Open Access

Mammalian sterile 20‑like kinase 1 expression and its prognostic significance in patients with breast cancer

  • Authors:
    • Xiao‑Yan Lin
    • Feng‑Feng Cai
    • Ming‑Hong Wang
    • Xin Pan
    • Fang Wang
    • Lu Cai
    • Rong‑Rong Cui
    • Su Chen
    • Ewelina Biskup
  • View Affiliations

  • Published online on: August 28, 2017     https://doi.org/10.3892/ol.2017.6852
  • Pages: 5457-5463
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Mammalian sterile 20‑like kinase 1 (Mst1) is a major inhibitor of cell proliferation, and is involved in apoptosis, oncogenesis and organ growth via its ubiquitously encoded serine threonine kinase. Previous studies have demonstrated that Mst1 has a tumor suppressor function in human breast cancer. Mst1 deletion or mutation is associated with tumorigenesis, whereas Mst1 overexpression leads to tumor cell apoptosis and decreases proliferation of tumor cells. Our previous study reported the tumor suppressive function of Mst1, and debated Mst1 as a prognostic factor in human breast cancer. In the present study, Mst1 levels were measured in the plasma of patients in order to elucidate their association with overall and disease‑free survival. The results of the present study indicated that Mst1 is a strong prognostic and predictive factor in human breast cancer and a promising anticancer target.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Lin XY, Cai FF, Wang MH, Pan X, Wang F, Cai L, Cui RR, Chen S and Biskup E: Mammalian sterile 20‑like kinase 1 expression and its prognostic significance in patients with breast cancer. Oncol Lett 14: 5457-5463, 2017.
APA
Lin, X., Cai, F., Wang, M., Pan, X., Wang, F., Cai, L. ... Biskup, E. (2017). Mammalian sterile 20‑like kinase 1 expression and its prognostic significance in patients with breast cancer. Oncology Letters, 14, 5457-5463. https://doi.org/10.3892/ol.2017.6852
MLA
Lin, X., Cai, F., Wang, M., Pan, X., Wang, F., Cai, L., Cui, R., Chen, S., Biskup, E."Mammalian sterile 20‑like kinase 1 expression and its prognostic significance in patients with breast cancer". Oncology Letters 14.5 (2017): 5457-5463.
Chicago
Lin, X., Cai, F., Wang, M., Pan, X., Wang, F., Cai, L., Cui, R., Chen, S., Biskup, E."Mammalian sterile 20‑like kinase 1 expression and its prognostic significance in patients with breast cancer". Oncology Letters 14, no. 5 (2017): 5457-5463. https://doi.org/10.3892/ol.2017.6852