Open Access

Classification and survival prediction for early‑stage lung adenocarcinoma and squamous cell carcinoma patients

  • Authors:
    • Suyan Tian
  • View Affiliations

  • Published online on: August 28, 2017     https://doi.org/10.3892/ol.2017.6835
  • Pages: 5464-5470
  • Copyright: © Tian . This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Non‑small cell lung cancer (NSCLC) is a leading cause of cancer‑associated mortality worldwide. Adenocarcinoma (AC) and squamous cell carcinoma (SCC) are two primary histological subtypes of NSCLC, accounting for ~70% of lung cancer cases. Increasing evidence suggests that AC and SCC differ in the composition of genes and molecular characteristics. Previous research has focused on distinguishing AC from SCC or predicting the NSCLC patient survival rates using gene expression profiles, usually with the aid of a feature selection method. The present study conducted a pre‑filtering to identify the genes that have significant expression values and a high connection with other genes in the gene network, and then used the radial coordinate visualization method to identify relevant genes. By applying the proposed procedure to NSCLC data, it was demonstrated that there is a clear segmentation between AC and SCC, however not between patients with a good prognosis and bad prognosis. The focus of discriminating AC and SCC differs from survival prediction and there are almost no overlaps between the two gene signatures. Overall, a supervised learning method is preferred and future studies aiming to identify prognostic gene signatures with an increased prediction efficiency are required.
View Figures
View References

Related Articles

Journal Cover

November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Tian S: Classification and survival prediction for early‑stage lung adenocarcinoma and squamous cell carcinoma patients. Oncol Lett 14: 5464-5470, 2017.
APA
Tian, S. (2017). Classification and survival prediction for early‑stage lung adenocarcinoma and squamous cell carcinoma patients. Oncology Letters, 14, 5464-5470. https://doi.org/10.3892/ol.2017.6835
MLA
Tian, S."Classification and survival prediction for early‑stage lung adenocarcinoma and squamous cell carcinoma patients". Oncology Letters 14.5 (2017): 5464-5470.
Chicago
Tian, S."Classification and survival prediction for early‑stage lung adenocarcinoma and squamous cell carcinoma patients". Oncology Letters 14, no. 5 (2017): 5464-5470. https://doi.org/10.3892/ol.2017.6835