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Anti‑HER3 monoclonal antibody exerts antitumor activity in a mouse model of colorectal adenocarcinoma

  • Authors:
    • Teizo Asano
    • Tomokazu Ohishi
    • Junko Takei
    • Takuro Nakamura
    • Ren Nanamiya
    • Hideki Hosono
    • Tomohiro Tanaka
    • Masato Sano
    • Hiroyuki Harada
    • Manabu Kawada
    • Mika K. Kaneko
    • Yukinari Kato
  • View Affiliations / Copyright

    Affiliations: Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980‑8575, Japan, Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu‑shi, Shizuoka 410‑0301, Japan, Department of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo‑ku, Tokyo 113‑8510, Japan
    Copyright: © Asano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 173
    |
    Published online on: June 28, 2021
       https://doi.org/10.3892/or.2021.8124
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Abstract

HER3 belongs to the epidermal growth factor receptor (EGFR) family and is known to form an active heterodimer with other three family members EGFR, HER2, and HER4. HER3 is overexpressed in lung, breast, colon, prostate, and gastric cancers. In the present study, we developed and validated an anti‑HER3 monoclonal antibody (mAb), H3Mab‑17 (IgG2a, kappa), by immunizing mice with HER3‑overexpressed CHO‑K1 cells (CHO/HER3). H3Mab‑17 was found to react specifically with endogenous HER3 in colorectal carcinoma cell lines, using flow cytometry. The KD for H3Mab‑17 in CHO/HER3 and Caco‑2 (a colon cancer cell line) were determined to be 3.0x10‑9 M and 1.5x10‑9 M via flow cytometry, respectively, suggesting high binding affinity of H3Mab‑17 to HER3. Then, we assessed the H3Mab‑17 antibody‑dependent cellular cytotoxicity (ADCC) and complement‑dependent cytotoxicity (CDC) against Caco‑2, and evaluated its antitumor capacity in a Caco‑2 xenograft model. In vitro experiments revealed H3Mab‑17 had strongly induced both ADCC and CDC against Caco‑2 cells. In vivo experiments on Caco‑2 xenografts revealed that H3Mab‑17 treatment significantly reduced tumor growth compared with the control mouse IgG. These data indicated that H3Mab‑17 could be a promising treatment option for HER3‑expressing colon cancers.
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1 

Gschwind A, Fischer OM and Ullrich A: The discovery of receptor tyrosine kinases: Targets for cancer therapy. Nat Rev Cancer. 4:361–370. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Yarden Y and Sliwkowski MX: Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2:127–137. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Schlessinger J: Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell. 110:669–672. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Scaltriti M and Baselga J: The epidermal growth factor receptor pathway: A model for targeted therapy. Clin Cancer Res. 12:5268–5272. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Schreiber AB, Libermann TA, Lax I, Yarden Y and Schlessinger J: Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies. J Biol Chem. 258:846–853. 1983. View Article : Google Scholar : PubMed/NCBI

6 

Linggi B and Carpenter G: ErbB receptors: New insights on mechanisms and biology. Trends Cell Biol. 16:649–656. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Harris RC, Chung E and Coffey RJ: EGF receptor ligands. Exp Cell Res. 284:2–13. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Citri A, Skaria KB and Yarden Y: The deaf and the dumb: The biology of ErbB-2 and ErbB-3. Exp Cell Res. 284:54–65. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Guy PM, Platko JV, Cantley LC, Cerione RA and Carraway KL III: Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proc Natl Acad Sci USA. 91:8132–8136. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Holbro T, Beerli RR, Maurer F, Koziczak M, Barbas CF 3rd and Hynes NE: The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci USA. 100:8933–8938. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Akhtar S, Chandrasekhar B, Attur S, Dhaunsi GS, Yousif MH and Benter IF: Transactivation of ErbB family of receptor tyrosine kinases is inhibited by angiotensin-(1–7) via its mas receptor. PLoS One. 10:e01416572015. View Article : Google Scholar : PubMed/NCBI

12 

Ceresa BP and Vanlandingham PA: Molecular mechanisms that regulate epidermal growth factor receptor inactivation. Clin Med Oncol. 2:47–61. 2008.PubMed/NCBI

13 

Henriksen L, Grandal MV, Knudsen SL, van Deurs B and Grøvdal LM: Internalization mechanisms of the epidermal growth factor receptor after activation with different ligands. PLoS One. 8:e581482013. View Article : Google Scholar : PubMed/NCBI

14 

Bublil EM and Yarden Y: The EGF receptor family: Spearheading a merger of signaling and therapeutics. Curr Opin Cell Biol. 19:124–134. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Yarden Y and Pines G: The ERBB network: At last, cancer therapy meets systems biology. Nat Rev Cancer. 12:553–563. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Hendler FJ and Ozanne BW: Human squamous cell lung cancers express increased epidermal growth factor receptors. J Clin Invest. 74:647–651. 1984. View Article : Google Scholar : PubMed/NCBI

17 

Kraus MH, Popescu NC, Amsbaugh SC and King CR: Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms. EMBO J. 6:605–610. 1987. View Article : Google Scholar : PubMed/NCBI

18 

Appert-Collin A, Hubert P, Crémel G and Bennasroune A: Role of ErbB receptors in cancer cell migration and invasion. Front Pharmacol. 6:2832015. View Article : Google Scholar : PubMed/NCBI

19 

Lai WW, Chen FF, Wu MH, Chow NH, Su WC, Ma MC, Su PF, Chen H, Lin MY and Tseng YL: Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer. Ann Thorac Surg. 72:1868–1876. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Koutsopoulos AV, Mavroudis D, Dambaki KI, Souglakos J, Tzortzaki EG, Drositis J, Delides GS, Georgoulias V and Stathopoulos EN: Simultaneous expression of c-erbB-1, c-erbB-2, c-erbB-3 and c-erbB-4 receptors in non-small-cell lung carcinomas: Correlation with clinical outcome. Lung Cancer. 57:193–200. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Davies S, Holmes A, Lomo L, Steinkamp MP, Kang H, Muller CY and Wilson BS: High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer. Int J Gynecol Pathol. 33:402–410. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Beji A, Horst D, Engel J, Kirchner T and Ullrich A: Toward the prognostic significance and therapeutic potential of HER3 receptor tyrosine kinase in human colon cancer. Clin Cancer Res. 18:956–968. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Ocana A, Vera-Badillo F, Seruga B, Templeton A, Pandiella A and Amir E: HER3 overexpression and survival in solid tumors: A meta-analysis. J Natl Cancer Inst. 105:266–273. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Ledel F, Hallstrom M, Ragnhammar P, Ohrling K and Edler D: HER3 expression in patients with primary colorectal cancer and corresponding lymph node metastases related to clinical outcome. Eur J Cancer. 50:656–662. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Nishimura H, Nose M, Hiai H, Minato N and Honjo T: Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity. 11:141–151. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Nishimura H, Minato N, Nakano T and Honjo T: Immunological studies on PD-1 deficient mice: Implication of PD-1 as a negative regulator for B cell responses. Int Immunol. 10:1563–1572. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Engelhardt JJ, Sullivan TJ and Allison JP: CTLA-4 overexpression inhibits T cell responses through a CD28-B7-dependent mechanism. J Immunol. 177:1052–1061. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Sharma P and Allison JP: The future of immune checkpoint therapy. Science. 348:56–61. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, Chow LQ, Vokes EE, Felip E, Holgado E, et al: Nivolumab versus docetaxel in advanced nonsquamous Non-Small-Cell lung cancer. N Engl J Med. 373:1627–1639. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, et al: Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 363:711–723. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Golshani G and Zhang Y: Advances in immunotherapy for colorectal cancer: A review. Therap Adv Gastroenterol. 13:17562848209175272020. View Article : Google Scholar : PubMed/NCBI

33 

Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, et al: Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science. 357:409–413. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Overman MJ, McDermott R, Leach JL, Lonardi S, Lenz HJ, Morse MA, Desai J, Hill A, Axelson M, Moss RA, et al: Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): An open-label, multicentre, phase 2 study. Lancet Oncol. 18:1182–1191. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Xiao Y and Freeman GJ: The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy. Cancer Discov. 5:16–18. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Llosa NJ, Cruise M, Tam A, Wicks EC, Hechenbleikner EM, Taube JM, Blosser RL, Fan H, Wang H, Luber BS, et al: The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Cancer Discov. 5:43–51. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, Skora AD, Luber BS, Azad NS, Laheru D, et al: PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 372:2509–2520. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Li S, Schmitz KR, Jeffrey PD, Wiltzius JJ, Kussie P and Ferguson KM: Structural basis for inhibition of the epidermal growth factor receptor by cetuximab. Cancer Cell. 7:301–311. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Flygare JA, Pillow TH and Aristoff P: Antibody-drug conjugates for the treatment of cancer. Chem Biol Drug Des. 81:113–121. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, Fleming T, Eiermann W, Wolter J, Pegram M, et al: Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 344:783–792. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, Lordick F, Ohtsu A, Omuro Y, Satoh T, et al: Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial. Lancet. 376:687–697. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Kute T, Lack CM, Willingham M, Bishwokama B, Williams H, Barrett K, Mitchell T and Vaughn JP: Development of Herceptin resistance in breast cancer cells. Cytometry A. 57:86–93. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Clynes RA, Towers TL, Presta LG and Ravetch JV: Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med. 6:443–446. 2000. View Article : Google Scholar : PubMed/NCBI

44 

Wang D, Qian G, Zhang H, Magliocca KR, Nannapaneni S, Amin AR, Rossi M, Patel M, El-Deiry M, Wadsworth JT, et al: HER3 targeting sensitizes HNSCC to Cetuximab by reducing HER3 activity and HER2/HER3 dimerization: Evidence from cell line and Patient-Derived xenograft models. Clin Cancer Res. 23:677–686. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Gandullo-Sánchez L, Capone E, Ocaña A, Iacobelli S, Sala G and Pandiella A: HER3 targeting with an antibody-drug conjugate bypasses resistance to anti-HER2 therapies. EMBO Mol Med. 12:e114982020. View Article : Google Scholar

46 

Mirschberger C, Schiller CB, Schräml M, Dimoudis N, Friess T, Gerdes CA, Reiff U, Lifke V, Hoelzlwimmer G, Kolm I, et al: RG7116, a therapeutic antibody that binds the inactive HER3 receptor and is optimized for immune effector activation. Cancer Res. 73:5183–5194. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Sequist LV, Gray JE, Harb WA, Lopez-Chavez A, Doebele RC, Modiano MR, Jackman DM, Baggstrom MQ, Atmaca A, Felip E, et al: Randomized Phase II trial of seribantumab in combination with erlotinib in patients with EGFR wild-type non-small cell lung cancer. Oncologist. 24:1095–1102. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Cejalvo JM, Jacob W, Fleitas Kanonnikoff T, Felip E, Navarro Mendivil A, Martinez Garcia M, Taus Garcia A, Leighl N, Lassen U, Mau-Soerensen M, et al: A phase Ib/II study of HER3-targeting lumretuzumab in combination with carboplatin and paclitaxel as first-line treatment in patients with advanced or metastatic squamous non-small cell lung cancer. ESMO Open. 4:e0005322019. View Article : Google Scholar : PubMed/NCBI

49 

Koganemaru S, Kuboki Y, Koga Y, Kojima T, Yamauchi M, Maeda N, Kagari T, Hirotani K, Yasunaga M, Matsumura Y and Doi T: U3-1402, a Novel HER3-Targeting Antibody-Drug conjugate, for the treatment of colorectal cancer. Mol Cancer Ther. 18:2043–2050. 2019. View Article : Google Scholar : PubMed/NCBI

50 

Masuda N, Yonemori K, Takahashi S, Kogawa T, Nakayama T, Iwase H, Takahashi M, Toyama T, Saeki T, Saji S, et al: Abstract PD1-03: Single agent activity of U3-1402, a HER3-targeting antibody-drug conjugate, in HER3-overexpressing metastatic breast cancer: Updated results of a phase 1/2 trial. Cancer Res. 79:2019.PubMed/NCBI

51 

Hashimoto Y, Koyama K, Kamai Y, Hirotani K, Ogitani Y, Zembutsu A, Abe M, Kaneda Y, Maeda N, Shiose Y, et al: A Novel HER3-Targeting Antibody-Drug Conjugate, U3-1402, exhibits potent therapeutic efficacy through the delivery of cytotoxic payload by efficient internalization. Clin Cancer Res. 25:7151–7161. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG and Varmus H: Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2:e732005. View Article : Google Scholar : PubMed/NCBI

53 

Kobayashi S, Boggon TJ, Dayaram T, Jänne PA, Kocher O, Meyerson M, Johnson BE, Eck MJ, Tenen DG and Halmos B: EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med. 352:786–792. 2005. View Article : Google Scholar : PubMed/NCBI

54 

Itai S, Fujii Y, Nakamura T, Chang YW, Yanaka M, Saidoh N, Handa S, Suzuki H, Harada H, Yamada S, et al: Establishment of CMab-43, a sensitive and specific Anti-CD133 monoclonal antibody, for immunohistochemistry. Monoclon Antib Immunodiagn Immunother. 36:231–235. 2017. View Article : Google Scholar : PubMed/NCBI

55 

Kato Y, Ohishi T, Yamada S, Itai S, Furusawa Y, Sano M, Nakamura T, Kawada M and Kaneko MK: Anti-CD133 Monoclonal Antibody CMab-43 exerts antitumor activity in a mouse xenograft model of colon cancer. Monoclon Antib Immunodiagn Immunother. 38:75–78. 2019. View Article : Google Scholar : PubMed/NCBI

56 

Schoeberl B, Faber AC, Li D, Liang MC, Crosby K, Onsum M, Burenkova O, Pace E, Walton Z, Nie L, et al: An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activation. Cancer Res. 70:2485–2494. 2010. View Article : Google Scholar : PubMed/NCBI

57 

Schoeberl B, Pace EA, Fitzgerald JB, Harms BD, Xu L, Nie L, Linggi B, Kalra A, Paragas V, Bukhalid R, et al: Therapeutically targeting ErbB3: A key node in ligand-induced activation of the ErbB receptor-PI3K axis. Sci Signal. 2:ra312009. View Article : Google Scholar : PubMed/NCBI

58 

Furusawa Y, Yamada S, Itai S, Nakamura T, Yanaka M, Sano M, Harada H, Fukui M, Kaneko MK and Kato Y: PMab-219: A monoclonal antibody for the immunohistochemical analysis of horse podoplanin. Biochem Biophys Rep. 18:1006162019.PubMed/NCBI

59 

Furusawa Y, Kaneko MK, Nakamura T, Itai S, Fukui M, Harada H, Yamada S and Kato Y: Establishment of a monoclonal antibody PMab-231 for tiger podoplanin. Monoclon Antib Immunodiagn Immunother. 38:89–95. 2019. View Article : Google Scholar : PubMed/NCBI

60 

Furusawa Y, Takei J, Sayama Y, Yamada S, Kaneko MK and Kato Y: Development of an anti-bear podoplanin monoclonal antibody PMab-247 for immunohistochemical analysis. Biochem Biophys Rep. 18:1006442019.PubMed/NCBI

61 

Furusawa Y, Yamada S, Itai S, Nakamura T, Takei J, Sano M, Harada H, Fukui M, Kaneko MK and Kato Y: Establishment of a monoclonal antibody PMab-233 for immunohistochemical analysis against Tasmanian devil podoplanin. Biochem Biophys Rep. 18:1006312019.PubMed/NCBI

62 

Furusawa Y, Kaneko MK and Kato Y: Establishment of C20Mab-11, a novel anti-CD20 monoclonal antibody, for the detection of B cells. Oncol Lett. 20:1961–1967. 2020. View Article : Google Scholar : PubMed/NCBI

63 

Yamada S, Itai S, Nakamura T, Yanaka M, Kaneko MK and Kato Y: Detection of high CD44 expression in oral cancers using the novel monoclonal antibody, C44Mab-5. Biochem Biophys Rep. 14:64–68. 2018.PubMed/NCBI

64 

Sayama Y, Kaneko MK and Kato Y: Development and characterization of TrMab-6, a novel anti-TROP2 monoclonal antibody for antigen detection in breast cancer. Mol Med Rep. 23:922021. View Article : Google Scholar : PubMed/NCBI

65 

Sayama Y, Kaneko MK, Takei J, Hosono H, Sano M, Asano T and Kato Y: Establishment of a novel anti-TROP2 monoclonal antibody TrMab-29 for immunohistochemical analysis. Biochem Biophys Rep. 25:1009022021.PubMed/NCBI

66 

Kato Y and Kaneko MK: A cancer-specific monoclonal antibody recognizes the aberrantly glycosylated podoplanin. Sci Rep. 4:59242014. View Article : Google Scholar : PubMed/NCBI

67 

Wang Y, Yang H and Duan G: HER3 over-expression and overall survival in gastrointestinal cancers. Oncotarget. 6:42868–42878. 2015. View Article : Google Scholar : PubMed/NCBI

68 

Stahler A, Heinemann V, Neumann J, Crispin A, Schalhorn A, Stintzing S, Giessen-Jung C, Fischer von Weikersthal L, Vehling-Kaiser U, Stauch M, et al: Prevalence and influence on outcome of HER2/neu, HER3 and NRG1 expression in patients with metastatic colorectal cancer. Anticancer Drugs. 28:717–722. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Asano T, Ohishi T, Takei J, Nakamura T, Nanamiya R, Hosono H, Tanaka T, Sano M, Harada H, Kawada M, Kawada M, et al: Anti‑HER3 monoclonal antibody exerts antitumor activity in a mouse model of colorectal adenocarcinoma. Oncol Rep 46: 173, 2021.
APA
Asano, T., Ohishi, T., Takei, J., Nakamura, T., Nanamiya, R., Hosono, H. ... Kato, Y. (2021). Anti‑HER3 monoclonal antibody exerts antitumor activity in a mouse model of colorectal adenocarcinoma. Oncology Reports, 46, 173. https://doi.org/10.3892/or.2021.8124
MLA
Asano, T., Ohishi, T., Takei, J., Nakamura, T., Nanamiya, R., Hosono, H., Tanaka, T., Sano, M., Harada, H., Kawada, M., Kaneko, M. K., Kato, Y."Anti‑HER3 monoclonal antibody exerts antitumor activity in a mouse model of colorectal adenocarcinoma". Oncology Reports 46.2 (2021): 173.
Chicago
Asano, T., Ohishi, T., Takei, J., Nakamura, T., Nanamiya, R., Hosono, H., Tanaka, T., Sano, M., Harada, H., Kawada, M., Kaneko, M. K., Kato, Y."Anti‑HER3 monoclonal antibody exerts antitumor activity in a mouse model of colorectal adenocarcinoma". Oncology Reports 46, no. 2 (2021): 173. https://doi.org/10.3892/or.2021.8124
Copy and paste a formatted citation
x
Spandidos Publications style
Asano T, Ohishi T, Takei J, Nakamura T, Nanamiya R, Hosono H, Tanaka T, Sano M, Harada H, Kawada M, Kawada M, et al: Anti‑HER3 monoclonal antibody exerts antitumor activity in a mouse model of colorectal adenocarcinoma. Oncol Rep 46: 173, 2021.
APA
Asano, T., Ohishi, T., Takei, J., Nakamura, T., Nanamiya, R., Hosono, H. ... Kato, Y. (2021). Anti‑HER3 monoclonal antibody exerts antitumor activity in a mouse model of colorectal adenocarcinoma. Oncology Reports, 46, 173. https://doi.org/10.3892/or.2021.8124
MLA
Asano, T., Ohishi, T., Takei, J., Nakamura, T., Nanamiya, R., Hosono, H., Tanaka, T., Sano, M., Harada, H., Kawada, M., Kaneko, M. K., Kato, Y."Anti‑HER3 monoclonal antibody exerts antitumor activity in a mouse model of colorectal adenocarcinoma". Oncology Reports 46.2 (2021): 173.
Chicago
Asano, T., Ohishi, T., Takei, J., Nakamura, T., Nanamiya, R., Hosono, H., Tanaka, T., Sano, M., Harada, H., Kawada, M., Kaneko, M. K., Kato, Y."Anti‑HER3 monoclonal antibody exerts antitumor activity in a mouse model of colorectal adenocarcinoma". Oncology Reports 46, no. 2 (2021): 173. https://doi.org/10.3892/or.2021.8124
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