|
1
|
Newman RA, Yang P, Pawlus AD and Block KI:
Cardiac glycosides as novel cancer therapeutic agents. Mol Interv.
8:36–49. 2008. View
Article : Google Scholar : PubMed/NCBI
|
|
2
|
Cerella C, Dicato M and Diederich M:
Assembling the puzzle of anti-cancer mechanisms triggered by
cardiac glycosides. Mitochondrion. 13:225–234. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
McConkey DJ, Lin Y, Nutt LK, Ozel HZ and
Newman RA: Cardiac glycosides stimulate Ca2+ increases
and apoptosis in androgen-independent, metastatic human prostate
adenocarcinoma cells. Cancer Res. 60:3807–3812. 2000.PubMed/NCBI
|
|
4
|
Hou Y, Shang C, Meng T and Lou W:
Anticancer potential of cardiac glycosides and steroid-azole
hybrids. Steroids. 171:1088522021. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Skubnik J, Pavlickova V and Rimpelova S:
Cardiac glycosides as immune system modulators. Biomolecules.
11:6592021. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Dai HF, Gan YJ, Que DM, Wu J, Wen ZC and
Mei WL: Two new cytotoxic cardenolides from the latex of antiaris
toxicaria. J Asian Nat Prod Res. 11:832–837. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Dai HF, Gan YJ, Que DM, Wu J, Wen ZC and
Mei WL: A new cytotoxic 19-nor-cardenolide from the latex of
antiaris toxicaria. Molecules. 14:3694–3699. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Huang YH, Sun Y, Huang FY, Li YN, Wang CC,
Mei WL, Dai HF, Tan GH and Huang C: Toxicarioside O induces
protective autophagy in a sirtuin-1-dependent manner in colorectal
cancer cells. Oncotarget. 8:52783–52791. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Janku F, McConkey DJ, Hong DS and Kurzrock
R: Autophagy as a target for anticancer therapy. Nat Rev Clin
Oncol. 8:528–539. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Xia H, Green DR and Zou W: Autophagy in
tumour immunity and therapy. Nat Rev Cancer. 21:281–297. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Kroemer G, Marino G and Levine B:
Autophagy and the integrated stress response. Mol Cell. 40:280–293.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Rubinsztein DC, Codogno P and Levine B:
Autophagy modulation as a potential therapeutic target for diverse
diseases. Nat Rev Drug Discov. 11:709–730. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Maes H, Rubio N, Garg AD and Agostinis P:
Autophagy: Shaping the tumor microenvironment and therapeutic
response. Trends Mol Med. 19:428–446. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Marino G, Niso-Santano M, Baehrecke EH and
Kroemer G: Self-consumption: The interplay of autophagy and
apoptosis. Nat Rev Mol Cell Biol. 15:81–94. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Shi YH, Ding ZB, Zhou J, Hui B, Shi GM, Ke
AW, Wang XY, Dai Z, Peng YF, Gu CY, et al: Targeting autophagy
enhances sorafenib lethality for hepatocellular carcinoma via ER
stress-related apoptosis. Autophagy. 7:1159–1172. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Elgendy M, Sheridan C, Brumatti G and
Martin SJ: Oncogenic Ras-induced expression of Noxa and Beclin-1
promotes autophagic cell death and limits clonogenic survival. Mol
Cell. 42:23–35. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Dou Q, Chen HN, Wang K, Yuan K, Lei Y, Li
K, Lan J, Chen Y, Huang Z, Xie N, et al: Ivermectin induces
cytostatic autophagy by blocking the PAK1/akt axis in breast
cancer. Cancer Res. 76:4457–4469. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Yu FX, Zhao B and Guan KL: Hippo pathway
in organ size control, tissue homeostasis, and cancer. Cell.
163:811–828. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Zanconato F, Cordenonsi M and Piccolo S:
YAP/TAZ at the roots of cancer. Cancer Cell. 29:783–803. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Crunkhorn S: New route to targeting the
Hippo pathway. Nat Rev Drug Discov. 20:3442021. View Article : Google Scholar
|
|
21
|
Meng Z, Moroishi T and Guan KL: Mechanisms
of Hippo pathway regulation. Genes Dev. 30:1–17. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Hao Y, Chun A, Cheung K, Rashidi B and
Yang X: Tumor suppressor LATS1 is a negative regulator of oncogene
YAP. J Biol Chem. 283:5496–5509. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Zhao B, Ye X, Yu J, Li L, Li W, Li S, Yu
J, Lin JD, Wang CY, Chinnaiyan AM, et al: TEAD mediates
YAP-dependent gene induction and growth control. Genes Dev.
22:1962–1971. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Cottini F, Hideshima T, Xu C, Sattler M,
Dori M, Agnelli L, ten Hacken E, Bertilaccio MT, Antonini E, Neri
A, et al: Rescue of Hippo coactivator YAP1 triggers DNA
damage-induced apoptosis in hematological cancers. Nat Med.
20:599–606. 2014. View
Article : Google Scholar : PubMed/NCBI
|
|
25
|
Avruch J, Zhou D and Bardeesy N: YAP
oncogene overexpression supercharges colon cancer proliferation.
Cell Cycle. 11:1090–1096. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Zhao B, Li L, Lei Q and Guan KL: The
Hippo-YAP pathway in organ size control and tumorigenesis: An
updated version. Genes Dev. 24:862–874. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Yang PM, Liu YL, Lin YC, Shun CT, Wu MS
and Chen CC: Inhibition of autophagy enhances anticancer effects of
atorvastatin in digestive malignancies. Cancer Res. 70:7699–7709.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Limpert AS, Lambert LJ, Bakas NA, Bata N,
Brun SN, Shaw RJ and Cosford NDP: Autophagy in cancer: Regulation
by small molecules. Trends Pharmacol Sci. 39:1021–1032. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Klionsky DJ, Abdalla FC, Abeliovich H,
Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M,
Agostinis P, Aguirre-Ghiso JA, et al: Guidelines for the use and
interpretation of assays for monitoring autophagy. Autophagy.
8:445–544. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Harvey KF, Zhang X and Thomas DM: The
Hippo pathway and human cancer. Nat Rev Cancer. 13:246–257. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Gordaliza M: Natural products as leads to
anticancer drugs. Clin Transl Oncol. 9:767–776. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Koehn FE and Carter GT: The evolving role
of natural products in drug discovery. Nat Rev Drug Discov.
4:206–220. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Mishra BB and Tiwari VK: Natural products:
An evolving role in future drug discovery. Eur J Med Chem.
46:4769–4807. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Prassas I and Diamandis EP: Novel
therapeutic applications of cardiac glycosides. Nat Rev Drug
Discov. 7:926–935. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Maoyuan YW, Wenli M, Yuanyuan D, Shenglan
L, Zhunian W and Haofu D: Cytotoxic cardenolides from the roots of
Calotropis gigantea. Modern Pharm Res. 1:4–9. 2008.
|
|
37
|
Wang K, Liu R, Li J, Mao J, Lei Y, Wu J,
Zeng J, Zhang T, Wu H, Chen L, et al: Quercetin induces protective
autophagy in gastric cancer cells: Involvement of Akt-mTOR- and
hypoxia-induced factor 1α-mediated signaling. Autophagy. 7:966–978.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Liu R, Li J, Zhang T, Zou L, Chen Y, Wang
K, Lei Y, Yuan K, Li Y, Lan J, et al: Itraconazole suppresses the
growth of glioblastoma through induction of autophagy: Involvement
of abnormal cholesterol trafficking. Autophagy. 10:1241–1255. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Jiang J, Zhang L, Chen H, Lei Y, Zhang T,
Wang Y, Jin P, Lan J, Zhou L, Huang Z, et al: Regorafenib induces
lethal autophagy arrest by stabilizing PSAT1 in glioblastoma.
Autophagy. 16:106–122. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Zhao X, Fang Y, Yang Y, Qin Y, Wu P, Wang
T, Lai H, Meng L, Wang D, Zheng Z, et al: Elaiophylin, a novel
autophagy inhibitor, exerts antitumor activity as a single agent in
ovarian cancer cells. Autophagy. 11:1849–1863. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng
Z, Zhao L, Peyman G, Ouyang H, Jiang W, et al: Mutant Gq/11 promote
uveal melanoma tumorigenesis by activating YAP. Cancer Cell.
25:822–830. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Barry ER, Morikawa T, Butler BL, Shrestha
K, de la Rosa R, Yan KS, Fuchs CS, Magness ST, Smits R, Ogino S, et
al: Restriction of intestinal stem cell expansion and the
regenerative response by YAP. Nature. 493:106–110. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Wang D, He J, Huang B, Liu S, Zhu H and Xu
T: Emerging role of the Hippo pathway in autophagy. Cell Death Dis.
11:8802020. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Tang F and Christofori G: The cross-talk
between the Hippo signaling pathway and autophagy:Implications on
physiology and cancer. Cell Cycle. 19:2563–2572. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Totaro A, Zhuang Q, Panciera T, Battilana
G, Azzolin L, Brumana G, Gandin A, Brusatin G, Cordenonsi M and
Piccolo S: Cell phenotypic plasticity requires autophagic flux
driven by YAP/TAZ mechanotransduction. Proc Natl Acad Sci USA.
116:17848–17857. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Tang F and Christofori G: LATS1-Beclin1
mediates a non-canonical connection between the Hippo pathway and
autophagy. Mol Cell Oncol. 7:17573782020. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Lee YA, Noon LA, Akat KM, Ybanez MD, Lee
TF, Berres ML, Fujiwara N, Goossens N, Chou HI, Parvin-Nejad FP, et
al: Autophagy is a gatekeeper of hepatic differentiation and
carcinogenesis by controlling the degradation of Yap. Nat Commun.
9:49622018. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Zhou Y, Wang Y, Zhou W, Chen T, Wu Q,
Chutturghoon VK, Lin B, Geng L, Yang Z, Zhou L and Zheng S: YAP
promotes multi-drug resistance and inhibits autophagy-related cell
death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway.
Cancer Cell Int. 19:1792019. View Article : Google Scholar : PubMed/NCBI
|
