microRNAs and thyroid cancer: Biological and clinical significance (Review)

  • Authors:
    • Giulia Costanza Leonardi
    • Saverio Candido
    • Maurizio Carbone
    • Valeria Colaianni
    • Sebastiano F. Garozzo
    • Diana Cinà
    • Massimo Libra
  • View Affiliations

  • Published online on: August 8, 2012     https://doi.org/10.3892/ijmm.2012.1089
  • Pages: 991-999
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Abstract

Despite recent advances in the management of thyroid cancer, the survival rate of this tumor may still be improved. Therefore, the identification of biological and molecular features of indolent and aggressive disease would be critical to define clinically useful predictors of high-risk lesions. microRNAs (miRNAs) are small RNA molecules with regulatory function and marked tissue specificity that modulate multiple targets belonging to several pathways. They are frequently deregulated in cancer and constitute a new class of blood-based biomarkers useful for cancer detection and prognosis definition, including thyroid cancer. In this review, the role of miRNAs in thyroid cancer development is described. The most common miRNAs detected in thyroid cancer along with their clinical significance are also discussed. Further studies aimed to detect plasma-based miRNA biomarkers in thyroid cancer patients may provide further insight into the management of thyroid cancer.
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November 2012
Volume 30 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Leonardi GC, Candido S, Carbone M, Colaianni V, Garozzo SF, Cinà D and Libra M: microRNAs and thyroid cancer: Biological and clinical significance (Review). Int J Mol Med 30: 991-999, 2012
APA
Leonardi, G.C., Candido, S., Carbone, M., Colaianni, V., Garozzo, S.F., Cinà, D., & Libra, M. (2012). microRNAs and thyroid cancer: Biological and clinical significance (Review). International Journal of Molecular Medicine, 30, 991-999. https://doi.org/10.3892/ijmm.2012.1089
MLA
Leonardi, G. C., Candido, S., Carbone, M., Colaianni, V., Garozzo, S. F., Cinà, D., Libra, M."microRNAs and thyroid cancer: Biological and clinical significance (Review)". International Journal of Molecular Medicine 30.5 (2012): 991-999.
Chicago
Leonardi, G. C., Candido, S., Carbone, M., Colaianni, V., Garozzo, S. F., Cinà, D., Libra, M."microRNAs and thyroid cancer: Biological and clinical significance (Review)". International Journal of Molecular Medicine 30, no. 5 (2012): 991-999. https://doi.org/10.3892/ijmm.2012.1089