MicroRNA-1271 functions as a metastasis and epithelial-mesenchymal transition inhibitor in human HCC by targeting the PTP4A1/c-Src axis

  • Authors:
    • Chao Li
    • Yezhen Jiang
    • Runchen Miao
    • Kai Qu
    • Jingyao Zhang
    • Chang Liu
  • View Affiliations

  • Published online on: December 11, 2017     https://doi.org/10.3892/ijo.2017.4224
  • Pages:536-546
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Abstract

MicroRNAs (miRNAs or miRs) have been shown to regulate hepatocellular carcinoma (HCC) metastasis. In the present study, we focused on the functions of miR-1271 in HCC metastasis. The downregulation of miR-1271 was found to be associated with to venous infiltration, an advanced TNM stage (III+IV stage) and a shorter survival time. Our in vitro and in vivo data demonstrated that miR-1271 prevented HCC cell migration and invasion, as well as the formation of lung metastatic clusters. In addition, miR-1271 was demonstrated to markedly inhibit the epithelial-mesenchymal transition (EMT) of HCC cells. Importantly, protein tyrosine phosphatase type IVA member 1 (PTP4A1) was identified as a direct downstream target of miR-1271 in HCC. Furthermore, we confirmed that the phosphorylation of c-Src at Tyr416 mediated by PTP4A1 was a potential anti-HCC mechanism of action of miR-1271. On the whole, our data indicate that miR-1271 inhibits HCC metastasis by targeting the PTP4A1/c-Src signaling pathway and may serve as a prospective cancer therapeutic target for HCC.

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February 2018
Volume 52 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Li, C., Jiang, Y., Miao, R., Qu, K., Zhang, J., & Liu, C. (2018). MicroRNA-1271 functions as a metastasis and epithelial-mesenchymal transition inhibitor in human HCC by targeting the PTP4A1/c-Src axis. International Journal of Oncology, 52, 536-546. https://doi.org/10.3892/ijo.2017.4224
MLA
Li, C., Jiang, Y., Miao, R., Qu, K., Zhang, J., Liu, C."MicroRNA-1271 functions as a metastasis and epithelial-mesenchymal transition inhibitor in human HCC by targeting the PTP4A1/c-Src axis". International Journal of Oncology 52.2 (2018): 536-546.
Chicago
Li, C., Jiang, Y., Miao, R., Qu, K., Zhang, J., Liu, C."MicroRNA-1271 functions as a metastasis and epithelial-mesenchymal transition inhibitor in human HCC by targeting the PTP4A1/c-Src axis". International Journal of Oncology 52, no. 2 (2018): 536-546. https://doi.org/10.3892/ijo.2017.4224