Open Access

Comprehensive in‑silico molecular analysis of early‑onset gastric cancer identifies novel genes implicated in disease characterization and progression (Review)

  • Authors:
    • Fernán Gómez‑Valenzuela
    • Ian Silva
    • Ignacio N. Retamal
    • Benjamín García‑Bloj
    • Tomás De Mayo Glasser
    • Matías Muñoz‑Medel
    • Alex Gómez
    • Cristopher San Martín
    • Carolina Sánchez
    • Felipe Pinto
    • Paola Aravena
    • Andrea C. Sabioncello
    • Marcelo Garrido Villanueva
    • Fernando Sigler Chávez
    • Ignacio Corvalán
    • Henry Barrios
    • José M. Erpel
    • Patricio A. Manque
    • Juan A. Godoy
    • Marcelo Garrido
  • View Affiliations

  • Published online on: June 17, 2025     https://doi.org/10.3892/or.2025.8931
  • Article Number: 98
  • Copyright: © Gómez‑Valenzuela et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer, a prevalent and fatal form of cancer worldwide, is manifested at different age ranges during the lifespan. Approximately one‑third of newly diagnosed gastric cancer cases are early‑onset gastric cancer (EO‑GC), which affects individuals under the age of 50 years. EO‑GC tends to be more aggressive than late‑onset gastric cancer (L‑GC), with a faster and multifocal disease progression. Furthermore, EO‑GC is associated with early metastatic disease. Recent research has underscored the need for a deeper understanding of EO‑GC that promotes therapeutic approaches specific to EO‑GC. The present study determined the main transcriptomic differences between EO‑GC and L‑GC. Transcriptomic expression data from The Cancer Genome Atlas‑Stomach Adenocarcinoma were explored to elucidate whether age is associated with a specific genomic expression pattern and is associated with gastric cancer. Subsequently, a differential gene expression analysis of the EO‑GC vs. L‑GC groups was performed, providing new insights into EO‑GC gene expression characteristics and their association with survival outcomes. Furthermore, the study focused on whether the influence of representative gene expression in EO‑GC cases (KLHL4, MAGEL2, CYP8B1, RNLS, CLDN6, MIOX, PNMA5 and ACTL8 genes) may be associated with its aggressive phenotype and methylation profiles of these patients. In this review, the necessity of incorporating age as a crucial element in understanding the disparities in outcomes for EO‑GC cases in public datasets was discussed. Furthermore, this insight may be useful for targeted early personalized clinical interventions to improve patient prognosis and survival rates in EO‑GC cases.
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August-2025
Volume 54 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Gómez‑Valenzuela F, Silva I, Retamal IN, García‑Bloj B, De Mayo Glasser T, Muñoz‑Medel M, Gómez A, San Martín C, Sánchez C, Pinto F, Pinto F, et al: Comprehensive <em>in‑silico</em> molecular analysis of early‑onset gastric cancer identifies novel genes implicated in disease characterization and progression (Review). Oncol Rep 54: 98, 2025.
APA
Gómez‑Valenzuela, F., Silva, I., Retamal, I.N., García‑Bloj, B., De Mayo Glasser, T., Muñoz‑Medel, M. ... Garrido, M. (2025). Comprehensive <em>in‑silico</em> molecular analysis of early‑onset gastric cancer identifies novel genes implicated in disease characterization and progression (Review). Oncology Reports, 54, 98. https://doi.org/10.3892/or.2025.8931
MLA
Gómez‑Valenzuela, F., Silva, I., Retamal, I. N., García‑Bloj, B., De Mayo Glasser, T., Muñoz‑Medel, M., Gómez, A., San Martín, C., Sánchez, C., Pinto, F., Aravena, P., Sabioncello, A. C., Garrido Villanueva, M., Sigler Chávez, F., Corvalán, I., Barrios, H., Erpel, J. M., Manque, P. A., Godoy, J. A., Garrido, M."Comprehensive <em>in‑silico</em> molecular analysis of early‑onset gastric cancer identifies novel genes implicated in disease characterization and progression (Review)". Oncology Reports 54.2 (2025): 98.
Chicago
Gómez‑Valenzuela, F., Silva, I., Retamal, I. N., García‑Bloj, B., De Mayo Glasser, T., Muñoz‑Medel, M., Gómez, A., San Martín, C., Sánchez, C., Pinto, F., Aravena, P., Sabioncello, A. C., Garrido Villanueva, M., Sigler Chávez, F., Corvalán, I., Barrios, H., Erpel, J. M., Manque, P. A., Godoy, J. A., Garrido, M."Comprehensive <em>in‑silico</em> molecular analysis of early‑onset gastric cancer identifies novel genes implicated in disease characterization and progression (Review)". Oncology Reports 54, no. 2 (2025): 98. https://doi.org/10.3892/or.2025.8931