Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer

Suzuki,Hidenori; Nishio,Masami; Nakanishi,Hayao; Hanai,Nobuhiro; Hirakawa,Hitoshi; Kodaira,Takeshi; Tamaki,Tsuneo; Hasegawa,Yasuhisa

doi:10.3892/ol.2016.4765

Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer

Authors:
- Hidenori Suzuki
- Masami Nishio
- Hayao Nakanishi
- Nobuhiro Hanai
- Hitoshi Hirakawa
- Takeshi Kodaira
- Tsuneo Tamaki
- Yasuhisa Hasegawa
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Affiliations: Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan, Department of Radiology, Nagoya Positron Emission Tomography Imaging Center, Nagoya, Aichi 454‑0933, Japan, Department of Pathology, Aichi Cancer Center Aichi Hospital, Okazaki, Aichi 444‑0011, Japan, Department of Radiation Oncology, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan, Department of Radiology, East Nagoya Positron Emission Tomography Imaging Center, Nagoya, Aichi 464‑0044, Japan
Published online on: June 23, 2016 https://doi.org/10.3892/ol.2016.4765
Pages: 1493-1500

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Abstract

The present study investigated the possible correlation between 18F-2-fluorodeoxyglucose (18F-FDG)-uptake parameters and clinicopathological parameters in hypopharyngeal squamous cell carcinoma (HPSCC). A total of 53 patients, newly diagnosed with HPSCC, received pretreatment 18F-FDG-positron emission tomography/computed tomography (PET/CT). Metabolic tumor volume (MTV), total lesion glycolysis (TLG), and maximum and peak standardized uptake values (SUVmax and SUVpeak) were calculated as 18F‑FDG‑uptake parameters of the primary tumor. Tumor thickness, depth of invasion and pathological tumor volume were pathologically measured. Upon univariate survival analysis, SUVmax ≥28.5, SUVpeak ≥19, MTV ≥12 and TLG ≥42 were significantly associated with a shorter overall survival (OS) time, and MTV ≥12 and TLG ≥42 were significantly associated with a shorter distant metastasis‑free survival (DMFS) time. Upon multivariate analysis with adjustment for clinical T category and treatment group, patients with SUVmax ≥28.5 exhibited a significantly shorter OS time, while TLG ≥42 was significantly correlated with shorter OS and DMFS times. Upon simple regression analysis, TLG was found to be significantly associated with tumor thickness and depth of invasion, while MTV was found to be closely associated with pathological tumor volume. In conclusion, pretreatment 18F‑FDG‑PET/CT is likely to provide valuable prognostic parameters in HPSCC.

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