Function and mechanism of F-box proteins in gastric cancer (Review)

  • Authors:
    • Jian Gong
    • Juan Cao
    • Guinan Liu
    • Ji-Rong Huo
  • View Affiliations

  • Published online on: May 4, 2015     https://doi.org/10.3892/ijo.2015.2983
  • Pages: 43-50
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Abstract

Gastric cancer (GC) is one of the commonest cancers with high mortality. Despite improvement in early detection and treatments, the outcome of advanced GC remains unsatisfactory due to the poor understanding of the intricate pathogenesis of GC. GC is a multifactorial and multistep disease which involves activation of oncogenes and inactivation of tumor suppressor genes. Ubiquitin proteasome system (UPS) catalyzing many critical protein substrates is involved in initiation and development of cancer. F-box proteins (FBPs) are the main functional components of UPS. Accumulated evidence strongly suggests that abnormal regulations of FBPs contribute to uncontrolled proliferation, genomic instability and cancer. In this review, we discuss how the dysregulated FBPs promote the occurrence and development of GC.
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July-2015
Volume 47 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Gong J, Cao J, Liu G and Huo J: Function and mechanism of F-box proteins in gastric cancer (Review). Int J Oncol 47: 43-50, 2015
APA
Gong, J., Cao, J., Liu, G., & Huo, J. (2015). Function and mechanism of F-box proteins in gastric cancer (Review). International Journal of Oncology, 47, 43-50. https://doi.org/10.3892/ijo.2015.2983
MLA
Gong, J., Cao, J., Liu, G., Huo, J."Function and mechanism of F-box proteins in gastric cancer (Review)". International Journal of Oncology 47.1 (2015): 43-50.
Chicago
Gong, J., Cao, J., Liu, G., Huo, J."Function and mechanism of F-box proteins in gastric cancer (Review)". International Journal of Oncology 47, no. 1 (2015): 43-50. https://doi.org/10.3892/ijo.2015.2983