AXL is a marker for epithelial‑mesenchymal transition in esophageal squamous cell carcinoma

  • Authors:
    • Guoan Zhang
    • Xia Kong
    • Meng Wang
    • Hongli Zhao
    • Sha Han
    • Ronghang Hu
    • Jian Huang
    • Wen Cui
  • View Affiliations

  • Published online on: November 20, 2017     https://doi.org/10.3892/ol.2017.7443
  • Pages:1900-1906
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Abstract

Esophageal squamous cell carcinoma (ESCC) is a common cancer in China and certain other parts of the world with a dismal prognosis for affected patients. AXL is a member of the TYRO3‑AXL‑MER family of receptor tyrosine kinases, and has been revealed to be an important mediator of epithelial‑mesenchymal transition (EMT) in several types of cancer. However, to the best of our knowledge, its function in EMT in ESCC cells has not yet been examined. The present study employed two independent ESCC mRNA profile datasets and revealed that AXL is associated with several EMT markers. Gene Set Enrichment Analysis indicated that EMT occurs more in ESCC with high AXL expression. Analysis on another dataset demonstrated further that increased expression of AXL in ESCC is associated with increased migratory ability. Collectively, the results of the present study provide evidence that AXL is a marker for EMT in ESCC.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Zhang, G., Kong, X., Wang, M., Zhao, H., Han, S., Hu, R. ... Cui, W. (2018). AXL is a marker for epithelial‑mesenchymal transition in esophageal squamous cell carcinoma. Oncology Letters, 15, 1900-1906. https://doi.org/10.3892/ol.2017.7443
MLA
Zhang, G., Kong, X., Wang, M., Zhao, H., Han, S., Hu, R., Huang, J., Cui, W."AXL is a marker for epithelial‑mesenchymal transition in esophageal squamous cell carcinoma". Oncology Letters 15.2 (2018): 1900-1906.
Chicago
Zhang, G., Kong, X., Wang, M., Zhao, H., Han, S., Hu, R., Huang, J., Cui, W."AXL is a marker for epithelial‑mesenchymal transition in esophageal squamous cell carcinoma". Oncology Letters 15, no. 2 (2018): 1900-1906. https://doi.org/10.3892/ol.2017.7443