Color flow mapping: a non-invasive tool for characterizing and differentiating between uveal melanomas and choroidal metastases

  • Authors:
    • Meira Neudorfer
    • Michael Waisbourd
    • Irene Anteby
    • Alon Liran
    • Dafna Goldenberg
    • Adiel Barak
    • Ada Kessler
  • View Affiliations

  • Published online on: January 1, 2011     https://doi.org/10.3892/or_00001046
  • Pages: 91-96
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Abstract

The objective of this study was to characterize and differentiate vascular patterns of choroidal melanomas and choroidal metastases by color flow mapping (CFM). We conducted a retrospective chart study on CFM findings in 18 patients with choroidal melanomas and 10 patients with choroidal metastases. We evaluated the possibilities of applying CFM to identify hypo- versus hyper-vascularity within the tumor, a central ‘dominant vessel’, and Doppler signals in the tumor's center and/or periphery. CFM demonstrated hypervascular patterns in 33% melanomas and 100% metastases (p<0.0001). CFM identified a central dominant vessel in 94% melanomas and 0/10 metastases (p<0.0001). Vascularity occupied the center of 11/18 melanomas and 0/10 metastases (p<0.0001), the periphery of 2/18 melanomas and 9/10 metastases (p<0.0001), and equally occupied the tumor's center and periphery of 5/18 melanomas and 1/10 metastases (p<0.0001). Based on our findings, we conclude that CFM was capable of non-invasively demonstrating different and distinct vascular patterns in malignant choroidal melanomas and choroidal metastases.

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January 2011
Volume 25 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Neudorfer M, Waisbourd M, Anteby I, Liran A, Goldenberg D, Barak A and Kessler A: Color flow mapping: a non-invasive tool for characterizing and differentiating between uveal melanomas and choroidal metastases . Oncol Rep 25: 91-96, 2011.
APA
Neudorfer, M., Waisbourd, M., Anteby, I., Liran, A., Goldenberg, D., Barak, A., & Kessler, A. (2011). Color flow mapping: a non-invasive tool for characterizing and differentiating between uveal melanomas and choroidal metastases . Oncology Reports, 25, 91-96. https://doi.org/10.3892/or_00001046
MLA
Neudorfer, M., Waisbourd, M., Anteby, I., Liran, A., Goldenberg, D., Barak, A., Kessler, A."Color flow mapping: a non-invasive tool for characterizing and differentiating between uveal melanomas and choroidal metastases ". Oncology Reports 25.1 (2011): 91-96.
Chicago
Neudorfer, M., Waisbourd, M., Anteby, I., Liran, A., Goldenberg, D., Barak, A., Kessler, A."Color flow mapping: a non-invasive tool for characterizing and differentiating between uveal melanomas and choroidal metastases ". Oncology Reports 25, no. 1 (2011): 91-96. https://doi.org/10.3892/or_00001046