MicroRNA-142-3p relieves neuropathic pain by targeting high mobility group box 1

  • Authors:
    • Yang Zhang
    • Junying Mou
    • Li Cao
    • Su Zhen
    • Hongjuan Huang
    • Hongguang Bao
  • View Affiliations

  • Published online on: October 27, 2017     https://doi.org/10.3892/ijmm.2017.3222
  • Pages:501-510
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Abstract

MicroRNA (miRNA) are emerging as critical regulators of neuropathic pain development. Neuroinflammation contributes to the development of neuropathic pain. miR‑142‑3p has been characterized as an inflammation‑related miRNA in various pathological processes. However, little is known about the role of miR‑142‑3p in neuroinflammation and neuropathic pain. The present study aimed to investigate the function of miR‑142‑3p in neuropathic pain by creating a murine model using spinal nerve ligation (SNL). A significant reduction in miR‑142‑3p expression was observed in the dorsal root ganglion of mice with SNL (P<0.05) compared with control mice. Overexpression of miR‑142‑3p significantly inhibited neuropathic pain and neuroinflammation in mice with SNL (P<0.05). High mobility group box 1 (HMGB1) was identified as a direct target gene of miR‑142‑3p by bioinformatic analysis and dual‑luciferase reporter assays. Overexpression of miR‑142‑3p significantly reduced the mRNA and protein expression levels of HMGB1 in vitro and in vivo (P<0.05). In addition, HMGB1 mRNA expression and miR‑142‑3p expression were inversely correlated in mice with SNL. Furthermore, overexpression of HMGB1 significantly reversed the inhibitory effect of miR‑142‑3p on neuroinflammation and neuropathic pain development (P<0.05). Overall, these results suggest that miR‑142‑3p functions as a negative regulator of neuropathic pain development through the downregulation of HMGB1, indicating that miR‑142‑3p may serve as a potential therapeutic target for neuropathic pain.

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January 2018
Volume 41 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

2016 Impact Factor: 2.341
Ranked #21/128 Medicine Research and Experimental
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APA
Zhang, Y., Mou, J., Cao, L., Zhen, S., Huang, H., & Bao, H. (2018). MicroRNA-142-3p relieves neuropathic pain by targeting high mobility group box 1. International Journal of Molecular Medicine, 41, 501-510. https://doi.org/10.3892/ijmm.2017.3222
MLA
Zhang, Y., Mou, J., Cao, L., Zhen, S., Huang, H., Bao, H."MicroRNA-142-3p relieves neuropathic pain by targeting high mobility group box 1". International Journal of Molecular Medicine 41.1 (2018): 501-510.
Chicago
Zhang, Y., Mou, J., Cao, L., Zhen, S., Huang, H., Bao, H."MicroRNA-142-3p relieves neuropathic pain by targeting high mobility group box 1". International Journal of Molecular Medicine 41, no. 1 (2018): 501-510. https://doi.org/10.3892/ijmm.2017.3222