Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review)

  • Authors:
    • Zhong‑Tian Bai
    • Bing Bai
    • Jun Zhu
    • Cui‑Xia Di
    • Xun Li
    • Wen‑Ce Zhou
  • View Affiliations

  • Published online on: December 13, 2017     https://doi.org/10.3892/ol.2017.7597
  • Pages:2049-2056
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Abstract

Carcinogenesis is known to be primarily associa­ted with gene mutations. Recently, increasing evidence has suggested that epigenetic events also serve crucial roles in tumor etiology. Environmental factors, including nutrition, toxicants and ethanol, are involved in carcinogenesis through inducing epigenetic modifications, such as DNA methylation, histone deacetylase and miRNA regulation. Studying epigenetic mechanisms has facilitated the development of early diagnostic strategies and potential therapeutic avenues. Modulation at the epigenetic level, including reversing epigenetic modifications using targeted drugs, has demonstrated promise in cancer therapy. Therefore, identifying novel epigenetic biomarkers and therapeutic targets has potential for the future of cancer therapy. The present review discusses the environmental factors involved in epigenetic modifications and potential drug candidates for cancer therapy.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
(total number of cites)

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APA
Bai, Z., Bai, B., Zhu, J., Di, C., Li, X., & Zhou, W. (2018). Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review). Oncology Letters, 15, 2049-2056. https://doi.org/10.3892/ol.2017.7597
MLA
Bai, Z., Bai, B., Zhu, J., Di, C., Li, X., Zhou, W."Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review)". Oncology Letters 15.2 (2018): 2049-2056.
Chicago
Bai, Z., Bai, B., Zhu, J., Di, C., Li, X., Zhou, W."Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review)". Oncology Letters 15, no. 2 (2018): 2049-2056. https://doi.org/10.3892/ol.2017.7597