Open Access

PKM2 and cancer: The function of PKM2 beyond glycolysis (Review)

  • Authors:
    • Gaochao Dong
    • Qixing Mao
    • Wenjie Xia
    • Youtao Xu
    • Jie Wang
    • Lin Xu
    • Feng Jiang
  • View Affiliations

  • Published online on: January 29, 2016     https://doi.org/10.3892/ol.2016.4168
  • Pages: 1980-1986
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Metabolic reprogramming is a hallmark of cancer cells and is used by cancer cells for growth and survival. Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth. The present review discusses the expression and regulation of PKM2, and reports the dominant role that PKM2 plays in glycolysis to achieve the nutrient demands of cancer cell proliferation. In addition, the present study discusses the non‑metabolic function of PKM2, and its role as a coactivator and protein kinase, which contributes to tumorigenesis. Furthermore, conflicting studies concerning the role of PKM2 as a therapeutic target are reviewed. The improved understanding of PKM2 may provide a noval approach for cancer treatment.

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March 2016
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Copy and paste a formatted citation
APA
Dong, G., Mao, Q., Xia, W., Xu, Y., Wang, J., Xu, L., & Jiang, F. (2016). PKM2 and cancer: The function of PKM2 beyond glycolysis (Review). Oncology Letters, 11, 1980-1986. https://doi.org/10.3892/ol.2016.4168
MLA
Dong, G., Mao, Q., Xia, W., Xu, Y., Wang, J., Xu, L., Jiang, F."PKM2 and cancer: The function of PKM2 beyond glycolysis (Review)". Oncology Letters 11.3 (2016): 1980-1986.
Chicago
Dong, G., Mao, Q., Xia, W., Xu, Y., Wang, J., Xu, L., Jiang, F."PKM2 and cancer: The function of PKM2 beyond glycolysis (Review)". Oncology Letters 11, no. 3 (2016): 1980-1986. https://doi.org/10.3892/ol.2016.4168