Open Access

Expression of the cytoskeleton regulatory protein Mena in human gastric carcinoma and its prognostic significance

  • Authors:
    • Lihua Xu
    • Huo Tan
    • Ruiming Liu
    • Qungai Huang
    • Nana Zhang
    • Xi Li
    • Jiani Wang
  • View Affiliations

  • Published online on: September 15, 2017     https://doi.org/10.3892/ol.2017.6974
  • Pages: 6024-6030
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The cytoskeleton regulatory protein Mena is reportedly overexpressed in breast cancer; however, data regarding its expression level and clinical significance in gastric carcinoma (GC) is limited. The aim of the present study was to investigate Mena expression levels and prognostic significance in GC. Mena mRNA expression level was determined by reverse transcription‑quantitative polymerase chain reaction in 10 paired GC and adjacent normal tissues. The Mena protein expression level was analyzed in paraffin‑embedded GC samples and adjacent normal tissues by immunohistochemistry. Statistical analyses were also performed to evaluate the clinicopathological significance of Mena. The results revealed that the mRNA expression level of Mena was significantly higher in G Ct issues compared with in adjacent normal tissues from10 paired samples. In the paraffin‑embedded tissue samples, the protein expression level of Mena was higher in G Ct issues compared with in adjacent normal tissues. Compared with adjacent normal tissues, Mena overexpression was observed in 52.83% (56/106) of patients. The overexpression of Mena was significantly associated with the T stage (P=0.033), tumor‑node‑metastasis (TNM) stage (P<0.001) and decreased overall survival (P<0.001). Based on a multivariate analysis, Mena expression level was an independent prognostic factor for overall survival time. In conclusion, Mena wasoverexpressed in G C tissues and significantly associated with the T stage, TNM stage and overall survival time. Mena may therefore be suitable as a prognostic indicator for patients with GC.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xu L, Tan H, Liu R, Huang Q, Zhang N, Li X and Wang J: Expression of the cytoskeleton regulatory protein Mena in human gastric carcinoma and its prognostic significance. Oncol Lett 14: 6024-6030, 2017
APA
Xu, L., Tan, H., Liu, R., Huang, Q., Zhang, N., Li, X., & Wang, J. (2017). Expression of the cytoskeleton regulatory protein Mena in human gastric carcinoma and its prognostic significance. Oncology Letters, 14, 6024-6030. https://doi.org/10.3892/ol.2017.6974
MLA
Xu, L., Tan, H., Liu, R., Huang, Q., Zhang, N., Li, X., Wang, J."Expression of the cytoskeleton regulatory protein Mena in human gastric carcinoma and its prognostic significance". Oncology Letters 14.5 (2017): 6024-6030.
Chicago
Xu, L., Tan, H., Liu, R., Huang, Q., Zhang, N., Li, X., Wang, J."Expression of the cytoskeleton regulatory protein Mena in human gastric carcinoma and its prognostic significance". Oncology Letters 14, no. 5 (2017): 6024-6030. https://doi.org/10.3892/ol.2017.6974