Salinomycin's potential to eliminate glioblastoma stem cells and treat glioblastoma multiforme (Review)

  • Authors:
    • Justin W. Magrath
    • Yonghyun Kim
  • View Affiliations

  • Published online on: July 27, 2017     https://doi.org/10.3892/ijo.2017.4082
  • Pages:753-759
Metrics: HTML 0 views | PDF 0 views     Cited By (CrossRef): 0 citations

Abstract

Glioblastoma multiforme (GBM) is the most common and deadliest form of primary brain tumor. Despite treatment with surgery, radiotherapy, and chemotherapy with the drug temozolomide, the expected survival after diagnosis remains low. The median survival is only 14.6 months and the two-year survival is a mere 30%. One reason for this is the heterogeneity of GBM including the presence of glioblastoma cancer stem cells (GSCs). GSCs are a subset of cells with the unique ability to proliferate, differentiate, and create tumors. GSCs are resistant to chemotherapy and radiation and thought to play an important role in recurrence. In order to effectively treat GBM, a drug must be identified that can kill GSCs. The ionophore salinomycin has been shown to kill cancer stem cells and is therefore a promising future treatment for GBM. This study focuses on salinomycin's potential to treat GBM including its ability to reduce the CSC population, its toxicity to normal brain cells, its mechanism of action, and its potential for combination treatment.

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Journal Cover

September 2017
Volume 51 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Magrath, J.W., & Magrath, J.W. (2017). Salinomycin's potential to eliminate glioblastoma stem cells and treat glioblastoma multiforme (Review). International Journal of Oncology, 51, 753-759. https://doi.org/10.3892/ijo.2017.4082
MLA
Magrath, J. W., Kim, Y."Salinomycin's potential to eliminate glioblastoma stem cells and treat glioblastoma multiforme (Review)". International Journal of Oncology 51.3 (2017): 753-759.
Chicago
Magrath, J. W., Kim, Y."Salinomycin's potential to eliminate glioblastoma stem cells and treat glioblastoma multiforme (Review)". International Journal of Oncology 51, no. 3 (2017): 753-759. https://doi.org/10.3892/ijo.2017.4082