Advances in the mechanisms of action of cancer-targeting oncolytic viruses (Review)

  • Authors:
    • Cun‑Zhi Lin
    • Gui‑Ling Xiang
    • Xin‑Hong Zhu
    • Lu‑Lu Xiu
    • Jia‑Xing Sun
    • Xiao‑Yuan Zhang
  • View Affiliations

  • Published online on: January 19, 2018     https://doi.org/10.3892/ol.2018.7829
  • Pages: 4053-4060
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Cancer virotherapy mediated by oncolytic viruses (OV), has emerged as a novel and effective strategy in cancer therapeutics. Preclinical models have demonstrated anticancer activity against numerous types of cancer. Currently, a number of recombinant viruses are in late phase clinical trials, many of which have demonstrated promising results regarding the safety and reliability of the treatments, particularly when combined with standard antineoplastic therapies. In addition to molecular‑targeted therapeutics, genetic engineering of the viruses allows functional complementation to chemotherapy or radiotherapy agents. Co‑administration of chemotherapy or radiotherapy is imperative for an effective treatment regime. Additionally, these approaches may be used in combination with current treatments to assist in cancer management. The near future may reveal whether this renewed interest in oncological virotherapy will result in meaningful therapeutic effects in patients. The aim of the present review was to highlight how the knowledge of oncolytic viral specificity and cytotoxicity has advanced in recent years, with a view to discuss OV in clinical application and the future directions of this field.
View Figures
View References

Related Articles

Journal Cover

April-2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Lin CZ, Xiang GL, Zhu XH, Xiu LL, Sun JX and Zhang XY: Advances in the mechanisms of action of cancer-targeting oncolytic viruses (Review). Oncol Lett 15: 4053-4060, 2018
APA
Lin, C., Xiang, G., Zhu, X., Xiu, L., Sun, J., & Zhang, X. (2018). Advances in the mechanisms of action of cancer-targeting oncolytic viruses (Review). Oncology Letters, 15, 4053-4060. https://doi.org/10.3892/ol.2018.7829
MLA
Lin, C., Xiang, G., Zhu, X., Xiu, L., Sun, J., Zhang, X."Advances in the mechanisms of action of cancer-targeting oncolytic viruses (Review)". Oncology Letters 15.4 (2018): 4053-4060.
Chicago
Lin, C., Xiang, G., Zhu, X., Xiu, L., Sun, J., Zhang, X."Advances in the mechanisms of action of cancer-targeting oncolytic viruses (Review)". Oncology Letters 15, no. 4 (2018): 4053-4060. https://doi.org/10.3892/ol.2018.7829