LncRNAs and cancer (Review)
- Authors:
- Rui Zhang
- Li Qiong Xia
- Wen Wen Lu
- Jing Zhang
- Jin‑Shui Zhu
-
Affiliations: Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Shanghai 200233, P.R. China - Published online on: June 23, 2016 https://doi.org/10.3892/ol.2016.4770
- Pages: 1233-1239
This article is mentioned in:
Abstract
|
Yu FJ, Zheng JJ, Dong PH and Fan XM: Long non-coding RNAs and hepatocellular carcinoma. Mol Clin Oncol. 3:13–17. 2015.PubMed/NCBI | |
|
Yao Y, Li J and Wang L: Large intervening non-coding RNA HOTAIR is an indicator of poor prognosis and a therapeutic target in human cancers. Int J Mol Sci. 15:18985–18999. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang HM, Yang FQ, Yan Y, Che JP and Zheng JH: High expression of long non-coding RNA SPRY4-IT1 predicts poor prognosis of clear cell renal cell carcinoma. Int J Clin Exp Pathol. 7:5801–5809. 2014.PubMed/NCBI | |
|
Hansji H, Leung EY, Baguley BC, Finlay GJ and Askarian-Amiri ME: Keeping abreast with long non-coding RNAs in mammary gland development and breast cancer. Front Genet. 5:3792014. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Zhang R, Qiu F, Li K, Zhou Y, Shang D and Xu Y: Construction of a lncRNA-PCG bipartite network and identification of cancer-related lncRNAs: A case study in prostate cancer. Mol BioSyst. 11:384–393. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, Guernec G, Martin D, Merkel A, Knowles DG, et al: The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution and expression. Genome Res. 22:1775–1789. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Chen LL and Carmichael GG: Long noncoding RNAs in mammalian cells: What, where and why? Wiley Interdiscip Rev RNA. 1:2–21. 2010.PubMed/NCBI | |
|
Wilusz JE, Sunwoo H and Spector DL: Long noncoding RNAs: Functional surprises from the RNA world. Genes Dev. 23:1494–1504. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Fritah S, Niclou SP and Azuaje F: Databases for lncRNAs: A comparative evaluation of emerging tools. RNA. 20:1655–1665. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Cogill SB and Wang L: Co-expression network analysis of human lncRNAs and cancer genes. Cancer Inform. 13(Suppl 5): S49–S59. 2014. | |
|
Xu Y, Wang J, Qiu M and Xu L, Li M, Jiang F, Yin R and Xu L: Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma. Tumour Biol. 36:1643–1651. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Guo H, Wu L, Yang Q, Ye M and Zhu X: Functional linc-POU3F3 is overexpressed and contributes to tumorigenesis in glioma. Gene. 554:114–119. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Li W, Zheng J, Deng J, You Y, Wu H, Li N, Lu J and Zhou Y: Increased levels of the long intergenic non-protein coding RNA POU3F3 promote DNA methylation in esophageal squamous cell carcinoma cells. Gastroenterology. 146:1714–1726. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Li Q, Shao Y, Zhang X, Miao M, Qin L, Wang B, Ye G, Xiao B and Guo J: Plasma long noncoding RNA protected by exosomes as a potential stable biomarker for gastric cancer. Tumour Biol. 36:2007–2012. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Hu Y, Wang J, Qian J, Kong X, Tang J, Wang Y, Chen H, Hong J, Zou W, Chen Y, et al: Long noncoding RNA GAPLINC regulates CD44-dependent cell invasiveness and associates with poor prognosis of gastric cancer. Cancer Res. 74:6890–6902. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Ding J, Li D, Gong M, Wang J, Huang X, Wu T and Wang C: Expression and clinical significance of the long non-coding RNA PVT1 in human gastric cancer. Onco Targets Ther. 7:1625–1630. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Guo W, Dong Z, Bai Y, Guo Y, Shen S, Kuang G and Xu J: Associations between polymorphisms of HOTAIR and risk of gastric cardia adenocarcinoma in a population of north China. Tumour Biol. 36:2845–2854. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Xu TP, Huang MD, Xia R, Liu XX, Sun M, Yin L, Chen WM, Han L, Zhang EB, Kong R, et al: Decreased expression of the long non-coding RNA FENDRR is associated with poor prognosis in gastric cancer and FENDRR regulates gastric cancer cell metastasis by affecting fibronectin1 expression. J Hematol Oncol. 7:632014. View Article : Google Scholar : PubMed/NCBI | |
|
Chen X, Sun J, Song Y, Gao P, Zhao J, Huang X, Liu B, Xu H and Wang Z: The novel long noncoding RNA AC138128.1 may be a predictive biomarker in gastric cancer. Med Oncol. 31:2622014. View Article : Google Scholar : PubMed/NCBI | |
|
Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E and Chang HY: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell. 129:1311–1323. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Xue Y, Gu D, Ma G, Zhu L, Hua Q, Chu H, Tong N, Chen J, Zhang Z and Wang M: Genetic variants in lncRNA HOTAIR are associated with risk of colorectal cancer. Mutagenesis. 30:303–310. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Xue Y, Ma G, Gu D, Zhu L, Hua Q, Du M, Chu H, Tong N, Chen J, Zhang Z and Wang M: Genome-wide analysis of long noncoding RNA signature in human colorectal cancer. Gene. 556:227–234. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wang P, Liu YH, Yao YL, Li Z, Li ZQ, Ma J and Xue YX: Long non-coding RNA CASC2 suppresses malignancy in human gliomas by miR-21. Cell Signal. 27:275–282. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Yin D, He X, Zhang E, Kong R, De W and Zhang Z: Long noncoding RNA GAS5 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer. Med Oncol. 31:2532014. View Article : Google Scholar : PubMed/NCBI | |
|
Xu X, Yuan J, Zuo Z, Yu Z, Liu Y and Fu C: Expression of long non-coding RNA associated with radiotherapy-resistance in colorectal cancer cell lines with different radiosensitivity. Zhonghua Wei Chang Wai Ke Za Zhi. 17:1096–1100. 2014.(In Chinese). PubMed/NCBI | |
|
Cao C, Sun J, Zhang D, Guo X, Xie L, Li X, Wu D and Liu L: The long intergenic noncoding RNA UFC1, a target of microRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of β-catenin in HCC cells. Gastroenterology. 148:415–426, e18. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Yu W, Qiao Y, Tang X, Ma L, Wang Y, Zhang X, Weng W, Pan Q, Yu Y, Sun F and Wang J: Tumor suppressor long non-coding RNA, MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver cancer cells. Cell Signal. 26:2961–2968. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Ma MZ, Kong X, Weng MZ, Zhang MD, Qin YY, Gong W, Zhang WJ and Quan ZW: Long non-coding RNA-LET is a positive prognostic factor and exhibits tumor-suppressive activity in gallbladder cancer. Mol Carcinog. 54:1397–1406. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Pang EJ, Yang R, Fu XB and Liu YF: Overexpression of long non-coding RNA MALAT1 is correlated with clinical progression and unfavorable prognosis in pancreatic cancer. Tumour Biol. 36:2403–2407. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Jiao F, Hu H, Yuan C and Wang L, Jiang W, Jin Z, Guo Z and Wang L: Elevated expression level of long noncoding RNA MALAT-1 facilitates cell growth, migration and invasion in pancreatic cancer. Oncol Rep. 32:2485–2492. 2014.PubMed/NCBI | |
|
Peng W, Gao W and Feng J: Long noncoding RNA HULC is a novel biomarker of poor prognosis in patients with pancreatic cancer. Med Oncol. 31:3462014. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Liu D, Hua R, Zhang J, Liu W, Huo Y, Cheng Y, Hong J and Sun Y: Long non-coding RNAs expressed in pancreatic ductal adenocarcinoma and lncRNA BC008363 an independent prognostic factor in PDAC. Pancreatology. 14:385–390. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Xu G, Chen W, Pan Q, Huang K, Pan J, Zhang W and Chen J: Detection of long-chain non-encoding RNA differential expression in non-small cell lung cancer by microarray analysis and preliminary verification. Mol Med Rep. 11:1925–1932. 2015.PubMed/NCBI | |
|
Yang YR, Zang SZ, Zhong CL, Li YX, Zhao SS and Feng XJ: Increased expression of the lncRNA PVT1 promotes tumorigenesis in non-small cell lung cancer. Int J Clin Exp Pathol. 7:6929–6935. 2014.PubMed/NCBI | |
|
Cheng N, Li X, Zhao C, Ren S, Chen X, Cai W, Zhao M, Zhang Y, Li J, Wang Q and Zhou C: Microarray expression profile of long non-coding RNAs in EGFR-TKIs resistance of human non-small cell lung cancer. Oncol Rep. 33:833–839. 2015.PubMed/NCBI | |
|
Liu Y, Luo F, Xu Y, Wang B, Zhao Y, Xu W, Shi L, Lu X and Liu Q: Epithelial-mesenchymal transition and cancer stem cells, mediated by a long non-coding RNA, HOTAIR, are involved in cell malignant transformation induced by cigarette smoke extract. Toxicol Appl Pharmacol. 282:9–19. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Loewen G, Jayawickramarajah J, Zhuo Y and Shan B: Functions of lncRNA HOTAIR in lung cancer. J Hematol Oncol. 7:902014. View Article : Google Scholar : PubMed/NCBI | |
|
Shen L, Chen L, Wang Y, Jiang X, Xia H and Zhuang Z: Long noncoding RNA MALAT1 promotes brain metastasis by inducing epithelial-mesenchymal transition in lung cancer. J Neurooncol. 121:101–108. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Luo J, Tang L, Zhang J, Ni J, Zhang HP, Zhang L, Xu JF and Zheng D: Long non-coding RNA CARLo-5 is a negative prognostic factor and exhibits tumor pro-oncogenic activity in non-small cell lung cancer. Tumour Biol. 35:11541–11549. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
You QY, Tao H and Ling B: Long noncoding RNA HOX transcript antisense intergenic RNA (HOTAIR) as a foe and novel potential therapeutic target for endometrial carcinoma. Int J Gynecol Cancer. 24:15362014. View Article : Google Scholar : PubMed/NCBI | |
|
Kim HJ, Lee DW, Yim GW, Nam EJ, Kim S, Kim SW and Kim YT: Long non-coding RNA HOTAIR is associated with human cervical cancer progression. Int J Oncol. 46:521–530. 2015.PubMed/NCBI | |
|
Cao S, Liu W, Li F, Zhao W and Qin C: Decreased expression of lncRNA GAS5 predicts a poor prognosis in cervical cancer. Int J Clin Exp Pathol. 7:6776–6783. 2014.PubMed/NCBI | |
|
Kang L, Sun J, Wen X, Cui J, Wang G, Hoffman AR, Hu JF and Li W: Aberrant allele-switch imprinting of a novel IGF1R intragenic antisense non-coding RNA in breast cancers. Eur J Cancer. 51:260–270. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Su X, Malouf GG, Chen Y, Zhang J, Yao H, Valero V, Weinstein JN, Spano JP, Meric-Bernstam F, Khayat D and Esteva FJ: Comprehensive analysis of long non-coding RNAs in human breast cancer clinical subtypes. Oncotarget. 5:9864–9876. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Chi Y, Huang S, Yuan L, Liu M, Huang N, Zhou S, Zhou B and Wu J: Role of BC040587 as a predictor of poor outcome in breast cancer. Cancer Cell Int. 14:1232014. View Article : Google Scholar : PubMed/NCBI | |
|
Gao Y, Meng H, Liu S, Hu J, Zhang Y, Jiao T, Liu Y, Ou J, Wang D, Yao L, et al: LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b. Hum Mol Genet. 24:841–852. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang HM, Yang FQ, Chen SJ, Che J and Zheng JH: Upregulation of long non-coding RNA MALAT1 correlates with tumor progression and poor prognosis in clear cell renal cell carcinoma. Tumour Biol. 36:2947–2955. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou W, Tao Z, Wang Z, Hu W, Shen M, Zhou L, Wen Z, Yu Z, Wu X, Huang K, et al: Long noncoding RNA PCA3 gene promoter region is related to the risk of prostate cancer on Chinese males. Exp Mol Pathol. 97:550–553. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Liu XJ and Yao XD: Function of PCA3 in prostate tissue and clinical research progress on developing a PCA3 score. Chin J Cancer Res. 26:493–500. 2014.PubMed/NCBI | |
|
Hu CC, Gan P, Zhang RY, Xue JX and Ran LK: Identification of Prostate Cancer LncRNAs by RNA-Seq. Asian Pac J Cancer Prev. 15:9439–9444. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Prensner JR, Chen W, Han S, Iyer MK, Cao Q, Kothari V, Evans JR, Knudsen KE, Paulsen MT, Ljungman M, et al: The long non-coding RNA PCAT-1 promotes prostate cancer cell proliferation through cMyc. Neoplasia. 16:900–908. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Chakravarty D, Sboner A, Nair SS, Giannopoulou E, Li R, Hennig S, Mosquera JM, Pauwels J, Park K, Kossai M, et al: The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nat Commun. 5:53832014. View Article : Google Scholar : PubMed/NCBI | |
|
Li LJ, Zhu JL, Bao WS, Chen DK, Huang WW and Weng ZL: Long noncoding RNA GHET1 promotes the development of bladder cancer. Int J Clin Exp Pathol. 7:7196–7205. 2014.PubMed/NCBI | |
|
Zhang K, Sun X, Zhou X, Han L, Chen L, Shi Z, Zhang A, Ye M, Wang Q, Liu C, et al: Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner. Oncotarget. 6:537–546. 2015.PubMed/NCBI | |
|
Galasso M, Dama P, Previati M, Sandhu S, Palatini J, Coppola V, Warner S, Sana ME, Zanella R, Abujarour R, et al: A large scale expression study associates uc.283-plus lncRNA with pluripotent stem cells and human glioma. Genome Med. 6:762014. View Article : Google Scholar : PubMed/NCBI | |
|
Zeng C, Xu Y, Xu L, Yu X, Cheng J, Yang L, Chen S and Li Y: Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells. BMC Cancer. 14:6932014. View Article : Google Scholar : PubMed/NCBI | |
|
Cho SF, Chang YC, Chang CS, Lin SF, Liu YC, Hsiao HH, Chang JG and Liu TC: MALAT1 long non-coding RNA is overexpressed in multiple myeloma and may serve as a marker to predict disease progression. BMC Cancer. 14:8092014. View Article : Google Scholar : PubMed/NCBI | |
|
Dong Y, Liang G, Yuan B, Yang C, Gao R and Zhou X: MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway. Tumour Biol. 36:1477–1486. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Pasic I, Shlien A, Durbin AD, Stavropoulos DJ, Baskin B, Ray PN, Novokmet A and Malkin D: Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma. Cancer Res. 70:160–171. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Guo Q, Zhao Y, Chen J, Wang S, Hu J and Sun Y: BRAF-activated long non-coding RNA contributes to cell proliferation and activates autophagy in papillary thyroid carcinoma. Oncol Lett. 8:1947–1952. 2014.PubMed/NCBI | |
|
Flockhart RJ, Webster DE, Qu K, Mascarenhas N, Kovalski J, Kretz M and Khavari PA: BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration. Genome Res. 22:1006–1014. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Mazar J, Zhao W, Khalil AM, Lee B, Shelley J, Govindarajan SS, Yamamoto F, Ratnam M, Aftab MN, Collins S, et al: The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma cells. Oncotarget. 5:8959–8969. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Rahimy E, Kuo SZ and Ongkeko WM: Evaluation of non-coding RNAs as potential targets in head and neck squamous cell carcinoma cancer stem cells. Curr Drug Targets. 15:1247–1260. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Liu G, Wang G, Zhong Q, Chen X, Fang J and Huang Z: Prediction of new long non-coding RNA of laryngeal carcinoma by high-throughput RNA-Seq data. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 49:637–642. 2014.(In Chinese). PubMed/NCBI | |
|
Sun M and Kraus WL: From discovery to function: The expanding roles of long non-coding RNAs in physiology and disease. Endocr Rev. Jan 7–2015.(Epub ahead of print). View Article : Google Scholar |
