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Review Open Access

Progress of radiological‑pathological workflows in the differential diagnosis between primary central nervous system lymphoma and high‑grade glioma (Review)

  • Authors:
    • Luming Cao
    • Mengchao Zhang
    • Ying Zhang
    • Bin Ji
    • Xuemei Wang
    • Xueju Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, China‑Japan Union Hospital, Jilin University, Changchun, Jilin 130033, P.R. China, Department of Radiology, China‑Japan Union Hospital, Jilin University, Changchun, Jilin 130033, P.R. China, Department of Nuclear Medicine, China‑Japan Union Hospital, Jilin University, Changchun, Jilin 130033, P.R. China
    Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 20
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    Published online on: December 8, 2022
       https://doi.org/10.3892/or.2022.8457
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Abstract

Primary central nervous system lymphoma (PCNSL) and high‑grade glioma (HGG) are distinct entities of the CNS with completely distinct treatments. The treatment of PCNSL is chemotherapy‑based, while surgery is the first choice for HGG. However, the clinical features of the two entities often overlap, and a clear pathological diagnosis is important for subsequent management, especially for the management of PCNSL. Stereotactic biopsy is recognized as one of the minimally invasive alternatives for evaluating the involvement of the CNS. However, in the case of limited tissue materials, the differential diagnosis between the two entities is still difficult. In addition, some patients are too ill to tolerate a needle biopsy. Therefore, combining imaging, histopathology and laboratory examinations is essential in order to make a clear diagnosis as soon as possible. The present study reviews the progress of comparative research on both imaging and laboratory tests based on the pathophysiological changes of the two entities, and proposes an integrative and optimized diagnostic process, with the purpose of building a better understanding for neurologists, hematologists, radiologists and pathologists.
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1 

Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C and Barnholtz-Sloan JS: CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2015–2019. Neuro Oncol. 24 (Suppl 5):v1–v95. 2022. View Article : Google Scholar : PubMed/NCBI

2 

Fox CP, Phillips EH, Smith J, Linton K, Gallop-Evans E, Hemmaway C, Auer DP, Fuller C, Davies AJ, McKay P, et al: Guidelines for the diagnosis and management of primary central nervous system diffuse large B-cell lymphoma. Br J Haematol. 184:348–363. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Sugita Y, Muta H, Ohshima K, Morioka M, Tsukamoto Y, Takahashi H and Kakita A: Primary central nervous system lymphomas and related diseases: Pathological characteristics and discussion of the differential diagnosis. Neuropathology. 36:313–324. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM and Batchelor TT: Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma. Neuro Oncol. 21:296–305. 2019. View Article : Google Scholar : PubMed/NCBI

5 

McKinnon C, Nandhabalan M, Murray SA and Plaha P: Glioblastoma: Clinical presentation, diagnosis, and management. BMJ. 374:n15602021. View Article : Google Scholar : PubMed/NCBI

6 

Alexander BM and Cloughesy TF: Adult Glioblastoma. J Clin Oncol. 35:2402–2409. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Chiavazza C, Pellerino A, Ferrio F, Cistaro A, Soffietti R and Ruda R: Primary CNS lymphomas: Challenges in diagnosis and monitoring. Biomed Res Int. 2018:36069702018. View Article : Google Scholar : PubMed/NCBI

8 

Grommes C and DeAngelis LM: Primary CNS Lymphoma. J Clin Oncol. 35:2410–2418. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Su L, Ding M, Chen L, Li C and Lao M: Primary central nervous system lymphoma in a patient with systemic lupus erythematosus mimicking high-grade glioma: A case report and review of literature. Medicine (Baltimore). 97:e110722018. View Article : Google Scholar : PubMed/NCBI

10 

Bhatt VR, Shrestha R, Shonka N and Bociek RG: Near misdiagnosis of glioblastoma as primary central nervous system lymphoma. J Clin Med Res. 6:299–301. 2014.PubMed/NCBI

11 

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P and Ellison DW: The 2016 World Health organization classification of tumors of the central nervous system: A summary. Acta Neuropathol. 131:803–820. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Giannini C, Dogan A and Salomão DR: CNS Lymphoma: A practical diagnostic approach. J Neuropathol Exp Neurol. 73:478–494. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Morell AA, Shah AH, Cavallo C, Eichberg DG, Sarkiss CA, Benveniste R, Ivan ME and Komotar RJ: Diagnosis of primary central nervous system lymphoma: A systematic review of the utility of CSF screening and the role of early brain biopsy. Neurooncol Pract. 6:415–423. 2019.PubMed/NCBI

14 

Patrick LB and Mohile NA: Advances in primary central nervous system lymphoma. Curr Oncol Rep. 17:602015. View Article : Google Scholar : PubMed/NCBI

15 

Velasco R, Mercadal S, Vidal N, Alañá M, Barceló MI, Ibáñez-Juliá MJ, Bobillo S, Caldú Agud R, García Molina E, Martínez P, et al: Diagnostic delay and outcome in immunocompetent patients with primary central nervous system lymphoma in Spain: A multicentric study. J Neurooncol. 148:545–554. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Nabors LB, Portnow J, Baehring J, Bloch O, Brem S, Butowski N, Cannon DM, Chao S, Chheda MG, Clark SW, et al: NCCN Clinical Practice Guidelines in Oncology Central Nervous System Cancers (Version 2.2022 - September 29, 2022). https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1425

17 

Chukwueke UN and Nayak L: Central nervous system lymphoma. Hematol Oncol Clin North Am. 33:597–611. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Ozturk K, Soylu E and Cayci Z: Differentiation between primary CNS lymphoma and atypical glioblastoma according to major genomic alterations using diffusion and susceptibility-weighted MR imaging. Eur J Radiol. 141:1097842021. View Article : Google Scholar : PubMed/NCBI

19 

Barajas RF, Politi LS, Anzalone N, Schöder H, Fox CP, Boxerman JL, Kaufmann TJ, Quarles CC, Ellingson BM, Auer D, et al: Consensus recommendations for MRI and PET imaging of primary central nervous system lymphoma: Guideline statement from the International primary CNS lymphoma collaborative group (IPCG). Neuro Oncol. 23:1056–1071. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Villanueva-Meyer JE, Mabray MC and Cha S: Current clinical brain tumor imaging. Neurosurgery. 81:397–415. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Lin X, Lee M, Buck O, Woo KM, Zhang Z, Hatzoglou V, Omuro A, Arevalo-Perez J, Thomas AA, Huse J, et al: Diagnostic accuracy of T1-Weighted dynamic contrast-enhanced-MRI and DWI-ADC for differentiation of glioblastoma and primary CNS Lymphoma. AJNR Am J Neuroradiol. 38:485–491. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Lu S, Wang S, Gao Q, Zhou M, Li Y, Cao P, Hong X and Shi H: Quantitative evaluation of diffusion and dynamic contrast-enhanced magnetic resonance imaging for differentiation between primary central nervous system lymphoma and glioblastoma. J Comput Assist Tomogr. 41:898–903. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Makino K, Hirai T, Nakamura H, Kuroda JI, Shinojima N, Uetani H, Kitajima M and Yano S: Differentiating between primary central nervous system lymphomas and glioblastomas: Combined use of perfusion-weighted and diffusion-weighted magnetic resonance imaging. World Neurosurg. 112:e1–e6. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Ahn SJ, Shin HJ, Chang JH and Lee SK: Differentiation between primary cerebral lymphoma and glioblastoma using the apparent diffusion coefficient: Comparison of three different ROI methods. PLoS One. 9:e1129482014. View Article : Google Scholar : PubMed/NCBI

25 

Nakajima S, Okada T, Yamamoto A, Kanagaki M, Fushimi Y, Okada T, Arakawa Y, Takagi Y, Miyamoto S and Togashi K: Primary central nervous system lymphoma and glioblastoma: Differentiation using dynamic susceptibility-contrast perfusion-weighted imaging, diffusion-weighted imaging, and (18)F-fluorodeoxyglucose positron emission tomography. Clin Imaging. 39:390–395. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Suh CH, Kim HS, Jung SC, Choi CG and Kim SJ: Clinically relevant imaging features for MGMT promoter methylation in multiple glioblastoma studies: A systematic review and meta-analysis. AJNR Am J Neuroradiol. 39:1439–1445. 2018.PubMed/NCBI

27 

Akbari H, Bakas S, Pisapia JM, Nasrallah MP, Rozycki M, Martinez-Lage M, Morrissette JJD, Dahmane N, O'Rourke DM and Davatzikos C: In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature. Neuro Oncol. 20:1068–1079. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Quarles CC, Bell LC and Stokes AM: Imaging vascular and hemodynamic features of the brain using dynamic susceptibility contrast and dynamic contrast enhanced MRI. Neuroimage. 187:32–55. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Suh CH, Kim HS, Jung SC, Park JE, Choi CG and Kim SJ: MRI as a diagnostic biomarker for differentiating primary central nervous system lymphoma from glioblastoma: A systematic review and meta-analysis. J Magn Reson Imaging. 50:560–572. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Neska-Matuszewska M, Bladowska J, Sasiadek M and Zimny A: Differentiation of glioblastoma multiforme, metastases and primary central nervous system lymphomas using multiparametric perfusion and diffusion MR imaging of a tumor core and a peritumoral zone-Searching for a practical approach. PLoS One. 13:e01913412018. View Article : Google Scholar : PubMed/NCBI

31 

Xu W, Wang Q, Shao A, Xu B and Zhang J: The performance of MR perfusion-weighted imaging for the differentiation of high-grade glioma from primary central nervous system lymphoma: A systematic review and meta-analysis. PLoS One. 12:e01734302017. View Article : Google Scholar : PubMed/NCBI

32 

Cindil E, Sendur HN, Cerit MN, Dag N, Erdogan N, Celebi FE, Oner Y and Tali T: Validation of combined use of DWI and percentage signal recovery-optimized protocol of DSC-MRI in differentiation of high-grade glioma, metastasis, and lymphoma. Neuroradiology. 63:331–342. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Chaganti J, Taylor M, Woodford H and Steel T: Differentiation of primary central nervous system lymphoma and high-grade glioma with dynamic susceptibility contrast-derived metrics: Pilot study. World Neurosurg. 151:e979–e987. 2021. View Article : Google Scholar : PubMed/NCBI

34 

Semmineh NB, Xu J, Skinner JT, Xie J, Li H, Ayers G and Quarles CC: Assessing tumor cytoarchitecture using multiecho DSC-MRI derived measures of the transverse relaxivity at tracer equilibrium (TRATE). Magn Reson Med. 74:772–784. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Lee MD, Baird GL, Bell LC, Quarles CC and Boxerman JL: Utility of percentage signal recovery and baseline signal in DSC-MRI optimized for relative CBV measurement for differentiating glioblastoma, lymphoma, metastasis, and meningioma. AJNR Am J Neuroradiol. 40:1445–1450. 2019.PubMed/NCBI

36 

Hsu CC, Watkins TW, Kwan GN and Haacke EM: Susceptibility-Weighted imaging of glioma: Update on current imaging status and future directions. J Neuroimaging. 26:383–390. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Saini J, Kumar Gupta P, Awasthi A, Pandey CM, Singh A, Patir R, Ahlawat S, Sadashiva N, Mahadevan A and Kumar Gupta R: Multiparametric imaging-based differentiation of lymphoma and glioblastoma: Using T1-perfusion, diffusion, and susceptibility-weighted MRI. Clin Radiol. 73:986e7–986e15. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Yamasaki F, Takayasu T, Nosaka R, Amatya VJ, Doskaliyev A, Akiyama Y, Tominaga A, Takeshima Y, Sugiyama K and Kurisu K: Magnetic resonance spectroscopy detection of high lipid levels in intraaxial tumors without central necrosis: A characteristic of malignant lymphoma. J Neurosurg. 122:1370–1379. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Nagashima H, Sasayama T, Tanaka K, Kyotani K, Sato N, Maeyama M, Kohta M, Sakata J, Yamamoto Y, Hosoda K, et al: Myo-inositol concentration in MR spectroscopy for differentiating high grade glioma from primary central nervous system lymphoma. J Neurooncol. 136:317–326. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Nomura Y, Asano Y, Shinoda J, Yano H, Ikegame Y, Kawasaki T, Nakayama N, Maruyama T, Muragaki Y and Iwama T: Characteristics of time-activity curves obtained from dynamic 11C-methionine PET in common primary brain tumors. J Neurooncol. 138:649–658. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Kong Z, Jiang C, Zhu R, Feng S, Wang Y, Li J, Chen W, Liu P, Zhao D, Ma W, et al: 18F-FDG-PET-based radiomics features to distinguish primary central nervous system lymphoma from glioblastoma. Neuroimage Clin. 23:1019122019. View Article : Google Scholar : PubMed/NCBI

42 

Zhou W, Wen J, Hua F, Xu W, Lu X, Yin B, Geng D and Guan Y: 18F-FDG PET/CT in immunocompetent patients with primary central nervous system lymphoma: Differentiation from glioblastoma and correlation with DWI. Eur J Radiol. 104:26–32. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Kim HO, Kim JS, Kim SO, Chae SY, Oh SJ, Seo M, Lee SH, Oh JS, Ryu JS, Huh JR and Kim JH: Clinicopathological characteristics of primary central nervous system lymphoma with low 18F-fludeoxyglucose uptake on brain positron emission tomography. Medicine (Baltimore). 99:e201402020. View Article : Google Scholar : PubMed/NCBI

44 

Wang H, Zhou Y, Li L, Hou W, Ma X and Tian R: Current status and quality of radiomics studies in lymphoma: A systematic review. Eur Radiol. 30:6228–6240. 2020. View Article : Google Scholar : PubMed/NCBI

45 

Lohmann P, Galldiks N, Kocher M, Heinzel A, Filss CP, Stegmayr C, Mottaghy FM, Fink GR, Jon Shah N and Langen KJ: Radiomics in neuro-oncology: Basics, workflow, and applications. Methods. 188:112–121. 2021. View Article : Google Scholar : PubMed/NCBI

46 

Priya S, Ward C, Locke T, Soni N, Maheshwarappa RP, Monga V, Agarwal A and Bathla G: Glioblastoma and primary central nervous system lymphoma: Differentiation using MRI derived first-order texture analysis-a machine learning study. Neuroradiol J. 34:320–328. 2021. View Article : Google Scholar : PubMed/NCBI

47 

Han Y, Wang ZJ, Li WH, Yang Y, Zhang J, Yang XB, Zuo L, Xiao G, Wang SZ, Yan LF and Cui GB: Differentiation between primary central nervous system lymphoma and atypical glioblastoma based on MRI morphological feature and signal intensity ratio: A retrospective multicenter study. Front Oncol. 12:8111972022. View Article : Google Scholar : PubMed/NCBI

48 

Suh HB, Choi YS, Bae S, Ahn SS, Chang JH, Kang SG, Kim EH, Kim SH and Lee SK: Primary central nervous system lymphoma and atypical glioblastoma: Differentiation using radiomics approach. Eur Radiol. 28:3832–3839. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Chen C, Zheng A, Ou X, Wang J and Ma X: Comparison of radiomics-based machine-learning classifiers in diagnosis of glioblastoma from primary central nervous system lymphoma. Front Oncol. 10:11512020. View Article : Google Scholar : PubMed/NCBI

50 

MacIver CL, Busaidi AA, Ganeshan B, Maynard JA, Wastling S, Hyare H, Brandner S, Markus JE, Lewis MA, Groves AM, et al: Filtration-Histogram based magnetic resonance texture analysis (MRTA) for the distinction of primary central nervous system lymphoma and glioblastoma. J Pers Med. 11:8762021. View Article : Google Scholar : PubMed/NCBI

51 

Mehrnahad M, Rostami S, Kimia F, Kord R, Taheri MS, Rad HS, Haghighatkhah H, Moradi A and Kord A: Differentiating glioblastoma multiforme from cerebral lymphoma: Application of advanced texture analysis of quantitative apparent diffusion coefficients. Neuroradiol J. 33:428–436. 2020. View Article : Google Scholar : PubMed/NCBI

52 

Kang D, Park JE, Kim YH, Kim JH, Oh JY, Kim J, Kim Y, Kim ST and Kim HS: Diffusion radiomics as a diagnostic model for atypical manifestation of primary central nervous system lymphoma: Development and multicenter external validation. Neuro Oncol. 20:1251–1261. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Xia W, Hu B, Li H, Geng C, Wu Q, Yang L, Yin B, Gao X, Li Y and Geng D: Multiparametric-MRI-Based radiomics model for differentiating primary central nervous system lymphoma from glioblastoma: Development and cross-vendor validation. J Magn Reson Imaging. 53:242–250. 2021. View Article : Google Scholar : PubMed/NCBI

54 

Kim Y, Cho HH, Kim ST, Park H, Nam D and Kong DS: Radiomics features to distinguish glioblastoma from primary central nervous system lymphoma on multi-parametric MRI. Neuroradiology. 60:1297–1305. 2018. View Article : Google Scholar : PubMed/NCBI

55 

Bathla G, Priya S, Liu Y, Ward C, Le NH, Soni N, Maheshwarappa RP, Monga V, Zhang H and Sonka M: Radiomics-based differentiation between glioblastoma and primary central nervous system lymphoma: A comparison of diagnostic performance across different MRI sequences and machine learning techniques. Eur Radiol. 31:8703–8713. 2021. View Article : Google Scholar : PubMed/NCBI

56 

Nakagawa M, Nakaura T, Namimoto T, Kitajima M, Uetani H, Tateishi M, Oda S, Utsunomiya D, Makino K, Nakamura H, et al: Machine learning based on multi-parametric magnetic resonance imaging to differentiate glioblastoma multiforme from primary cerebral nervous system lymphoma. Eur J Radiol. 108:147–154. 2018. View Article : Google Scholar : PubMed/NCBI

57 

McAvoy M, Prieto PC, Kaczmarzyk JR, Fernández IS, McNulty J, Smith T, Yu KH, Gormley WB and Arnaout O: Classification of glioblastoma versus primary central nervous system lymphoma using convolutional neural networks. Sci Rep. 11:152192021. View Article : Google Scholar : PubMed/NCBI

58 

Zhang Y, Liang K, He J, Ma H, Chen H, Zheng F, Zhang L, Wang X, Ma X and Chen X: Deep learning with data enhancement for the differentiation of solitary and multiple cerebral glioblastoma, lymphoma, and tumefactive demyelinating lesion. Front Oncol. 11:6658912021. View Article : Google Scholar : PubMed/NCBI

59 

Xia W, Hu B, Li H, Shi W, Tang Y, Yu Y, Geng C, Wu Q, Yang L, Yu Z, et al: Deep learning for automatic differential diagnosis of primary central nervous system lymphoma and glioblastoma: Multi-Parametric magnetic resonance imaging based convolutional neural network model. J Magn Reson Imaging. 54:880–887. 2021. View Article : Google Scholar : PubMed/NCBI

60 

Tariciotti L, Caccavella VM, Fiore G, Schisano L, Carrabba G, Borsa S, Giordano M, Palmisciano P, Remoli G, Remore LG, et al: A deep learning model for preoperative differentiation of glioblastoma, brain metastasis and primary central nervous system lymphoma: A pilot study. Front Oncol. 12:8166382022. View Article : Google Scholar : PubMed/NCBI

61 

Yun J, Park JE, Lee H, Ham S, Kim N and Kim HS: Radiomic features and multilayer perceptron network classifier: A robust MRI classification strategy for distinguishing glioblastoma from primary central nervous system lymphoma. Sci Rep. 9:57462019. View Article : Google Scholar : PubMed/NCBI

62 

Park JE, Kim HS, Lee J, Cheong EN, Shin I, Ahn SS and Shim WH: Deep-learned time-signal intensity pattern analysis using an autoencoder captures magnetic resonance perfusion heterogeneity for brain tumor differentiation. Sci Rep. 10:214852020. View Article : Google Scholar : PubMed/NCBI

63 

Chhieng DC, Elgert P, Cohen JM, Jhala NC and Cangiarella JF: Cytology of primary central nervous system neoplasms in cerebrospinal fluid specimens. Diagn Cytopathol. 26:209–212. 2002. View Article : Google Scholar : PubMed/NCBI

64 

Bromberg JE, Breems DA, Kraan J, Bikker G, van der Holt B, Smitt PS, van den Bent MJ, van't Veer M and Gratama JW: CSF flow cytometry greatly improves diagnostic accuracy in CNS hematologic malignancies. Neurology. 68:1674–1679. 2007. View Article : Google Scholar : PubMed/NCBI

65 

Schroers R, Baraniskin A, Heute C, Vorgerd M, Brunn A, Kuhnhenn J, Kowoll A, Alekseyev A, Schmiegel W, Schlegel U, et al: Diagnosis of leptomeningeal disease in diffuse large B-cell lymphomas of the central nervous system by flow cytometry and cytopathology. Eur J Haematol. 85:520–528. 2020. View Article : Google Scholar : PubMed/NCBI

66 

Baraniskin A, Deckert M, Schulte-Altedorneburg G, Schlegel U and Schroers R: Current strategies in the diagnosis of diffuse large B-cell lymphoma of the central nervous system. Br J Haematol. 156:421–432. 2012. View Article : Google Scholar : PubMed/NCBI

67 

van Westrhenen A, Smidt LCA, Seute T, Nierkens S, Stork ACJ, Minnema MC and Snijders TJ: Diagnostic markers for CNS lymphoma in blood and cerebrospinal fluid: A systematic review. Br J Haematol. 182:384–403. 2018. View Article : Google Scholar : PubMed/NCBI

68 

Yang ZZ, Grote DM, Ziesmer SC, Manske MK, Witzig TE, Novak AJ and Ansell SM: Soluble IL-2Rα facilitates IL-2-mediated immune responses and predicts reduced survival in follicular B-cell non-Hodgkin lymphoma. Blood. 118:2809–2820. 2011. View Article : Google Scholar : PubMed/NCBI

69 

Wolska A, Reimund M and Remaley AT: Apolipoprotein C-II: The re-emergence of a forgotten factor. Curr Opin Lipidol. 31:147–153. 2020. View Article : Google Scholar : PubMed/NCBI

70 

Saade M, Araujo de Souza G, Scavone C and Kinoshita PF: The Role of GPNMB in inflammation. Front Immunol. 12:6747392021. View Article : Google Scholar : PubMed/NCBI

71 

Waldera-Lupa DM, Poschmann G, Kirchgaessler N, Etemad-Parishanzadeh O, Baberg F, Brocksieper M, Seidel S, Kowalski T, Brunn A, Haghikia A, et al: A multiplex assay for the stratification of patients with primary central nervous system lymphoma using targeted mass spectrometry. Cancers (Basel). 12:17322020. View Article : Google Scholar : PubMed/NCBI

72 

Maeyama M, Sasayama T, Tanaka K, Nakamizo S, Tanaka H, Nishihara M, Fujita Y, Sekiguchi K, Kohta M, Mizukawa K, et al: Multi-marker algorithms based on CXCL13, IL-10, sIL-2 receptor, and β2-microglobulin in cerebrospinal fluid to diagnose CNS lymphoma. Cancer Med. 9:4114–4125. 2020. View Article : Google Scholar : PubMed/NCBI

73 

Rubenstein JL, Wong VS, Kadoch C, Gao HX, Barajas R, Chen L, Josephson SA, Scott B, Douglas V, Maiti M, et al: CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma. Blood. 121:4740–4748. 2013. View Article : Google Scholar : PubMed/NCBI

74 

Shao J, Chen K, Li Q, Ma J, Ma Y, Lin Z, Kang H and Chen B: High level of IL-10 in cerebrospinal fluid is specific for diagnosis of primary central nervous system lymphoma. Cancer Manag Res. 12:6261–6268. 2020. View Article : Google Scholar : PubMed/NCBI

75 

Masouris I, Manz K, Pfirrmann M, Dreyling M, Angele B, Straube A, Langer S, Huber M, Koedel U and Von Baumgarten L: CXCL13 and CXCL9 CSF levels in central nervous system lymphoma-diagnostic, therapeutic, and prognostic relevance. Front Neurol. 12:6545432021. View Article : Google Scholar : PubMed/NCBI

76 

McEwen AE, Leary SES and Lockwood CM: Beyond the blood: CSF-Derived cfDNA for diagnosis and characterization of CNS tumors. Front Cell Dev Biol. 8:452020. View Article : Google Scholar : PubMed/NCBI

77 

Wang Z, Jiang W, Wang Y, Guo Y, Cong Z, Du F and Song B: MGMT promoter methylation in serum and cerebrospinal fluid as a tumor-specific biomarker of glioma. Biomed Rep. 3:543–548. 2015. View Article : Google Scholar : PubMed/NCBI

78 

Juratli TA, Stasik S, Zolal A, Schuster C, Richter S, Daubner D, Juratli MA, Thowe R, Hennig S, Makina M, et al: TERT promoter mutation detection in cell-free tumor-derived DNA in patients with IDH wild-type glioblastomas: A pilot prospective study. Clin Cancer Res. 24:5282–5291. 2018. View Article : Google Scholar : PubMed/NCBI

79 

Nakamura T, Tateishi K, Niwa T, Matsushita Y, Tamura K, Kinoshita M, Tanaka K, Fukushima S, Takami H, Arita H, et al: Recurrent mutations of CD79B and MYD88 are the hallmark of primary central nervous system lymphomas. Neuropathol Appl Neurobiol. 42:279–290. 2016. View Article : Google Scholar : PubMed/NCBI

80 

Hiemcke-Jiwa LS, Leguit RJ, Snijders TJ, Bromberg JEC, Nierkens S, Jiwa NM, Minnema MC and Huibers MMH: MYD88 p.(L265P) detection on cell-free DNA in liquid biopsies of patients with primary central nervous system lymphoma. Br J Haematol. 185:974–977. 2019. View Article : Google Scholar : PubMed/NCBI

81 

Ferreri AJM, Calimeri T, Lopedote P, Francaviglia I, Daverio R, Iacona C, Belloni C, Steffanoni S, Gulino A, Anghileri E, et al: MYD88 L265P mutation and interleukin-10 detection in cerebrospinal fluid are highly specific discriminating markers in patients with primary central nervous system lymphoma: Results from a prospective study. Br J Haematol. 193:497–505. 2021. View Article : Google Scholar : PubMed/NCBI

82 

Downs BM, Ding W, Cope LM, Umbricht CB, Li W, He H, Ke X, Holdhoff M, Bettegowda C, Tao W and Sukumar S: Methylated markers accurately distinguish primary central nervous system lymphomas (PCNSL) from other CNS tumors. Clin Epigenetics. 13:1042021. View Article : Google Scholar : PubMed/NCBI

83 

Jelski W and Mroczko B: Molecular and circulating biomarkers of brain tumors. Int J Mol Sci. 22:70392021. View Article : Google Scholar : PubMed/NCBI

84 

Kim S, Jeon OH and Jeon YJ: Extracellular RNA: Emerging roles in cancer cell communication and biomarkers. Cancer Lett. 495:33–40. 2020. View Article : Google Scholar : PubMed/NCBI

85 

Birkó Z, Nagy B, Klekner Á and Virga J: Novel molecular markers in glioblastoma-benefits of liquid biopsy. Int J Mol Sci. 21:75222020. View Article : Google Scholar : PubMed/NCBI

86 

Colombo M, Raposo G and Théry C: Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 30:255–289. 2014. View Article : Google Scholar : PubMed/NCBI

87 

Yang K, Wang S, Cheng Y, Tian Y and Hou J: Role of miRNA-21 in the diagnosis and prediction of treatment efficacy of primary central nervous system lymphoma. Oncol Lett. 17:3475–3481. 2019.PubMed/NCBI

88 

Xia H, Qi Y, Ng SS, Chen X, Chen S, Fang M, Li D, Zhao Y, Ge R, Li G, et al: MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells. Biochem Biophys Res Commun. 380:205–210. 2009. View Article : Google Scholar : PubMed/NCBI

89 

Baraniskin A, Kuhnhenn J, Schlegel U, Maghnouj A, Zollner H, Schmiegel W, Hahn S and Schroers R: Identification of microRNAs in the cerebrospinal fluid as biomarker for the diagnosis of glioma. Neuro Oncol. 14:29–33. 2012. View Article : Google Scholar : PubMed/NCBI

90 

Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST and Patel T: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology. 133:647–658. 2007. View Article : Google Scholar : PubMed/NCBI

91 

Cabarcas S, Watabe K and Schramm L: Inhibition of U6 snRNA transcription by PTEN. Online J Biol Sci. 10:114–125. 2010. View Article : Google Scholar : PubMed/NCBI

92 

Puigdelloses M, Gonzalez-Huarriz M, Garcia-Moure M, Martinez-Velez N, Esparragosa Vazquez I, Bruna J, Zandio B, Agirre A, Marigil M, Petrirena G, et al: RNU6-1 in circulating exosomes differentiates GBM from non-neoplastic brain lesions and PCNSL but not from brain metastases. Neurooncol Adv. 2:vdaa0102020.PubMed/NCBI

93 

Eisenhut F, Schmidt MA, Putz F, Lettmaier S, Fröhlich K, Arinrad S, Coras R, Luecking H, Lang S, Fietkau R and Doerfler A: Classification of primary cerebral lymphoma and glioblastoma featuring dynamic susceptibility contrast and apparent diffusion coefficient. Brain Sci. 10:8862020. View Article : Google Scholar : PubMed/NCBI

94 

Mabray MC, Barajas RF, Villanueva-Meyer JE, Zhang CA, Valles FE, Rubenstein JL and Cha S: The combined performance of ADC, CSF CXC Chemokine Ligand 13, and CSF Interleukin 10 in the diagnosis of central nervous system lymphoma. AJNR Am J Neuroradiol. 37:74–79. 2016. View Article : Google Scholar : PubMed/NCBI

95 

Hatakeyama J, Ono T, Takahashi M, Oda M and Shimizu H: Differentiating between primary central nervous system lymphoma and glioblastoma: The diagnostic value of combining 18F-fluorodeoxyglucose positron emission tomography with arterial spin labeling. Neurol Med Chir (Tokyo). 61:367–375. 2021. View Article : Google Scholar : PubMed/NCBI

96 

Weller M, Martus P, Roth P, Thiel E and Korfel A; German PCNSL Study Group, : Surgery for primary CNS lymphoma? Challenging a paradigm. Neuro Oncol. 14:1481–1484. 2012. View Article : Google Scholar : PubMed/NCBI

97 

Deng X, Xu X, Lin D, Zhang X, Yu L, Sheng H, Yin B, Zhang N and Lin J: Real-World impact of surgical excision on overall survival in primary central nervous system lymphoma. Front Oncol. 10:1312020. View Article : Google Scholar : PubMed/NCBI

98 

Labak CM, Holdhoff M, Bettegowda C, Gallia GL, Lim M, Weingart JD and Mukherjee D: Surgical resection for primary central nervous system lymphoma: A systematic review. World Neurosurg. 126:e1436–e1448. 2019. View Article : Google Scholar : PubMed/NCBI

99 

Schellekes N, Barbotti A, Abramov Y, Sitt R, Di Meco F, Ram Z and Grossman R: Resection of primary central nervous system lymphoma: Impact of patient selection on overall survival. J Neurosurg. Feb 26–2021.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

100 

Bierman PJ: Surgery for primary central nervous system lymphoma: Is it time for reevaluation? Oncology (Williston Park). 28:632–637. 2014.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cao L, Zhang M, Zhang Y, Ji B, Wang X and Wang X: Progress of radiological‑pathological workflows in the differential diagnosis between primary central nervous system lymphoma and high‑grade glioma (Review). Oncol Rep 49: 20, 2023.
APA
Cao, L., Zhang, M., Zhang, Y., Ji, B., Wang, X., & Wang, X. (2023). Progress of radiological‑pathological workflows in the differential diagnosis between primary central nervous system lymphoma and high‑grade glioma (Review). Oncology Reports, 49, 20. https://doi.org/10.3892/or.2022.8457
MLA
Cao, L., Zhang, M., Zhang, Y., Ji, B., Wang, X., Wang, X."Progress of radiological‑pathological workflows in the differential diagnosis between primary central nervous system lymphoma and high‑grade glioma (Review)". Oncology Reports 49.1 (2023): 20.
Chicago
Cao, L., Zhang, M., Zhang, Y., Ji, B., Wang, X., Wang, X."Progress of radiological‑pathological workflows in the differential diagnosis between primary central nervous system lymphoma and high‑grade glioma (Review)". Oncology Reports 49, no. 1 (2023): 20. https://doi.org/10.3892/or.2022.8457
Copy and paste a formatted citation
x
Spandidos Publications style
Cao L, Zhang M, Zhang Y, Ji B, Wang X and Wang X: Progress of radiological‑pathological workflows in the differential diagnosis between primary central nervous system lymphoma and high‑grade glioma (Review). Oncol Rep 49: 20, 2023.
APA
Cao, L., Zhang, M., Zhang, Y., Ji, B., Wang, X., & Wang, X. (2023). Progress of radiological‑pathological workflows in the differential diagnosis between primary central nervous system lymphoma and high‑grade glioma (Review). Oncology Reports, 49, 20. https://doi.org/10.3892/or.2022.8457
MLA
Cao, L., Zhang, M., Zhang, Y., Ji, B., Wang, X., Wang, X."Progress of radiological‑pathological workflows in the differential diagnosis between primary central nervous system lymphoma and high‑grade glioma (Review)". Oncology Reports 49.1 (2023): 20.
Chicago
Cao, L., Zhang, M., Zhang, Y., Ji, B., Wang, X., Wang, X."Progress of radiological‑pathological workflows in the differential diagnosis between primary central nervous system lymphoma and high‑grade glioma (Review)". Oncology Reports 49, no. 1 (2023): 20. https://doi.org/10.3892/or.2022.8457
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