Open Access

Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC‑7901 cells

  • Authors:
    • Junlan Qiu
    • Liang Tao
    • Qiang Wei
    • Pingyang Zhang
  • View Affiliations

  • Published online on: December 8, 2017     https://doi.org/10.3892/ol.2017.7558
  • Pages:2147-2152
  • Copyright: © Qiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

ADP-ribosylation factor 6 (Arf6), a member of the ADP‑ribosylation factor family, is overexpressed in different types of cancer cell and promotes invasion, metastasis and drug resistance. However, the potential functions of Arf6 in gastric cancer (GC), and the molecular mechanism underlying these functions, remain to be fully elucidated. In the present study, the results demonstrated that in vitro knockdown of Arf6 decreased proliferation, colony formation, migration and invasion in SGC‑7901 cells. Arf6 knockdown also markedly decreased the activity of the extracellular signal‑regulated kinase 1/2 (ERK1/2) signaling pathway. Furthermore, knockdown of Arf6 was associated with elevated chemosensitivity of SGC‑7901 cells to 5‑fluorouracil through inactivation of the ERK1/2 signaling pathway. Taken together, these results suggest that Arf6 is involved in regulating proliferation, migration, invasion and drug resistance in GC, and may be a potential therapeutic target for the treatment of GC.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Qiu, J., Tao, L., Wei, Q., & Zhang, P. (2018). Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC‑7901 cells. Oncology Letters, 15, 2147-2152. https://doi.org/10.3892/ol.2017.7558
MLA
Qiu, J., Tao, L., Wei, Q., Zhang, P."Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC‑7901 cells". Oncology Letters 15.2 (2018): 2147-2152.
Chicago
Qiu, J., Tao, L., Wei, Q., Zhang, P."Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC‑7901 cells". Oncology Letters 15, no. 2 (2018): 2147-2152. https://doi.org/10.3892/ol.2017.7558