Low scavenger receptor class B type I expression is associated with gastric adenocarcinoma tumor aggressiveness

  • Authors:
    • Xingwen Wang
    • Changshun Wu
    • Baoying Yuan
    • Dan Wang
    • Huiling Liu
    • Hong Feng
    • Shui Sun
  • View Affiliations

  • Published online on: January 29, 2018     https://doi.org/10.3892/ol.2018.7889
  • Pages:4604-4610
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Abstract

Scavenger receptor class B type I (SR‑BI), a well‑documented high‑density lipoprotein receptor, has been implicated in the development and progression of human cancer. However, little is known regarding the expression profile and clinical value of SR‑BI in gastric adenocarcinoma. In the present study immunohistochemistry analysis was performed on a well‑annotated gastric adenocarcinoma tissue microarray to investigate the association between SR‑BI expression and clinicopathological parameters or patient outcome. The results revealed that SR‑BI expression was detected in 69% of the 84 gastric adenocarcinomas. Moreover, a significant association was observed between low SR‑BI expression and poor histological grade, higher Tumor‑Node‑Metastasis T stage, higher N stage and diffuse type carcinoma. Low SR‑BI expression was also significantly associated with a shorter overall survival time in patients with gastric adenocarcinoma, although it was not an independent prognostic factor. Overall, the results of the present study demonstrated that SR‑BI was possibly involved in gastric carcinogenesis and could be used as a biomarker to predict malignancy of gastric adenocarcinoma.

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April 2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Wang, X., Wu, C., Yuan, B., Wang, D., Liu, H., Feng, H., & Sun, S. (2018). Low scavenger receptor class B type I expression is associated with gastric adenocarcinoma tumor aggressiveness. Oncology Letters, 15, 4604-4610. https://doi.org/10.3892/ol.2018.7889
MLA
Wang, X., Wu, C., Yuan, B., Wang, D., Liu, H., Feng, H., Sun, S."Low scavenger receptor class B type I expression is associated with gastric adenocarcinoma tumor aggressiveness". Oncology Letters 15.4 (2018): 4604-4610.
Chicago
Wang, X., Wu, C., Yuan, B., Wang, D., Liu, H., Feng, H., Sun, S."Low scavenger receptor class B type I expression is associated with gastric adenocarcinoma tumor aggressiveness". Oncology Letters 15, no. 4 (2018): 4604-4610. https://doi.org/10.3892/ol.2018.7889