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Review

Tumor microenvironment manipulates chemoresistance in ovarian cancer (Review)

  • Authors:
    • Qiaoling Zhang
    • Jiashan Ding
    • Yingmei Wang
    • Linsheng He
    • Fengxia Xue
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, Department of Gynecology and Obstetrics, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
  • Article Number: 102
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    Published online on: March 31, 2022
       https://doi.org/10.3892/or.2022.8313
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Abstract

Ovarian cancer (OC) is the leading cause of mortality among the various types of gynecological cancer, and >75% of the cases are diagnosed at a late stage. Although platinum‑based chemotherapy is able to help the majority of patients to achieve remission, the disease frequently recurs and acquires chemoresistance, resulting in high mortality rates. The complexity of OC therapy is not solely governed by the intrinsic characteristics of the OC cells (OCCs) themselves, but is also largely dependent on the dynamic communication between OCCs and various components of their surrounding microenvironment. The present review attempts to describe the mutual interplay between OCCs and their surrounding microenvironment. Tumor‑associated macrophages (TAMs) and cancer‑associated fibroblasts (CAFs) are the most abundant stromal cell types in OC. Soluble factors derived from CAFs steadily nourish both the OCCs and TAMs, facilitating their proliferation and immune evasion. ATP binding cassette transporters facilitate the extrusion of cytotoxic molecules, eventually promoting cell survival and multidrug resistance. Extracellular vesicles fulfill their role as genetic exchange vectors, transferring cargo from the donor cells to the recipient cells and propagating oncogenic signaling. A greater understanding of the vital roles of the tumor microenvironment will allow researchers to be open to the prospect of developing therapeutic approaches for combating OC chemoresistance.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Ding J, Wang Y, He L and Xue F: Tumor microenvironment manipulates chemoresistance in ovarian cancer (Review). Oncol Rep 47: 102, 2022.
APA
Zhang, Q., Ding, J., Wang, Y., He, L., & Xue, F. (2022). Tumor microenvironment manipulates chemoresistance in ovarian cancer (Review). Oncology Reports, 47, 102. https://doi.org/10.3892/or.2022.8313
MLA
Zhang, Q., Ding, J., Wang, Y., He, L., Xue, F."Tumor microenvironment manipulates chemoresistance in ovarian cancer (Review)". Oncology Reports 47.5 (2022): 102.
Chicago
Zhang, Q., Ding, J., Wang, Y., He, L., Xue, F."Tumor microenvironment manipulates chemoresistance in ovarian cancer (Review)". Oncology Reports 47, no. 5 (2022): 102. https://doi.org/10.3892/or.2022.8313
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Ding J, Wang Y, He L and Xue F: Tumor microenvironment manipulates chemoresistance in ovarian cancer (Review). Oncol Rep 47: 102, 2022.
APA
Zhang, Q., Ding, J., Wang, Y., He, L., & Xue, F. (2022). Tumor microenvironment manipulates chemoresistance in ovarian cancer (Review). Oncology Reports, 47, 102. https://doi.org/10.3892/or.2022.8313
MLA
Zhang, Q., Ding, J., Wang, Y., He, L., Xue, F."Tumor microenvironment manipulates chemoresistance in ovarian cancer (Review)". Oncology Reports 47.5 (2022): 102.
Chicago
Zhang, Q., Ding, J., Wang, Y., He, L., Xue, F."Tumor microenvironment manipulates chemoresistance in ovarian cancer (Review)". Oncology Reports 47, no. 5 (2022): 102. https://doi.org/10.3892/or.2022.8313
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