Wnt signaling promotes tumor development in part through phosphofructokinase 1 platelet isoform upregulation

  • Authors:
    • So Mi Jeon
    • Je Sun Lim
    • Su Hwan Park
    • Jong-Ho Lee
  • View Affiliations

  • Published online on: September 10, 2021     https://doi.org/10.3892/or.2021.8185
  • Article Number: 234
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Abstract

The activation of Wnt signaling has been detected in various types of human cancer and has been shown to be associated with cancer development. In the present study, it was revealed that Wnt signaling induced the expression of phosphofructokinase 1 platelet isoform (PFKP), which has been reported to catalyze a rate‑limiting reaction in glycolysis and is important for the Warburg effect, proliferation, colony formation and cancer cell migration. Moreover, it was demonstrated that Wnt3A induced PFKP expression in a β‑catenin‑independent manner, resulting in increased PFK enzyme activity. Wnt3A‑induced epidermal growth factor receptor transactivation activated PI3K/AKT, which stabilized PFKP through PFKP S386 phosphorylation and subsequent PFKP upregulation. Wnt3A‑induced PFKP S386 phosphorylation increased PFKP expression and promoted the Warburg effect, cell proliferation, colony formation and the migratory ability of cancer cells. On the whole, the findings of the present study underscore the potential role of PFKP in Wnt signaling‑induced tumor development.
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November-2021
Volume 46 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Jeon SM, Lim JS, Park SH and Lee J: Wnt signaling promotes tumor development in part through phosphofructokinase 1 platelet isoform upregulation. Oncol Rep 46: 234, 2021
APA
Jeon, S.M., Lim, J.S., Park, S.H., & Lee, J. (2021). Wnt signaling promotes tumor development in part through phosphofructokinase 1 platelet isoform upregulation. Oncology Reports, 46, 234. https://doi.org/10.3892/or.2021.8185
MLA
Jeon, S. M., Lim, J. S., Park, S. H., Lee, J."Wnt signaling promotes tumor development in part through phosphofructokinase 1 platelet isoform upregulation". Oncology Reports 46.5 (2021): 234.
Chicago
Jeon, S. M., Lim, J. S., Park, S. H., Lee, J."Wnt signaling promotes tumor development in part through phosphofructokinase 1 platelet isoform upregulation". Oncology Reports 46, no. 5 (2021): 234. https://doi.org/10.3892/or.2021.8185