Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 
and matrix metallopeptidase-9 in vitro

Xu,Xiao-Man; Zhang,Yi; Qu,Dan; Feng,Xue-Wei; Chen,Yu; Zhao,Li

doi:10.3892/mmr.2012.1044

Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro

Authors:
- Xiao-Man Xu
- Yi Zhang
- Dan Qu
- Xue-Wei Feng
- Yu Chen
- Li Zhao
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Affiliations: Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
Published online on: August 21, 2012 https://doi.org/10.3892/mmr.2012.1044
Pages: 1018-1022

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Abstract

Osthole, a natural compound, may be extracted from Cnidium monnieri and other medicinal plants. Previous studies have shown that osthole has anticancer effects in various human cancer cell lines. There is, however, no available information concerning the effects of osthole on the migration and invasion of human lung cancer cells. In the current study, we used Transwell assays to demonstrate that osthole inhibited the migration and invasion of A549 human lung cancer cells. Western blot analysis revealed that osthole reduced the levels of matrix metalloproteinase-2 (MMP-2) and matrix metallopeptidase-9 (MMP-9) in the A549 human lung cancer cells. Our ﬁndings indicate that osthole may have a novel function as an inhibitor of the metastasis of human lung cancer.

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