Open Access

Apelin as a novel drug for treating preeclampsia

  • Authors:
    • Chengshu Wang
    • Xiaoli Liu
    • Desheng Kong
    • Xijing Qin
    • Yanqing Li
    • Xu Teng
    • Xianghua Huang
  • View Affiliations

  • Published online on: October 13, 2017     https://doi.org/10.3892/etm.2017.5304
  • Pages:5917-5923
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: PDF 0 views | HTML 0 views
0

Abstract

Preeclampsia is a pregnancy‑specific disorder of new‑onset hypertension and proteinuria after 20 weeks' gestation, often resulting in poor outcome. Previous studies demonstrated that apelin is an endogenous active peptide with visodilation and anti‑oxidative stress capabilities. The present study investigated the effects of apelin in a rat model of preeclampsia induced by reduced uterine perfusion pressure (RUPP). Rats with RUPP displayed hypertension and poor pregnancy outcomes, such as decreased fetal and placental weight. Of note, apelin treatment significantly ameliorated the symptoms of preeclampsia, improved the impaired endothelial nitric oxide synthase/nitric oxide signaling and attenuated activation of oxidative stress in RUPP rats. Apelin may be a potential agent for preventing and treating preeclampsia.

Related Articles

Journal Cover

December 2017
Volume 14 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Wang, C., Liu, X., Kong, D., Qin, X., Li, Y., Teng, X., & Huang, X. (2017). Apelin as a novel drug for treating preeclampsia. Experimental and Therapeutic Medicine, 14, 5917-5923. https://doi.org/10.3892/etm.2017.5304
MLA
Wang, C., Liu, X., Kong, D., Qin, X., Li, Y., Teng, X., Huang, X."Apelin as a novel drug for treating preeclampsia". Experimental and Therapeutic Medicine 14.6 (2017): 5917-5923.
Chicago
Wang, C., Liu, X., Kong, D., Qin, X., Li, Y., Teng, X., Huang, X."Apelin as a novel drug for treating preeclampsia". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5917-5923. https://doi.org/10.3892/etm.2017.5304