excision repair proteins in response to DNA damage induced by topoisomerase II inhibitors. Mutat Res Rev Mutat Res. 768:68–77. 2016. View Article : Google Scholar : PubMed/NCBI

33 

de Lange T: Shelterin-mediated telomere protection. Ann Rev Genet. 52:223–247. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Maiato H and Pereira AJ: Cell division: NuMA bears the load in the spindle. Curr Biol. 27:R765–R767. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Gallini S, Carminati M, De Mattia F, Pirovano L, Martini E, Oldani A, Asteriti IA, Guarguaglini G and Mapelli M: NuMA phosphorylation by Aurora-A orchestrates spindle orientation. Curr Biol. 26:458–469. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Kotak S and Gonczy P: Mechanisms of spindle positioning: Cortical force generators in the limelight. Curr Opin Cell Biol. 25:741–748. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Werner H, Sarfstein R and Bruchim I: Investigational IGF1R inhibitors in early stage clinical trials for cancer therapy. Expert Opin Investig Drugs. 28:1101–1112. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Qu X, Wu Z, Dong W, Zhang T, Wang L, Pang Z, Ma W and Du J: Update of IGF-1 receptor inhibitor (ganitumab, dalotuzumab, cixutumumab, teprotumumab and figitumumab) effects on cancer therapy. Oncotarget. 8:29501–29518. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Yee D: Anti-insulin-like growth factor therapy in breast cancer. J Mol Endocrinol. 61:T61–T68. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Pollak M: The insulin and insulin-like growth factor receptor family in neoplasia: An update. Nat Rev Cancer. 12:159–169. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Aleksic T, Gray N, Wu X, Rieunier G, Osher E, Mills J, Verrill C, Bryant RJ, Han C, Hutchinson K, et al: Nuclear IGF1R interacts with regulatory regions of chromatin to promote RNA Polymerase II recruitment and gene expression associated with advanced tumor stage. Cancer Res. 78:3497–3509. 2018.PubMed/NCBI

42 

Solomon-Zemler R, Pozniak Y, Geiger T and Werner H: Identification of nucleolar protein NOM1 as a novel nuclear IGF1R-interacting protein. Mol Genet Metab. 126:259–265. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Solomon-Zemler R, Sarfstein R and Werner H: Nuclear insulin-like growth factor-1 receptor (IGF1R) displays proliferative and regulatory activities in non-malignant cells. PLoS One. 12:e01851642017. View Article : Google Scholar : PubMed/NCBI

44 

Wickramasinghe VO and Venkitaraman AR: RNA processing and genome stability: Cause and consequence. Mol Cell. 61:496–505. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Radulescu AE and Cleveland DW: NuMA after 30 years: The matrix revisited. Trends Cell Biol. 20:214–222. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Wu J, Xu Z, He D and Lu G: Identification and characterization of novel NuMA isoforms. Biochem Biophys Res Commun. 454:387–392. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Panier S and Boulton SJ: Double-strand break repair: 53BP1 comes into focus. Nat Rev Mol Cell Biol. 15:7–18. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Serra-Marques A, Houtekamer R, Hintzen D, Canty JT, Yildiz A and Dumont S: The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics. J Cell Biol. 219:e2020042022020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang C, Zhang Y, Segar N, Huang C, Zeng P, Tan X, Mao L, Chen Z, Haglund F, Larsson O, Larsson O, et al: Nuclear IGF1R interacts with NuMA and regulates 53BP1‑dependent DNA double‑strand break repair in colorectal cancer. Oncol Rep 46: 168, 2021.
APA
Yang, C., Zhang, Y., Segar, N., Huang, C., Zeng, P., Tan, X. ... Lin, Y. (2021). Nuclear IGF1R interacts with NuMA and regulates 53BP1‑dependent DNA double‑strand break repair in colorectal cancer. Oncology Reports, 46, 168. https://doi.org/10.3892/or.2021.8119
MLA
Yang, C., Zhang, Y., Segar, N., Huang, C., Zeng, P., Tan, X., Mao, L., Chen, Z., Haglund, F., Larsson, O., Chen, Z., Lin, Y."Nuclear IGF1R interacts with NuMA and regulates 53BP1‑dependent DNA double‑strand break repair in colorectal cancer". Oncology Reports 46.2 (2021): 168.
Chicago
Yang, C., Zhang, Y., Segar, N., Huang, C., Zeng, P., Tan, X., Mao, L., Chen, Z., Haglund, F., Larsson, O., Chen, Z., Lin, Y."Nuclear IGF1R interacts with NuMA and regulates 53BP1‑dependent DNA double‑strand break repair in colorectal cancer". Oncology Reports 46, no. 2 (2021): 168. https://doi.org/10.3892/or.2021.8119
Copy and paste a formatted citation
x
Spandidos Publications style
Yang C, Zhang Y, Segar N, Huang C, Zeng P, Tan X, Mao L, Chen Z, Haglund F, Larsson O, Larsson O, et al: Nuclear IGF1R interacts with NuMA and regulates 53BP1‑dependent DNA double‑strand break repair in colorectal cancer. Oncol Rep 46: 168, 2021.
APA
Yang, C., Zhang, Y., Segar, N., Huang, C., Zeng, P., Tan, X. ... Lin, Y. (2021). Nuclear IGF1R interacts with NuMA and regulates 53BP1‑dependent DNA double‑strand break repair in colorectal cancer. Oncology Reports, 46, 168. https://doi.org/10.3892/or.2021.8119
MLA
Yang, C., Zhang, Y., Segar, N., Huang, C., Zeng, P., Tan, X., Mao, L., Chen, Z., Haglund, F., Larsson, O., Chen, Z., Lin, Y."Nuclear IGF1R interacts with NuMA and regulates 53BP1‑dependent DNA double‑strand break repair in colorectal cancer". Oncology Reports 46.2 (2021): 168.
Chicago
Yang, C., Zhang, Y., Segar, N., Huang, C., Zeng, P., Tan, X., Mao, L., Chen, Z., Haglund, F., Larsson, O., Chen, Z., Lin, Y."Nuclear IGF1R interacts with NuMA and regulates 53BP1‑dependent DNA double‑strand break repair in colorectal cancer". Oncology Reports 46, no. 2 (2021): 168. https://doi.org/10.3892/or.2021.8119
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team