Open Access

Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis

  • Authors:
    • Shou‑Feng Zhao
    • Ai‑Min Wang
    • Xin‑Juan Yu
    • Li‑Li Wang
    • Xiao‑Na Xu
    • Guang‑Jun Shi
  • View Affiliations

  • Published online on: February 21, 2019     https://doi.org/10.3892/etm.2019.7291
  • Pages: 3092-3100
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Increasing evidence connects gallstone disease (GD) to cardio‑cerebrovascular disease (CVD). The aim of the present systematic review and meta‑analysis was to determine whether and to what extent an association between GD and CVD existed. PubMed, EMBASE and the Cochrane Library were systemically searched up to March 3rd, 2018. A total of 10 studies (1,272,177 participants; 13,833 records; 5 prospective cohorts and 5 retrospective cohorts) were included. It was demonstrated that GD was associated with an increased risk of incidence [hazard ratio=1.24, 95% (CI) confidence interval: 1.17‑1.31] and prevalence (unadjusted odds ratio=1.23, 95% CI: 1.21‑1.25) of CVD. In conclusion, the presence of GD was associated with an increased risk of CVD incidence and prevalence. The association may be influenced by age and sex. These findings suggest that individuals identified with cardio‑cerebrovascular disease should be evaluated for GD.
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April-2019
Volume 17 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhao SF, Wang AM, Yu XJ, Wang LL, Xu XN and Shi GJ: Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis. Exp Ther Med 17: 3092-3100, 2019
APA
Zhao, S., Wang, A., Yu, X., Wang, L., Xu, X., & Shi, G. (2019). Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 17, 3092-3100. https://doi.org/10.3892/etm.2019.7291
MLA
Zhao, S., Wang, A., Yu, X., Wang, L., Xu, X., Shi, G."Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis". Experimental and Therapeutic Medicine 17.4 (2019): 3092-3100.
Chicago
Zhao, S., Wang, A., Yu, X., Wang, L., Xu, X., Shi, G."Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis". Experimental and Therapeutic Medicine 17, no. 4 (2019): 3092-3100. https://doi.org/10.3892/etm.2019.7291