Long-term exposure of MCF-7 breast cancer cells to ethanol stimulates oncogenic features
- Authors:
- Robert Gelfand
- Dolores Vernet
- Kevin W. Bruhn
- Suren Sarkissyan
- David Heber
- Jaydutt V. Vadgama
- Nestor F. Gonzalez-Cadavid
-
Affiliations: Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA, Department of Medicine and Human Nutrition, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA - Published online on: December 9, 2016 https://doi.org/10.3892/ijo.2016.3800
- Pages: 49-65
-
Copyright: © Gelfand et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
 |
 |
 |
 |
 |
 |
 |
|
Gelfand R, Vernet D, Bruhn K, Vadgama J and Gonzalez-Cadavid NF: Long-term exposure of MCF-12A normal human breast epithelial cells to ethanol induces epithelial mesenchymal transition and oncogenic features. Int J Oncol. 48:2399–2414. 2016.PubMed/NCBI | |
|
Seitz HK, Pelucchi C, Bagnardi V and La Vecchia C: Epidemiology and pathophysiology of alcohol and breast cancer: Update 2012. Alcohol Alcohol. 47:204–212. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Coronado GD, Beasley J and Livaudais J: Alcohol consumption and the risk of breast cancer. Salud Publica Mex. 53:440–447. 2011. | |
|
Pelucchi C, Tramacere I, Boffetta P, Negri E and La Vecchia C: Alcohol consumption and cancer risk. Nutr Cancer. 63:983–990. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Chen WY, Rosner B, Hankinson SE, Colditz GA and Willett WC: Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. JAMA. 306:1884–1890. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Narod SA: Alcohol and risk of breast cancer. JAMA. 306:1920–1921. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Saxena T, Lee E, Henderson KD, Clarke CA, West D, Marshall SF, Deapen D, Bernstein L and Ursin G: Menopausal hormone therapy and subsequent risk of specific invasive breast cancer subtypes in the California Teachers Study. Cancer Epidemiol Biomarkers Prev. 19:2366–2378. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Allemani C, Berrino F, Krogh V, Sieri S, Pupa SM, Tagliabue E, Tagliabue G and Sant M: Do pre-diagnostic drinking habits influence breast cancer survival? Tumori. 97:142–148. 2011.PubMed/NCBI | |
|
Jelski W, Chrostek L, Szmitkowski M and Markiewicz W: The activity of class I, II, III and IV alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in breast cancer. Clin Exp Med. 6:89–93. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Seitz HK and Stickel F: Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer. 7:599–612. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Hirano T: Alcohol consumption and oxidative DNA damage. Int J Environ Res Public Health. 8:2895–2906. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Balbo S, Meng L, Bliss RL, Jensen JA, Hatsukami DK and Hecht SS: Time course of DNA adduct formation in peripheral blood granulocytes and lymphocytes after drinking alcohol. Mutagenesis. 27:485–490. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Seitz HK and Stickel F: Acetaldehyde as an underestimated risk factor for cancer development: Role of genetics in ethanol metabolism. Genes Nutr. 5:121–128. 2010. View Article : Google Scholar : | |
|
Wong AW, Dunlap SM, Holcomb VB and Nunez NP: Alcohol promotes mammary tumor development via the estrogen pathway in estrogen receptor alpha-negative HER2/neu mice. Alcohol Clin Exp Res. 36:577–587. 2012. View Article : Google Scholar | |
|
Singletary KW, Frey RS and Yan W: Effect of ethanol on proliferation and estrogen receptor-alpha expression in human breast cancer cells. Cancer Lett. 165:131–137. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Etique N, Chardard D, Chesnel A, Merlin JL, Flament S and Grillier-Vuissoz I: Ethanol stimulates proliferation, ERalpha and aromatase expression in MCF-7 human breast cancer cells. Int J Mol Med. 13:149–155. 2004. | |
|
Etique N, Flament S, Lecomte J and Grillier-Vuissoz I: Ethanol-induced ligand-independent activation of ERalpha mediated by cyclic AMP/PKA signaling pathway: An in vitro study on MCF-7 breast cancer cells. Int J Oncol. 31:1509–1518. 2007.PubMed/NCBI | |
|
Etique N, Grillier-Vuissoz I, Lecomte J and Flament S: Crosstalk between adenosine receptor (A2A isoform) and ERalpha mediates ethanol action in MCF-7 breast cancer cells. Oncol Rep. 21:977–981. 2009.PubMed/NCBI | |
|
Przylipiak A, Rabe T, Hafner J, Przylipiak M and Runnebaum R: Influence of ethanol on in vitro growth of human mammary carcinoma cell line MCF-7. Arch Gynecol Obstet. 258:137–140. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Meng Q, Gao B, Goldberg ID, Rosen EM and Fan S: Stimulation of cell invasion and migration by alcohol in breast cancer cells. Biochem Biophys Res Commun. 273:448–453. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Luo J and Miller MW: Ethanol enhances erbB-mediated migration of human breast cancer cells in culture. Breast Cancer Res Treat. 63:61–69. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Izevbigie EB, Ekunwe SI, Jordan J and Howard CB: Ethanol modulates the growth of human breast cancer cells in vitro. Exp Biol Med (Maywood). 227:260–265. 2002. | |
|
Etique N, Chardard D, Chesnel A, Flament S and Grillier-Vuissoz I: Analysis of the effects of different alcohols on MCF-7 human breast cancer cells. Ann NY Acad Sci. 1030:78–85. 2004. View Article : Google Scholar | |
|
Etique N, Grillier-Vuissoz I and Flament S: Ethanol stimulates the secretion of matrix metalloproteinases 2 and 9 in MCF-7 human breast cancer cells. Oncol Rep. 15:603–608. 2006.PubMed/NCBI | |
|
Verma M and Davidson EA: MUC1 upregulation by ethanol. Cancer Biochem Biophys. 17:1–11. 1999. | |
|
Ma C, Lin H, Leonard SS, Shi X, Ye J and Luo J: Overexpression of ErbB2 enhances ethanol-stimulated intracellular signaling and invasion of human mammary epithelial and breast cancer cells in vitro. Oncogene. 22:5281–5290. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Aye MM, Ma C, Lin H, Bower KA, Wiggins RC and Luo J: Ethanol-induced in vitro invasion of breast cancer cells: The contribution of MMP-2 by fibroblasts. Int J Cancer. 112:738–746. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Ke Z, Lin H, Fan Z, Cai TQ, Kaplan RA, Ma C, Bower KA, Shi X and Luo J: MMP-2 mediates ethanol-induced invasion of mammary epithelial cells over-expressing ErbB2. Int J Cancer. 119:8–16. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Cordes T, Diesing D, Becker S, Diedrich K, Reichrath J and Friedrich M: Modulation of MAPK ERK1 and ERK2 in VDR-positive and -negative breast cancer cell lines. Anticancer Res. 26A:2749–2753. 2006. | |
|
Xu M, Bower KA, Wang S, Frank JA, Chen G, Ding M, Wang S, Shi X, Ke Z and Luo J: Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2. Mol Cancer. 9:2852010. View Article : Google Scholar : PubMed/NCBI | |
|
Raouf A, Sun Y, Chatterjee S and Basak P: The biology of human breast epithelial progenitors. Semin Cell Dev Biol. 23:606–612. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Bruno RD and Smith GH: Role of epithelial stem/progenitor cells in mammary cancer. Gene Expr. 15:133–140. 2011. View Article : Google Scholar | |
|
Korkaya H, Liu S and Wicha MS: Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J Clin Invest. 121:3804–3809. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Feifei N, Mingzhi Z, Yanyun Z, Huanle Z, Fang R, Mingzhu H, Mingzhi C, Yafei S and Fengchun Z: MicroRNA expression analysis of mammospheres cultured from human breast cancers. J Cancer Res Clin Oncol. 138:1937–1944. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Xie G, Zhan J, Tian Y, Liu Y, Chen Z, Ren C, Sun Q, Lian J, Chen L, Ruan J, et al: Mammosphere cells from high-passage MCF7 cell line show variable loss of tumorigenicity and radioresistance. Cancer Lett. 316:53–61. 2012. View Article : Google Scholar | |
|
Nash R, Krishnamoorthy M, Jenkins A and Csete M: Human embryonic stem cell model of ethanol-mediated early developmental toxicity. Exp Neurol. 234:127–135. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Worley SL, Vaughn BJ, Terry AI, Gardiner CS and DeKrey GK: Time- and dose-dependent effects of ethanol on mouse embryonic stem cells. Reprod Toxicol. 57:157–164. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Cortez MA, Welsh JW and Calin GA: Circulating microRNAs as noninvasive biomarkers in breast cancer. Recent Results Cancer Res. 195:151–161. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Krell J, Frampton AE, Jacob J, Castellano L and Stebbing J: miRNAs in breast cancer: Ready for real time? Pharmacogenomics. 13:709–719. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Shore AN, Herschkowitz JI and Rosen JM: Noncoding RNAs involved in mammary gland development and tumorigenesis: There's a long way to go. J Mammary Gland Biol Neoplasia. 17:43–58. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Valastyan S: Roles of microRNAs and other non-coding RNAs in breast cancer metastasis. J Mammary Gland Biol Neoplasia. 17:23–32. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Guttilla IK, Adams BD and White BA: ERα, microRNAs, and the epithelial-mesenchymal transition in breast cancer. Trends Endocrinol Metab. 23:73–82. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Jain P and Alahari SK: Breast cancer stem cells: A new challenge for breast cancer treatment. Front Biosci (Landmark Ed). 16:1824–1832. 2011. View Article : Google Scholar | |
|
Miranda RC, Pietrzykowski AZ, Tang Y, Sathyan P, Mayfield D, Keshavarzian A, Sampson W and Hereld D: MicroRNAs: Master regulators of ethanol abuse and toxicity? Alcohol Clin Exp Res. 34:575–587. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Meng F, Glaser SS, Francis H, Yang F, Han Y, Stokes A, Staloch D, McCarra J, Liu J, Venter J, et al: Epigenetic regulation of miR-34a expression in alcoholic liver injury. Am J Pathol. 181:804–817. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Klinge CM: miRNAs and estrogen action. Trends Endocrinol Metab. 23:223–233. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Guttilla IK, Phoenix KN, Hong X, Tirnauer JS, Claffey KP and White BA: Prolonged mammosphere culture of MCF-7 cells induces an EMT and repression of the estrogen receptor by microRNAs. Breast Cancer Res Treat. 132:75–85. 2012. View Article : Google Scholar | |
|
Li X, Mertens-Talcott SU, Zhang S, Kim K, Ball J and Safe S: MicroRNA-27a indirectly regulates estrogen receptor {alpha} expression and hormone responsiveness in MCF-7 breast cancer cells. Endocrinology. 151:2462–2473. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Reed TE, Kalant H, Gibbins RJ, Kapur BM and Rankin JG: Alcohol and acetaldehyde metabolism in Caucasians, Chinese and Amerinds. Can Med Assoc J. 115:851–855. 1976.PubMed/NCBI | |
|
Tsang JY, Kwok YK, Chan KW, Ni YB, Chow WN, Lau KF, Shao MM, Chan SK, Tan PH and Tse GM: Expression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in breast cancers. Breast Cancer Res Treat. 142:311–322. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Pece S, Tosoni D, Confalonieri S, Mazzarol G, Vecchi M, Ronzoni S, Bernard L, Viale G, Pelicci PG and Di Fiore PP: Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell. 140:62–73. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Ono S, Ishizaki Y, Tokuda E, Tabata K, Asami S and Suzuki T: Different patterns in the induction of metallothionein mRNA synthesis among isoforms after acute ethanol administration. Biol Trace Elem Res. 115:147–156. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Pedersen MO, Larsen A, Stoltenberg M and Penkowa M: The role of metallothionein in oncogenesis and cancer prognosis. Prog Histochem Cytochem. 44:29–64. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Ning MS, Kim AS, Prasad N, Levy SE, Zhang H and Andl T: Characterization of the Merkel Cell Carcinoma miRNome. J Skin Cancer. 2014:2895482014. View Article : Google Scholar : PubMed/NCBI | |
|
Rojas F, Hernandez ME, Silva M, Li L, Subramanian S, Wilson MJ and Liu P: The oncogenic response to MiR-335 is associated with cell surface expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) activity. PLoS One. 10:e01320262015. View Article : Google Scholar : PubMed/NCBI | |
|
Lu Y, Yang H, Yuan L, Liu G, Zhang C, Hong M, Liu Y, Zhou M, Chen F and Li X: Overexpression of miR-335 confers cell proliferation and tumour growth to colorectal carcinoma cells. Mol Cell Biochem. 412:235–245. 2016. View Article : Google Scholar | |
|
Saumet A, Vetter G, Bouttier M, Antoine E, Roubert C, Orsetti B, Theillet C and Lecellier CH: Estrogen and retinoic acid antagonistically regulate several microRNA genes to control aerobic glycolysis in breast cancer cells. Mol Biosyst. 8:3242–3253. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Ruiz-Llorente L, Ardila-González S, Fanjul LF, Martínez-Iglesias O and Aranda A: microRNAs 424 and 503 are mediators of the anti-proliferative and anti-invasive action of the thyroid hormone receptor beta. Oncotarget. 5:2918–2933. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Z, Zhang H, Zhang P, Li J, Shan Z and Teng W: Upregulation of miR-2861 and miR-451 expression in papillary thyroid carcinoma with lymph node metastasis. Med Oncol. 30:5772013. View Article : Google Scholar : PubMed/NCBI | |
|
Long C, Jiang L, Wei F, Ma C, Zhou H, Yang S, Liu X and Liu Z: Integrated miRNA-mRNA analysis revealing the potential roles of miRNAs in chordomas. PLoS One. 8:e666762013. View Article : Google Scholar : PubMed/NCBI | |
|
Nakazawa K, Dashzeveg N and Yoshida K: Tumor suppressor p53 induces miR-1915 processing to inhibit Bcl-2 in the apoptotic response to DNA damage. FEBS J. 281:2937–2944. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Boo L, Ho WY, Ali NM, Yeap SK, Ky H, Chan KG, Yin WF, Satharasinghe DA, Liew WC, Tan SW, et al: MiRNA transcriptome profiling of spheroid-enriched cells with cancer stem cell properties in human breast MCF-7 cell line. Int J Biol Sci. 12:427–445. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Yang B, Jing C, Wang J, Guo X, Chen Y, Xu R, Peng L, Liu J and Li L: Identification of microRNAs associated with lymphangiogenesis in human gastric cancer. Clin Transl Oncol. 16:374–379. 2014. View Article : Google Scholar | |
|
Xu C, Zhang L, Li H, Liu Z, Duan L and Lu C: MiRNA-1469 promotes lung cancer cells apoptosis through targeting STAT5a. Am J Cancer Res. 5:1180–1189. 2015.PubMed/NCBI | |
|
Yu CC, Chen YW, Chiou GY, Tsai LL, Huang PI, Chang CY, Tseng LM, Chiou SH, Yen SH, Chou MY, et al: MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation. Oral Oncol. 47:202–210. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Molina-Pinelo S, Gutiérrez G, Pastor MD, Hergueta M, Moreno-Bueno G, García-Carbonero R, Nogal A, Suárez R, Salinas A, Pozo-Rodríguez F, et al: MicroRNA-dependent regulation of transcription in non-small cell lung cancer. PLoS One. 9:e905242014. View Article : Google Scholar : PubMed/NCBI | |
|
Ogony JW, Malahias E, Vadigepalli R and Anni H: Ethanol alters the balance of Sox2, Oct4, and Nanog expression in distinct subpopulations during differentiation of embryonic stem cells. Stem Cells Dev. 22:2196–2210. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zeineddine D, Hammoud AA, Mortada M and Boeuf H: The Oct4 protein: More than a magic stemness marker. Am J Stem Cells. 3:74–82. 2014.PubMed/NCBI | |
|
Liu CG, Lu Y, Wang BB, Zhang YJ, Zhang RS, Lu Y, Chen B, Xu H, Jin F and Lu P: Clinical implications of stem cell gene Oct-4 expression in breast cancer. Ann Surg. 253:1165–1171. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Liu C, Cao X, Zhang Y, Xu H, Zhang R, Wu Y, Lu P and Jin F: Co-expression of Oct-4 and Nestin in human breast cancers. Mol Biol Rep. 39:5875–5881. 2012. View Article : Google Scholar | |
|
Leis O, Eguiara A, Lopez-Arribillaga E, Alberdi MJ, Hernandez-Garcia S, Elorriaga K, Pandiella A, Rezola R and Martin AG: Sox2 expression in breast tumours and activation in breast cancer stem cells. Oncogene. 31:1354–1365. 2012. View Article : Google Scholar | |
|
Lengerke C, Fehm T, Kurth R, Neubauer H, Scheble V, Müller F, Schneider F, Petersen K, Wallwiener D, Kanz L, et al: Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma. BMC Cancer. 11:422011. View Article : Google Scholar : PubMed/NCBI | |
|
Jung JW, Park SB, Lee SJ, Seo MS, Trosko JE and Kang KS: Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression. PLoS One. 6:e280682011. View Article : Google Scholar : PubMed/NCBI | |
|
Hu J, Qin K, Zhang Y, Gong J, Li N, Lv D, Xiang R and Tan X: Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells. Biochem Biophys Res Commun. 411:786–791. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Trosko JE: From adult stem cells to cancer stem cells: Oct-4 Gene, cell-cell communication, and hormones during tumor promotion. Ann NY Acad Sci. 1089:36–58. 2006. View Article : Google Scholar | |
|
Wu F, Zhang J, Wang P, Ye X, Jung K, Bone KM, Pearson JD, Ingham RJ, McMullen TP, Ma Y, et al: Identification of two novel phenotypically distinct breast cancer cell subsets based on Sox2 transcription activity. Cell Signal. 24:1989–1998. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Nagata T, Shimada Y, Sekine S, Hori R, Matsui K, Okumura T, Sawada S, Fukuoka J and Tsukada K: Prognostic significance of NANOG and KLF4 for breast cancer. Breast Cancer. 21:96–101. 2014. View Article : Google Scholar | |
|
Machida K, Tsukamoto H, Mkrtchyan H, Duan L, Dynnyk A, Liu HM, Asahina K, Govindarajan S, Ray R, Ou JH, et al: Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci USA. 106:1548–1553. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Lewis-Wambi JS, Cunliffe HE, Kim HR, Willis AL and Jordan VC: Overexpression of CEACAM6 promotes migration and invasion of oestrogen-deprived breast cancer cells. Eur J Cancer. 44:1770–1779. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Ihnen M, Kilic E, Köhler N, Löning T, Witzel I, Hagel C, Höller S, Kersten JF, Müller V, Jänicke F, et al: Protein expression analysis of ALCAM and CEACAM6 in breast cancer metastases reveals significantly increased ALCAM expression in metastases of the skin. J Clin Pathol. 64:146–152. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Maraqa L, Cummings M, Peter MB, Shaaban AM, Horgan K, Hanby AM and Speirs V: Carcinoembryonic antigen cell adhesion molecule 6 predicts breast cancer recurrence following adjuvant tamoxifen. Clin Cancer Res. 14:405–411. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Blumenthal RD, Leon E, Hansen HJ and Goldenberg DM: Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers. BMC Cancer. 7:22007. View Article : Google Scholar : PubMed/NCBI | |
|
Gomes IM, Maia CJ and Santos CR: STEAP proteins: From structure to applications in cancer therapy. Mol Cancer Res. 10:573–587. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Sano H, Wada S, Eguchi H, Osaki A, Saeki T and Nishiyama M: Quantitative prediction of tumor response to neoadjuvant chemotherapy in breast cancer: Novel marker genes and prediction model using the expression levels. Breast Cancer. 19:37–45. 2012. View Article : Google Scholar | |
|
Li CF, MacDonald JR, Wei RY, Ray J, Lau K, Kandel C, Koffman R, Bell S, Scherer SW and Alman BA: Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse. BMC Genomics. 8:922007. View Article : Google Scholar : PubMed/NCBI | |
|
Stone A, Valdés-Mora F, Gee JM, Farrow L, McClelland RA, Fiegl H, Dutkowski C, McCloy RA, Sutherland RL, Musgrove EA, et al: Tamoxifen-induced epigenetic silencing of oestrogen-regulated genes in anti-hormone resistant breast cancer. PLoS One. 7:e404662012. View Article : Google Scholar : PubMed/NCBI | |
|
Cimino D, Fuso L, Sfiligoi C, Biglia N, Ponzone R, Maggiorotto F, Russo G, Cicatiello L, Weisz A, Taverna D, et al: Identification of new genes associated with breast cancer progression by gene expression analysis of predefined sets of neoplastic tissues. Int J Cancer. 123:1327–1338. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Ito Y, Motoo Y, Yoshida H, Iovanna JL, Takamura Y, Miya A, Kuma K and Miyauchi A: Decreased expression of tumor protein p53-induced nuclear protein 1 (TP53INP1) in breast carcinoma. Anticancer Res. 26B:4391–4395. 2006. | |
|
Sorbello V, Fuso L, Sfiligoi C, Scafoglio C, Ponzone R, Biglia N, Weisz A, Sismondi P and De Bortoli M: Quantitative real-time RT-PCR analysis of eight novel estrogen-regulated genes in breast cancer. Int J Biol Markers. 18:123–129. 2003.PubMed/NCBI | |
|
He X, Dong DD, Yie SM, Yang H, Cao M, Ye SR, Li K, Liu J and Chen J: HLA-G expression in human breast cancer: Implications for diagnosis and prognosis, and effect on allocytotoxic lymphocyte response after hormone treatment in vitro. Ann Surg Oncol. 17:1459–1469. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Jia Y, Liu H, Zhuang Q, Xu S, Yang Z, Li J, Lou J and Zhang W: Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145. Oncol Rep. 27:1865–1872. 2012.PubMed/NCBI | |
|
Yin R, Zhang S, Wu Y, Fan X, Jiang F, Zhang Z, Feng D, Guo X and Xu L: MicroRNA-145 suppresses lung adenocarcinoma-initiating cell proliferation by targeting OCT4. Oncol Rep. 25:1747–1754. 2011.PubMed/NCBI | |
|
Xu N, Papagiannakopoulos T, Pan G, Thomson JA and Kosik KS: MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell. 137:647–658. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Kozomara A and Griffiths-Jones S: miRBase: Integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res. 39(Database): D152–D157. 2011. View Article : Google Scholar : | |
|
Cicatiello L, Mutarelli M, Grober OM, Paris O, Ferraro L, Ravo M, Tarallo R, Luo S, Schroth GP, Seifert M, et al: Estrogen receptor alpha controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs. Am J Pathol. 176:2113–2130. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Ali HO, Arroyo AB, González-Conejero R, Stavik B, Iversen N, Sandset PM, Martínez C and Skretting G: The role of microRNA-27a/b and microRNA-494 in estrogen-mediated downregulation of tissue factor pathway inhibitor α. J Thromb Haemost. 14:1226–1237. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Lee YM, Lee JY, Ho CC, Hong QS, Yu SL, Tzeng CR, Yang PC and Chen HW: miRNA-34b as a tumor suppressor in estrogen-dependent growth of breast cancer cells. Breast Cancer Res. 13:R1162011. View Article : Google Scholar : PubMed/NCBI | |
|
Bhat-Nakshatri P, Wang G, Collins NR, Thomson MJ, Geistlinger TR, Carroll JS, Brown M, Hammond S, Srour EF, Liu Y, et al: Estradiol-regulated microRNAs control estradiol response in breast cancer cells. Nucleic Acids Res. 37:4850–4861. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Tan S, Ding K, Li R, Zhang W, Li G, Kong X, Qian P, Lobie PE and Zhu T: Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2. Breast Cancer Res. 16:R402014. View Article : Google Scholar : PubMed/NCBI | |
|
Liao XH, Lu DL, Wang N, Liu LY, Wang Y, Li YQ, Yan TB, Sun XG, Hu P and Zhang TC: Estrogen receptor α mediates proliferation of breast cancer MCF-7 cells via a p21/PCNA/E2F1-dependent pathway. FEBS J. 281:927–942. 2014. View Article : Google Scholar | |
|
Zhang C, Zhao J and Deng H: 17β-estradiol up-regulates miR-155 expression and reduces TP53INP1 expression in MCF-7 breast cancer cells. Mol Cell Biochem. 379:201–211. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Masuda M, Miki Y, Hata S, Takagi K, Sakurai M, Ono K, Suzuki K, Yang Y, Abe E, Hirakawa H, et al: An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma. J Transl Med. 10(Suppl 1): S22012. View Article : Google Scholar : PubMed/NCBI | |
|
Manavalan TT, Teng Y, Litchfield LM, Muluhngwi P, Al-Rayyan N and Klinge CM: Reduced expression of miR-200 family members contributes to antiestrogen resistance in LY2 human breast cancer cells. PLoS One. 8:e623342013. View Article : Google Scholar : PubMed/NCBI | |
|
Yu Y, Xiao CH, Tan LD, Wang QS, Li XQ and Feng YM: Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-β signalling. Br J Cancer. 110:724–732. 2014. View Article : Google Scholar | |
|
Shibahara Y, Miki Y, Onodera Y, Hata S, Chan MS, Yiu CC, Loo TY, Nakamura Y, Akahira J, Ishida T, et al: Aromatase inhibitor treatment of breast cancer cells increases the expression of let-7f, a microRNA targeting CYP19A1. J Pathol. 227:357–366. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Yu X, Zhang X, Dhakal IB, Beggs M, Kadlubar S and Luo D: Induction of cell proliferation and survival genes by estradiol-repressed microRNAs in breast cancer cells. BMC Cancer. 12:292012. View Article : Google Scholar : PubMed/NCBI | |
|
Cittelly DM, Das PM, Spoelstra NS, Edgerton SM, Richer JK, Thor AD and Jones FE: Downregulation of miR-342 is associated with tamoxifen resistant breast tumors. Mol Cancer. 9:3172010. View Article : Google Scholar : PubMed/NCBI | |
|
Thornton JE and Gregory RI: How does Lin28 let-7 control development and disease? Trends Cell Biol. 22:474–482. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Quann K, Jing Y and Rigoutsos I: Post-transcriptional regulation of BRCA1 through its coding sequence by the miR-15/107 group of miRNAs. Front Genet. 6:2422015. View Article : Google Scholar : PubMed/NCBI | |
|
Fu XM, Zhou YZ, Cheng Z, Liao XB and Zhou XM: MicroRNAs: Novel players in aortic aneurysm. Biomed Res Int. 2015:8316412015. View Article : Google Scholar : PubMed/NCBI | |
|
Gambari R, Brognara E, Spandidos DA and Fabbri E: Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: New trends in the development of miRNA therapeutic strategies in oncology (Review). Int J Oncol. 49:5–32. 2016.PubMed/NCBI | |
|
Wang H, Zhang P, Chen W, Feng D, Jia Y and Xie LX: Evidence for serum miR-15a and miR-16 levels as biomarkers that distinguish sepsis from systemic inflammatory response syndrome in human subjects. Clin Chem Lab Med. 50:1423–1428. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
de Gonzalo-Calvo D, Davalos A, Montero A, Garcia-Gonzalez A, Tyshkovska I, Gonzalez-Medina A, Soares SM, Martínez-Camblor P, Casas-Agustench P, Rabadán M, et al: Circulating inflammatory miRNA signature in response to different doses of aerobic exercise. J Appl Physiol. 119:124–134. 1985. View Article : Google Scholar | |
|
Rodosthenous RS, Coull BA, Lu Q, Vokonas PS, Schwartz JD and Baccarelli AA: Ambient particulate matter and microRNAs in extracellular vesicles: A pilot study of older individuals. Part Fibre Toxicol. 13:132016. View Article : Google Scholar : PubMed/NCBI | |
|
Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R, Lovat F, Fadda P, Mao C, Nuovo GJ, et al: MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci USA. 109:E2110–E2116. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang L, Xu Y, Jin X, Wang Z, Wu Y, Zhao D, Chen G, LiD, Wang X, Cao H, et al: A circulating miRNA signature as a diagnostic biomarker for non-invasive early detection of breast cancer. Breast Cancer Res Treat. 154:423–434. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Zhang D, Wang F, Xu D, Guo Y and Cui W: Serum miRNAs panel (miR-16-2*, miR-195, miR-2861, miR-497) as novel non-invasive biomarkers for detection of cervical cancer. Sci Rep. 5:179422015. View Article : Google Scholar | |
|
Zhao Q, Deng S, Wang G, Liu C, Meng L, Qiao S, Shen L, Zhang Y, Lü J, Li W, et al: A direct quantification method for measuring plasma MicroRNAs identified potential biomarkers for detecting metastatic breast cancer. Oncotarget. 7:21865–21874. 2016.PubMed/NCBI |
